NPJ Schizophrenia最新文献_第8页

Author Correction: Understanding communicative intentions in schizophrenia using an error analysis approach. 作者更正:使用错误分析方法理解精神分裂症的沟通意图。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-04-30 DOI: 10.1038/s41537-021-00152-5

Alberto Parola, Claudio Brasso, Rosalba Morese, Paola Rocca, Francesca M Bosco

引用次数: 0

Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health. 精神分裂症患者自主神经系统功能障碍:对认知和代谢健康的影响。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-04-26 DOI: 10.1038/s41537-021-00151-6

Nicolette Stogios, Alexander Gdanski, Philip Gerretsen, Araba F Chintoh, Ariel Graff-Guerrero, Tarek K Rajji, Gary Remington, Margaret K Hahn, Sri Mahavir Agarwal

{"title":"Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health.","authors":"Nicolette Stogios, Alexander Gdanski, Philip Gerretsen, Araba F Chintoh, Ariel Graff-Guerrero, Tarek K Rajji, Gary Remington, Margaret K Hahn, Sri Mahavir Agarwal","doi":"10.1038/s41537-021-00151-6","DOIUrl":"https://doi.org/10.1038/s41537-021-00151-6","url":null,"abstract":"Schizophrenia (SCZ) is a psychiatric disorder characterized by a wide range of positive, negative and cognitive symptoms, along with an increased risk of metabolic syndrome and cardiovascular disease that contribute to a 15-20-year reduced life expectancy. Autonomic dysfunction, in the form of increased sympathetic activity and decreased parasympathetic activity, is postulated to be implicated in SCZ and its treatment. The aim of this narrative review is to view SCZ through an autonomic lens and synthesize the evidence relating autonomic dysfunction to different domains of SCZ. Using various methods of assessing autonomic activity, autonomic dysfunction was found to be associated with multiple aspects of SCZ pathophysiology, including symptom severity, cognitive impairment, and the development of cardiometabolic comorbidities, such as metabolic syndrome and high BMI. The strongest association of low heart rate variability was noted among patients on antipsychotic treatment with high-affinity muscarinic antagonism (i.e., clozapine, olanzapine and quetiapine). The review will also suggest ways in which studying autonomic dysfunction can help reduce morbidity and mortality associated with SCZ and its treatment.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":" ","pages":"22"},"PeriodicalIF":5.4,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41537-021-00151-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38912358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Association of visual motor processing and social cognition in schizophrenia. 精神分裂症患者视觉运动加工与社会认知的关系。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-04-13 DOI: 10.1038/s41537-021-00150-7

Pin-Yen Lu, Yu-Lien Huang, Pai-Chuan Huang, Yi-Chia Liu, Shyh-Yuh Wei, Wei-Yun Hsu, Kao Chin Chen, Po See Chen, Wen-Chen Wu, Yen Kuang Yang, Huai-Hsuan Tseng

{"title":"Association of visual motor processing and social cognition in schizophrenia.","authors":"Pin-Yen Lu, Yu-Lien Huang, Pai-Chuan Huang, Yi-Chia Liu, Shyh-Yuh Wei, Wei-Yun Hsu, Kao Chin Chen, Po See Chen, Wen-Chen Wu, Yen Kuang Yang, Huai-Hsuan Tseng","doi":"10.1038/s41537-021-00150-7","DOIUrl":"https://doi.org/10.1038/s41537-021-00150-7","url":null,"abstract":"Patients with schizophrenia have difficulties in social cognitive domains including emotion recognition and mentalization, and in sensorimotor processing and learning. The relationship between social cognitive deficits and sensorimotor function in patients with schizophrenia remains largely unexplored. With the hypothesis that impaired visual motor processing may decelerate information processing and subsequently affects various domains of social cognition, we examined the association of nonverbal emotion recognition, mentalization, and visual motor processing in schizophrenia. The study examined mentalization using the verbal subset of the Chinese version of Theory of Mind (CToM) Task, an equivalent task of the Faux Pas Test; emotion recognition using the Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version (DANVA-2-TW), and visual motor processing using a joystick tracking task controlled for basic motor function in 34 individuals with chronic schizophrenia in the community and 42 healthy controls. Patients with schizophrenia had significantly worse performance than healthy controls in social cognition, including facial, prosodic emotion recognition, and mentalization. Visual motor processing was also significantly worse in patients with schizophrenia. Only in patients with schizophrenia, both emotion recognition (mainly in prosodic modality, happy, and sad emotions) and mentalization were positively associated with their learning capacity of visual motor processing. These findings suggest a prospective role of sensorimotor function in their social cognitive deficits. Despite that the underlying neural mechanism needs further research, our findings may provide a new direction for restoration of social cognitive function in schizophrenia by enhancing visual motor processing ability.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":" ","pages":"21"},"PeriodicalIF":5.4,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41537-021-00150-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25597618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia. 药物治疗早期精神分裂症患者语言网络连接障碍的遗传决定因素。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-03-03 DOI: 10.1038/s41537-021-00141-8

Jingnan Du, Lena Palaniyappan, Zhaowen Liu, Wei Cheng, Weikang Gong, Mengmeng Zhu, Jijun Wang, Jie Zhang, Jianfeng Feng

{"title":"The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia.","authors":"Jingnan Du, Lena Palaniyappan, Zhaowen Liu, Wei Cheng, Weikang Gong, Mengmeng Zhu, Jijun Wang, Jie Zhang, Jianfeng Feng","doi":"10.1038/s41537-021-00141-8","DOIUrl":"10.1038/s41537-021-00141-8","url":null,"abstract":"Schizophrenia is a neurocognitive illness of synaptic and brain network-level dysconnectivity that often reaches a persistent chronic stage in many patients. Subtle language deficits are a core feature even in the early stages of schizophrenia. However, the primacy of language network dysconnectivity and language-related genetic variants in the observed phenotype in early stages of illness remains unclear. This study used two independent schizophrenia dataset consisting of 138 and 53 drug-naïve first-episode schizophrenia (FES) patients, and 112 and 56 healthy controls, respectively. A brain-wide voxel-level functional connectivity analysis was conducted to investigate functional dysconnectivity and its relationship with illness duration. We also explored the association between critical language-related genetic (such as FOXP2) mutations and the altered functional connectivity in patients. We found elevated functional connectivity involving Broca's area, thalamus and temporal cortex that were replicated in two FES datasets. In particular, Broca's area - anterior cingulate cortex dysconnectivity was more pronounced for patients with shorter illness duration, while thalamic dysconnectivity was predominant in those with longer illness duration. Polygenic risk scores obtained from FOXP2-related genes were strongly associated with functional dysconnectivity identified in patients with shorter illness duration. Our results highlight the criticality of language network dysconnectivity, involving the Broca's area in early stages of schizophrenia, and the role of language-related genes in this aberration, providing both imaging and genetic evidence for the association between schizophrenia and the determinants of language.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":"7 1","pages":"18"},"PeriodicalIF":5.4,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9185486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading. 高基因负荷精神分裂症患者未受影响亲属的后内侧皮质皮质回旋减少。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-03-01 DOI: 10.1038/s41537-021-00148-1

Inkyung Park, Minah Kim, Tae Young Lee, Wu Jeong Hwang, Yoo Bin Kwak, Sanghoon Oh, Silvia Kyungjin Lho, Sun-Young Moon, Jun Soo Kwon

{"title":"Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading.","authors":"Inkyung Park, Minah Kim, Tae Young Lee, Wu Jeong Hwang, Yoo Bin Kwak, Sanghoon Oh, Silvia Kyungjin Lho, Sun-Young Moon, Jun Soo Kwon","doi":"10.1038/s41537-021-00148-1","DOIUrl":"https://doi.org/10.1038/s41537-021-00148-1","url":null,"abstract":"Although abnormal cortical gyrification has been consistently reported in patients with schizophrenia, whether gyrification abnormalities reflect a genetic risk for the disorder remains unknown. This study investigated differences in cortical gyrification between unaffected relatives (URs) with high genetic loading for schizophrenia and healthy controls (HCs) to identify potential genetic vulnerability markers. A total of 50 URs of schizophrenia patients and 50 matched HCs underwent T1-weighted magnetic resonance imaging to compare whole-brain gyrification using the local gyrification index (lGI). Then, the lGI clusters showing significant differences were compared between the UR subgroups based on the number of first-degree relatives with schizophrenia to identify the effect of genetic loading on cortical gyrification changes. The URs exhibited significantly lower cortical gyrification than the HCs in clusters including medial parieto-occipital and cingulate regions comprising the bilateral precuneus, cuneus, pericalcarine, lingual, isthmus cingulate, and posterior cingulate gyri. Moreover, URs who had two or more first-degree relatives with schizophrenia showed greater gyrification reductions in these clusters than those who had at least one first-degree relative with schizophrenia. Our findings of reduced gyrification in URs, which are consistent with accumulated evidence of hypogyria observed in regions showing patient-control differences in previous studies, highlight that such hypogyria in posteromedial regions may serve as a genetic vulnerability marker and reflect early neurodevelopmental abnormalities resulting from a genetic risk for schizophrenia.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":" ","pages":"17"},"PeriodicalIF":5.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41537-021-00148-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25419164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The impact of creativity on functional outcome in schizophrenia: a mediational model. 创造力对精神分裂症功能结果的影响：一个中介模型。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00144-5

Agurne Sampedro, Javier Peña, Pedro Sánchez, Naroa Ibarretxe-Bilbao, Nagore Iriarte-Yoller, Cristóbal Pavón, Isabel Hervella, Mikel Tous-Espelosin, Natalia Ojeda

{"title":"The impact of creativity on functional outcome in schizophrenia: a mediational model.","authors":"Agurne Sampedro, Javier Peña, Pedro Sánchez, Naroa Ibarretxe-Bilbao, Nagore Iriarte-Yoller, Cristóbal Pavón, Isabel Hervella, Mikel Tous-Espelosin, Natalia Ojeda","doi":"10.1038/s41537-021-00144-5","DOIUrl":"10.1038/s41537-021-00144-5","url":null,"abstract":"Functional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively impact functional outcome, such as creativity, which is considered an adaptive capacity for real-life problem-solving. This study analyzed the predictive role of creativity on functional outcome in 96 patients with schizophrenia through a mediational model, including sociodemographic, clinical, neurocognitive, and social cognitive variables. Path analysis revealed that creativity significantly mediated the relationship between neurocognition and functional outcome, and that creativity mediated between negative symptoms and functional outcome. Additionally, neurocognition was directly associated with functional outcome and social functioning was associated with creativity. The involvement of creativity in functional outcome could have relevant implications for the development of new interventions. These findings open up a new field of research on additional personal resources as possible factors of functional outcome in schizophrenia and other diseases.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":"7 1","pages":"14"},"PeriodicalIF":5.4,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10684146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Avolition as the core negative symptom in schizophrenia: relevance to pharmacological treatment development. 作为精神分裂症核心阴性症状的妄想：与药物治疗发展的相关性。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00145-4

Gregory P Strauss, Lisa A Bartolomeo, Philip D Harvey

引用次数: 0

DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity. DNA水解IgG催化抗体:精神病和自身免疫之间的新联系。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00143-6

Rajendran Ramesh, Aparna Sundaresh, Ravi Philip Rajkumar, Vir Singh Negi, M A Vijayalakshmi, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, A S Kamalanathan

{"title":"DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity.","authors":"Rajendran Ramesh, Aparna Sundaresh, Ravi Philip Rajkumar, Vir Singh Negi, M A Vijayalakshmi, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, A S Kamalanathan","doi":"10.1038/s41537-021-00143-6","DOIUrl":"https://doi.org/10.1038/s41537-021-00143-6","url":null,"abstract":"It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":" ","pages":"13"},"PeriodicalIF":5.4,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41537-021-00143-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25409306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Understanding communicative intentions in schizophrenia using an error analysis approach. 利用错误分析方法了解精神分裂症患者的交际意图。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00142-7

Alberto Parola, Claudio Brasso, Rosalba Morese, Paola Rocca, Francesca M Bosco

{"title":"Understanding communicative intentions in schizophrenia using an error analysis approach.","authors":"Alberto Parola, Claudio Brasso, Rosalba Morese, Paola Rocca, Francesca M Bosco","doi":"10.1038/s41537-021-00142-7","DOIUrl":"10.1038/s41537-021-00142-7","url":null,"abstract":"Patients with schizophrenia (SCZ) have a core impairment in the communicative-pragmatic domain, characterized by severe difficulties in correctly inferring the speaker's communicative intentions. While several studies have investigated pragmatic performance of patients with SCZ, little research has analyzed the errors committed in the comprehension of different communicative acts. The present research investigated error patterns in 24 patients with SCZ and 24 healthy controls (HC) during a task assessing the comprehension of different communicative acts, i.e., sincere, deceitful and ironic, and their relationship with the clinical features of SCZ. We used signal detection analysis to quantify participants' ability to correctly detect the speakers' communicative intention, i.e., sensitivity, and their tendency to wrongly perceive a communicative intention when not present, i.e., response bias. Further, we investigated the relationship between sensitivity and response bias, and the clinical features of the disorder, namely symptom severity, pharmacotherapy, and personal and social functioning. The results showed that the ability to infer the speaker's communicative intention is impaired in SCZ, as patients exhibited lower sensitivity, compared to HC, for all the pragmatic phenomena evaluated, i.e., sincere, deceitful, and ironic communicative acts. Further, we found that the sensitivity measure for irony was related to disorganized/concrete symptoms. Moreover, patients with SCZ showed a stronger response bias for deceitful communicative acts compared to HC: when committing errors, they tended to misattribute deceitful intentions more often than sincere and ironic ones. This tendency to misattribute deceitful communicative intentions may be related to the attributional bias characterizing the disorder.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":"7 1","pages":"12"},"PeriodicalIF":5.4,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10631106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early intervention in psychiatry through a developmental perspective. 从发展的角度对精神病学进行早期干预。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-12 DOI: 10.1038/s41537-021-00137-4

Michele Poletti, Andrea Raballo

引用次数: 2