NPJ Schizophrenia最新文献_第9页

The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia. 药物治疗早期精神分裂症患者语言网络连接障碍的遗传决定因素。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-03-03 DOI: 10.1038/s41537-021-00141-8

Jingnan Du, Lena Palaniyappan, Zhaowen Liu, Wei Cheng, Weikang Gong, Mengmeng Zhu, Jijun Wang, Jie Zhang, Jianfeng Feng

{"title":"The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia.","authors":"Jingnan Du, Lena Palaniyappan, Zhaowen Liu, Wei Cheng, Weikang Gong, Mengmeng Zhu, Jijun Wang, Jie Zhang, Jianfeng Feng","doi":"10.1038/s41537-021-00141-8","DOIUrl":"10.1038/s41537-021-00141-8","url":null,"abstract":"Schizophrenia is a neurocognitive illness of synaptic and brain network-level dysconnectivity that often reaches a persistent chronic stage in many patients. Subtle language deficits are a core feature even in the early stages of schizophrenia. However, the primacy of language network dysconnectivity and language-related genetic variants in the observed phenotype in early stages of illness remains unclear. This study used two independent schizophrenia dataset consisting of 138 and 53 drug-naïve first-episode schizophrenia (FES) patients, and 112 and 56 healthy controls, respectively. A brain-wide voxel-level functional connectivity analysis was conducted to investigate functional dysconnectivity and its relationship with illness duration. We also explored the association between critical language-related genetic (such as FOXP2) mutations and the altered functional connectivity in patients. We found elevated functional connectivity involving Broca's area, thalamus and temporal cortex that were replicated in two FES datasets. In particular, Broca's area - anterior cingulate cortex dysconnectivity was more pronounced for patients with shorter illness duration, while thalamic dysconnectivity was predominant in those with longer illness duration. Polygenic risk scores obtained from FOXP2-related genes were strongly associated with functional dysconnectivity identified in patients with shorter illness duration. Our results highlight the criticality of language network dysconnectivity, involving the Broca's area in early stages of schizophrenia, and the role of language-related genes in this aberration, providing both imaging and genetic evidence for the association between schizophrenia and the determinants of language.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9185486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory. 精神分裂症患者在外显记忆过程中长轴海马亚区的功能连接异常

IF 5.7 2区医学

NPJ Schizophrenia Pub Date : 2021-03-03 DOI: 10.1038/s41537-021-00147-2

Jules R Dugré, Alexandre Dumais, Andras Tikasz, Adriana Mendrek, Stéphane Potvin

{"title":"Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory.","authors":"Jules R Dugré, Alexandre Dumais, Andras Tikasz, Adriana Mendrek, Stéphane Potvin","doi":"10.1038/s41537-021-00147-2","DOIUrl":"10.1038/s41537-021-00147-2","url":null,"abstract":"Past evidence suggests that hippocampal subregions, namely the anterior and posterior parts, may be engaged in distinct networks underlying the memory functions which may be altered in patients with schizophrenia. However, of the very few studies that have investigated the hippocampal longitudinal axis subdivisions functional connectivity in patients with schizophrenia, the majority was based on resting-state data, and yet, none aimed to examine these during an episodic memory task. A total of 41 patients with schizophrenia and 45 healthy controls were recruited for a magnetic resonance imaging protocol in which they performed an explicit memory task. Seed-based functional connectivity analysis was employed to assess connectivity abnormalities between hippocampal subregions and voxel-wise connectivity targets in patients with schizophrenia. We observed a significantly reduced connectivity between the posterior hippocampus and regions from the default mode network, but increased connectivity with the primary visual cortex, in patients with schizophrenia compared to healthy subjects. Increased connectivity between the anterior hippocampus and anterior temporal regions also characterized patients with schizophrenia. In the current study, we provided evidence and support for studying hippocampal subdivisions along the longitudinal axis in schizophrenia. Our results suggest that the abnormalities in hippocampal subregions functional connectivity reflect deficits in episodic memory that may be implicated in the pathophysiology of schizophrenia.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25433825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading. 高基因负荷精神分裂症患者未受影响亲属的后内侧皮质皮质回旋减少。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-03-01 DOI: 10.1038/s41537-021-00148-1

Inkyung Park, Minah Kim, Tae Young Lee, Wu Jeong Hwang, Yoo Bin Kwak, Sanghoon Oh, Silvia Kyungjin Lho, Sun-Young Moon, Jun Soo Kwon

{"title":"Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading.","authors":"Inkyung Park, Minah Kim, Tae Young Lee, Wu Jeong Hwang, Yoo Bin Kwak, Sanghoon Oh, Silvia Kyungjin Lho, Sun-Young Moon, Jun Soo Kwon","doi":"10.1038/s41537-021-00148-1","DOIUrl":"https://doi.org/10.1038/s41537-021-00148-1","url":null,"abstract":"Although abnormal cortical gyrification has been consistently reported in patients with schizophrenia, whether gyrification abnormalities reflect a genetic risk for the disorder remains unknown. This study investigated differences in cortical gyrification between unaffected relatives (URs) with high genetic loading for schizophrenia and healthy controls (HCs) to identify potential genetic vulnerability markers. A total of 50 URs of schizophrenia patients and 50 matched HCs underwent T1-weighted magnetic resonance imaging to compare whole-brain gyrification using the local gyrification index (lGI). Then, the lGI clusters showing significant differences were compared between the UR subgroups based on the number of first-degree relatives with schizophrenia to identify the effect of genetic loading on cortical gyrification changes. The URs exhibited significantly lower cortical gyrification than the HCs in clusters including medial parieto-occipital and cingulate regions comprising the bilateral precuneus, cuneus, pericalcarine, lingual, isthmus cingulate, and posterior cingulate gyri. Moreover, URs who had two or more first-degree relatives with schizophrenia showed greater gyrification reductions in these clusters than those who had at least one first-degree relative with schizophrenia. Our findings of reduced gyrification in URs, which are consistent with accumulated evidence of hypogyria observed in regions showing patient-control differences in previous studies, highlight that such hypogyria in posteromedial regions may serve as a genetic vulnerability marker and reflect early neurodevelopmental abnormalities resulting from a genetic risk for schizophrenia.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41537-021-00148-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25419164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The impact of creativity on functional outcome in schizophrenia: a mediational model. 创造力对精神分裂症功能结果的影响：一个中介模型。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00144-5

Agurne Sampedro, Javier Peña, Pedro Sánchez, Naroa Ibarretxe-Bilbao, Nagore Iriarte-Yoller, Cristóbal Pavón, Isabel Hervella, Mikel Tous-Espelosin, Natalia Ojeda

{"title":"The impact of creativity on functional outcome in schizophrenia: a mediational model.","authors":"Agurne Sampedro, Javier Peña, Pedro Sánchez, Naroa Ibarretxe-Bilbao, Nagore Iriarte-Yoller, Cristóbal Pavón, Isabel Hervella, Mikel Tous-Espelosin, Natalia Ojeda","doi":"10.1038/s41537-021-00144-5","DOIUrl":"10.1038/s41537-021-00144-5","url":null,"abstract":"Functional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively impact functional outcome, such as creativity, which is considered an adaptive capacity for real-life problem-solving. This study analyzed the predictive role of creativity on functional outcome in 96 patients with schizophrenia through a mediational model, including sociodemographic, clinical, neurocognitive, and social cognitive variables. Path analysis revealed that creativity significantly mediated the relationship between neurocognition and functional outcome, and that creativity mediated between negative symptoms and functional outcome. Additionally, neurocognition was directly associated with functional outcome and social functioning was associated with creativity. The involvement of creativity in functional outcome could have relevant implications for the development of new interventions. These findings open up a new field of research on additional personal resources as possible factors of functional outcome in schizophrenia and other diseases.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10684146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Avolition as the core negative symptom in schizophrenia: relevance to pharmacological treatment development. 作为精神分裂症核心阴性症状的妄想：与药物治疗发展的相关性。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00145-4

Gregory P Strauss, Lisa A Bartolomeo, Philip D Harvey

引用次数: 0

DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity. DNA水解IgG催化抗体:精神病和自身免疫之间的新联系。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00143-6

Rajendran Ramesh, Aparna Sundaresh, Ravi Philip Rajkumar, Vir Singh Negi, M A Vijayalakshmi, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, A S Kamalanathan

{"title":"DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity.","authors":"Rajendran Ramesh, Aparna Sundaresh, Ravi Philip Rajkumar, Vir Singh Negi, M A Vijayalakshmi, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, A S Kamalanathan","doi":"10.1038/s41537-021-00143-6","DOIUrl":"https://doi.org/10.1038/s41537-021-00143-6","url":null,"abstract":"It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41537-021-00143-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25409306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Understanding communicative intentions in schizophrenia using an error analysis approach. 利用错误分析方法了解精神分裂症患者的交际意图。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00142-7

Alberto Parola, Claudio Brasso, Rosalba Morese, Paola Rocca, Francesca M Bosco

{"title":"Understanding communicative intentions in schizophrenia using an error analysis approach.","authors":"Alberto Parola, Claudio Brasso, Rosalba Morese, Paola Rocca, Francesca M Bosco","doi":"10.1038/s41537-021-00142-7","DOIUrl":"10.1038/s41537-021-00142-7","url":null,"abstract":"Patients with schizophrenia (SCZ) have a core impairment in the communicative-pragmatic domain, characterized by severe difficulties in correctly inferring the speaker's communicative intentions. While several studies have investigated pragmatic performance of patients with SCZ, little research has analyzed the errors committed in the comprehension of different communicative acts. The present research investigated error patterns in 24 patients with SCZ and 24 healthy controls (HC) during a task assessing the comprehension of different communicative acts, i.e., sincere, deceitful and ironic, and their relationship with the clinical features of SCZ. We used signal detection analysis to quantify participants' ability to correctly detect the speakers' communicative intention, i.e., sensitivity, and their tendency to wrongly perceive a communicative intention when not present, i.e., response bias. Further, we investigated the relationship between sensitivity and response bias, and the clinical features of the disorder, namely symptom severity, pharmacotherapy, and personal and social functioning. The results showed that the ability to infer the speaker's communicative intention is impaired in SCZ, as patients exhibited lower sensitivity, compared to HC, for all the pragmatic phenomena evaluated, i.e., sincere, deceitful, and ironic communicative acts. Further, we found that the sensitivity measure for irony was related to disorganized/concrete symptoms. Moreover, patients with SCZ showed a stronger response bias for deceitful communicative acts compared to HC: when committing errors, they tended to misattribute deceitful intentions more often than sincere and ironic ones. This tendency to misattribute deceitful communicative intentions may be related to the attributional bias characterizing the disorder.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10631106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients. 从未接受过药物治疗的首发精神病患者与新奇相关的θ振荡和P3a受损。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-26 DOI: 10.1038/s41537-021-00146-3

Rodolfo Solís-Vivanco, Alejandra Mondragón-Maya, Francisco Reyes-Madrigal, Camilo de la Fuente-Sandoval

{"title":"Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients.","authors":"Rodolfo Solís-Vivanco, Alejandra Mondragón-Maya, Francisco Reyes-Madrigal, Camilo de la Fuente-Sandoval","doi":"10.1038/s41537-021-00146-3","DOIUrl":"10.1038/s41537-021-00146-3","url":null,"abstract":"We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acquisition. Time-frequency representations of power, phase locking, and fronto-parietal connectivity were calculated. The P3a event-related potential was extracted as well. Compared to controls, the FEP group showed reduced theta phase-locking and fronto-parietal connectivity evoked by deviant stimuli. Also, the P3a amplitude was significantly reduced. Moreover, reduced theta connectivity was associated with more severe negative symptoms within the FEP group. Reduced activity (phase-locking and connectivity) of novelty-related theta oscillations, along with P3a reduction, may represent a failure to synchronize large-scale neural populations closely related to fronto-parietal attentional networks, and might be explored as a potential biomarker of disease severity in patients with emerging psychosis, given its association with negative symptoms.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25410675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of self-assessment of real-life functioning in schizophrenia. 精神分裂症患者现实生活功能自我评估的准确性。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-15 DOI: 10.1038/s41537-021-00140-9

Paola Rocca, Claudio Brasso, Cristiana Montemagni, Silvio Bellino, Alessandro Rossi, Alessandro Bertolino, Dino Gibertoni, Eugenio Aguglia, Mario Amore, Ileana Andriola, Antonello Bellomo, Paola Bucci, Antonino Buzzanca, Bernardo Carpiniello, Alessandro Cuomo, Liliana Dell'Osso, Angela Favaro, Giulia Maria Giordano, Carlo Marchesi, Palmiero Monteleone, Lucio Oldani, Maurizio Pompili, Rita Roncone, Rodolfo Rossi, Alberto Siracusano, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj

{"title":"Accuracy of self-assessment of real-life functioning in schizophrenia.","authors":"Paola Rocca, Claudio Brasso, Cristiana Montemagni, Silvio Bellino, Alessandro Rossi, Alessandro Bertolino, Dino Gibertoni, Eugenio Aguglia, Mario Amore, Ileana Andriola, Antonello Bellomo, Paola Bucci, Antonino Buzzanca, Bernardo Carpiniello, Alessandro Cuomo, Liliana Dell'Osso, Angela Favaro, Giulia Maria Giordano, Carlo Marchesi, Palmiero Monteleone, Lucio Oldani, Maurizio Pompili, Rita Roncone, Rodolfo Rossi, Alberto Siracusano, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj","doi":"10.1038/s41537-021-00140-9","DOIUrl":"10.1038/s41537-021-00140-9","url":null,"abstract":"A consensus has not yet been reached regarding the accuracy of people with schizophrenia in self-reporting their real-life functioning. In a large (n = 618) cohort of stable, community-dwelling schizophrenia patients we sought to: (1) examine the concordance of patients' reports of their real-life functioning with the reports of their key caregiver; (2) identify which patient characteristics are associated to the differences between patients and informants. Patient-caregiver concordance of the ratings in three Specific Level of Functioning Scale (SLOF) domains (interpersonal relationships, everyday life skills, work skills) was evaluated with matched-pair t tests, the Lin's concordance correlation, Somers' D, and Bland-Altman plots with limits of agreement (LOA). Predictors of the patient-caregiver differences in SLOF ratings were assessed with a linear regression with multivariable fractional polynomials. Patients' self-evaluation of functioning was higher than caregivers' in all the evaluated domains of the SLOF and 17.6% of the patients exceeded the LOA, thus providing a self-evaluation discordant from their key caregivers. The strongest predictors of patient-caregiver discrepancies were caregivers' ratings in each SLOF domain. In clinically stable outpatients with a moderate degree of functional impairment, self-evaluation with the SLOF scale can become a useful, informative and reliable clinical tool to design a tailored rehabilitation program.","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41537-021-00140-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25371576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Early intervention in psychiatry through a developmental perspective. 从发展的角度对精神病学进行早期干预。

IF 5.4 2区医学

NPJ Schizophrenia Pub Date : 2021-02-12 DOI: 10.1038/s41537-021-00137-4

Michele Poletti, Andrea Raballo

引用次数: 2