Nihon saikingaku zasshi. Japanese journal of bacteriology最新文献_第5页

[Study on the interaction between Clostridium perfringens and the host]. [产气荚膜梭菌与宿主相互作用研究]。

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2021-01-01 DOI: 10.3412/jsb.76.149

Masaya Takehara

{"title":"[Study on the interaction between Clostridium perfringens and the host].","authors":"Masaya Takehara","doi":"10.3412/jsb.76.149","DOIUrl":"https://doi.org/10.3412/jsb.76.149","url":null,"abstract":"Clostridium perfringens type A causes gas gangrene, which is a serious disease caused by wound infection. α-Toxin produced by C. perfringens is known to be the primary pathogenic factor of gas gangrene. Although it has been proposed to induce tissue damage by impairing the host immune system and peripheral circulation, sufficient findings have not been obtained to explain the high virulence of C. perfringens. For the purpose of elucidating the pathogenic mechanism of this bacterium, I focused on the disease progressions such as the bacterial colonization, muscle tissue destruction and repair, and sepsis. In this review, focusing on the action of α-toxin, it will be explained together with the latest research results that the toxin suppresses the activation of the host immune response, represents toxicity to vascular endothelial cells, induces peripheral circulatory disorders due to hematopoietic disorders, inhibits muscle tissue repair, and induces excessive immune response. These mechanisms suggest that α-toxin acts in multiple steps to disrupt host defense and that C. perfringens attacks the host with a highly sophisticated mechanism. It is expected that the onset mechanism of gas gangrene would be elucidated, and I hope that new therapeutic strategies are developed.","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39899885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Keynote Lecture].

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2021-01-01 DOI: 10.3412/jsb.76.3

引用次数: 0

[Special Lecture].

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2021-01-01 DOI: 10.3412/jsb.76.4

引用次数: 0

[Studies on the biological activities and emetic mechanism of staphylococcal enterotoxins]. 【葡萄球菌肠毒素的生物活性及催吐机制研究】。

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2021-01-01 DOI: 10.3412/jsb.76.139

Hisaya Ono

{"title":"[Studies on the biological activities and emetic mechanism of staphylococcal enterotoxins].","authors":"Hisaya Ono","doi":"10.3412/jsb.76.139","DOIUrl":"https://doi.org/10.3412/jsb.76.139","url":null,"abstract":"Staphylococcus aureus food poisoning was shown by Dack et al. in 1930 to be caused by staphylococcal enterotoxin (SE) produced by S. aureus, rather than by the bacterial infection. However, the emetic mechanism of SE has remained unclear. In this study, we analyzed the emetic activity of SE in several emetic animal models and tried to elucidate the mechanism of emesis. We established a small primate, common marmoset, as a novel emetic model for SE. We also analyzed the immunofluorescence analysis of the gastrointestinal tract of the common marmoset and found that SE binds to submucosal mast cells in the gastrointestinal tract and SE induces degranulation of the mast cells. Furthermore, we showed that SE induces histamine releases, which is inhibited by mast cell stabilizer. In addition, treatment of common marmosets with either mast cell stabilizer or histamine H1 receptor antagonists suppressed the emetic response induced by SE. These results indicate that orally administered SE binds to submucosal mast cells in the gastrointestinal tract and causes degranulation, resulting in the release of histamine, which in turn causes emesis.","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39021850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sponsor On-demand Presentation]. [赞助商点播演讲]。

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2021-01-01 DOI: 10.3412/jsb.76.127

引用次数: 0

[Bacteriological analysis of therapeutic important antimicrobial resistance]. [治疗性重要抗菌素耐药性细菌学分析]。

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2021-01-01 DOI: 10.3412/jsb.76.161

Toyotaka Sato

{"title":"[Bacteriological analysis of therapeutic important antimicrobial resistance].","authors":"Toyotaka Sato","doi":"10.3412/jsb.76.161","DOIUrl":"https://doi.org/10.3412/jsb.76.161","url":null,"abstract":"Antimicrobial resistance in bacterial infections is a major concern for clinical settings. In recent years, the number of Extended-spectrum β-lactamase producing (ESBL)- and fluoroquinolones (FQ)-resistant Escherichia coli has been increasing in Japan, especially against third-generation cephalosporins and FQs, which are frequently used in medical practice. On the other hand, antimicrobial agents such as tazobactam-piperacillin, colistin, and tigecycline, which are not general-purpose agents but last-line drugs for multidrug-resistant bacteria, are also important. Enterobacteriaceae that are resistant to these antimicrobials have been reported, although the isolation rate of resistant bacteria is lower than that of frequent used antimicrobial resistance. The author has been studying antimicrobial drug resistance and multidrug resistance of bacteria isolated from clinical settings. In particular, bacteriological analysis of antimicrobial resistance, which is important for treatment, has been conducted mainly on E. coli isolated from clinical specimens at medical facilities in Sapporo City. In this article, the author describes the findings obtained so far.","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39899886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Commensal bacteria prevent pathogenic bacterial infection by inducing of activation of host immune system]. [共生菌通过诱导宿主免疫系统的激活来预防致病菌感染]。

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2020-01-01 DOI: 10.3412/jsb.75.185

Yoshiyuki Goto

{"title":"[Commensal bacteria prevent pathogenic bacterial infection by inducing of activation of host immune system].","authors":"Yoshiyuki Goto","doi":"10.3412/jsb.75.185","DOIUrl":"https://doi.org/10.3412/jsb.75.185","url":null,"abstract":"Countless numbers of bacteria inhabit the intestinal tract. One of the important functions of gut microbiota is the \"colonization resistance\" against infection by pathogenic microorganisms. However, detailed mechanism of the colonization resistance of intestinal bacteria is still largely unknown. We tried to identify molecular and cellular mechanism of it and found that antigen presentation by dendritic cells is required for the induction of intestinal segmented filamentous bacteria (SFB)-induced T helper 17 (Th17) cells that contribute to the protection against infection by Citrobacter rodentium. We further identified that gut Th17 cells selectively recognize antigens derived from SFB. We also revealed that SFB induce α1,2-fucose, one of carbohydrate chains, expressed on the intestinal epithelial cells mediated by group 3 innate lymphoid cells. Epithelial α1,2-fucose protected against infection by pathogenic bacterium Salmonella typhimurium. Furthermore, it was found that intestinal bacteria inhibit colonization of the pathogenic fungus Candida albicans as well as pathogenic bacteria. From these studies, detailed mechanism of \"colonization resistance\" against pathogenic microorganisms by intestinal bacteria has been clarified.","PeriodicalId":19308,"journal":{"name":"Nihon saikingaku zasshi. Japanese journal of bacteriology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38750025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

[Mechanisms of action of Vibrio parahaemoltyicus cytotoxins]. 副溶血性弧菌细胞毒素的作用机制

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2020-01-01 DOI: 10.3412/jsb.75.215

Shigeaki Matsuda

引用次数: 0

[Poster]. (海报)。

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2020-01-01 DOI: 10.3412/jsb.75.60

Poki Tse, A. Lines, S. Bryan, J. Shafer

引用次数: 0

[Flagellar related genes and functions in Vibrio]. [弧菌中鞭毛相关基因和功能]。

Nihon saikingaku zasshi. Japanese journal of bacteriology Pub Date : 2020-01-01 DOI: 10.3412/jsb.75.195

Tatsuro Nishikino, Seiji Kojima, Michio Homma

引用次数: 0