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Documento de consenso sobre técnicas neurosonológicas en cefaleas 关于脑部神经声波技术的协商一致文件
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2024.06.001
J. Rodríguez Vico , J. Fernández Domínguez , F.J. Julián Villaverde , N. González García , C. García-Cabo Fernández , A. Jaimes Sanchez , O. Ayo Martín , J.A. Membrilla López , R.G. Martínez Martín , J. García Ull , P. Martínez Sánchez , L. Dorado Bouix , R. Belvis Nieto , P. Irimia
{"title":"Documento de consenso sobre técnicas neurosonológicas en cefaleas","authors":"J. Rodríguez Vico ,&nbsp;J. Fernández Domínguez ,&nbsp;F.J. Julián Villaverde ,&nbsp;N. González García ,&nbsp;C. García-Cabo Fernández ,&nbsp;A. Jaimes Sanchez ,&nbsp;O. Ayo Martín ,&nbsp;J.A. Membrilla López ,&nbsp;R.G. Martínez Martín ,&nbsp;J. García Ull ,&nbsp;P. Martínez Sánchez ,&nbsp;L. Dorado Bouix ,&nbsp;R. Belvis Nieto ,&nbsp;P. Irimia","doi":"10.1016/j.nrl.2024.06.001","DOIUrl":"10.1016/j.nrl.2024.06.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Neurosonology is a medical discipline that utilizes ultrasound techniques to study the nervous system, with its applications progressively increasing. The indications and methodology for applying these techniques in patients with headaches are not well defined, thus there is a need for a consensus guideline, based on expert opinion, to standardize their application in clinical practice.</div></div><div><h3>Development</h3><div>Experts in headaches and neurosonology, appointed by the Headache Study Group of the Spanish Society of Neurology and the Spanish Society of Neurosonology, identified primary and secondary headaches where neurosonology has the greatest clinical application. A qualitative systematic review of the literature was conducted, based on available scientific evidence.</div></div><div><h3>Conclusions</h3><div>Cervical color duplex is considered a screening technique in patients with a high clinical suspicion of arterial dissection and may also be indicated for follow-up. Transcranial Doppler is a useful technique for evaluating the presence of vasospasm based on changes in mean flow velocity, and resistance and pulsatility indexes. Identification of the «halo sign» is highly specific for temporal arteritis. Measurement of the optic nerve sheath allows evaluation of the presence of intracranial hypertension. Finally, neurosonology may assist in occipital infiltration procedures or lumbar puncture and enables identification of changes in structures involved in the pathophysiology of migraine such as the periaqueductal gray matter and the raphe nuclei.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 599-607"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efecto de la combinación palidotomía-subtalamotomía realizada en hemisferios cerebrales opuestos para el tratamiento de los signos motores en la enfermedad de Parkinson 在对侧大脑半球实施苍白球-眼下肌联合切除术治疗帕金森病运动症状的效果
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.11.007
R.C. Braña Miranda , N.E. Quintanal Cordero , N. Pavón Fuentes , I. Pedroso Ibáñez , R. Macías González , C.J. Teijeiro Amador , A. Abreu Duque , R. Garbey Fernández
{"title":"Efecto de la combinación palidotomía-subtalamotomía realizada en hemisferios cerebrales opuestos para el tratamiento de los signos motores en la enfermedad de Parkinson","authors":"R.C. Braña Miranda ,&nbsp;N.E. Quintanal Cordero ,&nbsp;N. Pavón Fuentes ,&nbsp;I. Pedroso Ibáñez ,&nbsp;R. Macías González ,&nbsp;C.J. Teijeiro Amador ,&nbsp;A. Abreu Duque ,&nbsp;R. Garbey Fernández","doi":"10.1016/j.nrl.2023.11.007","DOIUrl":"10.1016/j.nrl.2023.11.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Functional neurosurgery constitutes a therapeutic alternative for patients with Parkinson's disease (PD). It is known that both bilateral subthalamotomy and bilateral pallidotomy cause neurological complications, so in ablative techniques a bilateral approach to the GPi is not recommended in PD and caution is suggested with the indication of bilateral subthalamotomy. Our group has refined the surgical technique for the ablation of the subthalamic nucleus seeking to reduce the appearance of dyskinesias induced by surgery and obtain a better therapeutic effect, so the approach to the NST in a second surgical procedure in the opposite hemisphere to the one performed previously pallidotomy, would avoid the complications derived from bilateral pallidotomy and can be a safe alternative for patients even when they present symptoms of dyskinesias. We set out to evaluate the effect and safety of the combination of GPi and NST lesion in opposite cerebral hemispheres in PD patients.</div></div><div><h3>Method</h3><div>A retrospective study was carried out that included all patients operated on at the CIREN in a period of 22 years, who underwent a pallidotomy contralateral to the most affected hemibody; followed by a subthalamotomy of the opposite hemisphere in a second surgical procedure. The effect on the neurological condition was evaluated using section III of the MDS-UPDRS scale. Safety was evaluated according to the adverse effects scale and the Clavien and Dindo scale.</div></div><div><h3>Results</h3><div>Both surgical interventions had a positive impact on the patients’ pharmacological treatment, significantly reducing the doses of L-dopa. A significant improvement was observed in the motor condition of the patients in relation to dyskinesias, as well as rigidity, bradykinesia and tremor.</div></div><div><h3>Conclusions</h3><div>The pallidotomy/Subthalamotomy combination showed to be an effective alternative for the treatment of complicated PD, capable of allowing better motor control and a reduction in the dose of L-Dopa with a low rate of complications; It also allows to avoid complications derived from bilateral pallidotomy and subthalamotomy, proving to be a safe alternative for patients even when they present symptoms of dyskinesias.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 518-532"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological quality of systematic reviews on treatments for Parkinson's disease: A cross-sectional study 帕金森氏病治疗系统评价的方法学质量:一项横断面研究
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.03.003
Y. Zhang , Y. Lin , C.C.W. Zhong , F.F. Ho , I.X.Y. Wu , C. Mao , X. Yang , V.C.H. Chung
{"title":"Methodological quality of systematic reviews on treatments for Parkinson's disease: A cross-sectional study","authors":"Y. Zhang ,&nbsp;Y. Lin ,&nbsp;C.C.W. Zhong ,&nbsp;F.F. Ho ,&nbsp;I.X.Y. Wu ,&nbsp;C. Mao ,&nbsp;X. Yang ,&nbsp;V.C.H. Chung","doi":"10.1016/j.nrl.2023.03.003","DOIUrl":"10.1016/j.nrl.2023.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Systematic reviews (SR) of high methodological quality can provide the best evidence for clinical practice. However, the methodological quality of SRs on Parkinson's disease treatments has not been evaluated comprehensively. The study aims to assess the methodological quality of a representative sample of SRs on Parkinson's disease treatments.</div></div><div><h3>Methods</h3><div>Four databases were searched to obtain potentially eligible SRs published between January 2016 and December 2021. A pre-designed questionnaire was used to extract the bibliographical characteristics of the included SRs. The AMSTAR-2 (Assessing the Methodological Quality of Systematic Reviews) tool was used to assess the methodological quality of SRs. Factors associated with methodological quality were assessed using multivariate regression analyses.</div></div><div><h3>Results</h3><div>A total of 119 eligible SRs were included and appraised. Only one SR (0.8%) was of high overall methodological quality. Four (3.4%) and 7 (5.9%) SRs were of moderate and low overall methodological quality, respectively. Among the appraised SRs, only 3 (2.5%) applied a comprehensive literature search strategy, 11 (9.2%) provided a list of excluded studies with justifications for exclusion, and 4 (3.4%) reported the sources of funding among the original studies included in the SR. Cochrane SRs and SRs published in journals with higher impact factors had relatively higher overall methodological quality.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that SRs on Parkinson's disease treatments are of low methodological quality. To enhance the quality and hence the trustworthiness of SRs, the protocols of future reviews should be designed and registered a priori, and researchers should conduct a comprehensive literature search, provide a list of excluded studies with justifications for exclusion, and report sources of funding for the included original studies.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 507-517"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valoración de la utilidad diagnóstica del electroencefalograma en urgencias pediátricas 评估脑电图在儿科急诊中的诊断效用
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2024.01.002
M.J. Abenza Abildúa , T. Olmedo Menchen , A. Pérez Villena , S. Ruhland Paulete , F. José Navacerrada Barrero , J. de Ojeda Ruíz de Luna , C. Algarra Lucas , G. Cordero Martín , S. Martínez Ubierna , C. Jimeno Montero , I.J. Navarro López , E. Suárez Gisbert , Á. Gómez de la Riva , C. Pérez López , M.L. Herreros Fernández
{"title":"Valoración de la utilidad diagnóstica del electroencefalograma en urgencias pediátricas","authors":"M.J. Abenza Abildúa ,&nbsp;T. Olmedo Menchen ,&nbsp;A. Pérez Villena ,&nbsp;S. Ruhland Paulete ,&nbsp;F. José Navacerrada Barrero ,&nbsp;J. de Ojeda Ruíz de Luna ,&nbsp;C. Algarra Lucas ,&nbsp;G. Cordero Martín ,&nbsp;S. Martínez Ubierna ,&nbsp;C. Jimeno Montero ,&nbsp;I.J. Navarro López ,&nbsp;E. Suárez Gisbert ,&nbsp;Á. Gómez de la Riva ,&nbsp;C. Pérez López ,&nbsp;M.L. Herreros Fernández","doi":"10.1016/j.nrl.2024.01.002","DOIUrl":"10.1016/j.nrl.2024.01.002","url":null,"abstract":"<div><h3>Introduction</h3><div>We analyze the diagnostic utility of urgent EEG (electroencephalogram) performed in children under 16 years of age in our center.</div></div><div><h3>Material and methods</h3><div>Descriptive, retrospective, observational study of consecutive patients from 0 to 16 years of age, who underwent an urgent EEG for any reason, from January to December 2022.</div></div><div><h3>Results</h3><div>Of the 388 patients, 70 were children: 37 (52.85%) women, and 33 (47.14%) men. Average age: 6.27<!--> <!-->±<!--> <!-->4.809. Of the 70 patients, 6 (8.57%) had previous epilepsy. Reasons for consultation: 17 febrile seizures, 10 first focal seizures, 10 first TCG seizures, 6 paroxysmal episodes, 6 absences, 3 myoclonus of extremities, 3 syncope, 2 SE, 2 visual alterations, 2 low level of consciousness, 2 cyanosis, 2 suspected meningitis or encephalitis, 1 choking, 1 atypical headache, 1 chorea, 1 presyncope, 1 language delay. Of the 70 patients, 47 had a normal EEG (67.14%). Of the 47 patients with a normal EEG, 10 were diagnosed with epilepsy, and 3 of them began receiving antiepileptic treatment upon discharge. None of the patients with suspected syncope or paroxysmal disorder (17 patients, 24.28%) had EEG abnormalities. Of the 17 patients with atypical febrile seizures, 3 had EEG abnormalities.</div></div><div><h3>Conclusions</h3><div>A third of the EEG records performed in the Emergency Department showed alterations, probably due to the time taken. Almost half of the patients with suspected epilepsy or EE showed EEG abnormalities, which confirmed the diagnosis in these cases and encouraged the clinician to start drug treatment. No case with a high suspicion of epilepsy was dismissed due to the normality of the EEG recording in our series. No patient diagnosed with syncope or paroxysmal disorder had EEG abnormalities. Nearly a quarter of patients with atypical febrile seizures showed EEG abnormalities. We barely register cases of status epilepticus, probably due to the degree of complexity of our center.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 499-506"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La carga económica de la migraña: un enfoque nacional del coste de la enfermedad desde la Encuesta Europea de Salud en España en el año 2020 偏头痛的经济负担:2020年西班牙欧洲健康调查以来对该疾病成本的国家方法
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.05.006
J. Fernández-Ferro , C. Ordás-Bandera , J. Rejas-Gutiérrez , B. Ferro-Rey , S. Gómez-Lus , J.M. Láinez Andrés
{"title":"La carga económica de la migraña: un enfoque nacional del coste de la enfermedad desde la Encuesta Europea de Salud en España en el año 2020","authors":"J. Fernández-Ferro ,&nbsp;C. Ordás-Bandera ,&nbsp;J. Rejas-Gutiérrez ,&nbsp;B. Ferro-Rey ,&nbsp;S. Gómez-Lus ,&nbsp;J.M. Láinez Andrés","doi":"10.1016/j.nrl.2023.05.006","DOIUrl":"10.1016/j.nrl.2023.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Migraine is a chronic highly disabling disease that manifests itself with recurrent episodes of headache. The objective of the study was to ascertain the cost-of-illness (COI) of migraine from the perspective of Society in Spain and to characterize its excess cost.</div></div><div><h3>Methods</h3><div>The nationwide year-2020 European-Health-Survey-in-Spain was used; 1,442 persons with migraine (77.3% women, 52.5 years) and 4,288 without migraine (76.7% women, 52.8 years) were abstracted by propensity score optimal matching. COI accounted healthcare resources utilization (HRU) and non-HRU (productivity loss). Costs were expressed as Per-Patient-Per-Year (PPPY) in Euros year 2020, and the excess cost was computed as the difference between persons with and without migraine.</div></div><div><h3>Results</h3><div>The PPPY cost was more than double in persons with migraine; €5,862 vs €2,981; excess cost of €2,881€ (95% CI: 2,410-3,353, p<!--> <!-->&lt;<!--> <!-->0.001), mainly attributable to labour productivity loss; €1,928 (1,532-2,325, p<!--> <!-->&lt;<!--> <!-->0.001) annually (66.9% of total excess cost). This excess labour cost is explained by the greater number of additional days of absenteeism, 22.35 (16.12; 28.57), and presenteeism, 31.39 (27.36; 35.41) in persons with migraine, p<!--> <!-->&lt;<!--> <!-->0.001 in both cases. National Health System (NHS)-funded healthcare PPPY cost represented the 29.0% of total excess cost; €836 (618-1,055), this because higher utilization of all-type medical visits.</div></div><div><h3>Conclusion</h3><div>In Spain, persons with migraine showed a meaningful excess cost compared with persons without migraine, particularly due to labour cost component, although the economic cost to the NHS was also considerable. Given the high prevalence of migraine, its overall attributable economic impact for Spain might range between 10,394 and 14,230 million Euros in year 2020.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 533-547"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and outcoMes of MInor stroke and high-risk traNsient ischEmic attack in NordicTus. IMMINENT study 北欧轻微中风和高危短暂性脑缺血发作的发病率和后果。IMMINENT 研究
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.02.006
M.E. Ramos-Araque , M. Castellanos , L. Naya Rios , E. López-Cancio , J. Molina Gil , J. Marta-Moreno , H. Tejada-Meza , M. Temprano Fernández , C. Antón González , D. Vidal de Francisco , J. Tejada-García , J.L. Maciñeiras Montero , P. Vicente Alba , J.M. García-Sánchez , B. Aguilera Irazabal , M. Martínez-Zabaleta , I.N. Diez , A. Pinedo Brochado , I. Azkune Calle , M.M. Freijo , J.F. Arenillas
{"title":"Incidence and outcoMes of MInor stroke and high-risk traNsient ischEmic attack in NordicTus. IMMINENT study","authors":"M.E. Ramos-Araque ,&nbsp;M. Castellanos ,&nbsp;L. Naya Rios ,&nbsp;E. López-Cancio ,&nbsp;J. Molina Gil ,&nbsp;J. Marta-Moreno ,&nbsp;H. Tejada-Meza ,&nbsp;M. Temprano Fernández ,&nbsp;C. Antón González ,&nbsp;D. Vidal de Francisco ,&nbsp;J. Tejada-García ,&nbsp;J.L. Maciñeiras Montero ,&nbsp;P. Vicente Alba ,&nbsp;J.M. García-Sánchez ,&nbsp;B. Aguilera Irazabal ,&nbsp;M. Martínez-Zabaleta ,&nbsp;I.N. Diez ,&nbsp;A. Pinedo Brochado ,&nbsp;I. Azkune Calle ,&nbsp;M.M. Freijo ,&nbsp;J.F. Arenillas","doi":"10.1016/j.nrl.2023.02.006","DOIUrl":"10.1016/j.nrl.2023.02.006","url":null,"abstract":"<div><h3>Background</h3><div>Our primary aim was to investigate the incidence of non-cardioembolic minor acute ischemic stroke (AIS) and high-risk transient ischemic attack (TIA) and to identify predictors of stroke recurrence/death and severe bleeding. We also evaluated the rates of TIA, major vascular events, therapeutic management and predictors of poor functional outcome at 3 months in these patients.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed data from all stroke patients evaluated at the emergency department of 19 hospitals belonging to the NORDICTUS stroke network between July and December 2019. Consecutive patients with non-cardioembolic minor AIS (NIHSS ≤5) and high-risk TIA (ABCD2 ≥6 or ipsilateral stenosis ≥50%) were included. We recorded clinical, neuroimaging and therapeutic variables. Follow-up was performed at 30 and 90 days. Functional prognosis was assessed with the modified Rankin scale score (mRS).</div></div><div><h3>Results</h3><div>Of 8275 patients, 1679 (20%) fulfilled IMMINENT criteria (1524 AIS/155 TIA), resulting in a global incidence of 48/100,000 inhabitants per-year. Recurrent stroke/death occurred in 73 (4.3%) patients. Extracranial ipsilateral stenosis (&gt;50%): HR 1.999 (95% CI: 1.115–3.585, <em>p</em> <!-->=<!--> <!-->0.020) and lack of hyperacute cerebral arterial assessment: HR 1.631 (95% CI: 1.009–2.636, <em>p</em> <!-->=<!--> <!-->0.046) were associated with recurrent stroke/death at 90 days. Intracranial stenosis was associated with poor prognosis (<em>p</em> <!-->=<!--> <!-->0.044). Reperfusion therapy was given to 147 (9%) and urgent double antiplatelet therapy (DAPT) to 320 (21%) patients.</div></div><div><h3>Conclusion</h3><div>Twenty percent of our stroke patients presented as non-cardioembolic high-risk TIA or minor AIS. Extracranial ipsilateral stenosis and lack of hyperacute cerebral arterial assessment were predictors of stroke recurrence/death; intracranial stenosis was associated with poor outcome. Despite current recommendations there was a low penetrance of DAPT.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 489-498"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between encephalopathy and clinical outcomes of COVID-19: Findings from the Philippine CORONA Study COVID-19 脑病与临床结果之间的关系:菲律宾 CORONA 研究的结果
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.11.008
V.M.M. Anlacan , F.G.C. Gabriel , R.D.G. Jamora , E.Q. Villanueva III , M.C.C. Sy , M.H.L. Lee Yu , A.I. Espiritu
{"title":"Association between encephalopathy and clinical outcomes of COVID-19: Findings from the Philippine CORONA Study","authors":"V.M.M. Anlacan ,&nbsp;F.G.C. Gabriel ,&nbsp;R.D.G. Jamora ,&nbsp;E.Q. Villanueva III ,&nbsp;M.C.C. Sy ,&nbsp;M.H.L. Lee Yu ,&nbsp;A.I. Espiritu","doi":"10.1016/j.nrl.2023.11.008","DOIUrl":"10.1016/j.nrl.2023.11.008","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to determine whether encephalopathy is associated with such COVID-19 outcomes as disease severity, mortality, respiratory failure, intensive care unit (ICU) admission, duration of ventilator dependence, and length of ICU and hospital stay.</div></div><div><h3>Methods</h3><div>We performed a subgroup analysis comparing outcomes in patients with and without encephalopathy, based on data from a nationwide retrospective cohort study among adult patients hospitalized with COVID-19 at 37 hospital sites in the Philippines. The patient outcomes included for analysis were disease severity, mortality, respiratory failure, ICU admission, duration of ventilator dependence, and length of ICU and hospital stay.</div></div><div><h3>Results</h3><div>Of a total of 10<!--> <!-->881 COVID-19 admissions, 622 patients had encephalopathy. The adjusted hazard ratios (aHR) for mortality among mild and severe cases were 9.26 and 1.63 times greater (<em>P</em> <!-->&lt;<!--> <!-->.001), respectively, in the encephalopathy group compared to the no-encephalopathy group. Encephalopathy was associated with increased risk of severe COVID-19 (adjusted odds ratio [aOR]: 7.95; <em>P</em> <!-->&lt;<!--> <!-->.001), respiratory failure (aHR: 5.40; <em>P</em> <!-->&lt;<!--> <!-->.001), longer hospital stays (aOR: 1.36; <em>P</em> <!-->&lt;<!--> <!-->.001), and admission to the ICU (aOR: 4.26; <em>P</em> <!-->&lt;<!--> <!-->.001). We found no sufficient evidence that encephalopathy was associated with length of ICU stay (aOR: 1.11; <em>P</em> <!-->=<!--> <!-->.522) or duration of ventilator dependence (aOR: 0.88; <em>P</em> <!-->=<!--> <!-->.428).</div></div><div><h3>Conclusions</h3><div>Encephalopathy was associated with COVID-19 severity, mortality, respiratory failure, ICU admission, and longer hospital stays.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 567-576"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estado de la neurosonología en España. Un estudio de la Sociedad Española de Neurosonología (SONES) 西班牙神经病学的现状。西班牙神经生理学学会(SONES)的研究
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.06.012
J. Rodríguez-Pardo , J. Carneado-Ruiz , M. Martínez-Martínez , J.M. Moltó-Jordá , P. Irimia , J. Serena-Leal , Ó. Ayo-Martín , P. Martínez-Sánchez , J. Pagola , J. Fernández-Domínguez , en nombre de la Sociedad Española de Neurosonología (SONES)
{"title":"Estado de la neurosonología en España. Un estudio de la Sociedad Española de Neurosonología (SONES)","authors":"J. Rodríguez-Pardo ,&nbsp;J. Carneado-Ruiz ,&nbsp;M. Martínez-Martínez ,&nbsp;J.M. Moltó-Jordá ,&nbsp;P. Irimia ,&nbsp;J. Serena-Leal ,&nbsp;Ó. Ayo-Martín ,&nbsp;P. Martínez-Sánchez ,&nbsp;J. Pagola ,&nbsp;J. Fernández-Domínguez ,&nbsp;en nombre de la Sociedad Española de Neurosonología (SONES)","doi":"10.1016/j.nrl.2023.06.012","DOIUrl":"10.1016/j.nrl.2023.06.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Neurosonology is the field of study of the ultrasound techniques applied to neurological diseases. The Spanish Society of Neurosonology –SONES– was funded in 1997 to promote training and education in these techniques, especially focused on the study of cerebrovascular diseases. After 25 years, the increased use of other advanced neurovascular imaging techniques and the emergence of novel applications of ultrasound in other fields of neurology have modified the classic role of neurosonology. From the SONES we aimed to evaluate the current status of neurosonology in Spain.</div></div><div><h3>Methods</h3><div>Cross-sectional survey of neurologists and neurology residents working in Spain regarding training, education, and local daily practice, including a strengths, weaknesses, opportunities and threats –SWOT– analysis.</div></div><div><h3>Results</h3><div>One-hundred seventy-eight neurologists and 34 neurology residents participated in the survey. A wide experience in vascular neurosonology (90% of respondents’ Neurology departments) and limited experience in brain parenchyma sonography (34%), cardiac echoscopy (25%), ultrasound-guided techniques (24%), and nerve ultrasound (14%) was reported. Fifty-three percent of the participants reported to have a full-time neurosonology lab in their department and only 14% reported to have neurologists dedicated exclusively to neurosonology. Most participants (53%) reported to lack continuous learning opportunities, and 97% to need training in one or more neurosonology techniques. Main SWOT were requiring expertise, shortage of time, versatility and comprehensive management of the neurological patient, respectively.</div></div><div><h3>Conclusions</h3><div>Vascular neurosonology is widely instituted in Spain, but the implementation of full-time neurosonology labs and training in non-vascular neurosonology techniques is yet scarce.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 548-557"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Síndrome de dolor regional complejo y fibromatosis palmar secundarios a tratamiento con primidona 用普萘醌治疗的复杂区域疼痛综合征和继发性棕榈纤维瘤病
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.10.001
C. Utrilla-Pérez, M.C. Mateos-de Pablo, C. Guijarro-Castro
{"title":"Síndrome de dolor regional complejo y fibromatosis palmar secundarios a tratamiento con primidona","authors":"C. Utrilla-Pérez,&nbsp;M.C. Mateos-de Pablo,&nbsp;C. Guijarro-Castro","doi":"10.1016/j.nrl.2023.10.001","DOIUrl":"10.1016/j.nrl.2023.10.001","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 608-609"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute inflammatory demyelinating polyneuropathy shortly after administration of intravitreal ranibizumab: A clinical and electrophysiological annotation 急性炎症脱髓鞘多神经病变后不久给予玻璃体内雷尼珠单抗:临床和电生理注释
IF 2.9 4区 医学
Neurologia Pub Date : 2025-07-01 DOI: 10.1016/j.nrl.2023.06.008
J. Berciano , A. García
{"title":"Acute inflammatory demyelinating polyneuropathy shortly after administration of intravitreal ranibizumab: A clinical and electrophysiological annotation","authors":"J. Berciano ,&nbsp;A. García","doi":"10.1016/j.nrl.2023.06.008","DOIUrl":"10.1016/j.nrl.2023.06.008","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 610-611"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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