Neurologia最新文献

{"title":"Psychological resilience mediates the relationship between perceived neuropsychological impairment and quality of life in a sample of patients with multiple sclerosis","authors":"Y. Broche-Pérez ,&nbsp;R.M. Jiménez-Morales ,&nbsp;L.O. Monasterio-Ramos ,&nbsp;J. Bauer","doi":"10.1016/j.nrl.2023.03.008","DOIUrl":"10.1016/j.nrl.2023.03.008","url":null,"abstract":"<div><h3>Introduction</h3><div>The impact of subjective cognitive concerns (SCCs) on the quality of life (QoL) of patients with multiple sclerosis (PwMS) has practically not been studied.</div></div><div><h3>Objectives</h3><div>In this study, the relationship between subjective cognitive concerns and quality of life in PwMS was explored. Furthermore, to explore whether psychological resilience acts as a mediator in the relationship between SCCs and QoL.</div></div><div><h3>Methods</h3><div>A total of 214 PwMS were surveyed using the Multiple Sclerosis Quality of Life Inventory, the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) and the Connor-Davidson Resilience Scale.</div></div><div><h3>Results</h3><div>Our results showed that, SCCs is a predictor of levels of perceived QoL in PwMS. Patients who report higher scores on the MSNQ also showed a worse quality of life in global terms. The results also showed that resilience mediates the relationship between SCCs and QoL, both for the physical dimension of quality of life (physical health composite) and for the mental health dimension (mental health composite). In our patients, as resilience levels increase, the negative impact of SCCs on QoL decreases.</div></div><div><h3>Conclusions</h3><div>Considering that resilience is a modifiable protective factor, the implementation of interventions aimed at enhancing resilience can have a favorable impact on the psychological well-being and quality of life of patients with multiple sclerosis.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 753-761"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronopatía sensitiva en paciente con anticuerpos anti-FGFR3 y adenocarcinoma de pulmón, ¿casualidad o causalidad?","authors":"L. Fernández-Llarena,&nbsp;A. Moreno-Estébanez,&nbsp;A. Gonzalez-Eizaguirre,&nbsp;A. Jauregi-Barrutia","doi":"10.1016/j.nrl.2024.08.001","DOIUrl":"10.1016/j.nrl.2024.08.001","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 807-810"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single institution series of intravascular lymphoma: Neurological manifestations and neuroimaging findings","authors":"J. Corroza ,&nbsp;C. Alburquerque ,&nbsp;L. Martínez-Martínez ,&nbsp;I. Gastón ,&nbsp;L. Torné ,&nbsp;M.C. Gil-Alzueta ,&nbsp;J. Oteiza ,&nbsp;T. Cabada ,&nbsp;M.C. Viguria ,&nbsp;A. Panizo ,&nbsp;M.E. Erro","doi":"10.1016/j.nrl.2023.11.009","DOIUrl":"10.1016/j.nrl.2023.11.009","url":null,"abstract":"<div><h3>Background</h3><div>Intravascular lymphoma (IVL) is a diffuse large B-cell lymphoma characterized by occlusion of small vessels of organs by malignant cells with special tropism for the nervous system. Our purpose has been to describe a series of IVL diagnosed in our center and to compare the results with those of the literature.</div></div><div><h3>Methods</h3><div>A retrospective review of the clinical, imaging, and pathological data of consecutive patients with IVL in the last 20 years was performed. Pathology department database was the source of patient identification.</div></div><div><h3>Results</h3><div>We identified six cases (three males and three females), with a median age at diagnosis of 54.64 (interquartile range (IR) 51.93–59.67). Five of them (83.3%) debuted with neurological manifestations. The median time to diagnosis was 3.77 months. On cranial magnetic resonance imaging, the findings consisted of multiple white matter and corpus callosum lesions (some of them with enhancement or hemorrhagic foci) and multifocal infarcts with hemorrhagic transformation. One patient displayed leptomeningeal branch aneurysms. A proton emission tomography with fluorodeoxyglucose (PET-FDG) was performed in five patients showing areas of elevated metabolism in all of them. Four patients underwent targeted biopsy, which allowed the diagnosis of IVL to be established in three. Four of the five patients who received treatment remained in complete remission with a median progression-free survival of 69.62 months (IR 49.11–162.82).</div></div><div><h3>Conclusions</h3><div>IVL begins frequently with neurological manifestations, which must alert the neurologist to be aware of this entity. PET-FDG helps to identify biopsy-accessible lesions and facilitate early diagnosis of IVL.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 768-776"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talamotomía unilateral con ultrasonidos focales de alta intensidad en el temblor refractario. Primeros resultados de un hospital público en España","authors":"G. Fernández-Pajarín ,&nbsp;M. Blanco-Ulla ,&nbsp;E. Arán ,&nbsp;B. Ares ,&nbsp;P. Román-Pena ,&nbsp;A. Jesús Mosqueira ,&nbsp;I. Jiménez-Martín ,&nbsp;M. Gelabert-González ,&nbsp;J.M. Prieto-González ,&nbsp;Á. Sesar","doi":"10.1016/j.nrl.2023.02.012","DOIUrl":"10.1016/j.nrl.2023.02.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Unilateral high-intensity focused ultrasound (HIFU) thalamotomy is a novel and efficient treatment for refractory tremor. In the most recent studies, the tremor is reduced by at least 70%. The objective of this study is to analyse the results of the first series of cases treated in a public hospital in Spain.</div></div><div><h3>Methods</h3><div>In our centre, from March 2021 to March 2022, 46 patients have undergone a HIFU thalamotomy. The treatment area was predetermined on the inferior surface of the ventral intermediate nucleus of the thalamus using automatic anatomical segmentation on an individual basis. The data of 44 patients 6<!--> <!-->months after the procedure have been analysed.</div></div><div><h3>Results</h3><div>The mean age of the treated patients was 70.5<!--> <!-->±<!--> <!-->14.4 years, and 68% were male. The most common diagnosis was essential tremor (40 cases). Prior to HIFU treatment, the Clinical Rating Scale for Tremor of the treated body side (CRST A<!--> <!-->+<!--> <!-->B) was 22.4<!--> <!-->±<!--> <!-->5.9, and tremor-related disability (CRST C) was 18.3<!--> <!-->±<!--> <!-->4.8. The mean number of sonications was 6.8<!--> <!-->±<!--> <!-->1.7. Six months after treatment, CRST scales were 4.5<!--> <!-->±<!--> <!-->5.6 and 4.2<!--> <!-->±<!--> <!-->5.2, respectively <em>(P</em>&lt;.0001). Twenty patients had head tremor. We observed a significant improvement with HIFU (1.9<!--> <!-->±<!--> <!-->0.7 to 0.7<!--> <!-->±<!--> <!-->0.8, <em>P</em>&lt;.0001). Only 4<!--> <!-->patients presented adverse effects at 6<!--> <!-->months, all of them mild.</div></div><div><h3>Conclusions</h3><div>The clinical benefit after HIFU thalamotomy reaches an 80% reduction in tremor and has a low rate of adverse effects 6<!--> <!-->months after the procedure. The target localisation method used allowed for fewer sonications.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 739-745"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto asistencial de la electroencefalografía realizada durante la guardia de Neurofisiología Clínica en un hospital de tercer nivel","authors":"F. Vázquez-Sánchez ,&nbsp;M.C. Lloria-Gil ,&nbsp;B. García-López ,&nbsp;O. Pérez-Gil ,&nbsp;A. Saponaro-González ,&nbsp;E. Rivas-Navas ,&nbsp;A.I. Gómez-Menéndez","doi":"10.1016/j.nrl.2023.02.013","DOIUrl":"10.1016/j.nrl.2023.02.013","url":null,"abstract":"<div><h3>Introduction</h3><div>The electroencephalogram (EEG) is a useful tool in the diagnosis of pathologies such as non-convulsive status epilepticus (NCSE) or brain death (BD), cardiac arrest (CA), and status epilepticus (SE) treatment monitoring. In addition, it provides irreplaceable information depending on the time it is performed, as is the case with the diagnosis of epilepsy after a first epileptic seizure (ES) or to differentiate these from non-epileptic paroxysmal events (NEPE). Its usefulness is maintained outside the usual working day, but it is not available in many centers.</div></div><div><h3>Subjects and methods</h3><div>Retrospective observational study based on the clinical history of 86 patients who underwent an on-call EEG (ocEEG) at our hospital during 2020.</div></div><div><h3>Results</h3><div>One hundred two records requested by Intensive Care (41.1%), Neurology (37.3%), Pediatrics (17.6%) or other services (4%) were made. Suspected NCSE represented 56.7%, followed by treatment monitoring in EE (21.6%). The ME accounted for only 6.9% of the total. The ocEEG avoided potential iatrogenesis in a 56.3% of cases with therapeutic implications, allowed to treat 27.58% of patients who would have remained without treatment until the conventional EEG. An increase in the level of care was required in only 22.2% of all cases. The ocEEG was anticipated a mean of 31.6<!--> <!-->h to the next conventional EEG that would have been available.</div></div><div><h3>Conclusions</h3><div>The availability of ocEEG is beneficial in terms of diagnosis, therapy, and hospital management, advancing decision-making and avoiding iatrogenesis. Its availability should become widespread.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 746-752"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clasificación de los paradigmas de evaluación neuropsicológica de la representación corporal tras una revisión crítica","authors":"J.F. Mozo ,&nbsp;J.M. Ruiz-Sánchez de León","doi":"10.1016/j.nrl.2023.02.011","DOIUrl":"10.1016/j.nrl.2023.02.011","url":null,"abstract":"<div><h3>Introduction</h3><div>The concept of <em>body representation</em> overlaps with others, such as body schema, body image, body semantics, structural description, body description or body map. A taxonomy is proposed that classifies body schema, body structural description and body semantics. The aim of this narrative review is to analyze the supply of instruments for neuropsychological assessment of body representation and to propose a classification of their paradigms.</div></div><div><h3>Method</h3><div>A total of 1109 articles were obtained and reduced to a total of 71 references by inclusion and exclusion criteria.</div></div><div><h3>Results</h3><div>A total of 66 instrument names were found, of which 22 were related to body schema, 32 to structural description of the body and 12 to body semantics. Forty five instruments about clinical manifestations not commonly related to neurological etiology (e.g., anorexia, bulimia, hypochondria or schizophrenia) were discarded.</div></div><div><h3>Discussion</h3><div>A synthesis and classification of paradigms and instruments of interest to the clinic is presented. The need for the creation of validated consensus protocols and their implications are discussed.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 790-806"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuidados paliativos en enfermedad de Parkinson y otros trastornos del movimiento. Recomendaciones y protocolo de un grupo multidisciplinar de expertos","authors":"M. Álvarez Saúco ,&nbsp;I. Legarda Ramírez ,&nbsp;S. Martí Martínez ,&nbsp;F. Carrillo García ,&nbsp;B. González García ,&nbsp;J. Fernández Bueno ,&nbsp;R. García-Ramos ,&nbsp;D. Santos-García","doi":"10.1016/j.nrl.2023.01.006","DOIUrl":"10.1016/j.nrl.2023.01.006","url":null,"abstract":"<div><h3>Introduction</h3><div>One of the current challenges in Parkinson's disease (PD) and other movement disorders (MD) is how and when to apply palliative care. Aware of the scarce training and implementation of this type of approach, we propose some consensual recommendations for palliative care (PC) in order to improve the quality of life of patients and their environment.</div></div><div><h3>Material and methods</h3><div>After a first phase of needs analysis through a survey carried out on Spanish neurologists and a review of the literature, we describe recommendations for action structured in: palliative care models, selection of the target population, when, where and how to implement the PC.</div></div><div><h3>Results</h3><div>Models of neuropalliative care are reviewed, advocating for the role of the neurologist as a driving force. The members of the multidisciplinary team are described, as well as the main clinical markers and tools that help the clinician to decide which patients have greater palliative needs; sender and receiver are defined and it is detailed in what evolutionary moment and how to proceed when sending the patient to palliative care. A scheme of steps to follow in any PC protocol, whether basic or specialized, is provided, emphasizing the framework in the shared planning of care and the comprehensive approach.</div></div><div><h3>Conclusions</h3><div>It would be desirable to integrate the PC in the management of PD and other MD and to validate models of neuropalliative care in our environment, analyzing their usefulness through the use of indicators, in order to improve the care and quality of life of our patients.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 717-728"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral hack sign not necessarily implies paraparesis","authors":"J. Finsterer ,&nbsp;F.A. Scorza ,&nbsp;A.C.G. Almeida","doi":"10.1016/j.nrl.2022.11.010","DOIUrl":"10.1016/j.nrl.2022.11.010","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 810-811"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidencia y factores asociados a discapacidad y dependencia en pacientes con síndrome de Guillain-Barré en la Región de Murcia: estudio poblacional del periodo 2009-2020","authors":"S. Rueda-Nieto ,&nbsp;M.P. Mira-Escolano ,&nbsp;A. Sánchez-Escámez ,&nbsp;J.M. Cayuela-Fuentes ,&nbsp;L.A. Maceda-Roldán ,&nbsp;P. Ciller-Montoya ,&nbsp;J.A. Palomar-Rodríguez","doi":"10.1016/j.nrl.2023.08.003","DOIUrl":"10.1016/j.nrl.2023.08.003","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of Guillain-Barré Syndrome (GBS) is variable and is still unknown in our geographical area. Poor prognostic factors have been studied, but few have analyzed those that influence long-term results. The objective of this study is to know the incidence, characteristics and factors associated with disability and dependency in these patients from a population registry.</div></div><div><h3>Subjects and method</h3><div>Observational study in patients diagnosed with GBS from 2009 to 2020 and registered in the Rare Disease Information System (SIER) of the Region of Murcia (Spain). The crude and adjusted rates for age, sex and year of the period were calculated and the associations between disability and/or dependency with the rest of the variables were analyzed.</div></div><div><h3>Results</h3><div>During the study period, 250 incident cases were diagnosed. The standardized incidence rate (SIR) was 1.52/100,000 person-years, higher in men and increasing with age in both sexes. The disease was more frequent after respiratory infections (46.4%) and in the cold months (56.4%), and the predominant variant was AIDP (54.3%). Greater disability and/or dependence were observed in patients with prolonged hospital stay (OR<!--> <!-->=<!--> <!-->13.19; 95%<!--> <!-->CI: 3.81-45.67), ICU admission (OR<!--> <!-->=<!--> <!-->2.37; 95%<!--> <!-->CI: 1.11- 5.06) and affected by axonal variants (OR<!--> <!-->=<!--> <!-->3.54; 95%<!--> <!-->CI: 1.64-7.69) (<em>P</em> <!-->&lt;<!--> <!-->.05).</div></div><div><h3>Conclusions</h3><div>The regional SIR is consistent with that reported in the national and international literature. 18.4% of the cases have recognized dependency and/or disability, associated with the axonal forms of the disease. Studies based on population registries offer representative and updated information and allow us to discover characteristics associated with a worse prognosis.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 777-789"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miopatía necrosante inmunomediada: experiencia en una unidad neuromuscular","authors":"S. Portela-Sánchez ,&nbsp;I. Catalina ,&nbsp;S. López Muñoz ,&nbsp;A. Lozano Ros ,&nbsp;A. Sánchez-Soblechero ,&nbsp;E. Sola Vendrel ,&nbsp;P. Sánchez-Mateos ,&nbsp;J.L. Muñoz-Blanco","doi":"10.1016/j.nrl.2023.03.005","DOIUrl":"10.1016/j.nrl.2023.03.005","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the main features and the clinical management of a cohort of patients with immune-mediated necrotizing myopathy (IMNM).</div></div><div><h3>Methods</h3><div>We conducted an observational, monocentric, retrospective study of IMNM patients diagnosed in the Neuromuscular Unit of a tertiary hospital in Madrid (Spain) between 2013 and 2021.</div></div><div><h3>Results</h3><div>Sixteen IMNM cases were diagnosed, with a median age of 71.5 years (range 36-80), 9<!--> <!-->of whom (56.3%) were female. Thirteen (81.3%) patients had previously been treated with statins. The time from symptoms onset to diagnosis was less than 6<!--> <!-->months in 11 patients (68.8%) and the most common clinical symptoms were proximal weakness and myalgia. The only myositis specific autoantibodies detected were anti-3-hydroxy-3-methyl-coenzyme A reductase in 13 patients. The treatment strategy was based on prednisone, although a combination with other immunosuppressive drugs was required in 8<!--> <!-->(50%) patients.</div></div><div><h3>Conclusions</h3><div>There has been an increase in the diagnosis of immune-mediated necrotizing myopathies in the last few years. The anti-HMGCR antibodies were the only ones detected in this sample, showing their key role in the diagnosis. Early recognition of the disease facilitates to start treatment as soon as possible, which should be based on the initial response to corticosteroids and usually requires a combination of several drugs.</div></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"40 8","pages":"Pages 729-738"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}