Neurologia最新文献

{"title":"Enfermedad de Parkinson: actualización de estudios preclínicos con el uso de células troncales pluripotentes inducidas","authors":"V. Valadez-Barba ,&nbsp;K. Juárez-Navarro ,&nbsp;E. Padilla-Camberos ,&nbsp;N.F. Díaz ,&nbsp;J.R. Guerra-Mora ,&nbsp;N.E. Díaz-Martínez","doi":"10.1016/j.nrl.2021.01.005","DOIUrl":"https://doi.org/10.1016/j.nrl.2021.01.005","url":null,"abstract":"<div><p>Parkinson's disease (PD) is the second most prevalent neurodegenerative disease among adults worldwide. It is characterised by the death of dopaminergic neurons in the substantia nigra pars compacta and, in some cases, presence of intracytoplasmic inclusions of α-synuclein, called Lewy bodies, a pathognomonic sign of the disease. Clinical diagnosis of PD is based on the presence of motor alterations. The treatments currently available have no neuroprotective effect. The exact causes of PD are poorly understood. Therefore, more precise preclinical models have been developed in recent years that use induced pluripotent stem cells. In vitro studies can provide new information on PD pathogenesis and may help to identify new therapeutic targets or to develop new drugs.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 681-694"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71835681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple system atrophy: Clinical, evolutive and histopathological characteristics of a series of cases","authors":"M. Carmona-Abellan ,&nbsp;R. Del Pino ,&nbsp;A. Murueta-Goyena ,&nbsp;M. Acera ,&nbsp;B. Tijero ,&nbsp;K. Berganzo ,&nbsp;I. Gabilondo ,&nbsp;J.C. Gómez-Esteban","doi":"10.1016/j.nrl.2021.04.007","DOIUrl":"10.1016/j.nrl.2021.04.007","url":null,"abstract":"<div><h3>Background and objective</h3><p>Multiple system atrophy is a rare and fatal neurodegenerative disorder, characterized by autonomic dysfunction in association with either parkinsonism or cerebellar signs. The pathologic hallmark is the presence of alpha-synuclein aggregates in oligodendrocytes, forming glial cytoplasmic inclusions. Clinically, it may be difficult to distinguish form other parkinsonisms or ataxias, particularly in the early stages of the disease. In this case series we aim to describe in detail the features of MSA patients.</p></div><div><h3>Material and methods</h3><p>Unified MSA Rating Scale (UMSARS) score, structural and functional imaging and cardiovascular autonomic testing, are summarized since early stages of the disease.</p></div><div><h3>Results</h3><p>UMSARS proved to be useful to perform a follow-up being longitudinal examination essential to stratify risk of poor outcome. Neuropathological diagnosis showed an overlap between parkinsonian and cerebellar subtypes, with some peculiarities that could help to distinguish from other subtypes.</p></div><div><h3>Conclusion</h3><p>A better description of MSA features with standardized test confirmed by means of neuropathological studies could help to increase sensitivity.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 609-616"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.04.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39032084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participación de rafts en enfermedades neurológicas","authors":"U. Meza,&nbsp;C. Romero-Méndez,&nbsp;S. Sánchez-Armáss,&nbsp;A.A. Rodríguez-Menchaca","doi":"10.1016/j.nrl.2021.01.008","DOIUrl":"https://doi.org/10.1016/j.nrl.2021.01.008","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Rafts</em> are function-structural cell membrane nano-domains. They contribute to explain the efficiency of signal transduction at the low physiological membrane concentrations of the signaling partners by their clustering inside specialized signaling domains.</p></div><div><h3>Development</h3><p>In this article, we review the current model of the membrane <em>rafts</em> and their physio-pathological relevance in the nervous system, including their role in Parkinson, Alzheimer, and Huntington diseases.</p></div><div><h3>Conclusions</h3><p><em>Rafts</em> disruption/dysfunction has been shown to relate diverse neurological diseases. Therefore, it has been suggested that preservation of membrane <em>rafts</em> may represent a strategy to prevent or delay neuronal dysfunctions in several diseases.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 671-680"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.01.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71835679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aplicación de la telemedicina en la asistencia a pacientes con cefaleas: situación actual y recomendaciones del Grupo de Estudio de Cefaleas de la Sociedad Española de Neurología","authors":"R. Belvís ,&nbsp;S. Santos-Lasaosa ,&nbsp;P. Irimia ,&nbsp;R. López Blanco ,&nbsp;M. Torres-Ferrús ,&nbsp;N. Morollón ,&nbsp;A. López-Bravo ,&nbsp;D. García-Azorín ,&nbsp;A. Mínguez-Olaondo ,&nbsp;Á. Guerrero ,&nbsp;J. Porta ,&nbsp;E. Giné-Ciprés ,&nbsp;Á. Sierra ,&nbsp;G. Latorre ,&nbsp;C. González-Oria ,&nbsp;J. Pascual ,&nbsp;D. Ezpeleta","doi":"10.1016/j.nrl.2021.01.018","DOIUrl":"https://doi.org/10.1016/j.nrl.2021.01.018","url":null,"abstract":"<div><h3>Introduction</h3><p>The COVID-19 pandemic has caused an unexpected boost to telemedicine. We analyse the impact of the pandemic on telemedicine applied in Spanish headache consultations, review the literature, and issue recommendations for the implementation of telemedicine in consultations.</p></div><div><h3>Method</h3><p>The study comprised 3 phases: <em>1)</em> review of the MEDLINE database since 1958 (first reported experience with telemedicine); <em>2)</em> Google Forms survey sent to all members of the Spanish Society of Neurology's Headache Study Group (GECSEN); and <em>3)</em> online consensus of GECSEN experts to issue recommendations for the implementation of telemedicine in Spain.</p></div><div><h3>Results</h3><p>COVID-19 has increased waiting times for face-to-face consultations, increasing the use of all telemedicine modalities: landline telephone (from 75% before April 2020 to 97% after), mobile telephone (from 9% to 27%), e-mail (from 30% to 36%), and video consultation (from 3% to 21%). Neurologists are aware of the need to expand the availability of video consultations, which are clearly growing, and other e-health and m-health tools.</p></div><div><h3>Conclusions</h3><p>The GECSEN recommends and encourages all neurologists who assist patients with headaches to implement telemedicine resources, with the optimal objective of offering video consultation to patients under 60-65 years of age and telephone calls to older patients, although each case must be considered on an individual basis. Prior approval and advice must be sought from legal and IT services and the centre's management. Most patients with stable headache and/or neuralgia are eligible for telemedicine follow-up, after a first consultation that must always be held in person.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 635-646"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.01.018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71835684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome de desequilibrio sintomático tras infección por SARS-CoV-2, a propósito de un caso","authors":"J. Lapeña-Motilva ,&nbsp;S. Gómez-Enjuto ,&nbsp;V. Hernando-Requejo ,&nbsp;N. Huertas-González","doi":"10.1016/j.nrl.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.nrl.2022.12.001","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 712-713"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213485323000208/pdfft?md5=5385d25763ab8ca50fbfc3d79b2e5f77&pid=1-s2.0-S0213485323000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71836050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular decompression for trigeminal neuralgia: A retrospective analysis of long-term outcomes and prognostic factors","authors":"L. Amaya Pascasio ,&nbsp;B. De La Casa-Fages ,&nbsp;E. Esteban de Antonio ,&nbsp;F. Grandas ,&nbsp;R. García-Leal ,&nbsp;F. Ruiz Juretschke","doi":"10.1016/j.nrl.2021.03.009","DOIUrl":"10.1016/j.nrl.2021.03.009","url":null,"abstract":"<div><h3>Introduction</h3><p>Microvascular decompression is considered to be the most effective and only etiological surgical treatment for classical trigeminal neuralgia, relieving the neurovascular compression found in up to 95% of cases. This study aims to report the long-term outcomes and to identify prognostic factors in a series of patients with trigeminal neuralgia treated by microvascular decompression.</p></div><div><h3>Methods</h3><p>A retrospective observational study of 152 consecutive patients operated by microvascular decompression with at least six months of follow-up. The surgical results, including pain relief according to the Barrow Neurological Institute pain scale, complications and the medical treatment during the follow-up period were reviewed. Binary regression analysis was performed to identify factors associated with a good long-term outcome.</p></div><div><h3>Results</h3><p>A total of 152 patients with a mean age of 60 years and a mean follow-up of 43 months were included. At the final follow-up visit, 83% of the patients had achieved significant relief of the pain and 63% could reduce the absolute drug doses by 50% or more. The most frequent complications were wound infection (4.5%) and CSF fistula (7%). Being over 70 years of age and having paroxysmal pain were associated with a long-term pain relief.</p></div><div><h3>Conclusions</h3><p>Our results support the notion that microvascular decompression is an effective and safe therapy in patients with trigeminal neuralgia. A multidisciplinary approach with an early referral to a neurosurgical unit many be beneficial in patients who are refractory to pharmacological treatment.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 625-634"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.03.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39029641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilidad diagnóstica y validez predictiva del uso conjunto de Fototest y Mini-Cog en deterioro cognitivo","authors":"C. Carnero-Pardo ,&nbsp;S. López-Alcalde ,&nbsp;M. Florido-Santiago ,&nbsp;M. Espinosa-García ,&nbsp;I. Rego-García ,&nbsp;R. Calle-Calle ,&nbsp;I. Carrera-Muñoz ,&nbsp;R. de la Vega-Cotarelo","doi":"10.1016/j.nrl.2021.01.017","DOIUrl":"https://doi.org/10.1016/j.nrl.2021.01.017","url":null,"abstract":"<div><h3>Introduction</h3><p>The Fototest and Mini-Cog include all the domains that are necessary in a cognitive assessment. This study aims to evaluate the diagnostic accuracy of the combined use of both instruments for detecting cognitive impairment.</p></div><div><h3>Methods</h3><p>We performed a phase <span>iii</span> diagnostic accuracy study with 2 independent samples: STUDY, which included 448 participants randomly allocated to 2 datasets (BASE [80%] and TEST [20%]); and EXTERNAL, which included 61 participants. The index test was consecutive administration of the Fototest and Mini-Cog, and the reference test was formal cognitive assessment. We evaluated the diagnostic accuracy of two-step vs. consecutive application of the tests and simple (Comb-Simple), logistic regression (Comb-LR), and random decision tree (Comb-RDT) models of their combined use for detecting cognitive impairment (Global Deterioration Scale score ≥ 3). We performed an exploratory analysis of the BASE dataset, selecting criteria that maximise accuracy; a pre-specified analysis was used to evaluate the selected criteria in the TEST and EXTERNAL datasets.</p></div><div><h3>Results</h3><p>The diagnostic accuracy (95% confidence interval) of the combined models in the BASE dataset (Comb-Simple: 88.3 [88.5-91.4]; Comb-LR: 91.6 [88.2-94.3]; Comb-RDT 95.2 [92.5-97.2]) was significantly higher than the individual values observed for the Mini-Cog and Fototest (81.6 [77.1-85.4] and 84.9 [80.8-88.5], respectively). These results were replicated in the TEST (Comb-Simple: 88.9; Comb-LR: 95.6; Comb-RDT: 92.2) and EXTERNAL datasets (Comb-Simple: 91.8; Comb-LR: 90.2; Comb-RDT: 88.5). Two-step application had the same diagnostic accuracy than consecutive application but required less time (mean [SD] of 197.3 s [56.7] vs. 233.9 s [45.2]; <em>P</em>&lt;.0001).</p></div><div><h3>Conclusions</h3><p>Combined application of the Fototest and Mini-Cog takes less than 4<!--> <!-->minutes and improves the diagnostic accuracy of both instruments. Two-step application is more efficient as it requires less time while maintaining the same diagnostic accuracy.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 653-662"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.01.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71835682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implicaciones de iniciar fármacos antiepilépticos previo a la realización de EEG en primeras crisis epilépticas","authors":"A. Llauradó ,&nbsp;M. Quintana ,&nbsp;E. Fonseca ,&nbsp;L. Abraira ,&nbsp;M. Toledo ,&nbsp;M. Requena ,&nbsp;M. Olivé ,&nbsp;A. Ballvé ,&nbsp;D. Campos ,&nbsp;M. Sueiras ,&nbsp;E. Santamarina","doi":"10.1016/j.nrl.2021.02.014","DOIUrl":"https://doi.org/10.1016/j.nrl.2021.02.014","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to determine whether the administration of antiepileptic drugs (AED) alters the likelihood of detecting epileptiform abnormalities in electroencephalographies (EEG) performed early after a first epileptic seizure.</p></div><div><h3>Method</h3><p>We performed a retrospective, observational study including patients with a first seizure attended at our centre's emergency department between July 2014 and November 2019. We collected clinical data, as well as technical data on the acquisition and interpretation of the EEG performed within the first 72<!--> <!-->hours after the seizure, and the factors related with seizure recurrence.</p></div><div><h3>Results</h3><p>We recruited 155 patients with a mean (SD) age of 48.6 (22.5) years; 61.3% were men. Regarding seizure type, 51% presented tonic-clonic seizures of unknown onset and 12% presented focal to bilateral tonic-clonic seizures. Thirty-nine patients (25.2%) received AED treatment before the EEG was performed: 33 received a non-benzodiazepine AED and 6 received a benzodiazepine. Epileptiform abnormalities were observed in 29.7% of patients. Previous administration of AEDs was not significantly associated with the probability of detecting interictal epileptiform abnormalities <em>(P</em>=.25) or with the risk of recurrence within 6 months <em>(P</em>=.63).</p></div><div><h3>Conclusions</h3><p>Administration of AEDs before an early EEG following a first seizure does not decrease the likelihood of detecting epileptiform abnormalities. These findings suggest that starting AED treatment immediately in patients with a high risk of early recurrence does not imply a reduction in the diagnostic accuracy of the test.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 647-652"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.02.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71835683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of patients with severe cerebral venous thrombosis treated with decompressive craniectomy","authors":"A. Arauz ,&nbsp;M.A. Barboza ,&nbsp;L.C. Quintero ,&nbsp;C. Cantu ,&nbsp;E. Chiquete ,&nbsp;F. Serrano","doi":"10.1016/j.nrl.2021.04.006","DOIUrl":"10.1016/j.nrl.2021.04.006","url":null,"abstract":"<div><h3>Introduction</h3><p>Despite the highly favorable prognosis, mortality occurs in nearly 2% of patients with cerebral venous thrombosis (CVT), in which decompressive craniectomy (DC) may be the only way to save the patient's life. The aim of this report is to describe the risk factors, neuroimaging features, in-hospital complications and functional outcome of severe CVT in patients treated with DC.</p></div><div><h3>Materials and methods</h3><p>Consecutive malignant CVT cases treated with DC from a retrospective third-level hospital database were analyzed. Demographic, clinical, and functional outcomes were analyzed.</p></div><div><h3>Results</h3><p>Twenty-six patients were included (20 female, age 35.4<!--> <!-->±<!--> <!-->12.1 years); 53.8% of the patients had acute CVT, with neurological focalization as the most common symptom in 92.3% of the patients. Superior sagittal sinus thromboses were found in 84.6% of cases. Bilateral lesions were present in 10 patients (38.5%). Imaging on admission showed a parenchymal lesion (venous infarction<!--> <!-->±<!--> <!-->hemorrhagic lesion)<!--> <!-->&gt;<!--> <!-->6<!--> <!-->cm measured along the longest diameter in 25 patients (96.2%). Mean duration of clinical neurological deterioration was 3.5 days; eleven patients (42.3%) died during hospitalization.</p></div><div><h3>Conclusion</h3><p>In patients with severe forms of CVT, we found higher mortality than previously reported. DC is an effective life-saving treatment with acceptable functional prognosis for survivors.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 617-624"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome clínico aislado: diagnóstico y riesgo de desarrollar esclerosis múltiple clínicamente definida","authors":"J. López-Gómez ,&nbsp;B. Sacristán-Enciso ,&nbsp;M.A. Caro-Miró ,&nbsp;M.R. Querol Pascual","doi":"10.1016/j.nrl.2021.01.011","DOIUrl":"https://doi.org/10.1016/j.nrl.2021.01.011","url":null,"abstract":"<div><h3>Introduction</h3><p>In most cases, multiple sclerosis (MS) initially presents as clinically isolated syndrome (CIS). Differentiating CIS from other acute or subacute neurological diseases and estimating the risk of progression to clinically definite MS is essential since presenting a second episode in a short time is associated with poorer long-term prognosis.</p></div><div><h3>Development</h3><p>We conducted a literature review to evaluate the usefulness of different variables in improving diagnostic accuracy and predicting progression from CIS to MS, including magnetic resonance imaging (MRI) and such biofluid markers as oligoclonal IgG and IgM bands, lipid-specific oligoclonal IgM bands in the CSF, CSF kappa free light-chain (KFLC) index, neurofilament light chain (NfL) in the CSF and serum, and chitinase 3–like protein 1 (CHI3L1) in the CSF and serum.</p></div><div><h3>Conclusions</h3><p>Codetection of oligoclonal IgG bands and MRI lesions reduces diagnostic delays and suggests a high risk of CIS progression to MS. A KFLC index &gt; 10.6 and CSF NfL concentrations &gt; 1150 ng/L indicate that CIS is more likely to progress to MS within one year (40-50%); 90% of patients with CIS and serum CHI3L1 levels &gt; 33 ng/mL and 100% of those with lipid-specific oligoclonal IgM bands present MS within one year of CIS onset.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 663-670"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.01.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71835680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}