Neurologia最新文献

{"title":"Encefalopatía epiléptica y del desarrollo asociada a mutación del SYNGAP1: descripción de un caso y respuesta al tratamiento con cannabidiol","authors":"Y. López-Moreno , P. Cabezudo-García , N.L. Ciano-Petersen , G. García-Martín , P.J. Serrano-Castro","doi":"10.1016/j.nrl.2023.01.002","DOIUrl":"10.1016/j.nrl.2023.01.002","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 101-103"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213485323000233/pdfft?md5=3b8ee22b939d026995274f07c19e2109&pid=1-s2.0-S0213485323000233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42061736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ludificación y neurorrehabilitación motora en niños y adolescentes: revisión sistemática","authors":"M. Pimentel-Ponce ,&nbsp;R.P. Romero-Galisteo ,&nbsp;R. Palomo-Carrión ,&nbsp;E. Pinero-Pinto ,&nbsp;J.A. Merchán-Baeza ,&nbsp;M. Ruiz-Muñoz ,&nbsp;J. Oliver-Pece ,&nbsp;M. González-Sánchez","doi":"10.1016/j.nrl.2021.02.011","DOIUrl":"10.1016/j.nrl.2021.02.011","url":null,"abstract":"<div><h3>Introduction</h3><p>Gamification consists of the use of games in non-playful contexts. It is widely employed in the motor rehabilitation of neurological diseases, but mainly in adult patients. The objective of this review was to describe the use of gamification in the rehabilitation of children and adolescents with neuromotor impairment.</p></div><div><h3>Methods</h3><p>We performed a systematic review of clinical trials published to date on the MEDLINE (PubMed), Scielo, SCOPUS, Dialnet, CINAHL, and PEDro databases, following the PRISMA protocol. The methodological quality of the studies identified was assessed using the PEDro scale.</p></div><div><h3>Results</h3><p>From a total of 469 studies, 10 clinical trials met the inclusion criteria. We analysed the gamification systems used as part of the rehabilitation treatment of different neuromotor conditions in children and adolescents. Cerebral palsy was the most frequently studied condition (6<!--> <!-->studies), followed by developmental coordination disorder (3), and neurological impairment of balance and coordination (1).</p></div><div><h3>Conclusion</h3><p>The use of gamification in rehabilitation is helpful in the conventional treatment of neuromotor disorders in children and adolescents, with increased motivation and therapeutic adherence being the benefits with the greatest consensus among authors. While strength, balance, functional status, and coordination also appear to improve, future research should aim to determine an optimal dosage.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 63-83"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.02.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38884044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miopatía nemalínica esporádica de inicio tardío manifestándose como una insuficiencia respiratoria hipercápnica","authors":"D.A. García Estévez ,&nbsp;A. Juanatey-García ,&nbsp;B. San Millán Tejado ,&nbsp;F. Barros Angueira","doi":"10.1016/j.nrl.2023.01.001","DOIUrl":"10.1016/j.nrl.2023.01.001","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 99-101"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213485323000221/pdfft?md5=bd4c5ebbce818119eb9f9689dd33481e&pid=1-s2.0-S0213485323000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47688930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Flail arm syndrome” with anti-Hu antibodies","authors":"M.M. Rosselló Vadell,&nbsp;F. Miralles","doi":"10.1016/j.nrl.2022.11.002","DOIUrl":"10.1016/j.nrl.2022.11.002","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 97-99"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S021348532300021X/pdfft?md5=abe8cf66d50a3353612f171c47448bc7&pid=1-s2.0-S021348532300021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47305150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the anticonvulsant and neuroprotective effect of intracerebral administration of growth hormone in rats","authors":"I. Zamora-Bello ,&nbsp;A. Martínez ,&nbsp;L. Beltrán-Parrazal ,&nbsp;I. Santiago-Roque ,&nbsp;E. Juárez-Aguilar ,&nbsp;M.L. López-Meraz","doi":"10.1016/j.nrl.2021.03.010","DOIUrl":"10.1016/j.nrl.2021.03.010","url":null,"abstract":"<div><h3>Introduction</h3><p>The growth hormone (GH) has been reported as a crucial neuronal survival factor in the hippocampus against insults of diverse nature. <em>Status epilepticus</em> (SE) is a prolonged seizure that produces extensive neuronal cell death. The goal of this study was to evaluate the effect of intracerebroventricular administration of GH on seizure severity and SE-induced hippocampal neurodegeneration.</p></div><div><h3>Methodology</h3><p>Adult male rats were implanted with a guide cannula in the left ventricle and different amounts of GH (70, 120 or 220<!--> <!-->ng/3<!--> <!-->μl) were microinjected for 5 days; artificial cerebrospinal fluid was used as the vehicle. Seizures were induced by the lithium–pilocarpine model (3<!--> <!-->mEq/kg LiCl and 30<!--> <!-->mg/kg pilocarpine hydrochloride) one day after the last GH administration. Neuronal injury was assessed by Fluoro-Jade B (F-JB) staining.</p></div><div><h3>Results</h3><p>Rats injected with 120<!--> <!-->ng of GH did not had SE after 30<!--> <!-->mg/kg pilocarpine, they required a higher number of pilocarpine injections to develop SE than the rats pretreated with the vehicle, 70<!--> <!-->ng or 220<!--> <!-->ng GH. Prefrontal and parietal cortex EEG recordings confirmed that latency to generalized seizures and SE was also significantly higher in the 120<!--> <!-->ng group when compared with all the experimental groups. FJ-B positive cells were detected in the hippocampus after SE in all rats, and no significant differences in the number of F-JB cells in the CA1 area and the hilus was observed between experimental groups.</p></div><div><h3>Conclusion</h3><p>Our results indicate that, although GH has an anticonvulsive effect in the lithium–pilocarpine model of SE, it does not exert hippocampal neuroprotection after SE.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 1-9"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.03.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39015112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelo de riesgo de crisis en acúmulos o estado epiléptico e intervención en servicios de urgencias","authors":"C. Fernández Alonso ,&nbsp;F. González Martínez ,&nbsp;R. Alonso Avilés ,&nbsp;M. Liñán López ,&nbsp;M.E. Fuentes Ferrer ,&nbsp;B. Gros Bañeres ,&nbsp;en representación de grupo ACESUR","doi":"10.1016/j.nrl.2021.02.015","DOIUrl":"10.1016/j.nrl.2021.02.015","url":null,"abstract":"<div><h3>Objectives</h3><p>To identify possible predictors of seizure cluster or status epilepticus (SE) and to evaluate whether these patients receive greater interventions in emergency departments.</p></div><div><h3>Methodology</h3><p>We conducted a secondary analysis of the ACESUR Registry, a multipurpose, observational, prospective, multicentre registry of adult patients with seizures from 18 emergency departments. Clinical and care-related variables were collected. We identified risk factors and risk models for seizure cluster or SE and assessed the effect of interventions by prehospital emergency services and the hospital emergency department.</p></div><div><h3>Results</h3><p>We identified a total of 186 (28%) patients from the ACESUR registry with seizure cluster (126 [19%]) or SE (60 [9%]); the remaining 478 patients (72%) had isolated seizures. The risk model for seizure cluster or SE in the emergency department included Charlson Comorbidity Index scores<!--> <!-->≥<!--> <!-->3 (OR: 1.60; 95% CI, 1.05-2.46; <em>P</em> <!-->=<!--> <!-->.030), ≥<!--> <!-->2 habitual antiepileptic drugs (OR: 2.29; 95% CI, 1.49-3.51; <em>P</em> <!-->&lt;<!--> <!-->.001), and focal seizures (OR: 1.56; 95% CI, 1.05-2.32; <em>P</em> <!-->=<!--> <!-->.027). The area under the curve of the model was 0.735 (95% CI, 0.693-0.777; <em>P</em> <!-->=<!--> <!-->.021). Patients with seizure cluster and SE received more aggressive interventions both by prehospital emergency services (OR: 2.89; 95% CI, 1.91-4.36; <em>P</em> <em>&lt;</em> <!-->.001) and at the emergency department (OR: 4.41; 95% CI, 2.69-7.22; <em>P</em> <!-->&lt;<!--> <!-->.001).</p></div><div><h3>Conclusions</h3><p>This risk model may be of prognostic value in identifying adult patients at risk of presenting seizure cluster or SE in the emergency department. In our sample, these patients received more aggressive treatment than adult patients with isolated seizures before arriving at hospital, and even more so in the emergency department.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"39 1","pages":"Pages 20-28"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.02.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39032791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midriasis unilateral episódica benigna: reporte de un caso y enfoque clínico-topográfico","authors":"V. Valencia-Cifuentes ,&nbsp;J. Quiñones","doi":"10.1016/j.nrl.2023.04.003","DOIUrl":"10.1016/j.nrl.2023.04.003","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"39 2","pages":"Pages 211-213"},"PeriodicalIF":3.9,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213485323000634/pdfft?md5=d3c8f34757bbbc9c770c868d35a831a3&pid=1-s2.0-S0213485323000634-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of gender bias in clinical trials of monoclonal antibodies for the treatment of multiple sclerosis","authors":"M. Alonso-Moreno,&nbsp;M. Ladrón-Guevara,&nbsp;P. Ciudad-Gutiérrez","doi":"10.1016/j.nrl.2021.01.003","DOIUrl":"10.1016/j.nrl.2021.01.003","url":null,"abstract":"<div><h3>Introduction</h3><p>This article analyses the presence of gender bias in clinical trials of monoclonal antibodies used to treat multiple sclerosis.</p></div><div><h3>Material and methods</h3><p>We performed a systematic review of controlled clinical trials of 4 monoclonal antibodies used to treat multiple sclerosis (natalizumab, rituximab, alemtuzumab, and ocrelizumab). We searched the PubMed/MEDLINE database for articles published in English before March 2020. The study was conducted in accordance with the relevant international recommendations.</p></div><div><h3>Results</h3><p>The search identified 89 articles, 55 of which met the inclusion criteria. Of all patients included in these trials, 64.6% were women. The lead authors of 10 of the studies were women. Fifteen of the 55 studies included a sex-based analysis of the primary endpoint. Only 8 articles discussed the results separately for men and for women.</p></div><div><h3>Conclusions</h3><p>The clinical trials of these 4 monoclonal antibodies present a significant gender bias. In most cases, the primary and secondary endpoints are not analyzed according to patient sex, despite the fact that international recommendations include this as a minimum requirement for ensuring scientific validity and obtaining appropriate results for extrapolation to the wider population.</p></div>","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 695-706"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nrl.2021.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25523612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraparesia espástica hereditaria por mutación en SPG5/CYP7B1 con potenciales implicaciones terapéuticas","authors":"P. Pérez-Torre ,&nbsp;E. García Galloway ,&nbsp;J.L. López-Sendón Moreno","doi":"10.1016/j.nrl.2023.05.001","DOIUrl":"10.1016/j.nrl.2023.05.001","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 710-711"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S021348532300018X/pdfft?md5=dbb9e52b92016a84fe2ce9843c3476d4&pid=1-s2.0-S021348532300018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45472647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuralgic amyotrophy with bilateral radial nerve torsion: A unique case and review of the literature","authors":"G. Rusin ,&nbsp;R. Morga ,&nbsp;M. Spaczyńska-Boczar ,&nbsp;W. Rudnicki ,&nbsp;B.M. Kwinta ,&nbsp;E. Luczynska ,&nbsp;A. Słowik ,&nbsp;J. Antczak","doi":"10.1016/j.nrl.2022.11.001","DOIUrl":"10.1016/j.nrl.2022.11.001","url":null,"abstract":"","PeriodicalId":19300,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 707-710"},"PeriodicalIF":3.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213485323000178/pdfft?md5=3654f58b5248b855c043fd7b5a970ca7&pid=1-s2.0-S0213485323000178-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46329525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}