Incidencia y factores asociados a discapacidad y dependencia en pacientes con síndrome de Guillain-Barré en la Región de Murcia: estudio poblacional del periodo 2009-2020

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2025-10-01 DOI:10.1016/j.nrl.2023.08.003

S. Rueda-Nieto , M.P. Mira-Escolano , A. Sánchez-Escámez , J.M. Cayuela-Fuentes , L.A. Maceda-Roldán , P. Ciller-Montoya , J.A. Palomar-Rodríguez

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引用次数: 0

Abstract

Background

The incidence of Guillain-Barré Syndrome (GBS) is variable and is still unknown in our geographical area. Poor prognostic factors have been studied, but few have analyzed those that influence long-term results. The objective of this study is to know the incidence, characteristics and factors associated with disability and dependency in these patients from a population registry.

Subjects and method

Observational study in patients diagnosed with GBS from 2009 to 2020 and registered in the Rare Disease Information System (SIER) of the Region of Murcia (Spain). The crude and adjusted rates for age, sex and year of the period were calculated and the associations between disability and/or dependency with the rest of the variables were analyzed.

Results

During the study period, 250 incident cases were diagnosed. The standardized incidence rate (SIR) was 1.52/100,000 person-years, higher in men and increasing with age in both sexes. The disease was more frequent after respiratory infections (46.4%) and in the cold months (56.4%), and the predominant variant was AIDP (54.3%). Greater disability and/or dependence were observed in patients with prolonged hospital stay (OR = 13.19; 95% CI: 3.81-45.67), ICU admission (OR = 2.37; 95% CI: 1.11- 5.06) and affected by axonal variants (OR = 3.54; 95% CI: 1.64-7.69) (P < .05).

Conclusions

The regional SIR is consistent with that reported in the national and international literature. 18.4% of the cases have recognized dependency and/or disability, associated with the axonal forms of the disease. Studies based on population registries offer representative and updated information and allow us to discover characteristics associated with a worse prognosis.

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穆尔西亚地区Guillain- Barre综合征患者残疾和依赖的发病率和相关因素：2009-2020年人口研究

背景：吉兰-巴勒综合征（GBS）的发病率是可变的，在我们的地理区域仍然未知。不良预后因素已被研究，但很少有人分析那些影响长期结果的因素。本研究的目的是从人口登记中了解这些患者的残疾和依赖的发生率、特征和相关因素。研究对象和方法观察性研究在西班牙穆尔西亚地区罕见疾病信息系统（SIER）登记的2009 - 2020年诊断为GBS的患者。计算了年龄、性别和期间年份的粗比率和调整后的比率，并分析了残疾和/或依赖与其他变量之间的关系。结果研究期间共确诊病例250例。标准化发病率（SIR）为1.52/ 100000人年，男性较高，且随年龄增长而增加。以呼吸道感染（46.4%）和寒冷月份（56.4%）多见，以AIDP（54.3%）为主。在住院时间较长（or = 13.19; 95% CI: 3.81-45.67）、ICU住院（or = 2.37; 95% CI: 1.11- 5.06）和轴突变异（or = 3.54; 95% CI: 1.64-7.69）的患者中观察到更大的残疾和/或依赖性（P < 0.05）。结论：区域性SIR与国内和国际文献报道一致。18.4%的病例具有与轴突型疾病相关的公认依赖性和/或残疾。基于人口登记的研究提供了具有代表性的最新信息，并使我们能够发现与预后较差相关的特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.