NFS Journal最新文献

{"title":"Development of an in vitro triculture model of intestine inflammation to assess the immunomodulatory properties of cassava and roselle, two African green leafy vegetables","authors":"Nelly Fioroni ,&nbsp;Maria Del Carmen Ponce de León Rodríguez ,&nbsp;Nicolas Leconte ,&nbsp;Claire Mouquet-Rivier ,&nbsp;Caroline Guzman ,&nbsp;Frédéric Boudard ,&nbsp;Claudie Dhuique-Mayer ,&nbsp;Myriam Collin ,&nbsp;Anaïs Deglos ,&nbsp;Emmanuelle Reboul ,&nbsp;Ángela Bravo-Núñez ,&nbsp;Caroline Laurent-Babot","doi":"10.1016/j.nfs.2025.100213","DOIUrl":"10.1016/j.nfs.2025.100213","url":null,"abstract":"<div><div>The intestine integrity and function are crucial for nutrient absorption and to prevent the entry of harmful antigens. In sub-Saharan Africa, frequent infections and enteric dysfunction can cause intestinal inflammation that is associated with stunting. Therefore, to study the anti-inflammatory effects of cassava and roselle leaves, commonly consumed as sauces, we developed an <em>in vitro</em> triculture model of intestine inflammation using intestinal Caco-2 (colorectal adenocarcinoma) and HT29-MTX (goblet cell-like) together with the macrophage-like THP-1 cells. Stimulation of this model with lipopolysaccharide/interferon-γ resulted in mucus over-production, higher pro-inflammatory cytokine release and loss of intestinal barrier integrity due to increased permeability. Polar/non-polar extracts and digested sauces from cassava and roselle leaves reduced cytokine production in both intestinal and THP-1 cells to different extents and restored barrier integrity and permeability. The developed and validated triculture model of inflamed intestine thus demonstrated the anti-inflammatory properties of cassava and roselle leaves, despite moderate responses.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100213"},"PeriodicalIF":4.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible impact of use of a ketogenic diet in pregnancy on the fetus: Review of animal and human studies","authors":"Agata Miłosz ,&nbsp;Justyna Michalczyk ,&nbsp;Iwona Morawik ,&nbsp;Klaudia Długoborska ,&nbsp;Monika Gesek","doi":"10.1016/j.nfs.2025.100212","DOIUrl":"10.1016/j.nfs.2025.100212","url":null,"abstract":"<div><div>Balanced diet sufficient in all nutrients is crucial to human development and health, especially for pregnant women, whose diet has a direct impact on the appropriate development of the fetus [1]. In addition, it may lead to epigenetic changes in the fetus that affect the child's health and functioning in adulthood [2]. The ketogenic diet is characterized by increased fat content with reduced carbohydrate supply [3, 4]. It is an effective form of treatment for many diseases including epilepsy, obesity, neurodegenerative diseases and some metabolic disorders.</div><div>In women with Polycystic Ovary Syndrome ketogenic diet has a positive effect on fertility by reducing weight, insulin resistance and hormonal regulation [4–7]. However, it can contribute to mineral and vitamin deficiencies, hypoproteinemia or the development of hepatic steatosis and kidney stones [4, 8]. Due to the duality of possible effects, the potential benefits of a ketogenic diet in pregnancy should be considered carefully. Moreover, there is a need for more human studies determining the safety of the ketogenic diet for both the fetus and the mother. The purpose of this review is to present recent studies evaluating the effects of maternal use of the ketogenic diet during pregnancy on fetal development and the possible advantages and drawbacks of its use.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100212"},"PeriodicalIF":4.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the in vitro hypolipidemic benefits of bamboo mushrooms: A study on their impact on lipid droplets and adipocytokine levels through metabolome and lipidome profiling","authors":"Sucheewin Krobthong ,&nbsp;Yodying Yingchutrakul ,&nbsp;Chartchai Chaichana ,&nbsp;Pawitrabhorn Samutrtai ,&nbsp;Jeeraprapa Siriwaseree ,&nbsp;Kiattawee Choowongkomon ,&nbsp;Pawin Pongkorpsakol ,&nbsp;Arnatchai Maiuthed ,&nbsp;Pithi Chanvorachote ,&nbsp;Chanat Aonbangkhen","doi":"10.1016/j.nfs.2024.100211","DOIUrl":"10.1016/j.nfs.2024.100211","url":null,"abstract":"<div><div>Functional foods from edible mushrooms, like the protein-rich and low-calorie <em>Phallus indusiatus</em> (Bamboo mushroom), are promising for obesity prevention. However, scientific evidence supporting its active compounds' benefits is limited. This study used tandem-mass spectroscopy (LC-MS/MS) to analyze Bamboo mushroom's metabolites and lipids, identifying over 1000 metabolites, with adenosine most abundant. Pathway analysis showed significant activity in amino acid and specific metabolism pathways. Lipidomic analysis revealed 131 molecular lipids across categories such as sphingolipids and glycerolipids. The extracts' cytotoxicity and hypolipidemic efficacy were evaluated using a mouse adipocytes model, demonstrating no cellular toxicity at 6.25–100 μg/mL and effective reduction in lipid droplets. Additionally, the extracts significantly reduced levels of monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1), suggesting potential hypolipidemic effects. These findings highlight Bamboo mushroom's capability as a functional food to combat obesity by influencing lipid metabolism.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100211"},"PeriodicalIF":4.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of camel milk and its products on diabetes mellitus management: A review of bioactive components and therapeutic potential","authors":"Mustapha Mbye ,&nbsp;Abdelmoneim H. Ali ,&nbsp;Afaf Kamal-Eldin ,&nbsp;Fawzi Banat","doi":"10.1016/j.nfs.2024.100204","DOIUrl":"10.1016/j.nfs.2024.100204","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a global health challenge with increasing prevalence. Camel milk (CM) and its derivatives have emerged as promising candidates for managing DM due to their unique composition and bioactive components, such as insulin-like proteins, lactoferrin, immunoglobulins, and oligosaccharides. These components exhibit hypoglycemic and anti-inflammatory properties, improving glycemic control, insulin sensitivity, and lipid profiles in individuals with DM. CM products, including fermented yogurt and powder formulations, have also shown beneficial effects on glucose metabolism and insulin regulation. The therapeutic effects of CM on DM are mediated through enhanced pancreatic β-cell function, modulation of insulin signaling pathways, and reduction of oxidative stress. Despite its potential, camel milk therapy in diabetes management faces several limitations. These include a lack of standardization in composition, limited clinical evidence, unclear mechanisms of action, and uncertainty regarding the optimal dose and duration of use. Comprehensive and robust clinical studies are essential to fully validate the therapeutic potential of camel milk and its derivatives. Previous reviews focus on using raw CM, with limited to no study on transformed camel milk products, such as fermented products, powder, and whey protein powders, which also possess anti-diabetic properties. This review discusses the effects of whole CM and its products, which form an effective, more practical, and easier to access than raw camel milk, and the mechanisms underlying the therapeutic potential of CM and its products in combating DM.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100204"},"PeriodicalIF":4.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 1-Deoxynojirimycin on glycemic control: A systematic review and meta-analysis","authors":"In Ho Cho ,&nbsp;RanRan Cheng ,&nbsp;Cheol Woon Jung ,&nbsp;Tae Hyung Won ,&nbsp;Daijie Wang ,&nbsp;Hwan-Hee Jang ,&nbsp;In Guk Hwang ,&nbsp;Sung Won Kwon","doi":"10.1016/j.nfs.2024.100210","DOIUrl":"10.1016/j.nfs.2024.100210","url":null,"abstract":"<div><div>This meta-analysis investigates the effects of 1-Deoxynojirimycin (DNJ), derived from mulberry leaves, on glycemic control in individuals with impaired glucose tolerance and type 2 diabetes. DNJ significantly reduced postprandial plasma glucose (PPG) at 30 min, postprandial plasma insulin (PPI) at 30 min, and both glucose and insulin incremental area under the curve (iAUC) at 120 min, with substantial heterogeneity across studies. These findings align with DNJ's role as an inhibitor of α-glucosidase and sucrase, delaying carbohydrate digestion and glucose absorption in the small intestine. However, the effects were short-lived, indicating DNJ's limited prolonged efficacy due to low bioavailability and rapid clearance. Future research is needed to further investigate its long-term effects and improve its therapeutic potential.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100210"},"PeriodicalIF":4.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations and patterns in lifestyle and body weight among university students over one year into the Covid-19 pandemic: A cluster analysis","authors":"Andreas Bschaden,&nbsp;Nanette Stroebele-Benschop","doi":"10.1016/j.nfs.2024.100206","DOIUrl":"10.1016/j.nfs.2024.100206","url":null,"abstract":"<div><div>In March 2020, the first wave of SARS-CoV-2 infections led to far-reaching measures worldwide to slow the spread of the virus. University students were particularly affected by the COVID-19 pandemic due to the shift to distance learning. Research found an increase in body weight among a significant proportion of students, as well as unfavourable changes in food consumption and physical activity in the first months of the pandemic. The present study aimed to examine changes in food consumption, physical activity, and body weight more than one year into the COVID-19 pandemic. A cross-sectional online survey was conducted among students at a German university in July/August 2021 (<em>n</em> = 951). Changes in food consumption, physical activity, and self-reported body weight since the beginning of the pandemic were assessed in comparison to pre-pandemic levels. Weight gain was reported by 38 % of students, weight loss by 30 %. Changes in sweet and savoury snacks consumption were positively, and changes in sporting frequency and fruit consumption were negatively associated with weight change. A cluster analysis revealed five groups of student clusters, two of which were able to benefit from the changes in their daily lives with increased physical activity and vegetable consumption. Negative consequences, such as reduced physical activity or increased sweet and savoury snack consumption, were found in two groups. One group appeared to be unaffected. The study helps to understand how the pandemic affected students differently. A closer look is needed to identify the reasons for these varied consequences and to develop strategies to assist those who are struggling to better cope with such situations.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100206"},"PeriodicalIF":4.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of microencapsulation using β-cyclodextrin and β-glucan as coating agents on physicochemical properties and phytocannabinoids retention of cannabis flower oil extract","authors":"Worakrit Saiyasombat,&nbsp;Chanittha Yimpetch,&nbsp;Wimonphan Chathiran,&nbsp;Jaruwan Chimasangkanan,&nbsp;Warangkana Srichamnong","doi":"10.1016/j.nfs.2024.100209","DOIUrl":"10.1016/j.nfs.2024.100209","url":null,"abstract":"<div><div>Phytocannabinoids possess various biological activities; however, their limited aqueous solubility and poor stability present problems for effective utilization. Encapsulation is a highly effective method to improve the stability and solubility of cannabis extracts. The potential of β-glucan as a coating material for cannabis extract has not been extensively studied. This study aimed to investigate encapsulation of cannabis extracts by freeze-drying using β-glucan or β-cyclodextrin as coating agents. The extract was mixed with coating agent, with core-to-coating ratio of 1:1 and 1:2 (<em>w</em>/w). Tween 20 or 40 % ethanol were employed for preparing emulsion. Characterization was performed using contact angle, SEM, FT-IR, NMR and TGA. Phytocannabinoids and antioxidant properties were analyzed using LC-MS/MS and three antioxidant assays (DPPH, FRAP and ORAC). Results showed that different encapsulation conditions affect the phytocannabinoids contents and their morphology. The microencapsulation with Tween 20 at core-to-coating ratio of 1:1 can retain CBD and THC at 0.19 μg/g oil and 0.04–0.07 μg/g oil. SEM image showed granular structure in β-glucan encapsulated products. FT-IR, NMR and TGA confirmed microencapsulation formation. These microcapsules demonstrated high thermal stability with encapsulation efficiency ranging from 13.38 % to 64.80 %. All microcapsules exhibited various antioxidant activity. This study demonstrates the potential for developing water-soluble cannabinoids for food and pharmaceutical applications.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100209"},"PeriodicalIF":4.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fresh orange, apple, mango and papaya fruit juices on postprandial glycemia in apparently healthy young adults","authors":"Yapo Hypolithe Kouadio ,&nbsp;Béda Frank Yapo ,&nbsp;Jean-Brice Gbakayoro ,&nbsp;Hadja Mawa Fatim Diabagate ,&nbsp;Ouattara Ahmed Farman","doi":"10.1016/j.nfs.2024.100205","DOIUrl":"10.1016/j.nfs.2024.100205","url":null,"abstract":"<div><div>The consumption of fruit juices remains controversial due to their potentially negative impact on postprandial glycemic response. The aim of this study was to determine the glycemic index and glycemic load of four fruit juices in apparently healthy adult subjects. This study included 16 healthy adults. Each subject consumed the reference food twice and the fruit juices once. The fruit juices studied were orange, papaya, apple, and mango, all freshly pressed with no added sugar. All juices were made from very ripe fruit. Blood glucose levels were measured using a calibrated glucometer (On Call Plus). The glycemic index (GI) and glycemic load (GL) were determined using standard methods. The results showed that mango juice had a moderate GI (56.41 ± 3.52) and a high GL (7.46 ± 0.47). Papaya, orange, and apple juices all had low GI (49.67 ± 5.05, 42.97 ± 2.93, and 31.50 ± 3.32, respectively) and low GL (4.23 ± 0.43, 3.91 ± 0.27, and 2.56 ± 0.38, respectively). This study indicates that although the GL of the fruit juices studied was low, particularly mango juice, should be consumed in moderation by diabetic subjects.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100205"},"PeriodicalIF":4.1,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in vitamin D2 content and physicochemical characteristics of food products enriched with UV-B irradiated oyster mushroom powder during cooking and storage","authors":"Chutikarn Kapcum ,&nbsp;Nongnuch Sungayuth ,&nbsp;Thitipak Theeratadsanakul ,&nbsp;Wishita Sutthi ,&nbsp;Kunchit Judprasong ,&nbsp;Piyanut Sridonpai ,&nbsp;Konpong Boonyingsathit ,&nbsp;Rungtiwa Wongsagonsup","doi":"10.1016/j.nfs.2024.100203","DOIUrl":"10.1016/j.nfs.2024.100203","url":null,"abstract":"<div><div>UV-B irradiation has been shown to increase vitamin D₂ content in oyster mushrooms. This study investigated changes in vitamin D₂ content and the physicochemical properties of food products (i.e., alkaline noodles, Mantous, cookies, and extruded snacks) enriched with 10 % UV-B irradiated oyster mushroom powder during cooking and storage. After cooking, alkaline noodles and Mantous were stored at 4 °C for 8 days, while cookies and snacks were stored in an accelerated condition at 45 °C for 90 days. Vitamin D₂ content in alkaline noodles and Mantous remained unchanged after cooking, but declined in cookies and extruded snacks by 27 % and 55 %, respectively. During storage, vitamin D₂ content in Mantous and cookies did not change, but decreased in alkaline noodles and snacks by 19–38 % and 26–51 %, respectively. The total phenolic content and antioxidant activities of the food products generally increased after cooking, except for alkaline noodles, and generally decreased during storage, except for Mantous. The texture properties of all products also changed during storage, which could be related to moisture content within the products. This study illustrated that significant amounts of vitamin D₂ and phenolic compounds remained in the food products after cooking and storage, especially in Mantous and cookies, thereby promoting human health benefits.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"38 ","pages":"Article 100203"},"PeriodicalIF":4.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of obligatory versus voluntary school food standard implementation on the fulfillment of the school food standard requirements in Germany","authors":"Cordula Hundeshagen ,&nbsp;Heike Rosmann ,&nbsp;Jörg Lindenmeier","doi":"10.1016/j.nfs.2024.100197","DOIUrl":"10.1016/j.nfs.2024.100197","url":null,"abstract":"<div><h3>Background</h3><div>In high income countries there is increased focus on health- and sustainability aspects concerning school feeding. To ensure this in Germany, a school food standard (SFS) was established. Implementation of the SFS is mandatory only in some federal states and has remained voluntary in others. The aim of this first exploratory study is to analyze school lunch menus regarding their fulfillment of the SFS requirements and detect differences between obligatory and voluntary implementation of the SFS.</div></div><div><h3>Methods</h3><div>After drawing a random sample of schools and reaching out for voluntary participation in this study, school menus of federal states with obligatory (OSFS) and voluntary (VSFS) SFS implementation were collected and analyzed. The SFS criteria are based on the conditions observed in the menu for a four-week mixed diet menu, an ovo-lacto-vegetarian dish, additional criteria for menu planning and menu criteria. In addition, we estimated binominal logistic regression models and two-step multiple regression models to control for the effects of geographical factors and socioeconomic status to the fulfillment of the SFS criteria.</div></div><div><h3>Results</h3><div>We assessed 48 menus from OSFS federal states and 102 menus from VSFS federal states. OFSF menus met the requirements to a higher extent and exhibited a better dietary pattern. School food-standardized meals included significantly less breaded and deep-fried components (96 % vs. 79 %, <em>p</em> = 0.009), contained more whole grain products (83 % vs. 30 %, <em>p</em> &lt; 0.001) and fewer meat products (60 % vs. 25 %, <em>p</em> &lt; 0.001), more fruits (81 % vs. 63 %, <em>p</em> = 0.023) and more vegetables, legumes and salad (85 % vs. 61 %, <em>p</em> = 0.002). Menus with SFS obligation emphasized nutrient optimized menus significantly more frequently (42 % vs. 28 %, <em>p</em> &lt; 0.001) and used unambiguous designations of meals more often (96 % vs. 82 %, <em>p</em> = 0.023). They contain more regional products (33 % vs. 13 %, <em>p</em> = 0.003), more organic products (71 % vs. 41 %, p &lt; 0.001) and meat from animal friendly husbandry (21 % vs. 7 %, <em>p</em> = 0.012). The effects of the covariates were rarely significant.</div></div><div><h3>Conclusion</h3><div>School menus with obligatory use of the SFS met the requirements to a greater extent and contain healthier and sustainable food components more frequently. Nevertheless, results show that even in federal states with obligational use, the standard implementation is not fulfilled completely. Further research is needed to detect barriers in the daily implementation of the SFS.</div></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"37 ","pages":"Article 100197"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}