Neurospine最新文献

{"title":"Changing the Learning Experience and Learning Outcomes of the Unilateral Biportal Endoscopic Spine Surgery Based on Applying a Competency Task Analysis.","authors":"Siravich Suvithayasiri, Piya Chavalparit, Win Boonsirikamchai, Borriwat Santipas, Michael Piccirillo, Jin-Sung Kim","doi":"10.14245/ns.2550060.030","DOIUrl":"10.14245/ns.2550060.030","url":null,"abstract":"","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 2","pages":"540-542"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility and Actionability of Failure to Rescue Prediction Model for Thoracolumbar Fusion: A Focus on Variable Relevance - A Commentary on \"A Predictive Model of Failure to Rescue After Thoracolumbar Fusion\".","authors":"Seyed Amirhossein Tabatabaei, Mohammad Reza Cheraghi","doi":"10.14245/ns.2550280.140","DOIUrl":"10.14245/ns.2550280.140","url":null,"abstract":"","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 2","pages":"615-616"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Nomogram for Predicting Adjacent Vertebral Fracture After Osteoporotic Vertebral Compression Fracture Surgery: A Multicenter Retrospective Cohort Study.","authors":"Hanwen Cheng, Huilong Wen, Yong Ma, Zhuojie Liu, Haoyu Wu, Lajing Luowu, Yong Xiao, Lianbin Liang, Fanjie Kong, Longyi Xiao, Chunhai Li","doi":"10.14245/ns.2449338.669","DOIUrl":"10.14245/ns.2449338.669","url":null,"abstract":"<p><strong>Objective: </strong>Osteoporotic vertebral compression fractures (OVCFs) are a major public health concern. While percutaneous vertebral augmentation (PVA) is an effective treatment for OVCF, adjacent vertebral fractures (AVF) often occur post-PVA, adversely affecting treatment outcomes. This study aims to develop a nomogram for predicting AVF risk using multicenter data to aid clinical decision-making for OVCF patients.</p><p><strong>Methods: </strong>We retrospectively analyzed patients who underwent PVA at 3 hospitals between 2017 and 2022. The cohort was divided into a training set (80%) and a validation set (20%). Independent risk factors for AVF were identified using LASSO (least absolute shrinkage and selection operator) and logistic regression. Seven significant factors were: bone mineral density, diabetes, total fractured vertebrae, intravertebral vacuum cleft sign, recovery of local kyphosis angle, regular aerobic exercise, and lumbar brace use.</p><p><strong>Results: </strong>Among the 483 patients, 52 (10.76%) developed adjacent vertebral refractures within 2 years. The nomogram demonstrated high predictive accuracy, with area under the curves of 89.21% in the training set and 98.33% in the validation set.</p><p><strong>Conclusion: </strong>This pioneering nomogram, incorporating baseline, surgical, and postoperative factors, provides valuable guidance for spine surgeons in preoperative planning and postoperative management, enabling personalized prognosis and rehabilitation for OVCF patients.</p>","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":" ","pages":"592-602"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Facet Joint Block Versus a Medial Branch Block in Spinal Pain Management: A Systematic Review and Meta-Analysis.","authors":"Sung Hyeon Noh, Kyoung-Tae Kim, Dong Ah Shin, Je Hwi Yun, Pyung Goo Cho, Sang Hyun Kim","doi":"10.14245/ns.2550384.192","DOIUrl":"10.14245/ns.2550384.192","url":null,"abstract":"<p><strong>Objective: </strong>Facet joint injections (FJIs) and medial branch blocks (MBBs) are commonly used interventions for chronic spinal pain, but their comparative effectiveness remains unclear. This meta-analysis aimed to compare the pain relief, functional improvement, complications, and patient satisfaction associated with FJI and MBB.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of randomized controlled trials and observational studies were conducted. Primary outcomes included pain relief (numerical rating scale) and functional improvement (Oswestry Disability Index [ODI]/Neck Disability Index). Secondary outcomes assessed adverse effects and patient satisfaction. The differences in characteristics between patients who were readmitted and those who were not were identified and analyzed using the Review Manager software.</p><p><strong>Results: </strong>FJI resulted in lower pain and ODI scores compared to MBB, but the differences were not statistically significant. However, patient satisfaction was significantly higher in the FJI group (odds ratio, 1.81; 95% confidence interval, 1.02-3.24; p=0.04). Additionally, FJI had fewer adverse effects than MBB.</p><p><strong>Conclusion: </strong>Both FJI and MBB are effective for chronic spinal pain, but FJI may be preferred for patients seeking immediate pain relief with fewer complications. Further high-quality studies are needed to refine treatment guidelines.</p>","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 2","pages":"441-450"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Therapeutic Applications of CRISPR Genome Editing for Spinal Pain Management.","authors":"Chan Young Kang, Kyung Wook Been, Myoung-Hee Kang, Myung Su Choi, Rae Hee Kang, Junseok W Hur, Junho K Hur","doi":"10.14245/ns.2550462.231","DOIUrl":"10.14245/ns.2550462.231","url":null,"abstract":"<p><p>Neuropathic pain remains a significant clinical challenge due to the limited efficacy and sustainability of existing pharmacological treatments, underscoring the urgent need for mechanism-based therapeutic strategies. In recent years, gene-targeted interventions have emerged as promising modalities capable of modulating key molecular pathways implicated in chronic pain. Approaches such as antisense oligonucleotides and RNA interference have demonstrated encouraging preclinical results by selectively downregulating pain-associated genes. Based on these developments, genome-editing technologies-particularly the clustered regularly interspaced short palindromic repeats (CRISPR) system-have enabled more precise and long-lasting modifications at both the DNA and RNA levels. This review highlights how CRISPR-based approaches in addressing the critical issues of specificity and long-term efficacy in pain gene therapy and exploring the functional roles of key gene targets and regulatory elements. Although challenges such as off-target activity and immunogenic responses remain, growing preclinical evidence supports the feasibility of CRISPR-based approaches in neuropathic pain. Collectively, these developments position CRISPR as a transformative tool to innovate the standard care for persistent pain syndromes and contribute to broader biomedical and pharmaceutical developments through continued refinement of targeting strategies and safety profiles.</p>","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 2","pages":"421-440"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the K Line - A Commentary on \"The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study\".","authors":"Fabrizio Russo, Gianluca Vadalà, Vincenzo Denaro","doi":"10.14245/ns.2550882.441","DOIUrl":"10.14245/ns.2550882.441","url":null,"abstract":"","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 2","pages":"351-353"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply Letter: A Commentary on \"A Predictive Model of Failure to Rescue After Thoracolumbar Fusion\".","authors":"Joanna M Roy, Aaron C Segura, Michael M Covell, Christian A Bowers","doi":"10.14245/ns.2550238.119","DOIUrl":"10.14245/ns.2550238.119","url":null,"abstract":"","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 2","pages":"617-618"},"PeriodicalIF":3.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Ubiquitin Enhances Autophagy and Inhibits Mitochondrial Apoptosis Pathway to Protect Neurons Against Spinal Cord Ischemic Injury via CXCR4.","authors":"Hao Feng, Dehui Chen, Huina Chen, Dingwei Wu, Dandan Wang, Zhengxi Yu, Linquan Zhou, Zhenyu Wang, Wenge Liu","doi":"10.14245/ns.2448878.439","DOIUrl":"10.14245/ns.2448878.439","url":null,"abstract":"<p><strong>Objective: </strong>Neuronal apoptosis is considered to be a critical process in spinal cord injury (SCI). Despite growing evidence of the antiapoptotic, anti-inflammatory, and modulation of ischemic injury tolerance effects of extracellular ubiquitin (eUb), existing studies have paid less attention to the impact of eUb in neurological injury disorders, particularly in SCI. This study aimed to investigate whether eUb can play a protective role in neurons, both in vitro and in vivo, and explores the underlying mechanisms.</p><p><strong>Methods: </strong>By utilizing an oxygen glucose deprivation cellular model and a SCI rat model, we firstly investigated the therapeutic effects of eUb on SCI and further explored its effects on neuronal autophagy and mitochondria-dependent apoptosis-related indicators, as well as the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mechanical target of rapamycin (mTOR) signaling pathway.</p><p><strong>Results: </strong>In the SCI models both in vivo and in vitro, early intervention with eUb enhanced neuronal autophagy and inhibited mitochondrial apoptotic pathways, significantly mitigating SCI. Further studies had shown that this protective effect of eUb was mediated through its receptor, CXC chemokine receptor type 4 (CXCR4). Additionally, eUb-enhanced autophagy and antiapoptotic effects were possibly associated with inhibiting the PI3K/Akt/mTOR pathway.</p><p><strong>Conclusion: </strong>In summary, the study demonstrates that early eUb intervention can enhance autophagy and inhibit mitochondrial apoptotic pathways via CXCR4, protecting neurons and promoting SCI repair.</p>","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":" ","pages":"157-172"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes and Patient Perspectives in Full Endoscopic Cervical Surgery: A Systematic Review.","authors":"Wongthawat Liawrungrueang, Sung Tan Cho, Ayush Sharma, Watcharaporn Cholamjiak, Meng-Huang Wu, Lo Cho Yau, Hyun-Jin Park, Ho-Jin Lee","doi":"10.14245/ns.2449086.534","DOIUrl":"https://doi.org/10.14245/ns.2449086.534","url":null,"abstract":"<p><strong>Objective: </strong>Full endoscopic cervical surgery (FECS) is an evolving minimally invasive approach for treating cervical spine disorders. This systematic review synthesizes current evidence on the clinical outcomes and patient perspectives associated with FECS, specifically evaluating its safety, efficacy, and overall patient satisfaction.</p><p><strong>Methods: </strong>A systematic search of the PubMed/MEDLINE, Cochrane Library, Embase, and Web of Science databases was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies published between January 2000 and September 2024 that reported on clinical outcomes or patient perspectives related to FECS were included. Risk of bias was assessed using the ROBINS-I (Risk Of Bias In Non-randomized Studies - of Interventions) tool and the Cochrane Risk of Bias tool. Inclusion criteria encompassed randomized controlled trials, prospective cohort studies, retrospective studies, and observational studies focused on adult populations undergoing FECS for cervical spine surgery.</p><p><strong>Results: </strong>The final synthesis included 30 studies. FECS was associated with significant reductions in both cervical and radicular pain, as well as meaningful functional improvements, measured by standardized clinical scales such as the Neck Disability Index and visual analogue scale. Patient satisfaction rates were consistently high, with most studies reporting satisfaction exceeding 85%. Complication rates were low, primarily involving transient neurological deficits that were typically resolved without the need for further intervention. Nonrandomized studies generally presented a moderate risk of bias due to confounding and selection, whereas randomized controlled trials exhibited a low risk of bias.</p><p><strong>Conclusion: </strong>FECS is a safe and effective minimally invasive surgical option for cervical spine disorders associated with substantial pain relief, functional improvement and high levels of patient satisfaction.</p>","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 1","pages":"81-104"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on \"Impact of Paraspinal Muscle Degeneration on Surgical Outcomes and Radiographical Sagittal Alignment in Adult Spinal Deformity: A Multicenter Study\".","authors":"Yutaro Kanda","doi":"10.14245/ns.2550248.124","DOIUrl":"https://doi.org/10.14245/ns.2550248.124","url":null,"abstract":"","PeriodicalId":19269,"journal":{"name":"Neurospine","volume":"22 1","pages":"38-39"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}