Nuklearmedizin-nuclear Medicine最新文献

{"title":"[Breakeven Analysis for Imaging Devices: Basic Introduction with Presentation of a User-Friendly Tool for in-clinic Calculation Using PET/CT as an Example].","authors":"Claus Zippel,&nbsp;Christina Antke,&nbsp;Yuriko Mori,&nbsp;Antje Sombetzki,&nbsp;Gerald Antoch,&nbsp;Frederik L Giesel","doi":"10.1055/a-2036-7694","DOIUrl":"https://doi.org/10.1055/a-2036-7694","url":null,"abstract":"<p><strong>Background: </strong>Imaging devices such as PET/CT are becoming increasingly important in view of the growing range of innovative nuclear medicine diagnostic procedures. Since the procurement and commissioning as well as the ongoing operation of imaging devices leads to comparatively high costs, it is of great interest for clinics and practices to know the number of scans from which the (planned) device operation leads to a profit. In the following, we will introduce the breakeven point analysis and present a calculation tool that users in nuclear medicine clinics and practices can use in everyday operations using PET/CT as an example.</p><p><strong>Methods: </strong>In the breakeven point analysis, the intersection point is determined from which the organisation- or device-specific revenues exceed the total costs incurred for personnel, material resources, etc. For this purpose, the fixed and variable (planned) cost components for the procurement and operation of the device must be prepared on the cost side and the respective device-related (planned) revenue structure on the revenue side.</p><p><strong>Results: </strong>The authors present the break-even analysis method with the data processing required for this using the example of the planned procurement or ongoing operation of a PET/CT. In addition, a calculation tool was developed, that interested users can use to prepare a device-specific break-even analysis. For this purpose, various cost and revenue data are discussed, which have to be compiled and processed within the clinic and entered into prepared spreadsheets.</p><p><strong>Conclusion: </strong>The breakeven point analysis can be used to determine the profit/loss (point) for the (planned) operation of imaging devices such as PET/CT. Users from imaging clinics/practices and administration can adapt the calculation tool presented to their specific facility and thus use it as a basic document for both the planned procurement and the ongoing operational control of imaging devices in everyday clinical practice.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"62 3","pages":"185-191"},"PeriodicalIF":1.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[68Ga]Ga-PSMA-11 uptake in planepitheliale lung cancer: a pitfall in prostate cancer imaging.","authors":"Paulina Cegla,&nbsp;Marta Wojewodzka-Mirocha,&nbsp;Wioletta Chalewska,&nbsp;Marek Dedecjus","doi":"10.1055/a-2000-5589","DOIUrl":"https://doi.org/10.1055/a-2000-5589","url":null,"abstract":"Prostate cancer (PCa) is the second most frequent cancer diagnosis made in men and the fifth leading cause of death worldwide [1]. Prostate-specific membrane antigen labeled with gallium 68 ([68Ga]GaPSMA-11) is a promising radiotracer frequently used in diagnostics of the patients with biochemical recurrence of PCa. PSMA’s expression in non-small cell lung cancer (NSCLC) ranks around 16 %, while tumor neovasculature expression is seen in 59% of tumor samples and is dependent on NSCLC histopathological type. The highest (71%) is seen in large cell carcinoma (LCC) and in squamous cell carcinoma (SCC) – 64%, while the lowest (45%) is noted in adenocarcinoma (AC) [2, 3]. A 77-year-old man with prostate adenocarcinoma, Gleason 7 (3 + 4), TNM T2bNxM0, during hormonotherapy and urothelial carcinoma (T1bNxM0) during BCG therapy, was referred to [68Ga]GaPSMA-11 PET/CT study due to biochemical recurrence (total prostate specific antigen (t-PSA) 0.449 ng/ml). A cystoscopy performed one week before PET/CT examination was clear. The [68Ga]Ga-PSMA-11 showed an increased focal PSMA ligand uptake at the right side of the small pelvis (SUVmaxlbm up to 9.2, ▶ Fig. 1A), lump in segment 6 of the right lung (SUVmaxlbm up to 2.4, ▶ Fig. 1B) and area of parenchyma consolidation in segment 10 of the right lung (SUVmaxlbm up to 2.6, ▶ Fig. 1C). Moreover, [68Ga]Ga-PSMA-11 also revealed areas of pathological osteosclerotic remodeling in both hip bones and in both pubic bones without increased PSMA uptake. Patient underwent a resection of a lump (segment 6) in the right lung which revealed planoepitheliale lung cancer G3, pT1R0L1V1. Three months after resection, patient was referred to [18F]FDG PET/CT study which revealed (shown earlier in [68Ga]Ga-PSMA-11) tumor in segment 10 of the right lung (50 × 38 mm, SUVmaxlbm up to 12.3, ▶ Fig. 1D), branch of the diaphragm lymph node (18 × 20mm, SUVmaxlbm up to 5.8) and metastatic lesion in III right rib. Other changes in bones did not show any pathological uptake. Patient because of the comorbidities, age and extension of the disease was treated with palliative radiotherapy of the lung. A 69-year-old man t-PSA level 2.47 [ng/ mL], after prostatectomy followed by radiotherapy of regional lymph nodes and complementary hormonotherapy in 2007, currently under palliative hormonotherapy underwent [68Ga]Ga-PSMA-11 PET/CT study because of biochemical recurrence. The scan revealed a focal PSMA ligand uptake in the small pelvis (SUVmaxlbm up to 3.6), in enlarged right hilar lymph node SUVmaxlbm up to 2.7 (▶ Fig. 2A) and a soft-tissue lesion in left lung lower lobe (▶ Fig. 2B) with SUVmaxlbm up to 2.0. Patient a few months after [68Ga]Ga-PSMA11 PET/CT underwent a computed tomography (CT) examination of a thorax which showed right upper lobe mass extending round the main bronchus and involving hilar lymph nodes (▶ Fig. 2C). The soft-tissue lesion in the left lung lower lobe was less consolidated and more irregular in shape with a small cavity,","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"62 3","pages":"220-221"},"PeriodicalIF":1.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Synthesis of Prospective Multiple Time Points F-18 FDG PET Images from a Single Scan Using a Supervised Generative Adversarial Network.","authors":"Merhnoosh Karimipourfard,&nbsp;Sedigheh Sina,&nbsp;Fereshteh Khodadai Shoshtari,&nbsp;Mehrosadat Alavi","doi":"10.1055/a-2095-2016","DOIUrl":"https://doi.org/10.1055/a-2095-2016","url":null,"abstract":"","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"62 2","pages":"e1"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Prospective Multiple Time Points F-18 FDG PET Images from a Single Scan Using a Supervised Generative Adversarial Network.","authors":"Merhnoosh Karimipourfard,&nbsp;Sedigheh Sina,&nbsp;Fereshteh Khodadai Shoshtari,&nbsp;Mehrsadat Alavi","doi":"10.1055/a-2026-0784","DOIUrl":"https://doi.org/10.1055/a-2026-0784","url":null,"abstract":"<p><p>The cumulative activity map estimation are essential tools for patient specific dosimetry with high accuracy, which is estimated using biokinetic models instead of patient dynamic data or the number of static PET scans, owing to economical and time-consuming points of view. In the era of deep learning applications in medicine, the pix-to-pix (p2 p) GAN neural networks play a significant role in image translation between imaging modalities. In this pilot study, we extended the p2 p GAN networks to generate PET images of patients at different times according to a 60 min scan time after the injection of F-18 FDG. In this regard, the study was conducted in two sections: phantom and patient studies. In the phantom study section, the SSIM, PSNR, and MSE metric results of the generated images varied from 0.98-0.99, 31-34 and 1-2 respectively and the fine-tuned Resnet-50 network classified the different timing images with high performance. In the patient study, these values varied from 0.88-0.93, 36-41 and 1.7-2.2, respectively and the classification network classified the generated images in the true group with high accuracy. The results of phantom studies showed high values of evaluation metrics owing to ideal image quality conditions. However, in the patient study, promising results were achieved which showed that the image quality and training data number affected the network performance. This study aims to assess the feasibility of p2 p GAN network application for different timing image generation.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"62 2","pages":"61-72"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Is there an unmet need to establish a young talent section \"Young DGN\" within the German Society of Nuclear Medicine (DGN)? - Results of a 2021/2022 web-based survey among German Nuclear Medicine professionals].","authors":"Yasemin Aylin Sahin,&nbsp;Friederike Eilsberger,&nbsp;Eric Einspänner,&nbsp;Johannes Kunz,&nbsp;Sarah Spreckelmeyer,&nbsp;Markus Luster,&nbsp;Winfried Brenner,&nbsp;Benjamin Kläsner,&nbsp;Adrien Holzgreve","doi":"10.1055/a-1984-8116","DOIUrl":"https://doi.org/10.1055/a-1984-8116","url":null,"abstract":"<p><strong>Aim: </strong>In various medical societies, dedicated young talent sections provide an important basis for promoting young members. However, the German Society of Nuclear Medicine (DGN) had not yet implemented such a section. Therefore, the aim of this work was to assess the opinion of nuclear medicine professionals in Germany on establishing a young talent section within the DGN (\"Young DGN\").</p><p><strong>Methods: </strong>An initiative group of young DGN members developed a survey questionnaire comprising 18 questions. The questionnaire was initially sent as a PDF to the members of the DGN University Committee (<i>Hochschulausschuss</i>) by e-mail on 10/12/2021. As an online survey, the questionnaire was then emailed at four additional time points between 12/23/2021 and 3/18/2022 via the <i>DGN eBrief</i> and on 2/23/2022 to the members of the mailing list of the <i>Berufsverband Deutscher Nuklearmediziner</i> (BDN).</p><p><strong>Results: </strong>The survey closed on 3/31/2022 with 111 responses (n=104 online surveys, n=7 PDFs). The median age of participants was 32.5 years (range, 20-80). 86% of participants indicated that they were interested in a Young DGN section, of which 67% were willing to participate. 79% indicated that nuclear medicine was an exciting field for them. 96% expressed interest in additional education offers and 60% in the establishment of a mentoring program. 75% believed that Young DGN would improve the visibility of the specialty.</p><p><strong>Conclusion: </strong>The survey results indicate strong support for the establishment of a young talent section within the DGN among nuclear medicine professionals in Germany. A large proportion of those who participated in the survey would envision active involvement. There was a particular consensus on the desire to expand the range of education and training activities.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"62 2","pages":"55-60"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9586094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"F18-FDG PET/CT in a patient with Antisynthetase Syndrome.","authors":"Tina Nazerani-Zemann,&nbsp;Susanne Stanzel,&nbsp;Christian Gstettner,&nbsp;Reingard Maria Aigner,&nbsp;Birgit Pernthaler","doi":"10.1055/a-1996-0157","DOIUrl":"https://doi.org/10.1055/a-1996-0157","url":null,"abstract":"<p><p>More prevalent in women than men, Antisynthetase Syndrome is a rare and poorly defined autoimmune disease associated with interstitial lung disease, polymyositis, and dermatomyositis. In addition to various diagnostic tools, imaging modalities are needed in certain situations. A 42-year-old woman with Anti-Jo-1-positive Antisynthetase Syndrome presented with thoracic muscular pain. She underwent whole-body Fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) to evaluate the total extent of the muscles affected. Depicting symptomatic symmetric myositis of the intercostal muscles, F18-FDG PET/CT additionally revealed unusually extensive fasciitis of the lower extremities.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"62 2","pages":"73-74"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/8b/10-1055-a-1996-0157.PMC10063341.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hand in hand - the future of SPECT and PET imaging].","authors":"Friederike Eilsberger,&nbsp;Constantin Lapa,&nbsp;Benjamin Kläsner,&nbsp;Michael Andreas Schäfers,&nbsp;Markus Luster","doi":"10.1055/a-1998-8402","DOIUrl":"https://doi.org/10.1055/a-1998-8402","url":null,"abstract":"Institute 1 Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany 2 Medical Faculty, Nuclear Medicine, University of Augsburg, Augsburg, Germany 3 Department of Nuclear Medicine, Klinikum Konstanz, Konstanz, Germany 4 Department of Nuclear Medicine, University Hospital Münster, Münster, Germany Bibliografie Nuklearmedizin 2023; 62: 52–53 DOI 10.1055/a-1998-8402 ISSN 0029-5566 © 2023. Thieme. All rights reserved. Georg Thieme Verlag KG, Rüdigerstraße 14, 70469 Stuttgart, Germany","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"62 2","pages":"52-53"},"PeriodicalIF":1.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9352942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lutetium-177 PSMA radioligand therapy for metastatic castration resistant prostate cancer in Germany: population-based data with multicenter validation from 2016 to 2020","authors":"L. Flegar, S. Thoduka, D. Librizzi, M. Luster, A. Zacharis, H. Heers, N. Eisenmenger, H. Ahmadzadehfar, M. Eiber, W. Weber, C. Groeben, J. Huber","doi":"10.1055/s-0043-1766222","DOIUrl":"https://doi.org/10.1055/s-0043-1766222","url":null,"abstract":"Ziel/Aim To investigate the adoption and current trends of Lutetium-177 PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) in Germany.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"92 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135419773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Ga-68-FAPI PET/CT offers oncologic staging without COVID-19 vaccine-related pitfalls","authors":"T. Demmert, I. Maric, K. Pomykala, K. Lückerath, J. Siveke, B. Schaarschmidt, R. Hamacher, L. Kessler, N. Hirmas, K. Pabst, T. Bartel, K. Herrmann, W. Fendler","doi":"10.1055/s-0043-1766277","DOIUrl":"https://doi.org/10.1055/s-0043-1766277","url":null,"abstract":"Ziel/Aim The global SARS-CoV-2 vaccination campaign brought attention to a recent pitfall in tumor staging by PET/CT. Several publications reported a non-specific F-18-FDG tracer uptake in axillary lymph nodes after COVID-19 vaccination. Ga-68-FAPI PET/CT is a new oncologic imaging tool that may overcome this limitation.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135419774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective α-Synuclein PET Radiotracer Development- Characterization","authors":"B. Hooshyar Yousefi, B. C. Uzuegbunam, W. Paslawski, G. B. Kotipalli, M. Luster, D. Librizzi, W. Weber, P. Svenningsson, T. Arzberger","doi":"10.1055/s-0043-1766158","DOIUrl":"https://doi.org/10.1055/s-0043-1766158","url":null,"abstract":"Ziel/Aim The deposition of α-synuclein fibrils (α-syn) is a major feature that unites a group of neurodegenerative diseases collectively known as the synucleinopathies. Presently, the in vivo detection of this biomarker is not possible due to lack of suitable radiotracers. Scientists from academics and industry are interested to develop radiotracers for the early diagnosis of α-synucleinopathies. Disarylbisthiazoles (DABTAs) based ligands have been showing high affinity towards α-syn and excellent selectivity over tau and Aβ aggregates. The aim of this work is characterization of the radiotracers within competition binding assays, autoradiography and pharmacokinetics (PK) study to confirm their high binding affinity and optimized pharmacokinetics and utilize them as a promising α-syn PET tracer.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135419775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}