{"title":"Growth dynamics of incidental meningiomas: A prospective long-term follow-up study.","authors":"Torbjørn Austveg Strømsnes, Morten Lund-Johansen, Geir Olve Skeie, Geir Egil Eide, Maziar Behbahani, Bente Sandvei Skeie","doi":"10.1093/nop/npac088","DOIUrl":"10.1093/nop/npac088","url":null,"abstract":"<p><strong>Background: </strong>There is no consensus on the management of incidental meningiomas. The literature on long-term growth dynamics is sparse and the natural history of these tumors remains to be illuminated.</p><p><strong>Methods: </strong>We prospectively assessed long-term tumor growth dynamics and survival rates during active monitoring of 62 patients (45 female, mean age 63.9 years) harboring 68 tumors. Clinical and radiological data were obtained every 6 months for 2 years, annually until 5 years, then every second year.</p><p><strong>Results: </strong>The natural progression of incidental meningiomas during 12 years of monitoring was growth (<i>P</i> < .001). However, mean growth decelerated at 1.5 years and became insignificant after 8 years. Self-limiting growth patterns were seen in 43 (63.2%) tumors, non-decelerating in 20 (29.4%) and 5 (7.4%) were inconclusive due to ≤ 2 measurements. Decelerating growth persisted once established. Within 5 years, 38 (97.4%) of 39 interventions were initiated. None developed symptoms prior to intervention. Large tumors (<i>P</i> < .001) involving venous sinuses (<i>P</i> = .039) grew most aggressively. Since inclusion 19 (30.6%) patients have died of unrelated causes and 2 (3%) from grade 2 meningiomas.</p><p><strong>Conclusion: </strong>Active monitoring seems a safe and appropriate first-line management of incidental meningiomas. Intervention was avoided in > 40% with indolent tumors in this cohort. Treatment was not compromised by tumor growth. Clinical follow-up seems sufficient beyond 5 years if self-limiting growth is established. Steady or accelerating growth warrant monitoring until they reach a stable state or intervention is initiated.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 3","pages":"238-248"},"PeriodicalIF":2.7,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9530412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-11-11eCollection Date: 2023-02-01DOI: 10.1093/nop/npac092
Raoull Hoogendijk, Pieter Wesseling
{"title":"Registration of molecular markers in population-based cancer registries: Hopes and hurdles.","authors":"Raoull Hoogendijk, Pieter Wesseling","doi":"10.1093/nop/npac092","DOIUrl":"10.1093/nop/npac092","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 1","pages":"3-4"},"PeriodicalIF":2.4,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9116983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-11-07eCollection Date: 2023-04-01DOI: 10.1093/nop/npac090
Sameera Ramjan, Cara Levitch, Stephen Sands, Soo Young Kim, Marie Barnett, Jesse Bledsoe, Alice Ann Holland
{"title":"Executive and social functioning in pediatric posterior fossa tumor survivors and healthy controls.","authors":"Sameera Ramjan, Cara Levitch, Stephen Sands, Soo Young Kim, Marie Barnett, Jesse Bledsoe, Alice Ann Holland","doi":"10.1093/nop/npac090","DOIUrl":"10.1093/nop/npac090","url":null,"abstract":"<p><strong>Background: </strong>Executive and social functioning difficulty is well established in pediatric brain tumor survivors. Few studies have compared posterior fossa (PF) tumor survivors in comparison to their peers. The relationship between attention, processing speed, working memory, fatigue, and executive and social functioning was investigated to better understand the factors that impact executive and social functioning in PF tumor populations.</p><p><strong>Methods: </strong>Sixteen medulloblastomas, 9 low-grade astrocytomas (LGAs), and 17 healthy controls recruited from 4 sites completed measures of working memory and processing speed, and self-reported fatigue. One parent completed questionnaires on executive and social functioning.</p><p><strong>Results: </strong>There were no significant differences among all 3 groups on parent-reported executive and social functioning; of note, parents of LGA survivors expressed greater concerns regarding behavioral and cognitive regulation than did parents of medulloblastoma survivors and healthy controls. Parent-reported attention was related to parent-reported emotion, behavior, and cognitive regulation. Worse self-reported fatigue was associated with greater emotional dysregulation for the 2 PF tumor groups.</p><p><strong>Conclusions: </strong>Parents of PF tumor survivors described their children as performing similarly to their peers in most facets of executive and social functioning. While LGA survivors are traditionally thought to have more favorable outcomes, our finding of parent-reported executive functioning concerns to be worse for this group highlights the importance of long-term follow-up for all PF tumor survivors. Additionally, significant effects of attention on aspects of executive functioning in PF tumor survivors may inform current clinical practice and the future development of more effective interventions.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 2","pages":"152-161"},"PeriodicalIF":2.7,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-11-05eCollection Date: 2023-02-01DOI: 10.1093/nop/npac091
Pim B van der Meer, Johan A F Koekkoek
{"title":"Valproic acid in glioma: Will the anticancer issue ever be solved?","authors":"Pim B van der Meer, Johan A F Koekkoek","doi":"10.1093/nop/npac091","DOIUrl":"10.1093/nop/npac091","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 1","pages":"1-2"},"PeriodicalIF":2.4,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9116981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-10-26eCollection Date: 2023-02-01DOI: 10.1093/nop/npac083
Antonio Di Ieva
{"title":"Debunking the debulking in glioma surgery.","authors":"Antonio Di Ieva","doi":"10.1093/nop/npac083","DOIUrl":"10.1093/nop/npac083","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 1","pages":"104-105"},"PeriodicalIF":2.7,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9116985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-10-25eCollection Date: 2023-04-01DOI: 10.1093/nop/npac085
Anne Sophie L Helligsoe, Louise T Henriksen, Line Kenborg, Yasmin Lassen-Ramshad, Lisa M Wu, Jeanette F Winther, Henrik Hasle, Ali Amidi
{"title":"Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors.","authors":"Anne Sophie L Helligsoe, Louise T Henriksen, Line Kenborg, Yasmin Lassen-Ramshad, Lisa M Wu, Jeanette F Winther, Henrik Hasle, Ali Amidi","doi":"10.1093/nop/npac085","DOIUrl":"10.1093/nop/npac085","url":null,"abstract":"<p><strong>Background: </strong>Childhood brain tumor survivors are at high risk of late effects, especially neurocognitive impairment. Limited data are available examining neurocognitive function and associations with quality of life (QoL) in childhood brain tumor survivors. Our aim was to examine neurocognitive function in childhood brain tumor survivors, and associations with QoL and symptom burden.</p><p><strong>Methods: </strong>Five-year survivors of brain tumors over the age of 15 were identified in the Danish Childhood Cancer Registry (<i>n</i> = 423). Eligible and consenting participants completed neuropsychological tests and questionnaires assessing QoL, insomnia, fatigue, anxiety, and depression. Survivors treated with radiation (<i>n</i> = 59) were statistically compared with survivors not treated with radiation (<i>n</i> = 102).</p><p><strong>Results: </strong>In total, 170 survivors participated (40.2% participation rate). Sixty-six percent of the survivors who completed neurocognitive tests (<i>n</i> = 161) exhibited overall neurocognitive impairment. Survivors treated with radiation, especially whole-brain irradiation, exhibited poorer neurocognitive outcomes than survivors not treated with radiation. Neurocognitive outcomes for survivors treated with surgery were below normative expectations. Furthermore, a number of survivors experienced significant fatigue (40%), anxiety (23%), insomnia (13%), and/or depression (6%). Survivors treated with radiation reported lower quality of life (QoL) and higher symptom burden scores than survivors not treated with radiation; particularly in physical functioning, and social functioning with symptoms of fatigue. Neurocognitive impairment was not associated with QoL or symptom burden.</p><p><strong>Conclusions: </strong>In this study, a majority of the childhood brain tumor survivors experienced neurocognitive impairment, reduced QoL, and high symptom burden. Although not associated with each other, it is apparent that childhood brain tumor survivors experience not only neurocognitive dysfunction but may also experience QoL impairments and significant symptom burden.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 2","pages":"140-151"},"PeriodicalIF":2.7,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-10-22eCollection Date: 2023-04-01DOI: 10.1093/nop/npac087
Alipi V Bonm, Anthony Menghini, Caroline E Drolet, Jerome J Graber
{"title":"Temporalis muscle thickness predicts early relapse and short survival in primary CNS lymphoma.","authors":"Alipi V Bonm, Anthony Menghini, Caroline E Drolet, Jerome J Graber","doi":"10.1093/nop/npac087","DOIUrl":"10.1093/nop/npac087","url":null,"abstract":"<p><strong>Background: </strong>Most patients with primary CNS lymphoma (PCNSL) achieve durable remission whereas a minority die in the first year. Sarcopenia is a powerful predictor of mortality in the brain and systemic cancers. Temporalis muscle thickness (TMT) is a validated radiographic measure of sarcopenia. We hypothesized that patients with thin TMT at diagnosis would have early progression and short survival.</p><p><strong>Methods: </strong>Two blinded operators retrospectively measured TMT in 99 consecutive brain MRIs from untreated patients with PCNSL.</p><p><strong>Results: </strong>We generated a receiver operator characteristic curve and chose a single threshold defining thin TMT in all patients as <5.65 mm, at which specificity and sensitivity for 1-year progression were 98.4% and 29.7% and for 1-year mortality were 97.4% and 43.5% respectively. Those with thin TMT were both more likely to progress (<i>P</i> < .001) and had higher rates of mortality (<i>P</i> < .001). These effects were independent of the effect of age, sex, and Eastern Cooperative Oncology Group performance status in a cox regression. Memorial Sloan Kettering Cancer Center score did not predict progression-free survival or overall survival as well as TMT. Patients with thin TMT received fewer cycles of high-dose methotrexate and were less likely to receive consolidation but neither variable could be included in the Cox regression due to violation of the proportional hazards assumption.</p><p><strong>Conclusions: </strong>We conclude that PCNSL patients with thin TMT are at high risk for early relapse and short survival. Future trials should stratify patients by TMT to avoid confounding.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 2","pages":"162-168"},"PeriodicalIF":2.7,"publicationDate":"2022-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-10-14eCollection Date: 2023-06-01DOI: 10.1093/nop/npac086
Alasdair G Rooney, William Hewins, Amie Walker, Mairi Mackinnon, Lisa Withington, Sara Robson, Claire Torrens, Lisa E M Hopcroft, Antony Clark, Garry Anderson, Helen Bulbeck, Joanna Dunlop, Michelle Welsh, Aimee Dyson, Julie Emerson, Carol Cochrane, Robert Hill, Jade Carruthers, Julia Day, David Gillespie, Christopher Hewitt, Emanuela Molinari, Mary Wells, Catherine McBain, Anthony J Chalmers, Robin Grant
{"title":"Lifestyle coaching is feasible in fatigued brain tumor patients: A phase I/feasibility, multi-center, mixed-methods randomized controlled trial.","authors":"Alasdair G Rooney, William Hewins, Amie Walker, Mairi Mackinnon, Lisa Withington, Sara Robson, Claire Torrens, Lisa E M Hopcroft, Antony Clark, Garry Anderson, Helen Bulbeck, Joanna Dunlop, Michelle Welsh, Aimee Dyson, Julie Emerson, Carol Cochrane, Robert Hill, Jade Carruthers, Julia Day, David Gillespie, Christopher Hewitt, Emanuela Molinari, Mary Wells, Catherine McBain, Anthony J Chalmers, Robin Grant","doi":"10.1093/nop/npac086","DOIUrl":"10.1093/nop/npac086","url":null,"abstract":"<p><strong>Background: </strong>There are no effective treatments for brain tumor-related fatigue. We studied the feasibility of two novel lifestyle coaching interventions in fatigued brain tumor patients.</p><p><strong>Methods: </strong>This phase I/feasibility multi-center RCT recruited patients with a clinically stable primary brain tumor and significant fatigue (mean Brief Fatigue Inventory [BFI] score ≥ 4/10). Participants were randomized in a 1-1-1 allocation ratio to: Control (usual care); Health Coaching (\"HC\", an eight-week program targeting lifestyle behaviors); or HC plus Activation Coaching (\"HC + AC\", further targeting self-efficacy). The primary outcome was feasibility of recruitment and retention. Secondary outcomes were intervention acceptability, which was evaluated via qualitative interview, and safety. Exploratory quantitative outcomes were measured at baseline (T0), post-interventions (T1, 10 weeks), and endpoint (T2, 16 weeks).</p><p><strong>Results: </strong><i>n</i> = 46 fatigued brain tumor patients (T0 BFI mean = 6.8/10) were recruited and 34 were retained to endpoint, establishing feasibility. Engagement with interventions was sustained over time. Qualitative interviews (<i>n</i> = 21) suggested that coaching interventions were broadly acceptable, although mediated by participant outlook and prior lifestyle. Coaching led to significant improvements in fatigue (improvement in BFI versus control at T1: HC=2.2 points [95% CI 0.6, 3.8], HC + AC = 1.8 [0.1, 3.4], Cohen's <i>d</i> [HC] = 1.9; improvement in FACIT-Fatigue: HC = 4.8 points [-3.7, 13.3]; HC + AC = 12 [3.5, 20.5], <i>d</i> [HC and AC] = 0.9). Coaching also improved depressive and mental health outcomes. Modeling suggested a potential limiting effect of higher baseline depressive symptoms.</p><p><strong>Conclusions: </strong>Lifestyle coaching interventions are feasible to deliver to fatigued brain tumor patients. They were manageable, acceptable, and safe, with preliminary evidence of benefit on fatigue and mental health outcomes. Larger trials of efficacy are justified.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 3","pages":"249-260"},"PeriodicalIF":2.7,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9530407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuro-oncology practicePub Date : 2022-10-07eCollection Date: 2023-02-01DOI: 10.1093/nop/npac079
Corey Neff, Gino Cioffi, Kristin Waite, Carol Kruchko, Jill S Barnholtz-Sloan, Quinn T Ostrom, J Bryan Iorgulescu
{"title":"Molecular marker testing and reporting completeness for adult-type diffuse gliomas in the United States.","authors":"Corey Neff, Gino Cioffi, Kristin Waite, Carol Kruchko, Jill S Barnholtz-Sloan, Quinn T Ostrom, J Bryan Iorgulescu","doi":"10.1093/nop/npac079","DOIUrl":"10.1093/nop/npac079","url":null,"abstract":"<p><strong>Background: </strong>A newly developed brain molecular marker (BMM) data item was implemented by US cancer registries for individuals diagnosed with brain tumors in 2018-including IDH and 1p/19q-co-deletion statuses for adult-type diffuse gliomas. We thus investigated the testing/reporting completeness of BMM in the United States.</p><p><strong>Methods: </strong>Cases of histopathologically confirmed glioblastoma, astrocytoma, and oligodendroglioma diagnosed in 2018 were identified in the National Cancer Database. Adjusted odds ratios (OR<sub>adj</sub>) and 95% confidence intervals (CI) of BMM testing/reporting were evaluated for association with the selected patient, treatment, and facility-level characteristics using multivariable logistic regression. As a secondary analysis, predictors of <i>MGMT</i> promoter methylation testing/reporting among IDH-wildtype glioblastoma individuals were assessed. Key limitations of the BMM data item were that it did not include any details regarding testing technique or assay type and could not distinguish between a lack of testing and a lack of cancer registry reporting of testing results.</p><p><strong>Results: </strong>Among 8306 histopathologically diagnosed adult-type diffuse gliomas nationally, overall BMM testing/reporting completeness was 81.1%. Compared to biopsy-only cases, odds of testing/reporting increased for subtotal (OR<sub>adj</sub>= 1.38 [95% CI: 1.20-1.59], <i>P</i> < .001) and gross total resection (OR<sub>adj</sub>=1.50 [95% CI: 1.31-1.72], <i>P</i> < .001). Furthermore, the odds were lowest at community centers (hospitals (67.3%; OR<sub>adj</sub>=0.35 [95% CI: 0.26-0.46], <i>P</i> < .001) and highest at academic/NCI-designated comprehensive cancer centers (85.4%; referent). By geographical location, BMM testing/reporting completeness ranged from a high of 86.8% at New England (referent) to a low of 76.0 % in the West South Central region (OR<sub>adj</sub>=0.57 [95% CI: 0.42-0.78]; <i>P</i> < .001). Extent of resection, Commission-on-Cancer facility type, and facility location were additionally significant predictors of <i>MGMT</i> testing/reporting among IDH-wildtype glioblastoma cases.</p><p><strong>Conclusions: </strong>Initial BMM testing/reporting completeness for individuals with adult-type diffuse gliomas in the United States was promising, although patterns varied by hospital attributes and extent of resection.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 1","pages":"24-33"},"PeriodicalIF":2.7,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837780/pdf/npac079.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9116984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ethnic and socioeconomic disparities in survival of children and adolescents with CNS tumors in Southern Israel.","authors":"Abed Abu-Quider, Mahdi Asleh","doi":"10.1093/nop/npac041","DOIUrl":"https://doi.org/10.1093/nop/npac041","url":null,"abstract":"<p><strong>Background: </strong>This study sought to evaluate survival of pediatric and adolescent patients with central nervous system (CNS) cancer in southern Israel, outline disparities between ethnic and socioeconomic groups (Bedouin Arabs compared to Jews) and evaluate the role of socioeconomic status (SES) in ethnic disparities.</p><p><strong>Methods: </strong>A retrospective study was conducted among 91 patients aged one to 20 years, who were diagnosed with CNS tumors between 2001 and 2017, and followed-up through 2020. Ethnic differences in survival were measured by age, sex, stage, histology and SES. One and 3-year survival rates were calculated. Multivariable regression analysis was used to estimate adjusted ethnic differences in survival rates.</p><p><strong>Results: </strong>Ethnic differences in survival existed within all studied variables. All Bedouin patients lived in low SES settlements (All Bedouin settlement in Southern Israel are ranked in lower socioeconomic deciles). Twenty-eight patients had medulloblastoma. Seven (25%) presented with leptomeningeal disease or distant metastases. Medulloblastoma molecular subgroups were not assessed for logistic reasons. Three-year overall survival of Bedouins was 50% compared to 92.3% for Jews. Adjusted risk of death at 3 years was significantly higher for Bedouin patients (aHR 3.36, 95% CI 1.41-7.98, <i>P</i> = .006).</p><p><strong>Conclusions: </strong>We conclude that Bedouin children with CNS tumors have significantly lower survival rates compared to Jewish children, and SES seems to play a major part in these disparities. Factors influencing these disparities should be addressed and public health interventions to eliminate these disparities should be developed.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"9 5","pages":"441-448"},"PeriodicalIF":2.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476970/pdf/npac041.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9485951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}