Neuro-oncology practice最新文献

{"title":"Advancing the characterization of enlarging lesions after stereotactic radiosurgery: The combined role of clinical timing and dosimetric profiles in distinguishing radiation necrosis from tumor recurrence.","authors":"Antonio Pontoriero, Gianluca Ferini","doi":"10.1093/nop/npag022","DOIUrl":"10.1093/nop/npag022","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 3","pages":"435-437"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving quality of care for patients with high-grade glioma and their informal caregivers: Insights from focus groups with healthcare professionals.","authors":"Tomás Gómez Vecchio, Ingela Henoch, Ramona Schenell, Stina Nyblom, Anneli Ozanne","doi":"10.1093/nop/npag028","DOIUrl":"10.1093/nop/npag028","url":null,"abstract":"<p><strong>Background: </strong>There is a concerning prevalence of unmet needs affecting both patients with high-grade glioma and their informal caregivers. By exploring the experiences and attitudes of healthcare professionals (HCPs) in regional and municipal services, this study aims to identify barriers and enablers in improving the quality of care for patients with high-grade glioma and their informal caregivers through the disease trajectory.</p><p><strong>Methods: </strong>A qualitative approach using focus group interviews was employed, involving HCPs across healthcare levels. The interviews, conducted physically and digitally from November 2024 to March 2025, followed semi-structured guides. The inclusion criteria were HCPs with direct experience in caring for patients with high-grade glioma or those who were in contact with their informal caregivers. The data was analyzed using inductive qualitative content analysis.</p><p><strong>Results: </strong>A total of 12 interviews were conducted with 44 HCPs. The sample included 35 (79%) participants from 4 regional hospitals and 9 (21%) participants from municipal healthcare services. Two categories were derived from the data: <i>Organization and structural decisions</i> and <i>Interactions and interpersonal dynamics</i>. These categories illustrate advantages and limitations in the local healthcare system together with interpersonal dynamics and mental attitudes as expressed by the HCPs interviewed.</p><p><strong>Conclusions: </strong>The study underscores the need for collaboration and better communication strategies across healthcare services, together with comprehensive patient and informal caregiver education on the potential future needs associated with the patients' health trajectory. Also, the study shows that a better understanding of the consequences of cognitive impairments are critical steps towards enhancing care effectiveness.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 4","pages":"694-704"},"PeriodicalIF":2.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural history study of adults with primary central nervous system tumors: Initial results for first 1000 participants.","authors":"Kimberly R Robins, Hope Miller, Michelle L Cassidy, Vivian A Guedes, Ewa Grajkowska, Tricia Kunst, Anna Choi, Alvina Acquaye-Mallory, Marta Penas-Prado, Jennifer Reyes, Kenneth Aldape, Mark R Gilbert, Elizabeth Vera, Terri S Armstrong","doi":"10.1093/nop/npag026","DOIUrl":"10.1093/nop/npag026","url":null,"abstract":"<p><strong>Background: </strong>Primary central nervous system tumors (PCNST) are rare, understudied tumors for which knowledge of their clinical course, biology, physical, and psychological impact is limited. The National Cancer Institute's Neuro-Oncology Branch Natural History Study was developed to better understand the long-term disease course and outcomes experienced by these patients.</p><p><strong>Methods: </strong>Past medical histories, tumor tissue (if available), and patient-reported outcomes assessing symptom burden, general health status, anxiety, depression, and perceived cognitive deficits were collected at study enrollment. Sociodemographic, clinical, molecular, and patient-reported outcome data were analyzed descriptively.</p><p><strong>Results: </strong>Among the first 1000 participants, 796 had primary brain tumors (PBT) and 92 had primary spine tumors (PST); 88 were excluded. The cohort was predominantly male (56%), White (81%), and non-Hispanic (89%). Based on advanced molecular testing at enrollment, 190 (21%) patients had a change in diagnosis or subclassification since their initial diagnosis. Meningioma cases reported family brain tumor history more frequently than others. Most PBTs were diagnosed within 6 months of symptoms, while most PSTs were diagnosed ≥1 year after. Patients with PBT and PST reported an average of 10 symptoms, with 4 and 5 symptoms rated as moderate/severe, respectively. Nearly half of PBT participants reported anxiety or depression (46%) and difficulty with usual activities (48%). PST participants reported higher functional impairment and worse general health status.</p><p><strong>Conclusion: </strong>These findings underscore the substantial burden of PCNSTs and highlight the value of longitudinal, tumor-agnostic data in generating real-world insights into the disease trajectories of these rare and heterogeneous tumors to inform clinical research.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 4","pages":"743-758"},"PeriodicalIF":2.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor boundary delineation in IDH-wildtype glioblastoma: A prospective comparative analysis of ¹¹C-MET PET and FLAIR MRI in surgical decision-making.","authors":"Maria Pia Tropeano, Zefferino Rossini, Andrea Pizzi, Ettore Bresciani, Andrea Franzini, Beatrice Claudia Bono, Pierina Navarria, Elena Clerici, Matteo Simonelli, Marta Scorsetti, Letterio Salvatore Politi, Federico Pessina","doi":"10.1093/nop/npag023","DOIUrl":"10.1093/nop/npag023","url":null,"abstract":"<p><strong>Background: </strong>Supramaximal resection (SUPR) in IDH-wildtype glioblastoma (GBM) aims to improve survival by extending resection beyond contrast-enhancing lesions into non-enhancing FLAIR-hyperintense regions. The role of metabolically guided resection with ¹¹C-methionine positron emission tomography (¹¹C-MET PET) as an alternative approach has not been systematically investigated. This study compares volumetric and clinical outcomes of ¹¹C-MET PET versus MRI guidance in IDH-wildtype GBM.</p><p><strong>Methods: </strong>We performed a prospective, single-center study (2020-2024) including patients undergoing PET-guided resection for newly diagnosed, contrast-enhancing GBM. All patients received preoperative MRI and ¹¹C-MET PET, followed by early postoperative imaging. Survival outcomes were compared with those of a matched SUPR, NTR (Near-total resection), and CR (Complete resection) cohort, according to the updated RANO criteria.</p><p><strong>Results: </strong>In all cases, preoperative PET volume exceeded the contrast-enhancing (CE) volume. Spatial overlap between PET-based volume and FLAIR tumor volume (FLAIR-TV) was observed in 91.2% of cases, while in 8.8% the PET volume was larger. Strong correlations were found between FLAIR-TV and PET volumes (<i>r</i>  =  0.90) and between CE and PET volumes (<i>r</i>  =  0.84). No baseline differences were identified between groups in sex, age, MGMT promoter methylation, tumor location, or preoperative Karnofsky Performance Status. Median progression-free survival (PFS) and overall survival (OS) were significantly longer in the SUPR group compared with the PET group (PFS: 20 vs. 14.9 months, <i>P</i>  =  .0003; OS: 24 vs. 21.9 months, <i>P</i>  =  .025), with the NTR group (PFS: 20 vs 11 months, <i>P</i>  <  .001; OS: 24 vs 15 months, <i>P</i>  =  .001) and CR group (PFS: 20 vs 13 months, <i>P</i>  <  .001; OS 24 vs 17 months, <i>P</i>  =  .001).</p><p><strong>Conclusions: </strong>¹¹C-MET PET effectively delineates infiltrative margins and detects aggressive subclones. However, SUPR provides superior survival compared with PET-guided resections alone, supporting PET as a complementary tool rather than a stand-alone modality in surgical planning for IDH-wildtype GBM.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 4","pages":"767-774"},"PeriodicalIF":2.5,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living with brain metastases-A longitudinal qualitative study of patient experiences from time of diagnosis.","authors":"Tonje Lundeby, Asta Bye, Olav Eric Yri, Torunn Elin Wester, Nina Aass, Sjur Bjørnar Hanssen, Stein Kaasa, Marianne Jensen Hjermstad","doi":"10.1093/nop/npag019","DOIUrl":"10.1093/nop/npag019","url":null,"abstract":"<p><strong>Background: </strong>Brain metastases (BM) are prevalent intracranial neoplasms in adults, affecting 20%-40% of cancer patients. With improved systemic therapies and neuroimaging, the frequency of BM diagnoses is rising. Despite advancements and longer survival time, the prognosis remains poor, with survival rates ranging from 3 months to over a year, depending on the diagnosis. This qualitative study provides insight into the patients' needs, experiences, and perspectives upon BM diagnosis. The aim of the study was to explore how patients experience being diagnosed with BM, their care and follow-up, and how BM impacts their lives and concerns.</p><p><strong>Methods: </strong>A qualitative study using longitudinal semi-structured interviews with patients recently diagnosed with first-time BM. Participants were recruited from one Norwegian hospital, with interviews conducted at 3 intervals over 4 months. Inclusion criteria included age ≥18, verified BM diagnosis, and ability to consent and participate in interviews. Inductive thematic analyses were performed to identify overarching themes.</p><p><strong>Results: </strong>Twenty-two patients participated, with interviews revealing 4 themes: (1) BM as either an additional burden or more of the same, (2) trust in the healthcare system despite unmet needs, (3) distancing from illness, and (4) acceptance of and adjustment to symptom burden. Patients expressed varied emotional responses, practical challenges, and evolving information needs over time.</p><p><strong>Conclusion: </strong>Patients diagnosed with BM face multifaceted challenges. A patient-centered approach, emphasizing clear communication, symptom management, and tailored care, is essential. Understanding patient experiences can help healthcare providers offer personalized care. Continued research is needed to address the unique needs of this population and improve care practices.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 4","pages":"723-732"},"PeriodicalIF":2.5,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming molecular neuropathology-Progress and persistent challenges in UK brain tumor care.","authors":"Angela Mastronuzzi","doi":"10.1093/nop/npag008","DOIUrl":"10.1093/nop/npag008","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 3","pages":"433-434"},"PeriodicalIF":2.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perspectives on diagnostic uncertainty and novel diagnostic tests in neuro-oncology.","authors":"Veerle J Ruijters, Marloes M Bauer, Nelleke Tolboom, Tatjana Seute, Leonie N C Visser, Tom J Snijders","doi":"10.1093/nop/npag021","DOIUrl":"10.1093/nop/npag021","url":null,"abstract":"<p><strong>Background: </strong>In the follow-up of glioma patients, differentiating treatment-associated changes from tumor progression on MRI is challenging. In the Netherlands, this diagnostic uncertainty often leads to watchful waiting, delayed treatment, and patient distress. So far, research on new diagnostic tests has primarily focused on accuracy, while patient perspectives remain largely unexplored. This qualitative study aimed to explore glioma patients' perspectives on diagnostic uncertainty and the implementation of tests aimed at reducing uncertainty.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with 10 diffuse glioma patients (31-70 years old; 50% female) treated at UMC Utrecht, the Netherlands. Two independent coders analyzed interview transcripts thematically to identify key themes in patient perspectives.</p><p><strong>Results: </strong>Four themes were found: (1) Most patients experienced diagnostic uncertainty, which was stressful for themselves and their loved ones. (2) A new test was considered meaningful if it provided early certainty. Patients wanted certainty to guide treatment, and even without therapeutic options, a certain diagnosis could optimize quality of life by living more consciously. (3) All patients wished to participate in decision-making regarding undergoing new tests, with variable preferences regarding the amount of information to be received. (4) Patients expressed the need for continuity of care, honest communication, and immediate disclosure of test results.</p><p><strong>Conclusion: </strong>Patients value faster certainty from new diagnostic tests, both to guide treatment for improved survival and quality of life and to optimize quality of life when no therapeutic options remain. Integrating this emphasis on quality of life into diagnostic research may stimulate patient-centered test implementation, ultimately improving neuro-oncological care.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 4","pages":"733-742"},"PeriodicalIF":2.5,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewer lists for 2025.","authors":"","doi":"10.1093/nop/npaf132","DOIUrl":"10.1093/nop/npaf132","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 1","pages":"222-223"},"PeriodicalIF":2.5,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary prophylaxis of seizures in glioma: An unanswered question?","authors":"Josien C C Scheepens, Johan A F Koekkoek","doi":"10.1093/nop/npag003","DOIUrl":"https://doi.org/10.1093/nop/npag003","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 2","pages":"225-226"},"PeriodicalIF":2.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the cure becomes the curse: Radiation-induced glioma of the pons in children surviving craniopharyngioma.","authors":"Rahat Ul Ain, Hamza S Gorsi, Celine Habre, Andrea Bartoli, Sebastien Tran, Rabia A Qaiser, Laeeq Ur Rehman, Steven R Miller, Eric Bouffet, André O von Bueren","doi":"10.1093/nop/npag018","DOIUrl":"10.1093/nop/npag018","url":null,"abstract":"<p><strong>Background: </strong>The standard of care for pediatric craniopharyngioma (CP) is either complete surgical resection or limited debulking surgery followed by adjuvant radiotherapy (RT). Recent data favor the latter approach.</p><p><strong>Methods: </strong>We present a multi-center case series of three children with CP treated with subtotal surgery and adjuvant RT for CP who eventually developed radiation-induced glioma (RIG) of the pons.</p><p><strong>Results: </strong>The median age at diagnosis of CP was 6 years. Photon RT was administered in two patients and proton RT in one, at a median dose of 54 Gy delivered in 30 fractions. Pontine glioma was first identified on imaging after a median interval of 8 years from initial RT (range 4.5 - 9.75 years), incidentally in two asymptomatic patients during routine surveillance, and associated with symptoms of brainstem involvement in one. A biopsy was performed in two patients. One showed diffuse astrocytoma with <i>MYCN</i>, <i>PDGFRA</i>, and <i>MDM2</i> amplification and a novel fusion (RBD7-FLI1), while the other case had an inconclusive histopathology. Re-irradiation (re-RT) (54 Gy/30 fractions and 30 Gy/10 fractions) was applied in two patients, and one patient received bevacizumab treatment. All three patients succumbed with a median survival of 7.5 months (range 4.0-58 months).</p><p><strong>Conclusions: </strong>Radiation-induced glioma of the pons is a rare and serious complication occurring in patients previously treated by RT for childhood CP. This secondary tumor is uniformly associated with a dramatic course regardless of the treatment modalities and resources. This highlights the need for clinical vigilance and further research to prevent it.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"13 4","pages":"816-822"},"PeriodicalIF":2.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}