Neuro-oncology practice最新文献

The 2021 WHO classification of tumors of the central nervous system: Responding to the challenge in low- and middle-income countries. 世卫组织2021年中枢神经系统肿瘤分类：应对低收入和中等收入国家的挑战。

IF 2.4

Neuro-oncology practice Pub Date : 2025-03-08 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npaf028

Michael J Sullivan, David D Eisenstat

引用次数: 0

Focusing attention on brain metastasis: Hot issues. 关注脑转移：热点问题。

IF 2.4

Neuro-oncology practice Pub Date : 2025-03-01 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npaf025

Roberta Rudà, Riccardo Soffietti

引用次数: 0

Reviewer List for the year 2024. 2024年的评审名单。

IF 2.4

Neuro-oncology practice Pub Date : 2025-02-05 eCollection Date: 2025-02-01 DOI: 10.1093/nop/npae126

引用次数: 0

"What is this brain's story?" Healthcare professionals' perspectives on managing brain tumor-related personality and behavior changes. “这个大脑的故事是什么？”医疗保健专业人员对管理脑肿瘤相关人格和行为改变的看法。

IF 2.4

Neuro-oncology practice Pub Date : 2025-01-17 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npaf007

Emma McDougall, Anna K Nowak, Haryana M Dhillon, Lauren J Breen, Karin Piil, Georgia K B Halkett

{"title":"\"What is this brain's story?\" Healthcare professionals' perspectives on managing brain tumor-related personality and behavior changes.","authors":"Emma McDougall, Anna K Nowak, Haryana M Dhillon, Lauren J Breen, Karin Piil, Georgia K B Halkett","doi":"10.1093/nop/npaf007","DOIUrl":"10.1093/nop/npaf007","url":null,"abstract":"Background: Managing brain tumor-related personality and behavior changes (BTrPBc) is complex with contributors including tumor location, type, and grade; treatment side effects; and psychological adjustment to a primary brain tumor diagnosis. Although carers of people with high-grade glioma consistently report BTrPBc as an area where they require support, there is a lack of guidelines for healthcare professionals to address BTrPBc. We aimed to explore how neuro-oncology healthcare professionals manage personality and behavior changes in adults with a primary brain tumor.Methods: This study used an interpretive description approach. Semi-structured interviews were conducted with healthcare professionals practicing in neuro-oncology across Australia via face-to-face, telephone, and video conference. Codebook thematic analysis methods were used.Results: Healthcare professionals (N = 22) from a range of medical and allied health disciplines participated in interviews with an average duration of 34 minutes. Four themes described how healthcare professionals seek to manage patients' personality and behavior changes: (i) Building trusting relationships, (ii) What is this brain's story?, (iii) Brief intervention; and (iv) Targeted intervention. Sub-themes were developed within each theme.Conclusions: Our results highlight the diverse support healthcare professionals provide for the management of BTrPBc. There is a need for interventions to be formulation-driven, involve individualized care, provide education, and focus on the patient-carer dyad. A stepped-care approach to managing BTrPBc is recommended; however, further evaluation in clinical practice is necessary.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"12 3","pages":"437-447"},"PeriodicalIF":2.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should we be testing for germline and "actionable" mutations in all glioma patients? 我们是否应该在所有神经胶质瘤患者中测试生殖系和“可操作”突变？

IF 2.4

Neuro-oncology practice Pub Date : 2025-01-15 eCollection Date: 2025-02-01 DOI: 10.1093/nop/npae121

Jerome J Graber

引用次数: 0

Seizure risk factors and management approaches in patients with brain metastases. 脑转移患者癫痫发作的危险因素及治疗方法。

IF 2.4

Neuro-oncology practice Pub Date : 2025-01-13 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npaf001

Eugene J Vaios, Spencer Maingi, Kristen Batich, Sebastian F Winter, Jorg Dietrich, Trey Mullikin, Scott R Floyd, John P Kirkpatrick, Zachary J Reitman, Katherine B Peters

{"title":"Seizure risk factors and management approaches in patients with brain metastases.","authors":"Eugene J Vaios, Spencer Maingi, Kristen Batich, Sebastian F Winter, Jorg Dietrich, Trey Mullikin, Scott R Floyd, John P Kirkpatrick, Zachary J Reitman, Katherine B Peters","doi":"10.1093/nop/npaf001","DOIUrl":"10.1093/nop/npaf001","url":null,"abstract":"A significant proportion of patients with brain metastases experience a seizure event during their disease course, which can impact morbidity and long-term outcomes. A host of factors elevate the risk for seizures in patients with brain metastases, including patient factors, metabolic imbalances, tumor burden, and treatment modality. While reducing tumor burden via local and systemic therapies remains a critical component to mitigating seizure events, select patients may remain at risk. The use of prophylactic anti-seizure medications may be warranted in a subset of patients, though several clinical trials and guidelines from medical societies currently recommend against prophylactic use. Variability in the use of prophylactic anti-seizure medications in clinical practice underscores the need to update our current understanding of seizure risk in the era of multi-modality treatment and to identify opportunities to improve risk stratification and management. Herein, we provide a comprehensive literature review summarizing the current standard for seizure management in patients with brain metastases and assess the impact of multi-modal therapies on seizure risk. We additionally highlight gaps in the literature and present opportunities for future investigation.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"12 3","pages":"389-400"},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting critical surgical characteristics of intracranial meningiomas on MRI-A prospective study on 100 consecutive patients. 在mri上预测颅内脑膜瘤的关键手术特征——一项连续100例患者的前瞻性研究。

IF 2.4

Neuro-oncology practice Pub Date : 2025-01-10 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npaf004

Fabian Winter, Julia Furtner, Astrid Dunst, Gregor Kasprian, Michael Weber, Adelheid Woehrer, Karl Roessler, Christian Dorfer

{"title":"Predicting critical surgical characteristics of intracranial meningiomas on MRI-A prospective study on 100 consecutive patients.","authors":"Fabian Winter, Julia Furtner, Astrid Dunst, Gregor Kasprian, Michael Weber, Adelheid Woehrer, Karl Roessler, Christian Dorfer","doi":"10.1093/nop/npaf004","DOIUrl":"10.1093/nop/npaf004","url":null,"abstract":"Background: This study aimed to identify magnetic resonance imaging (MRI) markers predictive of essential surgical characteristics in meningiomas, including consistency, ease of dissection of meningioma from surrounding brain tissue, and vascularity, which are crucial for surgical decisions and outcomes.Methods: We conducted preoperative MRI using a standardized protocol to measure signal intensities (SI) within meningiomas. Additionally, we administered intraoperative questionnaires and performed histological analyses on each tumor.Results: A total of 100 consecutive patients (mean age, 58 years ± 13, 69 female) were enrolled in this prospective clinical trial. Meningioma volumes varied (0.4-185.6 cm3) with surgeries lasting on average 176 min (range 35-610 min). SI measurements on T1-weighted, time-of-flight (TOF), and T2-weighted imaging were significantly associated with tumor consistency and vascularity. Specifically, the sensitivity and specificity for predicting consistency grades above 3 (on a 1-5 grade scale) were 75% and 55% postcontrast on T1-weighted imaging (SI ≥ 711) and 73% and 70% on TOF imaging (SI ≥ 124.5). For vascularity grades above 5 (on a 1-10 grade scale), the values were 73% sensitivity and 54% specificity on TOF imaging (SI ≥ 123). No correlation was found between the surgical cleavage plane and MRI data; however, dissection plane type significantly influenced surgery duration and hospitalization length. A lower SI on T2-weighted imaging correlated with specific histological features.Conclusion: Key surgical aspects of meningiomas can be predicted using conventional MRI sequences. This may improve patient counseling and surgical planning.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"12 3","pages":"458-466"},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Well-being and coping: Key aspects of unmet need of people living with glioma. 幸福和应对：胶质瘤患者未满足需求的关键方面。

IF 2.4

Neuro-oncology practice Pub Date : 2025-01-09 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npae127

Elin Baddeley, Stephanie Sivell, Ameeta Retzer, Annmarie Nelson, Helen Bulbeck, Kathy Seddon, Robin Grant, Richard Adams, Colin Watts, Olalekan Lee Aiyegbusi, Melanie Calvert, Anthony Byrne

{"title":"Well-being and coping: Key aspects of unmet need of people living with glioma.","authors":"Elin Baddeley, Stephanie Sivell, Ameeta Retzer, Annmarie Nelson, Helen Bulbeck, Kathy Seddon, Robin Grant, Richard Adams, Colin Watts, Olalekan Lee Aiyegbusi, Melanie Calvert, Anthony Byrne","doi":"10.1093/nop/npae127","DOIUrl":"10.1093/nop/npae127","url":null,"abstract":"Background: The challenges and needs of people with brain tumors are complex and unique, particularly-but not limited to-the neurocognitive impacts they experience. These effects are subsequently impactful on their primary caregivers. Evidence suggests people with glioma and their caregivers experience a range of unmet needs in the clinical care setting.Methods: Semi-structured interviews with people across the spectrum of glioma, and their caregivers in the United Kingdom, as part of a study exploring core outcomes for use across glioma trials. Interviews were analyzed using thematic analysis.Results: Nineteen people with glioma and seven caregivers were interviewed. Three major themes were identified: (1) Well-being, support and coping, (2) Communication and care, and (3) Impact on caregivers. People with glioma and their caregivers experience uncertainty, and progressive impacts long after diagnosis. People with glioma across the spectrum of the disease have many challenges in common including long-term adjustments, impacts of glioma and its treatment, and communication/information gaps including prognostic uncertainty. These impacts also affect caregivers. While most patients and caregivers engaged in self-directed approaches to mitigate the impacts of glioma, gaps in follow-up support for lasting effects were a major source of frustration, impacting on ability to cope and manage the effects of glioma.Conclusions: These interviews highlight the unmet needs of people with glioma and their caregivers. A consistent, systematic, and focused approach to assessing the needs of glioma patients and their caregivers in the clinical setting and support for long-term adjustment is required.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"12 3","pages":"413-425"},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying components of care coordination for primary brain tumor: A scoping review. 确定原发性脑肿瘤护理协调的组成部分：范围综述。

IF 2.4

Neuro-oncology practice Pub Date : 2025-01-09 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npaf003

Megan S Jeon, Hannah Banks, Sharon He, Thomas Carlick, Joanne M Shaw, Brian Kelly, Eng-Siew Koh, Georgia K B Halkett, Tamara Ownsworth, Raymond J Chan, Mark B Pinkham, Ursula M Sansom-Daly, Haryana M Dhillon

{"title":"Identifying components of care coordination for primary brain tumor: A scoping review.","authors":"Megan S Jeon, Hannah Banks, Sharon He, Thomas Carlick, Joanne M Shaw, Brian Kelly, Eng-Siew Koh, Georgia K B Halkett, Tamara Ownsworth, Raymond J Chan, Mark B Pinkham, Ursula M Sansom-Daly, Haryana M Dhillon","doi":"10.1093/nop/npaf003","DOIUrl":"10.1093/nop/npaf003","url":null,"abstract":"For people with primary brain tumors (PBT) and their carers, care coordination (CC) offers comprehensive, timely, person-centered care. This review aimed to systematically scope the breadth of literature relevant to approaches to CC for PBT. Four databases were searched (PubMed, PsycINFO, EMBASE, and CINAHL) for empirical research, and gray literature was searched for doctoral theses, clinical guidelines, and education resources for healthcare professionals (HCPs) related to the concept/model of CC in neuro-oncology. Data were systematically evaluated and synthesized following PRISMA-SCR guidelines. From 1163 screened abstracts, 30 eligible reports were reviewed (13 addressed CC interventions, 9 narrative reports, 5 describing CC/navigator positions, and 3 clinical guidelines). Most reports described nurse-led models of care within single tertiary care centers in metropolitan settings: a single HCP acting as primary contact, educator, and liaison, screening patient/carer distress and providing referrals as key components of CC. Clinical guidelines emphasize healthcare system navigation and access to medical care in CC. A CC approach overseeing the whole PBT trajectory was lacking. Facilitators of CC included availability of HCP dedicated to CC; HCPs' competency in relationship-based and communication skills; and improved access to resources. System-level and resource barriers to CC were identified. Knowledge about CC is largely based on descriptions of nurse-led models of PBT care. Further research is required to refine the framework of CC reflecting factors of known importance in PBT care, and identify training and support needs of HCPs who may play a pivotal role in current models of neuro-oncology CC.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"12 3","pages":"357-375"},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot study to quantify and describe personal social networks in patients with glioblastoma. 一项量化和描述胶质母细胞瘤患者个人社会网络的初步研究。

IF 2.4

Neuro-oncology practice Pub Date : 2025-01-08 eCollection Date: 2025-06-01 DOI: 10.1093/nop/npaf002

John Y Rhee, Carissa Mastrangelo, Paul J Miller, Gilbert Youssef, Zachary Tentor, Zachary R Rothfeld-Wehrwein, Vrushali A Dhongade, Vihang Nakhate, Tracy Batchelor, Amar Dhand

{"title":"A pilot study to quantify and describe personal social networks in patients with glioblastoma.","authors":"John Y Rhee, Carissa Mastrangelo, Paul J Miller, Gilbert Youssef, Zachary Tentor, Zachary R Rothfeld-Wehrwein, Vrushali A Dhongade, Vihang Nakhate, Tracy Batchelor, Amar Dhand","doi":"10.1093/nop/npaf002","DOIUrl":"10.1093/nop/npaf002","url":null,"abstract":"Background: Patients with glioblastoma experience high physical and psychosocial symptom burden. Poor social relationships have been shown to increase the risk of neurologic illnesses and decline, and conversely, strong personal social networks (PSN) have been shown to reduce the risk of mortality and improve quality of life. The aim of this pilot study is to determine the feasibility of measuring PSN in glioblastoma patients.Methods: We recruited 25 adult glioblastoma patients between the initial diagnosis and the first cycle of adjuvant chemotherapy from March to September 2023 in the outpatient neuro-oncology clinic and adapted PERSNET, a quantitative PSN assessment tool, to this population. We collected demographics, tumor measures, treatment courses, and the European Organization for Research and Treatment of Cancer QOL for Patients with Brain Tumors (EORTC QLQ-BN20) and conducted qualitative interviews.Results: The average age was 64.5 years old, 56% were female, and 84% had a Karnofsky Performance Status of 70 or higher. Patients had large network sizes (total size of patient's PSN; mean = 8.8). Participants stressed the importance of social support and how different people filled different roles in their oncology care. Behavioral and/or cognitive changes resulted in delayed presentation, and children, especially daughters, were important in advocating for presentation to the hospital.Conclusion: This is the first proof-of-concept study showing that PSN can be measured in patients with glioblastoma. Qualitative data showed that patients felt social support was very important, and different people in their networks addressed different domains of care: physical, emotional, and logistical.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"12 3","pages":"426-436"},"PeriodicalIF":2.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0