约旦儿童脑肿瘤幸存者治疗后的健康相关生活质量

IF 2.4 Q2 CLINICAL NEUROLOGY

Neuro-oncology practice Pub Date : 2023-08-31 DOI:10.1093/nop/npad054

Han Choi, Amr S Soliman, Randa Al Mousa, Jennifer Yeh, Jamal Khader, Iyad Sultan, Ahmad K H Ibrahimi

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引用次数: 0

摘要

摘要背景癌症幸存者的数量和生存率都在不断增加。与健康相关的生活质量(HRQOL)尚未在低收入和中等收入国家(LMICs)得到广泛研究。本研究的目的是探讨约旦儿童脑肿瘤幸存者的HRQOL及其决定因素。方法采用阿拉伯语儿科生活质量量表(PedsQL)通用核心量表，收集侯赛因国王癌症中心治疗的80例患者及其父母的健康相关生活质量信息。使用多变量线性OLS回归模型分析HRQOL的相关因素，并比较儿童和父母报告的反应之间的差异。结果幸存者和父母报告的健康相关生活质量评分在所有子量表和PedsQL总分上均呈正相关(r = 0.59, P = 0.001)。幸存者在认知亚量表中HRQOL较好(β = 0.56, P = 0.03)，在工作亚量表中HRQOL较差(β = 0.43, P = 0.04)，但在身体、情感和社会亚量表以及PedsQL总分上无显著差异。父母和孩子报告的HRQOL的显著预测因子存在差异。幕上肿瘤位置与物理HRQOL评分降低10.97个单位相关，肿瘤复发预测总HRQOL评分降低17.5个单位，表明生活质量较差。男性(β = 14.9, P = 0.002)和垂体功能减退(β = 16.1, P = 0.03)与较好的HRQOL相关。此外，单纯放疗患者的情绪HRQOL优于放化疗患者(β = 32.9, P = 0.006)。结论本研究为约旦儿童脑肿瘤患者HRQOL的影响因素提供了证据。未来的研究需要利用这项研究的结果，建立一个定期评估约旦和其他具有类似卫生保健系统和社会文化背景的国家儿童癌症患者生活质量的系统。

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Health-related Quality of Life of Pediatric Brain Tumor Survivors after Treatment in Jordan

Abstract Background The number of cancer survivors and survivorship are increasing. Health-related quality of life (HRQOL) has not been widely studied in low-and-middle-income countries (LMICs). The aim of this study is to explore HRQOL of childhood brain tumor survivors and its determinants in Jordan. Methods Health-related quality of life information was collected from 80 patients treated at the King Hussein Cancer Center and their parents using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales questionnaire in Arabic. Multivariable linear OLS regression models were used to analyze correlates of HRQOL and compare differences between child- and parent-reported responses. Results Health-related quality of life scores reported by survivors and by parents were positively correlated on all subscales and total PedsQL scores (r = 0.59, P = .001). Survivors reported better HRQOL in cognitive subscale (β = 0.56, P = .03) and worse HRQOL in work subscale (β = 0.43, P = .04), but no significant differences in the physical, emotional, and social subscales and total PedsQL scores. Significant predictors of HRQOL reported by parents and by children were different. Supratentorial tumor location was associated with a 10.97-unit lower physical HRQOL score, and recurrence of tumors predicted a 17.5-unit lower total HRQOL score, indicating worse quality of life. Male gender (β = 14.9, P = .002) and diagnosis of hypopituitarism (β = 16.1, P = .03) were associated with better HRQOL. Furthermore, patients that only had radiotherapy treatment had better emotional HRQOL (β = 32.9, P = .006) compared to patients that had combined radiotherapy and chemotherapy. Conclusion This study provides evidence on determinants of HRQOL of pediatric brain tumor patients in Jordan. Future studies need to capitalize on the findings of this study to institute a system for regular assessment of quality of life of pediatric cancer patients in Jordan and other countries with similar health care systems and sociocultural backgrounds.

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来源期刊

Neuro-oncology practice CLINICAL NEUROLOGY-

CiteScore

5.30

自引率

11.10%

发文量

期刊介绍： Neuro-Oncology Practice focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines including physicians, nurses, physical/occupational therapists, neuropsychologists, and palliative care specialists, who have focused their careers on clinical patient care and who want to apply the latest treatment advances to their practice. These include: Applying new trial results to improve standards of patient care Translating scientific advances such as tumor molecular profiling and advanced imaging into clinical treatment decision making and personalized brain tumor therapies Raising awareness of basic, translational and clinical research in areas of symptom management, survivorship, neurocognitive function, end of life issues and caregiving