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A novel mechanism linking periodontitis and rheumatoid arthritis 一种联系牙周炎和类风湿性关节炎的新机制
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-09-30 DOI: 10.2329/perio.61.142
Keisuke Sato, K. Yamazaki
{"title":"A novel mechanism linking periodontitis and rheumatoid arthritis","authors":"Keisuke Sato, K. Yamazaki","doi":"10.2329/perio.61.142","DOIUrl":"https://doi.org/10.2329/perio.61.142","url":null,"abstract":"歯周病と関節リウマチの関連メカニズムとして,抗 シトルリン化タンパク質抗体(Anti-cyclic citrullinated protein antibody:ACPA)がこれまで注目されてき た。生体由来の Peptidyl arginine deiminase(PAD)に よって生成したシトルリン化タンパク質に対して自己 抗体が産生され,自己免疫応答が誘発されると考えら れている2)。代表的な歯周病原細菌である Porphyromonas gingivalis は PADを産生する唯一の口腔細 菌であることが知られており3),P. gingivalis が産生す る細菌性の PAD(PPAD)が歯周病と関節リウマチの 関連メカニズムのターゲットとしてこれまでに多く研 究されてきた4)。 実際に,初期の関節リウマチ患者のうち P. gingivalis に対する抗体応答が亢進している患者ではその値と ACPAが相関していることが報告されているが5), PPADによるメカニズムには否定的な意見も存在 し6),そのメカニズムについては未だに明らかになっ ていない。","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80138700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical and educational effects of a new interprofessional program for dental students and dental hygiene students in practical clinical training 一种新的跨专业方案对牙科学生和口腔卫生学学生临床实践培训的临床和教育效果
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-09-30 DOI: 10.2329/perio.61.148
K. Mizutani, Kanako Noritake, J. Tsuruta, N. Seki, K. Kondo, Sayaka Katagiri, Y. Takeuchi, T. Akizuki, Hidehiro Shioyama, A. Aoki, Y. Izumi, T. Iwata, S. Arakawa, K. Araki
{"title":"Clinical and educational effects of a new interprofessional program for dental students and dental hygiene students in practical clinical training","authors":"K. Mizutani, Kanako Noritake, J. Tsuruta, N. Seki, K. Kondo, Sayaka Katagiri, Y. Takeuchi, T. Akizuki, Hidehiro Shioyama, A. Aoki, Y. Izumi, T. Iwata, S. Arakawa, K. Araki","doi":"10.2329/perio.61.148","DOIUrl":"https://doi.org/10.2329/perio.61.148","url":null,"abstract":": [Introduction] The purpose of this study was to evaluate the effectiveness of a newly developed Interprofessional Education (IPE) program in clinical practicum for dental and dental hygiene students. [Materials and methods] Dental and dental hygiene students cooperatively provided periodontal treatment to selected patients. The treatment consisted of a total of two to three sessions in addition to pre-treatment discussions with supervisors, student meetings for information sharing and treatment plan-ning, and self- and peer reflections and assessments of the performance. [Results] A total of 44 patients were admitted to this program in 2016. Clinically, the mean OʼLeary plaque control record score decreased significantly after the dental hygiene students provided instruc-tions on the oral hygiene. Based on the results of the self- and peer assessments and assessment of the performances on the web-based assignments, we demonstrated significant progression in IPE competencies throughout the practice. Furthermore, 95% of the dental students and 85% of the dental hygiene students gave a positive valuation of this program. Our program improved but interprofessional col-laboration, and","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87390094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic and clinical analyses of the relationship between periodontal disease and cardiovascular diseases 牙周病与心血管疾病关系的基础与临床分析
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-09-30 DOI: 10.2329/perio.61.107
N. Aoyama
{"title":"Basic and clinical analyses of the relationship between periodontal disease and cardiovascular diseases","authors":"N. Aoyama","doi":"10.2329/perio.61.107","DOIUrl":"https://doi.org/10.2329/perio.61.107","url":null,"abstract":"これまで,歯周病と循環器疾患の関連がさかんに検 討されてきた。その結果,歯周病患者では循環器疾患 を発症する可能性が高いことが示唆されている。一方 で,歯周病と循環器疾患との関連の重要性は認められ るものの,その因果関係については未知なることが多 いとの評価もなされている。歯周病と循環器疾患の関 連は,因果関係によるものであるのか,あるいは遺伝 子や個体の表現型の違いに起因するものであるのかと いった,関連メカニズムの解析が急務となっている。 近年,医科歯科連携の必要性がしきりに指摘されて いる。医科歯科連携を進めるにあたり,歯科からの科 学的根拠の蓄積は大いなる課題であろう。循環器疾患 の予防に歯周病管理が重要だと示されれば,その波及 効果は大きい。歯科介入による循環器疾患予防は,ま ず,患者の QOLの向上や死亡率の減少につながる。ま た,一般市民へ口腔の健康管理の大切さを新たな側面 から伝えていくことが可能となる。さらに,歯周病の 検査や治療がより一般的に広がれば,歯科ニーズのま すますの創出が期待できる。","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88504312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptidoglycan and periodontal diseases 肽聚糖与牙周病
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-06-28 DOI: 10.2329/PERIO.61.73
T. Kaneko
{"title":"Peptidoglycan and periodontal diseases","authors":"T. Kaneko","doi":"10.2329/PERIO.61.73","DOIUrl":"https://doi.org/10.2329/PERIO.61.73","url":null,"abstract":"ヒトにおいて自然免疫(Innate immunity)は細菌感 染に対する最初の防御反応であり,細菌に共通して存 在するが宿主生体内には存在しない構造や分子,すな わち Pathogen-associated molecular patterns (PAMPs) を特異的に認識するパターン分子認識受容体 (PRRs)が細菌感染を検知することにより誘導される。 PRRsは遺伝子にコードされているタンパク質で,好 中球やマクロファージ,樹状細胞などの食細胞に強く 発現し,自然免疫応答においてはこれらの細胞が中心 的に働いている。しかし,それら以外の細胞や体液中 にも発現しており,基本的には我々を構成するすべて の細胞,体液中で自然免疫応答を惹起することができ る。このことは歯周組織をはじめとする生体のどの部 位に病原細菌が侵入しても素早くその侵入を検知,防 御反応を惹起することで病原体のクリアランスに寄与 する点で優れている。さらに細菌構成物によるマクロ ファージや樹状細胞の PRRs刺激による活性化は,T 細胞への抗原提示を介した獲得免疫を活性化し,より 強固な防御反応を誘導すること,そして組織損傷後の 修復において重要な役割を果たしていることも知られ ている。 ペプチドグリカン(PGN)はグラム陽性細菌および グラム陰性細菌の細胞壁を構成し,グラム陽性菌では 細胞膜外に,歯周病原細菌などのグラム陰性菌では細 胞外膜と内膜の間に存在している。PGNは様々な PRRsを刺激し,発熱作用,炎症誘発能,アジュバント 作用,補体の活性化能,マクロファージを活性化しサ イトカインや iNOSの発現作用,オートファジー誘導 能,上皮細胞による抗菌ペプチドの誘導能などの生物 学的活性を有することから1),歯周病原細菌感染によ る歯周病の病態形成との関連性が考えられている。本 総説においては,歯周病原細菌の PGNとそれらの生 物学的活性,受容体と細胞内シグナリング,歯周病と の関連性について解説する。","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75638782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Comprehensive Treatment For a Type 2 Diabetes Patient with Generalized Severe Chronic Periodontitis 病例报告:综合治疗1例2型糖尿病合并广泛性重度慢性牙周炎
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-06-28 DOI: 10.2329/PERIO.61.95
T. Katsunuma
{"title":"Case Report: Comprehensive Treatment For a Type 2 Diabetes Patient with Generalized Severe Chronic Periodontitis","authors":"T. Katsunuma","doi":"10.2329/PERIO.61.95","DOIUrl":"https://doi.org/10.2329/PERIO.61.95","url":null,"abstract":"","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78610632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long Term Observation of Guided Tissue Regeneration with Bone Swaging Technique 骨挤压技术引导组织再生的远期观察
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-06-28 DOI: 10.2329/perio.61.81
T. Kodama
{"title":"Long Term Observation of Guided Tissue Regeneration with Bone Swaging Technique","authors":"T. Kodama","doi":"10.2329/perio.61.81","DOIUrl":"https://doi.org/10.2329/perio.61.81","url":null,"abstract":"","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73129271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The possibility of application of bone morphogenetic protein-9 (BMP-9) for the periodontal and bone regenerative therapy 骨形态发生蛋白-9 (BMP-9)在牙周及骨再生治疗中的应用前景
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-03-29 DOI: 10.2329/perio.61.9
Toshiaki Nakamura, Y. Shirakata, Yukiya Shinohara, K. Noguchi
{"title":"The possibility of application of bone morphogenetic protein-9 (BMP-9) for the periodontal and bone regenerative therapy","authors":"Toshiaki Nakamura, Y. Shirakata, Yukiya Shinohara, K. Noguchi","doi":"10.2329/perio.61.9","DOIUrl":"https://doi.org/10.2329/perio.61.9","url":null,"abstract":"","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89842070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts -in vitro study 乳铁蛋白促进人牙龈成纤维细胞增殖和伤口愈合的体外研究
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-03-29 DOI: 10.2329/PERIO.61.18
Naho Suzuki
{"title":"Lactoferrin Promotes Proliferation and Wound Healing of Human Gingival Fibroblasts -in vitro study","authors":"Naho Suzuki","doi":"10.2329/PERIO.61.18","DOIUrl":"https://doi.org/10.2329/PERIO.61.18","url":null,"abstract":"","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83991026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of comprehensive treatment for a patient with localized aggressive periodontitis 局部侵袭性牙周炎综合治疗1例报告
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-03-29 DOI: 10.2329/PERIO.61.28
Toshinaga Sase
{"title":"A case report of comprehensive treatment for a patient with localized aggressive periodontitis","authors":"Toshinaga Sase","doi":"10.2329/PERIO.61.28","DOIUrl":"https://doi.org/10.2329/PERIO.61.28","url":null,"abstract":"","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91401307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Report of Comprehensive Periodontal Treatment of a Case of Severe Drug-induced Gingival Overgrowth with Malaligned Teeth 1例严重药物性牙龈过度生长并牙列不正综合牙周治疗报告
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Pub Date : 2019-03-29 DOI: 10.2329/PERIO.61.37
M. Ninomiya
{"title":"Report of Comprehensive Periodontal Treatment of a Case of Severe Drug-induced Gingival Overgrowth with Malaligned Teeth","authors":"M. Ninomiya","doi":"10.2329/PERIO.61.37","DOIUrl":"https://doi.org/10.2329/PERIO.61.37","url":null,"abstract":": Gingival hyperplasia is well known to occur as an adverse effect of antihypertensive drugs, anticonvulsants, and immunosuppressants. Herein, we report a case of comprehensive periodontal treatment in a patient with severe drug-induced gingival hyperplasia accompanied by malaligned teeth and occlusion collapse caused by intake of a Ca-channel blocker (as an antihypertensive) for over 10 years, in which marked improvement of the periodontal condition was confirmed. Changing the antihypertensive drug (Ca-channel blocker) was not possible because the drug proved essential for good control of the blood pressure, but the supportive periodontal therapy was able to prevent recurrence. The periodontal condition has been well maintained post treatment.","PeriodicalId":19230,"journal":{"name":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76651793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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