Nutrition & Metabolism最新文献

{"title":"Dietary modulation for the hypertension risk group in Koreans: a cross-sectional study.","authors":"Youngmin Han, Ryun Huh, Keum Ji Jung, Heejin Kimm, Sun Ha Jee","doi":"10.1186/s12986-025-00921-4","DOIUrl":"https://doi.org/10.1186/s12986-025-00921-4","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is a critical global health issue, contributing to high morbidity and mortality rates. Representative risk factors for HTN include aging, genetics, obesity, alcohol drinking, smoking, and diet. Dietary interventions like the Dietary Approaches to Stop HTN (DASH) diet plan effectively prevent and manage HTN. We intend to evaluate the influence of eating patterns on HTN, applying multiple risk factors.</p><p><strong>Methods: </strong>For cross-sectional design, study subjects were grouped into four groups: optimal (n = 7,712), normal (n = 1,220), high normal (n = 3,655), and HTN (n = 4,355) according to the 2022 HTN treatment guidelines of Korea. Factor analysis was performed to identify major dietary patterns based on nutritional data obtained from a brief dietary questionnaire, including 17 food items. Finally, we conducted a moderation analysis to evaluate the impact of dietary patterns on the HTN risk score, which is determined by genetic variables, body mass index, alcohol consumption, and smoking status.</p><p><strong>Results: </strong>We identified three principal dietary patterns (Korean, Western, and New diet) in the study population. Adherence to the New diet was linked to lower HTN risk in all models (p < 0.001), while the Western and Korean diets were associated with a higher risk of HTN in some models. In high HTN-risk individuals, adherence to the Western diet increased the HTN risk trend (p < 0.001), whereas the New diet showed a potential protective trend (p = 0.059).</p><p><strong>Conclusions: </strong>The nutritional moderation effect was evident in the HTN high-risk group, where the Western diet increased risk, while the New diet showed a borderline protective effect. If the findings are validated by longitudinal investigation, our findings could serve as the basis for developing dietary guidelines for HTN.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"30"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the interplay among skin microbiota, cytokines, and T2DM: an insightful Mendelian randomization study.","authors":"Zhe Zhang, Chunyu Jiang, Yi-Qi Xing, Tianke Yang, Linxuan Zou, Zhuqiang Jia, Lin Zhao, Xin Han, Xueling Qu, Zhen Zhang, Junwei Zong, Shouyu Wang","doi":"10.1186/s12986-025-00922-3","DOIUrl":"https://doi.org/10.1186/s12986-025-00922-3","url":null,"abstract":"<p><strong>Background: </strong>Previous observational studies have indicated a correlation between the skin microbiome and Type 2 diabetes (T2DM). It is hypothesized that this causal relationship may be influenced by inflammatory responses. However, these factors as determinants of T2DM remain largely unexplored.</p><p><strong>Method: </strong>This study incorporated data from the GWAS database on the skin microbiome, 91 types of inflammatory cytokines, and T2DM. We employed two-sample MR and multivariable MR methods to assess the correlation between the skin microbiome and T2DM, and to investigate whether this correlation is affected by inflammatory cytokines.</p><p><strong>Results: </strong>The results of the two-sample MR analysis indicate that within the skin microbiome, genetically predicted genus: Acinetobacter, class: Alphaproteobacteria, genus: Bacteroides, ASV005[Propionibacterium granulosum], and ASV072[Rothia mucilaginosa] are associated with an increased risk of T2DM, while phylum: Proteobacteria, genus: Enhydrobacter, family: Clostridiales, ASV006[Staphylococcus hominis] serve as protective factors against T2DM. Among the inflammatory cytokines, levels of Macrophage colony-stimulating factor 1, Tumor necrosis factor receptor superfamily member 9, Urokinase-type plasminogen activator, and C-C motif chemokine 28 are associated with an increased risk of T2DM. Multivariable MR analysis further revealed that Macrophage colony-stimulating factor 1 levels act as a mediating factor between ASV072[Rothia mucilaginosa] and T2DM.</p><p><strong>Conclusion: </strong>In this study, we found a connection between the skin microbiome and T2DM, with inflammatory cytokines playing a key role in this relationship. This research helps us better understand this complex link and shows that addressing inflammation is important for preventing and treating diabetes. This could greatly benefit public health by reducing the impact of diabetes and its complications. Our results suggest that future studies should explore the specific biological interactions between the skin microbiome and diabetes to develop more effective risk management and treatment strategies from a microbial perspective.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"29"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between erythritol and lung cancer: a two-sample Mendelian randomization study.","authors":"Yongsheng Zhao, Renyan Zheng, Kexin Luo, Haiyang Zhao, Wanping Xiang","doi":"10.1186/s12986-025-00916-1","DOIUrl":"10.1186/s12986-025-00916-1","url":null,"abstract":"<p><strong>Background: </strong>Sweeteners have been widely added to food and beverages due to their low-calorie and sweetening properties. However, the role of sweeteners in cancer risk has been a subject of extensive debate over the past few decades.</p><p><strong>Objective: </strong>We aimed to elucidate the causation between the commonly used natural sweetener erythritol and the risk of lung cancer (LC) using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Data on erythritol and its metabolites were obtained from publicly available genome-wide association studies data. Summary data on LC and its subtypes were obtained from a large-scale genetic study conducted by the Transdisciplinary Research of Cancer in Lung of the International Lung Cancer Consortium and the Lung Cancer Cohort Consortium. We conducted independent two-sample MR analyses to assess the causation between erythritol and LC and its subtypes.</p><p><strong>Results: </strong>The inverse variance weighted method of MR analysis showed no evidence supporting causation between erythritol and LC or its histological subtypes. Sensitivity analysis further supported the results.</p><p><strong>Conclusion: </strong>Our study findings do not support genetic association between erythritol and LC or its subtypes.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"28"},"PeriodicalIF":3.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of rye consumption on markers of glycemic control: evidence on the \"rye factor\": a systematic review and meta-analysis of randomized controlled trials.","authors":"Mohammad Ghazvini, Faezeh Ghanbari-Gohari, Sahar Foshati, Masoumeh Akhlaghi","doi":"10.1186/s12986-025-00901-8","DOIUrl":"10.1186/s12986-025-00901-8","url":null,"abstract":"<p><p>Rye, as a source of dietary fiber, may have beneficial effects in glycemic control. In the current meta-analysis, we collected randomized controlled trials (RCTs) that examined the effect of rye consumption on glucose and insulin markers. PubMed, Scopus, and Web of Science databases were searched to find the RCTs. Random-effects model was used to calculate mean difference and 95% confidence intervals. Thirty-one RCTs, including 922 participants, passed the screening and eligibility stages and were included in the meta-analysis. Rye consumption did not have a significant effect on glucose indices including fasting, postprandial, and area under the curve (AUC). Subgroup analysis did not make a difference in the results, except that there was trends for increased postprandial glucose in two subgroups: individuals aged > 50 y (weighted mean difference (WMD) = 0.93, 95% CI: -0.03, 1.90 mmol/l, P = 0.058) and short intervention lengths (≤ 270 min) (WMD = 0.48, 95% CI: -0.03, 0.99 mmol/l, P = 0.066), and a trend for decreased AUC for glucose in rye fiber doses ≥ 12 g (WMD = -0.22, 95% CI: -0.46, 0.01 mmol/l, P = 0.059). Rye consumption did not show an effect on fasting and postprandial insulin but indicated a reduction in AUC for insulin (WMD = -0.48, 95% CI: -0.66, -0.30 mU/l, P < 0.001). Overall, results of this meta-analysis suggest that rye consumption may reduce insulin postprandial AUC without affecting glucose markers. Prospective cohorts are needed to determine the clinical importance of the finding.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"27"},"PeriodicalIF":3.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic nutritional index and diabetic peripheral neuropathy in type 2 diabetes: a machine learning approach.","authors":"Ya Wu, Danmeng Dong, Yang Liu, Xiaoyun Xie","doi":"10.1186/s12986-025-00917-0","DOIUrl":"10.1186/s12986-025-00917-0","url":null,"abstract":"<p><strong>Background: </strong>The prognostic nutritional index (PNI), an indicator of nutritional status, has been linked to various diabetic complications. However, its relationship with diabetic peripheral neuropathy (DPN) remains unclear. This study aimed to explore the association between PNI and DPN using machine learning (ML) approaches.</p><p><strong>Methods: </strong>A total of 625 patients with type 2 diabetes (T2D) were enrolled, with 282 diagnosed with DPN. PNI was calculated based on serum albumin and lymphocyte count. Random forest (RF) and eXtreme Gradient Boosting (XGBoost) models were developed to predict DPN using clinical and biochemical data. SHapley Additive exPlanations (SHAP) were applied to determine feature importance. Multivariate logistic regression was used to evaluate the relationship between PNI quartile and DPN risks.</p><p><strong>Results: </strong>Both RF and XGBoost models exhibited strong performance. The RF model achieved a recall of 78.4%, specificity of 87.8%, and accuracy of 84.0%, while the XGBoost model showed a recall of 77.4%, specificity of 92.1%, and accuracy of 84.8%. SHAP analysis identified lower PNI as a key factor for DPN. Multivariate logistic regression revealed that patients in the lowest PNI quartile had a significantly higher DPN risk compared to those in the highest quartile (OR: 3.271, 95% CI: 1.782-6.006, P < 0.001). Additionally, lower PNI levels were associated with impaired peripheral nerve function, including reduced motor and sensory nerve conduction velocity and action potential amplitudes.</p><p><strong>Conclusions: </strong>Lower PNI levels were associated with increased DPN risk and poorer nerve function, highlighting the importance of nutritional status in DPN management. Further longitudinal studies are needed to confirm these findings.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"26"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effect of life-course adiposity on the risk of respiratory diseases: a Mendelian randomization study.","authors":"Xi Xi Chen, Fang Ying Lu, Yi Wang, Liu Zhang, Shi Qi Li, Ying Ni Lin, Ya Ru Yan, Yong Jie Ding, Ning Li, Jian Ping Zhou, Xian Wen Sun, Qing Yun Li","doi":"10.1186/s12986-025-00915-2","DOIUrl":"10.1186/s12986-025-00915-2","url":null,"abstract":"<p><strong>Background: </strong>There is limited evidence on the causal associations of life-course adiposity with the risk of respiratory diseases. This study aimed to elucidate these associations.</p><p><strong>Methods: </strong>Two-sample Mendelian randomization was conducted using genetic instruments of life-course adiposity (including birth weight, childhood BMI, and adulthood adiposity) to estimate their causal effect on respiratory diseases in participants of European ancestry from the UK Biobank, the FinnGen consortium, and other large consortia.</p><p><strong>Results: </strong>Genetically predicted higher birth weight was associated with decreased risk of acute upper respiratory infections and increased risk of pulmonary embolism, sleep apnea, and lung cancer. Genetically predicted high childhood BMI was associated with increased risk of asthma, COPD, pulmonary embolism, and sleep apnea. However, most of these observed associations were no longer significant after adjusting for adult BMI. Genetically predicted higher adult BMI and WHR were associated with 10 and 4 respiratory diseases, respectively. High adult body fat percentage and visceral adiposity were genetically associated with increased risk of 9 and 11 respiratory diseases, respectively. Consistently, genetically predicted higher whole-body fat mass was associated with increased risk of 8 respiratory diseases.</p><p><strong>Conclusions: </strong>This study provides genetic evidence that greater adiposity in childhood and adulthood has a causal effect in increasing the risk of a wide range of respiratory diseases. Furthermore, the effects of childhood obesity on respiratory outcomes may be mediated by adult obesity.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"25"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoid intake, inflammation, and atherosclerotic cardiovascular disease risk in U.S. adults: a cross-sectional study.","authors":"Qin Hu, Xiangyu Ma, Tongjian Cai, Yafei Li","doi":"10.1186/s12986-025-00913-4","DOIUrl":"10.1186/s12986-025-00913-4","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the relationship between the dietary intake of total flavonoids and their six subclasses and the risk of atherosclerotic cardiovascular disease (ASCVD) in adults, and to evaluate the potential mediating effect of inflammation in this association.</p><p><strong>Methods: </strong>Cross-sectional data from 3841 individuals participating in the National Health and Nutrition Examination Survey 2017-2018 were included in the analysis. Flavonoid intake was assessed using a 2-day dietary recall method, and ASCVD status was determined by extracting relevant information from the medical condition questionnaire. To determine the relationship between flavonoid intake and ASCVD risk, we employed logistic regression, subgroup, mediation, and restricted cubic spline analyses.</p><p><strong>Results: </strong>Intake of flavan-3-ols, flavones, flavonols, and total flavonoids was negatively correlated with ASCVD risk. Subgroup analysis revealed that the association between flavonoid intake and ASCVD risk exhibits sex-specific differences, with the relationship being more pronounced among women. The significant associations between increased flavonoid intake and reduced ASCVD risk were observed in smokers, non-alcohol consumers, physically inactive individuals, those with hypertension. A nonlinear relationship was observed between the intake of total flavonoids, flavan-3-ols and flavonols and ASCVD risk. Additionally, high-sensitivity C-reactive protein (hs-CRP) and the neutrophil-to-lymphocyte ratio (NLR), inflammatory markers relevant to ASCVD, were found to mediate the association between flavonoid intake and ASCVD risk. Flavonoids demonstrated a dose‒response relationship with reductions in the levels of hs-CRP and the NLR.</p><p><strong>Conclusions: </strong>This study indicates the inverse association between flavonoid intake, particularly flavan-3-ols, flavones, and flavonols, and the risk of ASCVD. It highlights the mediating role of CRP and NLR in this relationship. Furthermore, the study emphasizes the importance of considering lifestyle factors and sex when evaluating the cardiovascular benefits of flavonoids.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"24"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of serum fasting glucagon in hypothyroidism-related nonalcoholic fatty liver disease.","authors":"Mervat M El-Eshmawy, Amira A Barakat, Azza A El-Baiomy, Mohamed M Abo El-Naga, Mohamed Elbasiony","doi":"10.1186/s12986-025-00899-z","DOIUrl":"10.1186/s12986-025-00899-z","url":null,"abstract":"<p><strong>Background: </strong>A bidirectional relationship between hypothyroidism and nonalcoholic fatty liver disease (NAFLD) has been proposed. Fasting hyperglucagonemia in patients with hypothyroidism induced NAFLD needs to be further clarified. The aim of the present study was to determine fasting serum glucagon levels in hypothyroid adults with and without NAFLD. The possible association between fasting glucagon and NAFLD in patients with hypothyroidism was also evaluated.</p><p><strong>Methods: </strong>This study was comprised 60 patients with uncontrolled hypothyroidism and 30 healthy controls matched for age and sex. Patients with hypothyroidism were divided into 2 groups: 30 patients with NAFLD and 30 patients without NAFLD. Diagnosis of NAFLD was based on the combination of hepatic steatosis index (HSI) at a cutoff value of 36 and measurements of steatosis using fibroScan. Anthropometric measurements, lipids profile, homeostasis model assessment of insulin resistance (HOMA-IR), free thyroxine (FT4), triiodothyronine (FT3), thyroid stimulating hormone (TSH) and serum fasting glucagon were assessed.</p><p><strong>Results: </strong>Serum fasting glucagon concentration was significantly higher in hypothyroid patients with and without NAFLD than in healthy controls; glucagon was also significantly higher in the hypothyroid patients with NAFLD than in those without NAFLD. Fasting glucagon was significantly correlated with waist circumference (WC), body mass index (BMI), TSH, HSI and fibroScan parameters in hypothyroid patients with NAFLD. Fasting glucagon predicts NAFLD in patients with hypothyroidism at a cutoff value 85 ng/L with 90% sensitivity, 100% specificity and p < 0.001. With multivariable analysis, age, BMI and TSH were significant positive predictors of NAFLD in patients with hypothyroidism.</p><p><strong>Conclusion: </strong>Fasting glucagon concentration may play a role in the development of NAFLD in patients with hypothyroidism. However, the exact underlying mechanism needs further studies.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"19"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vegan diet, processed foods, and body weight: a secondary analysis of a randomized clinical trial.","authors":"Hana Kahleova, Tatiana Znayenko-Miller, Arathi Jayaraman, Giulianna Motoa, Laura Chiavaroli, Richard Holubkov, Neal D Barnard","doi":"10.1186/s12986-025-00912-5","DOIUrl":"10.1186/s12986-025-00912-5","url":null,"abstract":"<p><p>Low-fat plant-based diets cause weight loss in clinical trials. However, many foods are highly processed, raising the question as to their effect on body weight. This secondary analysis assessed the associations between changes in processed food intake and weight loss in 244 overweight adults randomly assigned to a vegan (n = 122) or control group (n = 122) for 16 weeks. Three-day dietary records were analyzed using the NOVA system, which categorizes foods from 1 to 4, based on degree of processing. A repeated measure ANOVA, Pearson correlations, and a multivariate regression model were used for statistical analysis. The consumption of animal foods in categories 1-4 decreased in the vegan group, compared with the control group. Body weight decreased in the vegan group (treatment effect - 5.9 kg [95% CI -6.7 to -5.0]; Gxt, p < 0.001). Changes in consumption of animal foods in categories 1-4 were positively associated with changes in body weight: r = + 0.34; p < 0.001 for category 1; r = + 0.18; p = 0.008 for category 2; r = + 0.17; p = 0.01 for category 3; and r = + 0.22; p = 0.001 for category 4. In no NOVA category was the consumption of plant-based processed foods positively and significantly associated with weight gain. The top three independent predictors of weight loss were reduced intakes of processed, unprocessed or minimally processed, and ultra-processed animal foods. These findings suggest that replacing animal products with plant-based foods may be an effective weight-loss strategy, even when processed plant-based foods are included.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"21"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evidence of sesame (Sesamum indicum L.) products and its bioactive compounds on anthropometric measures, blood pressure, glycemic control, inflammatory biomarkers, lipid profile, and oxidative stress parameters in humans: a GRADE-assessed systematic review and dose-response meta-analysis.","authors":"Ali Jafari, Bahare Parsi Nezhad, Niloufar Rasaei, Elahe Aleebrahim-Dehkordi, Abdolhalim Rajabi, Alireza Alaghi","doi":"10.1186/s12986-025-00910-7","DOIUrl":"10.1186/s12986-025-00910-7","url":null,"abstract":"<p><p>This comprehensive systematic review and meta-analysis aimed to assess the impact of sesame (Sesamum indicum L.) supplementation on cardiovascular disease risk factors. Relevant research was discovered via PubMed, Scopus, Web of Science, CENTRAL, and EMBASE up to June 2024. The assessment of study quality was conducted using the Cochrane risk-of-bias tool. Thirteen trials, with interventions ranging from 4 to 12 weeks and involving 521 participants, demonstrated significant reductions in glycated hemoglobin (HbA1c) (Standardized Mean Difference [SMD] = - 0.67; 95% Confidence Interval [CI] - 1.01, - 0.32; P < 0.001), C-reactive protein (CRP) (SMD = - 0.51; 95% CI - 0.96, - 0.05; P = 0.028), and interleukin-6 (IL-6) (SMD = - 0.74; 95% CI - 1.16, - 0.32; P < 0.001), and a marginally significant effect on fasting blood sugar (FBS) (SMD = - 0.57; 95% CI - 1.16, 0.02; P = 0.057). Subgroup analyses revealed that sesame supplementation significantly reduced CRP and malondialdehyde (MDA) in populations without chronic diseases, while total cholesterol (TC) and MDA were reduced in those with chronic diseases. MDA was significantly reduced in females, especially those aged 50 or older. At dosages of 10 g per day or less, CRP, high-density lipoprotein cholesterol (HDL), and TC showed significant improvements. Meta-regression highlighted a significant dose-dependent reduction in TC levels at 10 g/day, and a significant duration-dependent decrease in TG levels at 8 weeks of supplementation. Sesame supplementation demonstrates potential benefits in improving glycemic control, inflammatory markers, and lipid profiles, making it a promising adjunct therapy for reducing cardiovascular disease risk factors.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"22"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}