Neurotoxicity Research最新文献

{"title":"Regional Crosstalk Between the Amygdala, Hippocampus, and Prefrontal Cortex Following Na⁺,K⁺-ATPase Inhibition by Ouabain.","authors":"Bianca Estefani Schmidt, Ana Karla Oliveira Leite, Clarissa Penha Farias, Alessandra Schmitt Rieder, Gustavo Ricardo Krupp Prauchner, Carlos Alexandre Netto, Angela T S Wyse","doi":"10.1007/s12640-026-00800-7","DOIUrl":"https://doi.org/10.1007/s12640-026-00800-7","url":null,"abstract":"<p><p>The Na⁺,K⁺-ATPase plays a fundamental role in memory formation by regulating neuronal excitability and NMDA receptor-dependent synaptic plasticity. While this enzyme's dysfunction is broadly linked to cognitive disorders, its specific contribution to fear memory consolidation, particularly within the key brain structure of the basolateral amygdala (BLA), remains undefined. We investigate whether Na⁺,K⁺-ATPase inhibition disrupts contextual fear conditioning (CFC) memory consolidation and examine downstream molecular, oxidative, and inflammatory responses in interconnected brain regions. Fifty-day-old male Wistar rats received bilateral cerebral infusions of the Na⁺,K⁺-ATPase inhibitor ouabain (1 μm) or vehicle immediately after CFC training. Memory retention was assessed 24 h later. Additional cohorts were euthanized 6-24 h after infusion for biochemical analysis of Na⁺,K⁺-ATPase activity, expression of Na⁺,K⁺-ATPase isoforms (α1, α2, α3, β1), oxidative stress markers, and pro-inflammatory cytokines in the amygdala, hippocampus, and prefrontal cortex. Post-training Na⁺,K⁺-ATPase inhibition in the BLA selectively impaired fear memory consolidation. Ouabain induced changes in Na⁺,K⁺-ATPase activity in the hippocampus and prefrontal cortex, and induces time-dependent upregulation of α1 and β1 isoforms. Six hours after infusion, ouabain triggered oxidative imbalance - characterized by reduced CAT activity. Pro-inflammatory cytokine expression was markedly elevated in the hippocampus and prefrontal cortex, while D-serine co-administration failed to rescue memory deficits. These findings establish a previously unrecognized role for Na⁺,K⁺-ATPase signaling in the BLA in coordinating the neurobiological processes essential for fear memory consolidation, indicating that its precise regulation is required for adaptive fear memory formation.</p>","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TDP-43 Dysfunction Causes Hyper-Lactate State, Increased AARS1 Expression and Enhanced Protein Lactylation.","authors":"Tianshuo Zhang, Kaixin Yan, Qiao Liao, Ruiyang Liu, Ruyuan Liu, Jinxia Zhou, Yongmin Liu, Fangfang Bi","doi":"10.1007/s12640-026-00797-z","DOIUrl":"https://doi.org/10.1007/s12640-026-00797-z","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From In Vitro Genotoxicity Assays to Human Biomarkers: Interpreting DNA Damage Signals in Long-Term SSRI Therapy through a Translational Neurotoxicology Lens.","authors":"Emadeldin M Kamel, Sally Mostafa Khadrawy, Nour Y S Yassin, Noha A Ahmed","doi":"10.1007/s12640-026-00795-1","DOIUrl":"https://doi.org/10.1007/s12640-026-00795-1","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trifloxystrobin-Induced Neurotoxicity in Wistar Rats: Biomarkers of Oxidative Stress, Cholinergic Dysfunction, and DNA Damage.","authors":"Hanen Chaabani, Asma Mnassri, Siwar Rich, Karima Rjiba, Imed Massoudi, Yosra Guedri, Moncef Mokni, Salwa Abid, Imen Ayed-Boussema","doi":"10.1007/s12640-026-00799-x","DOIUrl":"https://doi.org/10.1007/s12640-026-00799-x","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-132 Alleviates Ischemia-Reperfusion-Induced Neuronal Apoptosis by Targeting Mecp2 in Stroke Models.","authors":"Xiang Wang, Rui Ma, Zilu Liu, Wenjin Sun, Lin Xia, Yurou Wang, Donghua Shao, Caixia Sun","doi":"10.1007/s12640-026-00796-0","DOIUrl":"10.1007/s12640-026-00796-0","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Ozone against Quinolinic Acid-Induced Redox Imbalance in Murine BV-2 Microglial Cells.","authors":"Pedro Henrique Zatti, Nicole Peyrot da Silva, Marina Rigotti, Fernando Joel Scariot, Carolina Bordin Davidson, Alencar Kolinski Machado, Catia Santos Branco","doi":"10.1007/s12640-026-00798-y","DOIUrl":"10.1007/s12640-026-00798-y","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.","authors":"Kana Kimura, Ira Driscoll, Noah Cook, Sonia Shahzad, Tobey J Betthauser, Sterling C Johnson, Sanjay Asthana, Catherine L Gallagher, Bruce P Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M Carlsson, Gwendlyn Kollmorgen, Ozioma C Okonkwo","doi":"10.1007/s12640-026-00786-2","DOIUrl":"10.1007/s12640-026-00786-2","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipopolysaccharide-induced Neuroimmune Alteration and Memory Decline in Aging Mice: The Role of Augmented Cellular Senescence.","authors":"Miracle K Nekabari, Benneth Ben-Azu, Bienose S Chijioke, Daniel T Esuku, Emmanuel O Chidebe, Faith B Friday, Saviour G Usin, Prosper Iwhiwhu, Ayereoghene S Moses, Ovovwe Diakparomre, Onyeka B Onyeukwu","doi":"10.1007/s12640-026-00785-3","DOIUrl":"10.1007/s12640-026-00785-3","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoid Rutin Reduces Intestinal Inflammation in an Experimental Model of Parkinson's Disease.","authors":"Livia Bacelar De Jesus, Annyta Fernandes Frota, Fillipe Mendes De Araújo, Fabine Correia Passos, Nestor Adrian Guerrero Gutierrez, Luana Brunelly Araujo de Lima, Victor Diogenes Amaral Silva, Gyselle Chrystina Baccan, Marcelo Biondaro Gois, Silvia Lima Costa","doi":"10.1007/s12640-026-00789-z","DOIUrl":"10.1007/s12640-026-00789-z","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the RNA Shield: HNRNPC and YTHDF2 Act as Guardians of Neurons in Parkinson's Disease.","authors":"Shreya, Khadga Raj Aran","doi":"10.1007/s12640-026-00790-6","DOIUrl":"10.1007/s12640-026-00790-6","url":null,"abstract":"","PeriodicalId":19193,"journal":{"name":"Neurotoxicity Research","volume":"44 2","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}