NIgerian Journal of Neuroscience最新文献_第3页

Ameliorative Effect of Rutin Supplement on Chronic Unpredictable Mild Stress-Induced Depressive Phenotypes in Mice 芦丁补充剂对小鼠慢性不可预测的轻度应激性抑郁表型的改善作用

NIgerian Journal of Neuroscience Pub Date : 2022-12-31 DOI: 10.47081/njn2022.13.4/004

Aliyu Kabir, Y. Yusha’u, U. Adam, S. Ibrahim, Mariya Muhammad

{"title":"Ameliorative Effect of Rutin Supplement on Chronic Unpredictable Mild Stress-Induced Depressive Phenotypes in Mice","authors":"Aliyu Kabir, Y. Yusha’u, U. Adam, S. Ibrahim, Mariya Muhammad","doi":"10.47081/njn2022.13.4/004","DOIUrl":"https://doi.org/10.47081/njn2022.13.4/004","url":null,"abstract":"Depression is a severe disorder that results in poor quality of life and affects hundreds of millions worldwide. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in disease development. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity and hence, suggested by studies to be exciting prototypes for new antidepressant drugs. Rutin is a flavonoid glycoside abundantly found in plants. The study evaluated the effect of rutin supplementation on depression using the chronic unpredictable mild stress depression mice models. Twenty-five mice were grouped into 5 (n = 5) and subjected to chronic unpredictable mild stressors. Groups 1-5 were orally served distilled water (no treatment), Rutin 30 mg/kg, 60 mg/kg, 120 mg/kg, and fluoxetine 20 mg/kg respectively. The study was conducted in the span of 30 days. Administration of rutin produced a reduction in immobility time at a dose of 120 mg/kg, a significant (p<0.05) decrease in the concentration of serum superoxide dismutase at doses of 30 and 60 mg/kg, and showed no significant difference on catalase and malondialdehyde levels. Rutin supplementation showed the potential of positively reversing behavioural despair. Thus, may be considered a possible treatment option for depressive symptoms in view of it attaining lesser side effects compared to orthodox treatments","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81979366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-acetylcysteine Alleviates Depression through Up-regulation of Synaptophysin, Inhibition of Reactivity Astrocytes, and Anhedonia in the Forced Swim Test Animal Model 在强迫游泳实验动物模型中，n -乙酰半胱氨酸通过上调突触素、抑制星形胶质细胞的反应性和快感缺乏症来缓解抑郁

NIgerian Journal of Neuroscience Pub Date : 2022-10-18 DOI: 10.47081/njn2022.13.3/004

A. Memudu

{"title":"N-acetylcysteine Alleviates Depression through Up-regulation of Synaptophysin, Inhibition of Reactivity Astrocytes, and Anhedonia in the Forced Swim Test Animal Model","authors":"A. Memudu","doi":"10.47081/njn2022.13.3/004","DOIUrl":"https://doi.org/10.47081/njn2022.13.3/004","url":null,"abstract":"Depression is a mental disorder of global concern, with chronic psychological stress being one of the underlying predisposing factors. This study evaluated the role of the antioxidant, N-acetylcysteine (NAC), as an antidepressant using the forced swim test (FST) animal model. Thirty adult male Wistar rats (250 g average weight) were randomly grouped into six (n=5): Control (1 ml/day of normal saline); FST model; NAC (200 mg/kg/day); Fluoxetine (20 mg/kg/day); FST model treated with NAC (200 mg/kg/day), and FST model treated with Fluoxetine (20 mg/kg/day). All the treatments were orally. The FST, sucrose-preference test (SPT), and brain weights were assessed, and data analysed. The histo-architecture of the prefrontal cortex (PFC), as well as the immunohistochemistry of astrocytes and synaptophysin were also assessed. Findings showed that NAC prevented FST-induced depressive behaviour demonstrated by increased SPT and mobility time. NAC also prevented the FST-induced decreased brain weights and neuronal loss, reduced proliferation of reactive astrocytes, and diminished synaptophysin immunoreactivity in the PFC similar to that of fluoxetine, a standard antidepressant drug. NAC exhibited its neuroprotective mechanism via inhibiting the proliferation of reactive astrocytes, and protecting neurons and synapses from oxidative tissue damage induced by FST, hence, an increase in synaptophysin activity that culminated in increased neural activity, increased SPT, and reduced immobility time.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73580358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caffeine Improves Neurobehavioural Impairments in Fructose-Fed Swiss Mice via Multiple Neurochemical Mechanisms 咖啡因通过多种神经化学机制改善果糖喂养的瑞士小鼠的神经行为障碍

NIgerian Journal of Neuroscience Pub Date : 2022-10-02 DOI: 10.47081/njn2022.13.3/003

I. Abi, Vincent Mwaikyoga, Beatrice Orungwa, Josephine Orkar

{"title":"Caffeine Improves Neurobehavioural Impairments in Fructose-Fed Swiss Mice via Multiple Neurochemical Mechanisms","authors":"I. Abi, Vincent Mwaikyoga, Beatrice Orungwa, Josephine Orkar","doi":"10.47081/njn2022.13.3/003","DOIUrl":"https://doi.org/10.47081/njn2022.13.3/003","url":null,"abstract":"Caffeine is a substance that has attracted more research attention in recent years as it forms the main ingredient in many beverages, including coffee. It has stimulant activity with low toxicity. Fructose on the other hand has been shown to impair neurocognitive functions in experimental animals. This study investigated the effect of caffeine on fructose-induced neurobehavioural impairment in mice. Twenty-seven Swiss mice (n=9) were randomly grouped as follows: Control (water and rat chow ad libitum); fructose treated group (100% fructose solution ad libitum); and fructose-caffeine treated group (100% fructose solution + 1 g/L of caffeine ad libitum). Treatment lasted for 6 weeks after which the mice were subjected to Morris water maze, Y-maze, elevated plus maze and beam walk tests. Thereafter, the animals were humanely sacrificed. Whole brain samples were harvested and gently homogenized in sodium phosphate buffer, and cold centrifuged for neurotransmitters assay. The results showed that fructose significantly (p<0.05) increased body weight, impaired memory functions and inhibited the brain levels of dopamine, serotonin and acetylcholine. Caffeine co-administered with fructose was however, found to significantly (p<0.05) reduce body weight, improved memory and locomotor performances and increased brain levels of the aforementioned neurotransmitters and enzyme. It was concluded that fructose impairs neurobehavioural activities via impaired brain neurotransmitter and enzyme activities, which was ameliorated by caffeine.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79958854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin B Complex Protects Against Maternal Deprivation-Induced Cerebellar Damage in Adolescent Rats 维生素B复合物保护青春期大鼠免受母体剥夺引起的小脑损伤

NIgerian Journal of Neuroscience Pub Date : 2022-09-30 DOI: 10.47081/njn2022.13.3/002

Fatimah Abdulsalam, N. Mutholib, Abdulkabir Bature, I. Gbadamosi, G. Omotoso

{"title":"Vitamin B Complex Protects Against Maternal Deprivation-Induced Cerebellar Damage in Adolescent Rats","authors":"Fatimah Abdulsalam, N. Mutholib, Abdulkabir Bature, I. Gbadamosi, G. Omotoso","doi":"10.47081/njn2022.13.3/002","DOIUrl":"https://doi.org/10.47081/njn2022.13.3/002","url":null,"abstract":"Maternal deprivation during the early neonatal period is linked to many neurodevelopmental disorders. This study was designed to investigate the protective action of vitamin B complex (Vit Bco) on maternal deprivation-induced cerebellar damage in Wistar rats. Pups were divided into four groups: control, which received 50 ml/kg of normal saline from postnatal day (PND) 21-35; Second group received 40 mg/kg of Vit Bco orally from PND 21-35; Third and fourth groups were maternally deprived for 24 h on PND 9, but the fourth group received Vit Bco in addition from PND 21-35. The pups were sacrificed on PND 36 and the cerebellar tissues were harvested and processed for histological and immunohistochemical studies, as well as oxidative status using enzymatic markers (superoxide dismutase and catalase). Cerebellar microarchitecture of maternally deprived pups revealed disruption of cortical layers, pyknotic Purkinje cells and activated astrocytes. Superoxide dismutase and catalase activities were significantly reduced in maternally deprived pups when compared with the control and the Vit Bco alone group. Pups that received Vit Bco after maternal deprivation had well-delineated cortical layout, moderately stained Purkinje cells and non-activated astrocytes, while the oxidative enzymes activities were increased compared with pups that did not receive Vit Bco intervention. Conclusively, Vit Bco ameliorates cerebellar histomorphological, neurochemical and oxidative alterations associated with maternal deprivation.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88579846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Combined Psychoactive Effects of Caffeine, Nicotine and MDMA on the Prefrontal Cortex of Juvenile Male Wistar Rats 咖啡因、尼古丁和MDMA对幼年雄性Wistar大鼠前额皮质的联合精神活性作用

NIgerian Journal of Neuroscience Pub Date : 2022-09-01 DOI: 10.47081/njn2022.13.3/001

Victor C Ogbolu, Sunday O Fabiyi, O. Ogunbiyi, J. Owolabi

{"title":"The Combined Psychoactive Effects of Caffeine, Nicotine and MDMA on the Prefrontal Cortex of Juvenile Male Wistar Rats","authors":"Victor C Ogbolu, Sunday O Fabiyi, O. Ogunbiyi, J. Owolabi","doi":"10.47081/njn2022.13.3/001","DOIUrl":"https://doi.org/10.47081/njn2022.13.3/001","url":null,"abstract":"The juvenile is vulnerable to psychoactive agents and environmental influences. Caffeine, nicotine, and 3,4-Methylenedioxymethamphetamine (MDMA) could influence the developing brain with potential consequences on mental attributes including memory, cognition, behaviour, and learning. This research studied the structural and functional changes attributable to the combined use of caffeine, nicotine and MDMA on the prefrontal cortex. Thirty-two juvenile male Wistar rats were grouped into four (n=8) and administered water-dissolved caffeine, nicotine and MDMA by oral gavages. An untreated group served as control. The second group received caffeine (100mg/kg bw) and nicotine (50mg/kg bw), the third group received caffeine (100mg/kg bw) and MDMA (10mg/kg bw) and the last group received nicotine (50mg/kg bw) and MDMA (10mg/kg bw). Treatments lasted thirty days, after which animals were sacrificed. The prefrontal cortices were fixed in formal saline, processed, and demonstrated using eosin and haematoxylin (H&E), Cresyl fast violet, and Luxol fast blue histological methods as well as glial-acidic fibrillary protein (GFAP) immunohistochemistry. Representative photomicrographs were obtained and analysed. Combined ingestion of caffeine, nicotine and MDMA affected the brain causing neuronal morphological aberrations, aberrations in Nissl expression, and astrocyte reactions especially with the combination of caffeine + nicotine as well as caffeine + MDMA with mild aberrations in myelin integrity. Effects also included significant elevations in GABA and serotonin activities with the combination of nicotine and MDMA (p< 0.05). Results showed that the combined use of psychoactive agents could elicit peculiar effects","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81470506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameliorative Effects of Vernonia amygdalina and Moringa oleifera Extracts on Cognitive Impairment in Diabetic Wistar Rats 苦杏仁和辣木提取物对糖尿病大鼠认知功能损害的改善作用

NIgerian Journal of Neuroscience Pub Date : 2022-08-19 DOI: 10.47081/njn2022.13.2/004

Koofreh Davies, E. Olorunsola, Nathaniel Udokang, Kubiat Umana, M. Alozie, I. Edagha

{"title":"Ameliorative Effects of Vernonia amygdalina and Moringa oleifera Extracts on Cognitive Impairment in Diabetic Wistar Rats","authors":"Koofreh Davies, E. Olorunsola, Nathaniel Udokang, Kubiat Umana, M. Alozie, I. Edagha","doi":"10.47081/njn2022.13.2/004","DOIUrl":"https://doi.org/10.47081/njn2022.13.2/004","url":null,"abstract":"This study investigated the ameliorative effects of Vernonia amygdalina and Moringa oleifera on cogni-tive impairment in alloxan-induced diabetes mellitus in male Wistar rats. The animals were allotted into eight groups of five. Group 1 were not induced nor treated. Diabetes was induced with alloxan (135 mg/kg body weight) in groups 2-8. Group 2 which served as diabetic control received distilled water (10 mL/kg). Groups 3-8 were administered ethanol extracts of V. amygdalina (200 mg), M. oleifera (500 mg), V. amygdalina (400 mg), M. oleifera (1,500 mg), V. amygdalina (300 mg) + M. oleifera (1,000) mg, and Metformin (14.29 mg) per kg body weights respectively, for 28 days starting 72 h post induction of diabetes. Novel object recognition, T-maze simple alternation, transfer latency and neurohistology were assessed. Rats in diabetic control had negative discrimination ratio and scored less than 50% in simple alternation. These memory deficits were reversed in the treated groups. The nootropic effect was higher in M. oleifera 1,500 mg/kg than any other group. Severe neuronal degeneration, shrinkage and clumping observed in the diabetic group were ameliorated with administration of V. amygdalina and M. oleifera extracts individually and in combination. Histological findings showed decreased glial fibrillary acidic protein expression. V. amygdalina (400 mg/kg) and M. oleifera (500 mg/kg) were the most effective in ameliorating neuronal damage. The neuroprotective effects of both plants are attributed to their constituent antioxidants, and appear not to be synergistic.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90239848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interplay between Pain, Anxiety and Depression 疼痛、焦虑和抑郁之间的相互作用

NIgerian Journal of Neuroscience Pub Date : 2022-06-30 DOI: 10.47081/njn2022.13.2/001

B. Owoyele, Patrick Abolarin

{"title":"The Interplay between Pain, Anxiety and Depression","authors":"B. Owoyele, Patrick Abolarin","doi":"10.47081/njn2022.13.2/001","DOIUrl":"https://doi.org/10.47081/njn2022.13.2/001","url":null,"abstract":"Pain is a subjective experience with two inseparable components: sensory and emotional. The personal property of pain experience makes it difficult to manage and treat due to the influence of genetics, age, gender, spiritual beliefs, social-economic status, and cultural factors. Similarly, medical care methods partly control pain experience and regulate pain progression. Contrary to chronic pain, which is continuous and recurrent, acute pain is primarily due to trauma, acute medical conditions, or treatment. Whatever the case, both can cause mood disorders. The interplay between mood disorders and pain upholds a progressively significant bidirectional link, as mood disorders and pain are risk factors for each other. Depression and anxiety heighten pain perception or decrease pain tolerance. Acute or chronic pain can also increase the chances of mood dysregulation. Although depression and anxiety have a close relationship with acute pain, the interplay between depression and acute pain is more comprehensively studied. Most depressed patients present pain as their sole complaint in primary care practices, which unfortunately is overlooked by physicians. Howbeit, reports on experimentally induced pain perception in depressed patients are mixed, presenting both an amplified and reduced pain threshold and tolerance. Although there are less published data about pain and anxiety, the association is regular because increased anxiety equally increases pain perception while decreasing tolerance. The aim of this review was to elucidate more on the mechanisms delineating the interconnectivity of pain and mood disorders.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75572185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobehavioural Evaluation of Antidepressant and Anticonvulsant Potentials of Tizanidine in Balb/c Mice 替扎尼定对Balb/c小鼠抗抑郁和抗惊厥电位的神经行为评价

NIgerian Journal of Neuroscience Pub Date : 2022-06-30 DOI: 10.47081/njn2022.13.2/003

E. Patrick, S. Otimenyin, B. Bukar, B. Chindo, D. Mallam

{"title":"Neurobehavioural Evaluation of Antidepressant and Anticonvulsant Potentials of Tizanidine in Balb/c Mice","authors":"E. Patrick, S. Otimenyin, B. Bukar, B. Chindo, D. Mallam","doi":"10.47081/njn2022.13.2/003","DOIUrl":"https://doi.org/10.47081/njn2022.13.2/003","url":null,"abstract":"Tizanidine is a selective α2-adrenergic receptor agonist that stimulates the central nervous system through the adrenergic pathway. This study evaluated the antidepressant and anticonvulsant activity of tizanidine in mice. The various limitations of currently available anti-depressive and epileptic drugs and the bidirectional relationship between the two neurological disorders warrant improved pharmacotherapy interventions. 125 Balb/c mice were divided into 75 and 50 for antidepressant and anticonvulsant stud-ies, respectively. Forced swim (FST), tail suspension (TST), and open field (OFT) antidepressant models were used. In each model, twenty-five mice were divided into five groups (n=5); 1 mL/kg dis-tilled water group (negative control), 15 mg/kg imipramine (positive control in FST and TST), 0.05 mg/kg diazepam (positive control for OFT) group, and 1 mg/kg, 2 mg/kg, and 4 mg/kg tizanidine groups respectively. Anticonvulsant screening was conducted using pentylenetetrazole (PTZ) and picrotoxin models of seizure in which mice were treated with 2 mg/kg, 4 mg/kg and 8 mg/kg tizanidine. Tizanidine at all the doses significantly reduced the immobility time of the mice in FST (p≤0.0001) and TST (p≤ 0.05). There was no significant increase in line crossing frequency between tizanidine and 0.05 mg/kg diazepam in the OFT (p˃0.05). Tizanidine significantly delayed the onset of myoclonic jerks (p≤0.001) in the PTZ model but not in the picrotoxin model (p˃0.05). This study showed that tizanidine possesses antidepressant-like activity, but little anticonvulsant activity.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86622575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin C Attenuate Neurological Changes in the Medial Prefrontal Cortex of Juvenile Mice Exposed to Diclofenac Sodium 维生素C减弱双氯芬酸钠暴露的幼年小鼠内侧前额叶皮层的神经变化

NIgerian Journal of Neuroscience Pub Date : 2022-06-30 DOI: 10.47081/njn2022.13.2/002

D. Adekomi, A. Adekeye, O. Adewale, Olufunke F Dada, Oreoluwa Omotoso, Olutayo Fabiyi, O. Osuntokun, P. Fakunle, S. Alabi, A. Hussein, J. Fatoki

{"title":"Vitamin C Attenuate Neurological Changes in the Medial Prefrontal Cortex of Juvenile Mice Exposed to Diclofenac Sodium","authors":"D. Adekomi, A. Adekeye, O. Adewale, Olufunke F Dada, Oreoluwa Omotoso, Olutayo Fabiyi, O. Osuntokun, P. Fakunle, S. Alabi, A. Hussein, J. Fatoki","doi":"10.47081/njn2022.13.2/002","DOIUrl":"https://doi.org/10.47081/njn2022.13.2/002","url":null,"abstract":"Diclofenac sodium is one of the commonly used therapeutic non-steroidal anti-inflammatory drugs; notwithstanding, diverse adverse effects are clearly described. In humans, vitamin C is an essential nutrient that is ubiquitously a water-soluble electron donor with biological characteristics. To a greater extent, it has been widely recognized not only as an antioxidant but also as a specific co-factor in patho-enzymatic processes and reactions. This study investigated the effect of vitamin C on the medial prefrontal cortex (mPFC) of juvenile mice exposed to Diclofenac sodium. Thirty juvenile mice were randomly assigned into 5 experimental groups; control, saline-treated, vitamin C treated, Diclofenac sodium treated, and vitamin C + Diclofenac sodium. Histochemical, immunohistochemical, stereologi-cal, and quantitative neurochemical studies were respectively, employed to assess the effect of vitamin C on Diclofenac sodium-associated neurological damage. Results showed that the histoarchitectural profile of the mPFC was well preserved in the control, saline, vitamin C, and vitamin C + Diclofenac sodium treated groups compared with the Diclofenac sodium treated group. Exposure to Diclofenac sodium during elicited significant glutamate level reduction in the mPFC. Furthermore, co-administration of vitamin C + Diclofenac sodium significantly decreased (p<0.05) glutamate level compared with the Diclofenac sodium-treated group. It could be concluded from this study that vitamin C conferred neuroprotective effect on the mPFC of the juvenile mice exposed to Diclofenac sodium.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86426629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modifiable Risk Factors as Predictors of Global Cognition in Adults: A Pilot Study of Two Rural Communities in Anambra State, Nigeria 可改变的风险因素作为成年人全球认知的预测因素:尼日利亚阿南布拉州两个农村社区的试点研究

NIgerian Journal of Neuroscience Pub Date : 2022-03-31 DOI: 10.47081/njn2022.13.1/001

V. Ucheagwu, Rita Ugokwe-Joseph, C. Ajaelu

{"title":"Modifiable Risk Factors as Predictors of Global Cognition in Adults: A Pilot Study of Two Rural Communities in Anambra State, Nigeria","authors":"V. Ucheagwu, Rita Ugokwe-Joseph, C. Ajaelu","doi":"10.47081/njn2022.13.1/001","DOIUrl":"https://doi.org/10.47081/njn2022.13.1/001","url":null,"abstract":"Modifiable risk factors are behaviours and exposures that can raise or lower a person's risk of developing diseases. These risk factors by themselves are modifiable and have been shown to drive midlife chronic diseases. This study investigated the roles of modifiable risk factors (i.e., hypertension, diabetes, stroke, measures of adiposity, and physical activity among others) on global cognition in rural community dwellers from southeast Nigeria. One hundred and fifty participants (95 females and 55 males; age = 58.6; SD age = 4.8) were recruited for the study through a door-to-door approach. Montreal Cognitive Assessment was used to capture global cognition. Self-report measures and standardized instruments were used respectively, to gather information on modifiable risk factors and measures of adiposity. Because this was a pilot study, two rural communities were selected based on proximity and convenience for the research team. Linear analysis of variance and multiple regression statistics were used for data analysis. Result showed significant differences at p< 0.05 level on global cognition between diabetic and non-diabetic groups as well as stroke and non-stroke groups. Physical activity was shown as significant predictor of global cognition while sleep and social relations were not. Equally, arm (Beta = 0.31) and waist (Beta= 0.12) circumferences significantly predicted global cognition and underweight participants performed significantly worse F(3,148) = 2.6) on global cognition.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72633810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0