NIgerian Journal of Neuroscience最新文献

Bromelain Administration Ameliorates Neurobehavioural Deficits Mediated by Cadmium Neurotoxicity via Oxido-Nitrosative Stress, Cholinergic and Neuroinflammatory Modulations in Male Wistar Rats 通过氧化亚硝酸盐应激、胆碱能和神经炎症调节，服用菠萝蛋白酶可改善雄性 Wistar 大鼠由镉神经毒性引发的神经行为缺陷

NIgerian Journal of Neuroscience Pub Date : 2024-07-18 DOI: 10.47081/njn2024.15.2/001

A. Bayo-Olugbami, Al-Hassan Muritala, Habeebullahi Abdur-Rahman, Ah-med Bakare, Tolulope Arogundade, T. Atere, B. Owoyele

{"title":"Bromelain Administration Ameliorates Neurobehavioural Deficits Mediated by Cadmium Neurotoxicity via Oxido-Nitrosative Stress, Cholinergic and Neuroinflammatory Modulations in Male Wistar Rats","authors":"A. Bayo-Olugbami, Al-Hassan Muritala, Habeebullahi Abdur-Rahman, Ah-med Bakare, Tolulope Arogundade, T. Atere, B. Owoyele","doi":"10.47081/njn2024.15.2/001","DOIUrl":"https://doi.org/10.47081/njn2024.15.2/001","url":null,"abstract":"Cadmium (Cd) is a toxic metal widely present in the environment. Certain plant-based natural or active compounds are gaining attention for their neuroprotective effects against chemically induced toxicity. However, there is no report on the impact of bromelain on Cd-induced neurotoxicity, hence the rationale behind this study. Twenty-four adult male rats were divided into four groups: control (normal saline, 5mL/kg), Cd (orally, 5mg/kg), bromelain (50mg/kg), and Cd+bromelain. Rats received bromelain or normal saline for 14 days. Cd was administered concurrently with bromelain and normal saline in the last 7 days. Neurobehavioural responses to locomotion, cognition, anxiety, and depression were assessed. Plasma was assayed for the levels of superoxide dismutase (SOD) and malondialdehyde (MDA), while the prefrontal cortex (PFC) was processed for the concentration of Cd and levels of SOD, MDA, nitric oxide (NO), acetylcholinesterase (AChE), interleukin-6 (IL-6), and tumour necrotic factor-α (TNF-α). Data were analysed using one-way ANOVA (Tukey’s post hoc), with the level of significance set at p<0.05. Exposure to Cd caused a significant behavioural deficit, as indicated by a decline in motor coordination, memory index, and enhanced depressive and anxiety-like behaviours. Biochemically, Cd concentration was significantly increased in the PFC of Cd group compared to the control. There was a reduction in the level of SOD and increased levels of MDA, NO, IL-6, AChE, and TNF-α following Cd exposure. Bromelain significantly improved the behavioural outcomes and reversed some of the biochemical markers altered by Cd toxicity. Bromelain reduced neurobehavioural impairment, cholinergic alteration, and oxido-inflammatory deficits induced by Cd exposure.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Buchholzia coriacea (Wonderful Kola) on Aluminium Chloride Induced Neurotoxicity on the Prefrontal Cortex of Adult Male Wistar Rat Buchholzia coriacea（神奇可乐）对氯化铝诱导的成年雄性 Wistar 大鼠前额叶皮层神经毒性的保护作用

NIgerian Journal of Neuroscience Pub Date : 2024-07-18 DOI: 10.47081/njn2024.15.1/003

Abigail Abraham, M. Auza, Enene Marcus

{"title":"Protective Effect of Buchholzia coriacea (Wonderful Kola) on Aluminium Chloride Induced Neurotoxicity on the Prefrontal Cortex of Adult Male Wistar Rat","authors":"Abigail Abraham, M. Auza, Enene Marcus","doi":"10.47081/njn2024.15.1/003","DOIUrl":"https://doi.org/10.47081/njn2024.15.1/003","url":null,"abstract":"Aluminium is highly prevalent in the environment, and due to its possible neurotoxicity, this study assessed the neuroprotective effect of Buchholzia coriacea seed extract (B.C.) on the prefrontal cortex of aluminium chloride (AlCl3)-induced neurotoxicity in adult Wistar rats. Twenty-five male rats weighing 119 to 286 g were divided into five groups of five rats each. 1 mL of distilled water was administered to the control group, while other groups received 250 mg/kg B.C. only, 200 mg/kg AlCl3 only, 200 mg/kg AlCl3 + 50 mg/kg B.C., and 200 mg/kg AlCl3 + 250 mg/kg B.C. The study employed the Y-maze test to assess for spatial memory, bio-chemical analyses of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and cata-lase (CAT) levels to determine possible oxidative stress and cellular damage, as well as histological tech-niques using haematoxylin and eosin (H&E) staining to determine morphological changes in the cells. Results showed a significant decrease (p<0.05) in the total arm entries, percentage alternation, SOD, CAT, and GSH. However, the MDA level was significantly (p<0.05) increased in the AlCl3 group when compared to the control. Prefrontal cortex histology revealed several fragmentations, vacuolated cells, dark pyknotic neurons, and neuropil in AlCl3-treated groups, which suggest neurodegeneration. B.C., on the other hand, caused a significant decrease in MDA levels and a significant increase in CAT and SOD levels and attenuated the prefrontal cortex neuronal cells following AlCl3 exposure. This study therefore concludes that AlCl3-induced oxidative stress and neurotoxic effects, which the B.C. protected from.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Anti-Stress Properties of a Polyherbal-Formulated Tea (Citrus limon, Curcuma longa, Zingiber officinale, Allium sativum, and Moringa oleifera) Using a Non-Social Stressor Animal Model 利用非社会应激动物模型研究多草药配方茶（柠檬、莪术、细辛、薤白和辣木）的慢性抗应激特性

NIgerian Journal of Neuroscience Pub Date : 2024-07-18 DOI: 10.47081/njn2024.15.1/004

Onyenmulo Uwaya, Osakpolor Osagie, John Atughara

{"title":"Chronic Anti-Stress Properties of a Polyherbal-Formulated Tea (Citrus limon, Curcuma longa, Zingiber officinale, Allium sativum, and Moringa oleifera) Using a Non-Social Stressor Animal Model","authors":"Onyenmulo Uwaya, Osakpolor Osagie, John Atughara","doi":"10.47081/njn2024.15.1/004","DOIUrl":"https://doi.org/10.47081/njn2024.15.1/004","url":null,"abstract":"Polyherbal remedies used for stress relief are considered a cost-effective and safe choice. This warranted a study to evaluate the chronic anti-stress activity of a polyherbal-formulated tea (Citrus limon, Curcuma longa, Zingiber officinale, Allium sativum, and Moringa oleifera) using a non-social stressor animal model. Chronic stress was induced using a non-social stressor mouse model. Sixteen mice were allotted into 4 groups of 4 mice each: Group one received 10 mL/kg of distilled water, while groups 2-4 received 5 mg/kg and 10 mg/kg extracts of polyherbal-formulated tea and 20 mg/kg of fluoxetine, respectively. The tea was administered orally, along with the various stressors, for 21 days. The mice were sacrificed, and blood was collected from the abdominal aorta for cortisol analysis, and the brain was homogenised for antioxidant analysis of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and malondialdehyde. In the forced swimming test, the polyherbal-formulated tea at 5 mg/kg, 10 mg/kg, and fluoxetine increased the swimming time when compared with chronic stress control (p<0.01). In the tail suspension test, 10 mg/kg of polyherbal-formulated tea and fluoxetine decreased the time of immobility when compared with chronic stress control (p<0.05). Tea at 10 mg/kg and fluoxetine decreased the level of cortisol when compared with chronic stress control (p<0.05). The tea at 10 mg/kg increased the level of catalase and glutathione reductase when compared with chronic stress control (p<0.01). The tea had no effect on glutathione peroxidase, superoxide dismutase, or malondialdehyde. Conclusively, the polyherbal-formulated tea has stress-relieving properties.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical Investigations of the Thalamic Region in Rats Following Combined Exposure to Metals and Restraint Stress 联合暴露于金属和束缚应激后大鼠丘脑区的免疫组化研究

NIgerian Journal of Neuroscience Pub Date : 2023-12-25 DOI: 10.47081/njn2023.14.4/002

Victor Anadu, Oritoke Okeowo, Joy Adejuwon, Olamide Akinola, Endurance Akinnagbe, O. Ijomone

{"title":"Immunohistochemical Investigations of the Thalamic Region in Rats Following Combined Exposure to Metals and Restraint Stress","authors":"Victor Anadu, Oritoke Okeowo, Joy Adejuwon, Olamide Akinola, Endurance Akinnagbe, O. Ijomone","doi":"10.47081/njn2023.14.4/002","DOIUrl":"https://doi.org/10.47081/njn2023.14.4/002","url":null,"abstract":"Chronic exposure to stress has been linked to the perturbation of normal brain functioning. Further, metal overexposure due to their increasing applications can negatively impact brain health. Combined exposure to stressful events and metals is common but has not yet been studied. Thus, this study focused on the thalamic region for its role as a vital relay station in the brain to investigate apoptotic and microglia activation, oxidative stress regulation, and myelin damage following co-exposures to restraint stress and metals, manganese (Mn) and nickel (Ni). Thirty-six adult male rats were divided into six groups and, respectively, exposed to the following for 15 days: control group (normal saline), stress group (3 hours of restraint stress daily), Mn and Ni only groups (intraperitoneal injection of 25 mg/kg of metals), and stress + metal groups received Mn or Ni prior to being subjected to restraint stress. Following treatments, immunohistochemical procedures were used to evaluate relevant neurochemical markers. Results show significantly increased activation of caspase-3 in stressed, metal-only, and combined stress-plus-metal treatments, particularly with Mn treatments. Also, the results show a varying response to Iba1, the microglia activation marker. Furthermore, the study reports significant decreases in Nrf2 (nuclear factor erythroid 2-related factor 2) expression that is potentiated by combined stress and metal treatments as well as altered myelination-linked proteins, Olig2 (oligodendrocyte lineage transcription factor 2), and MBP (myelin basic protein). Overall, the result from this study indicates that the combination of stress and metal exposure could exacerbate the neurotoxic impact of metal toxicity or stressful events.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Air Pollution and a Link with Neurodegenerative Diseases in Nigeria 尼日利亚空气污染及其与神经退行性疾病的关系综述

NIgerian Journal of Neuroscience Pub Date : 2023-12-25 DOI: 10.47081/njn2023.14.4/001

A. Ajagbe, O. Onigbinde, Ebenezer Ajiboye, Michael Ajenikoko, Lukeman Shittu, Y. Dabi, Ifukibot Usende

{"title":"A Review on Air Pollution and a Link with Neurodegenerative Diseases in Nigeria","authors":"A. Ajagbe, O. Onigbinde, Ebenezer Ajiboye, Michael Ajenikoko, Lukeman Shittu, Y. Dabi, Ifukibot Usende","doi":"10.47081/njn2023.14.4/001","DOIUrl":"https://doi.org/10.47081/njn2023.14.4/001","url":null,"abstract":"Pollution is a common and inevitable situation, encompassing environmental threats and virulent composites from the air, water, soil, and food. Air pollution is becoming a global health challenge, affecting millions of lives. Although many of these pollutants have been identified, this paper is reviewing the established link between air pollution and neurodegenerative disease due to the increase in cases of neurodegenerative disease in middle- and low-income countries like Nigeria. This article reviewed the establishment of a possible relationship between air pollution and neurodegenerative diseases in Nigeria and Africa. Different literature sources were reviewed to identify the sources of air pollution, determine the level of awareness among citizens on the effects of air pollution, know the incidence of neurodegenerative diseases in air-polluted areas, life expectancy in such areas, existing diseases caused by air pollution, and their relationship with neurodegenerative diseases. Available literature on heavy metal pollutants in the brains of animal models from different zones of Nigeria and evidence of neurodegeneration in different animal species was also reviewed. In conclusion, one major setback is that there is no specific data on the prevalence of neurodegenerative diseases in major air-polluted areas in Nigeria, hence, the need for awareness to alert occupants and citizens to neurodegenerative diseases and their connection with air pollution. It is also advised that the government implement steps to solve these difficulties, such as the employment of biodegradation and bioremediation in the removal of contaminants.","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solanum aethiopicum Leaves Extract Attenuates Brain Dysfunction in Chronic Mild Stress Depressed Rats 茄属植物叶提取物可减轻慢性轻度应激抑郁大鼠的脑功能障碍

NIgerian Journal of Neuroscience Pub Date : 2023-09-30 DOI: 10.47081/njn2023.14.3/002

A. Nwakanma, Annastasia Okeudoye, Moses B. Ekong, Chukwuebuka Elemuo, Francis Odinukaeze, Elizabeth Umoren, Emmanuella Igwe

{"title":"Solanum aethiopicum Leaves Extract Attenuates Brain Dysfunction in Chronic Mild Stress Depressed Rats","authors":"A. Nwakanma, Annastasia Okeudoye, Moses B. Ekong, Chukwuebuka Elemuo, Francis Odinukaeze, Elizabeth Umoren, Emmanuella Igwe","doi":"10.47081/njn2023.14.3/002","DOIUrl":"https://doi.org/10.47081/njn2023.14.3/002","url":null,"abstract":"Depression is a mental health condition arising from neurochemical alterations that can result from chronic stress. Its management is complex, requiring targeted pathways for intervention, however, the role of antioxidants is essential. Solanum aethiopicum (SA) is one of such antioxidant sources that may abate stress. This study, therefore, investigated the effect of SA leaves ethanol extract on the hippocampus and cerebellum in rats following chronic mild stress (CMS). Twenty-five male adult Wistar rats weighing 180-250g were assigned into five groups (n=5): Control (10mL/kg distilled water); CMS group (CMS-only for 28 days), CMS-SA200 and CMS-SA400 [CMS and SA leaf extract (at 200 and 400mg/kg respectively, from day 15-28)] and 400 mg/kg SA group for 14 days. All the treatments were oral, and the rats were tested for sucrose preference, learning and anxiety, and subsequently sacrificed. Serum superoxide dismutase (SOD) and malondialdehyde (MDA) were analysed, and the hippocampus and cerebellum were processed for haematoxylin and eosin staining. Results showed significantly (p<0.05) decreased sucrose preference, spontaneous alternation, open arm entry/duration and SOD, as well as increased (p<0.05) MDA and slightly enlarged hippocampal pyramidal and cerebellar Purkinje cells nuclei in the CMS-only group. Treatment with SA in the CMS-SA200, CMS-SA400 and SA400 groups significantly (p<0.05) reversed the anhedonia, spontaneous alternation and anxiety-like activities, while there was no significant (p<0.05) change to SOD and MDA levels compared with the CMS-only group. However, the enlarged hippocampal and cerebellar cells nuclei persisted, which may be physiological. In conclusion, SA reversed chronic mild-stressed-impaired cognition, anhedonia, and anxiety-like effects, whose action was better at the higher dose","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticholinesterase and Antioxidant Potential of Aqueous Phyllanthus amarus Leaf Extract in Aluminium Chloride-Exposed Drosophila melanogaster 叶黄素水提取物在暴露于氯化铝的黑腹果蝇中的抗胆碱酯酶和抗氧化潜力

NIgerian Journal of Neuroscience Pub Date : 2023-09-30 DOI: 10.47081/njn2023.14.3/004

C. Inneh, A. Enogieru

{"title":"Anticholinesterase and Antioxidant Potential of Aqueous Phyllanthus amarus Leaf Extract in Aluminium Chloride-Exposed Drosophila melanogaster","authors":"C. Inneh, A. Enogieru","doi":"10.47081/njn2023.14.3/004","DOIUrl":"https://doi.org/10.47081/njn2023.14.3/004","url":null,"abstract":"Aluminium chloride (AlCl3) toxicity is associated with several neurodegenerative disorders, including Alzheimer’s dis-ease, via mechanisms of oxidative stress, impairment of cholinergic neurotransmission, and enhancement of acetyl-cholinesterase activity. Phyllanthus amarus (P. amarus) is a widely used medicinal plant with reported antioxidant properties, and accordingly, this study investigated the anticholinesterase and antioxidant potential of P. amarus against AlCl3-induced toxicity in Drosophila melanogaster. 200 drosophilas were divided into four groups, with 50 per group. The control group was reared on a cornmeal diet, while the AlCl3 group was treated with 40 mM of AlCl3 via their diet. The P. amarus group was treated with 2.5 mg of P. amarus, while the co-treatment group was co-treated with 40 mM AlCl3 and 2.5 mg of P. amarus via their diet for seven days. At the end of the experimental period, negative geotaxis was carried out to evaluate locomotor performance. The drosophilas were thereafter homogenised, and the supernatants were used to assay for acetylcholinesterase (AChE), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) activities. Results showed a significant decrease in the survival rate, climbing activity, SOD, and CAT, as well as a significant increase in MDA and AChE activity in AlCl3-exposed drosophilas. However, co-treatment with P. amarus was able to significantly attenuate the toxicity of AlCl3. Taken together, the protective effect of P. amarus against AlCl3 is mediated possibly through its anti-cholinesterase and antioxidant properties and could therefore be relevant in the development of novel therapeutic agents useful for the treatment of AlCl3 toxicity and its related disorders","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"64 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer’s- and Multiple Sclerosis-Like Features on Key Brain Centres of Wistar Rats Exposed to Cypermethrin and Dichlorvos 暴露于氯氰菊酯和敌敌畏的 Wistar 大鼠大脑关键中枢的阿尔茨海默氏症和多发性硬化症样特征

NIgerian Journal of Neuroscience Pub Date : 2023-09-30 DOI: 10.47081/njn2023.14.3/001

Damian Ezejindu, Princewill Udodi

{"title":"Alzheimer’s- and Multiple Sclerosis-Like Features on Key Brain Centres of Wistar Rats Exposed to Cypermethrin and Dichlorvos","authors":"Damian Ezejindu, Princewill Udodi","doi":"10.47081/njn2023.14.3/001","DOIUrl":"https://doi.org/10.47081/njn2023.14.3/001","url":null,"abstract":"Insecticides are suspected environmental factors in the aetiology of Alzheimer’s and multiple sclerosis diseases. Several studies have reported long-term exposure to insecticides in the development of plaques, neurofibrillary tangles, and demyelination. However, there is no literature on the impact of short-term combined insecticide exposure on specific neurological conditions. This investigation assessed the role of short-term exposure to the mixture of cypermethrin and dichlorvos on Alzheimer’s- and multiple sclerosis-like features. Thirty-two male adult Wistar rats were divided into four groups: the control group was exposed to normal atmospheric air, and the test groups were exposed to a combined cypermethrin and dichlorvos at 2, 3, and 4 h/day [LC50 of 5 mm-1 (4.4 ppm) of dichlorvos and 10 mm-1 (8.7 ppm) of cypermethrin] for four weeks. In the last three days of exposure, neurobehavioural tests were conducted. Twenty-four hours after the last exposure, the animals were anesthetized using chloroform vapour. The brains were harvested by making an occipitofrontal incision for biochemical and histological assessment. The fixation was done in 10% neutral buffered formalin for 48 h following the brain mapping to isolate the brain tissue of interest. The insecticide-exposed rats showed significant (p<=0.05) progressive behavioural deficits and oxidative stress when compared to the control group. Neurofibrillary tangles, senile plaques, and demyelination of the neurons were observed in the brains of the insecticide-exposed rats. This study indicates that the mixture of cypermethrin and dichlorvos can induce the development of Alzheimer’s and multiple sclerosis within a short time","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zingiber officinale Exhibits Neuroprotective Properties against Tramadol-Induced Spatial Memory Impairment and Histopathological Changes 姜根对曲马多诱导的空间记忆损伤和组织病理学变化具有神经保护作用

NIgerian Journal of Neuroscience Pub Date : 2023-09-30 DOI: 10.47081/njn2023.14.3/003

Ubong Ekpo, Uduak Umana, Abubakar Sadeeq, Yasir Shuaib, G. Oderinde, Kizito Dauda, Gerrard Teryila

{"title":"Zingiber officinale Exhibits Neuroprotective Properties against Tramadol-Induced Spatial Memory Impairment and Histopathological Changes","authors":"Ubong Ekpo, Uduak Umana, Abubakar Sadeeq, Yasir Shuaib, G. Oderinde, Kizito Dauda, Gerrard Teryila","doi":"10.47081/njn2023.14.3/003","DOIUrl":"https://doi.org/10.47081/njn2023.14.3/003","url":null,"abstract":"Drug abuse has been on the increase in recent years. Tramadol is one of such drug commonly misused and reported to have neurotoxic effects. However, Zingiber officinale has been reported to have neuroprotective properties. This study aimed to evaluate the neuroprotective effects of Z. officinale on spatial memory deficits in tramadol-treated Wistar rats. Thirty adult male Wistar rats were divided into five groups, and respectively, orally administered the following for 21 days: the control group (2 ml/kg of distilled water), tramadol (Tram, 50 mg/kg), tramadol (50 mg/kg)+naltrexone (12.5 mg/kg), and tramadol (50 mg/kg)+Z. officinale (500 mg/kg+1000 mg/kg, respectively). A Morris water maze test was conducted for the assessment of spatial memory. The rats were euthanized by transcardiac perfusion, and the brains were harvested, fixed, and processed using haematoxylin and eosin stain for histology. A remarkable decrease in latency time and an increase in distance covered to locate the platform were observed in the tramadol-treated group compared to the control in the acquisition phase. The probe test showed a remarkable decrease in the time spent in the escape platform quadrant in the tramadol-treated group compared with the control. Neurodegenerative changes were observed in the hippocampus of the tramadol group, presenting as karyorrhexis, gliosis, and perineural vacuolation. These neurodegenerative changes were attenuated in Z. officinale-treated groups in a dose-dependent manner. Z. officinale improved the learning and memory of tramadol-treated rats. Findings from this study suggest that Z. officinale attenuated tramadol-induced neurotoxicity in Wistar rats","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139333550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cola acuminata Mitigates Cognitive Deficit and Oxidative Stress in Mercury Chloride-induced Neurotoxicity in Male Wistar Rats 可乐可减轻氯化汞诱导的雄性Wistar大鼠神经毒性的认知缺陷和氧化应激

NIgerian Journal of Neuroscience Pub Date : 2023-07-27 DOI: 10.47081/njn2023.14.2/001

Abraham Asuku, M. Ayinla, Tobiloba Olajide, Zaidat Yakub, B. Owoyele

{"title":"Cola acuminata Mitigates Cognitive Deficit and Oxidative Stress in Mercury Chloride-induced Neurotoxicity in Male Wistar Rats","authors":"Abraham Asuku, M. Ayinla, Tobiloba Olajide, Zaidat Yakub, B. Owoyele","doi":"10.47081/njn2023.14.2/001","DOIUrl":"https://doi.org/10.47081/njn2023.14.2/001","url":null,"abstract":"Cola acuminata is used in traditional medicine for the management of memory impairment and other neurodegenera-tive conditions. This study investigated the effects of Cola acuminata aqueous leaves extract (ALECA) on mercury chloride-induced neurotoxicity in Wistar rats. Twenty male Wistar rats weighing between 160 and 210 g were randomly assigned to four groups (n = 5). The control group received 0.5 mL of distilled water; the mercury chloride (HgCl2) group received HgCl2 (5 mg/kg b.w.); the ALECA100 and ALECA300 groups received ALECA (100 and 300 mg/kg b.w., respectively), followed by the administration of HgCl2 (5 mg/kg b.w.) for two weeks. The rats were subjected to behavioural tests in the Morris water maze and light and dark field box. The rats were then sacrificed to obtain their brains, which were homogenized for biochemical assays of acetylcholinesterase (AChE), malondialdehyde (MDA), total protein (TP), and glutathione (GSH) using standard methods. The results revealed a significant increase in escape latency, a significant decrease in probing frequency and brain GSH, and a significant (p<0.05) increase in brain MDA and TP levels and AChE activity in the rats exposed to HgCl2. However, administration of either 100 or 300 mg/kg ALECA protected against memory impairment with a significantly reduced escape latency, increased probing frequency and brain GSH, and decreased (p<0.05) MDA, TP and AChE. This study concludes that ALECA mitigated HgCl2-induced neurotoxicity via reduction of oxidative stress and enhanced cholinergic functions","PeriodicalId":19166,"journal":{"name":"NIgerian Journal of Neuroscience","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73363792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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