Northern Clinics of Istanbul最新文献

{"title":"Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?","authors":"Huseyin Kaplan,&nbsp;Mustafa Calis,&nbsp;Cevat Yazici,&nbsp;Inayet Gunturk,&nbsp;Isa Cuce,&nbsp;Abdurrahman Soner Senel","doi":"10.14744/nci.2022.54189","DOIUrl":"https://doi.org/10.14744/nci.2022.54189","url":null,"abstract":"<p><strong>Objective: </strong>Follistatin-like protein 1 (FSTL-1) and follistatin-like protein 3 (FSTL-3) are glycoproteins whose associations with inflammatory cytokines were reported in previous studies. However, it is not yet known whether they have an effect on the pathogenesis of familial Mediterranean fever (FMF). We aimed to detect the FSTL-1 and FSTL-3 levels and to determine their relationship to the attack status and mutation types in patients with FMF.</p><p><strong>Methods: </strong>Fifty-six FMF patients and 22 healthy controls (HCs) were included in the study. Serum FSTL-1 and FSTL-3 levels were measured with the enzyme-linked immunosorbent assay method from collected serum samples. In addition, the MEditerranean FeVer (MEFV) gene mutation types of the patients were noted.</p><p><strong>Results: </strong>Serum FSTL-1 levels were significantly higher in FMF patients than in HCs (p=0.005). However, there was no significant difference in FSTL-1 levels between patients in the attack period (n=26) and in the attack-free period (n=30). FSTL-3 levels were similar between FMF patients and HCs or patients in the attack period and in the attack-free period. Furthermore, the MEFV mutation type and attack status had no significant effect on FSTL-1 and FSTL-3 levels (p>0.05).</p><p><strong>Conclusion: </strong>Our results suggest that FSTL-1 may be associated with the pathogenesis of FMF, rather than FSTL-3. However, neither serum FSTL-1 nor FSTL-3 seems to be good markers to reflect inflammatory activity.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 3","pages":"306-313"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/25/NCI-10-306.PMC10331238.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9812398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral pulsed high-dose dexamethasone therapy for rheumatic diseases: An alternative safe and effective scheme.","authors":"Jozélio Freire de Carvalho,&nbsp;Thelma Skare","doi":"10.14744/nci.2023.03704","DOIUrl":"https://doi.org/10.14744/nci.2023.03704","url":null,"abstract":"To the Editor, Since its discovery by Kendall and Hench in 1950, glucocorticoids have been widely prescribed for the treatment of rheumatic diseases, although it has been recognized that this drug may be a double-edged sword. For example, suppose, on the one hand, it has a rapid and potent anti-inflammatory action that may be lifesaving, on the other hand. Unfortunately, in that case, it has various side effects, such as cushingoid facies, hyperglycemia, dyslipidemia, osteoporosis, myopathy, hypertension, and acne, among others. Several strategies have been designed aiming to obtain the best possible results from this treatment with minimum collateral effects. Glucocorticoid pulse therapy has emerged as an option and has been used to control severe disease activity quickly. It is traditionally used as 1000 mg methylprednisolone/day for 3 days, although it has been recognized that lower doses may be as effective. The use of the intravenous route has been associated with cardiovascular collapse, hypokalemia, and myocardial infarction [1]. Although the intravenous route is the most popular form of administration for pulse therapy, this treatment can also be done using the oral route or intramuscular injections. Dexamethasone has been frequently used in oral administration due to its low mineralocorticoid action. Oral pulse therapy (OPT) has been commonly used in dermatology for alopecia areata, vitiligo, and alopecia Universalis, among others, with good results [2, 3]; in neurology, it has been used to treat chronic inflammatory demyelinating polyneuropathy [4]. An exciting work by Luetic et al. [5], from Argentina, that, in times of Covid, with the impossibility of performing conventional pulse therapy, OPT has been used to treat multiple sclerosis with good efficacy. In hematology, this is one of the first-line treatments for idiopathic thrombocytopenic purpura [6]. However, in rheumatology, this form of treatment is not well known. A review of the literature points to only four studies: two in inflammatory myositis (with a total of 70 observed patients), one in rheumatoid arthritis (with 14 patients), and one in systemic lupus erythematosus (with the observation of 50 patients) [7–9]. They are summarized in Appendix 1. The analysis of this table shows that OPT is at least as effective as other forms of glucocorticoid administration, with apparently fewer side effects than continuous oral use. However, the existing studies are few with small samples, justifying more extensive and long-term controlled trials to compare with standard treatment forms adequately. OPT remains an option to be explored in rheumatology.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 3","pages":"398-400"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/23/NCI-10-398.PMC10331250.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9812401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentalization and emotion regulation abilities in parents of children with nocturnal enuresis and its relationship with perceived caregiver burden.","authors":"Tuncay Toprak,&nbsp;Basar Ayribas,&nbsp;Recep Burak Degirmentepe,&nbsp;Mehmet Ozay Ozgur,&nbsp;Mehmet Yilmaz,&nbsp;Ayhan Verit","doi":"10.14744/nci.2021.40225","DOIUrl":"https://doi.org/10.14744/nci.2021.40225","url":null,"abstract":"<p><strong>Objective: </strong>Various psychological factors play a role in the development of nocturnal enuresis (NE) which causes significant distress both on children and their parents. However, current studies cannot attribute a role to the psychiatric conditions that cause or result from NE. This study aims to reveal some psychiatric parameters related to the parents of patients with NE which may play a role in the etiopathogenesis of NE.</p><p><strong>Methods: </strong>Seventy-nine parents of primary 53 NE children and 78 parents of 44 healthy children were enrolled to the study. Parents of children with daytime voiding symptoms, additional comorbidity, or secondary enuresis were excluded from the study. Age- and sex-matched parents of healthy children with the absence of voiding symptoms were included as the control group. Parental Reflective Functioning (RF) Questionnaire, Interpersonal Emotion Regulation (ER) Questionnaire, and Zarit Caregiver Burden Scale were recorded to measure psychiatric conditions.</p><p><strong>Results: </strong>Parents of children with NE showed significantly poorer RF and ER abilities compared to the control group. Moreover, the perceived caregiver burden was also significantly higher in parents of NE patients. Correlation analyses also showed that RF and ER are negatively correlated with caregiver burden.</p><p><strong>Conclusion: </strong>This study revealed that the parents of primary NE patients may have difficulty mentalizing and ER in interpersonal relationships. These difficulties may be a cause or a consequence of the NE. In addition, our findings showed that parents of NE patients perceive more caregiving burden. Therefore, it may be advisable for parents of NE patients to seek psychological counseling.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 3","pages":"281-288"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/e8/NCI-10-281.PMC10331249.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9812402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of diffusion weighted imaging in sacroiliac joint MRI in children.","authors":"Sevinc Tasar,&nbsp;Saliha Ciraci,&nbsp;Pinar Diydem Yilmaz,&nbsp;Aslihan Semiz Oysu,&nbsp;Yasar Bukte,&nbsp;Betul Sozeri","doi":"10.14744/nci.2023.90907","DOIUrl":"https://doi.org/10.14744/nci.2023.90907","url":null,"abstract":"<p><strong>Objective: </strong>Because of the immature bone marrow signal in children, assessment of the sacroiliac joint is more difficult than in adults. Aim of this study is to evaluate the efficacy of diffusion-weighted imaging (DWI) in sacroiliac joint magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Sacroiliac joint MRI, including DWI sequences, were evaluated by two pediatric radiologists in 54 patients with sacroiliitis and 85 completely normal controls. In MRI evaluation, subchondral bone marrow edema and contrast enhancement in the sacroiliac joints were considered as active sacroiliitis. Apparent diffusion coefficient (ADC) measurements were made in six areas from each sacroiliac joint. A total of 1668 fields were evaluated retrospectively without their diagnosis being known.</p><p><strong>Results: </strong>When the postcontrast T1W series were referenced, the sensitivity, specificity, positive predictive value, and negative predictive value of short time inversion recovery (STIR) images in the diagnosis of sacroiliitis were 88%, 92%, 83% and 94% respectively, compared to contrast-enhanced images. False positive results in STIR images were observed secondary to the flaring signal in the immature bone marrow. ADC measurements obtained from diffusion-weighted images were recorded in all patients and healthy groups. The ADC values were 1.35x10^-3 mm²/s (SD: 0.21) in the areas of sacroiliitis, 0.44x10^-3 mm²/s (SD: 0.71) in the normal bone marrow and 0.72x10^-3 mm²/s (SD: 0.76) in the immature bone marrow areas.</p><p><strong>Conclusion: </strong>Although STIR studies are an effective sequence in the diagnosis of sacroiliitis, they cause false positive results in immature bone marrow in children in inexperienced hands. DWI is an objective method that prevents errors in the assessment of sacroiliitis by means of ADC measurements in the immature skeleton. In addition, it is a short and effective MRI series that makes important contributions to the diagnosis without the need for contrast-enhanced examinations in children.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 2","pages":"131-138"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/ab/NCI-10-131.PMC10170380.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9822342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of hematological indices NLR, PLR, and MPV to determine the clinical outcome of placental abruption in women regarding stillbirth.","authors":"Filiz Yarsilikal Guleroglu,&nbsp;Murat Ekmez,&nbsp;Busra Seker Atas,&nbsp;Ali Cetin","doi":"10.14744/nci.2022.94752","DOIUrl":"https://doi.org/10.14744/nci.2022.94752","url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to elucidate the predictive value of hematological indices, the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV), to determine the clinical outcome of placental abruption in women regarding stillbirth.</p><p><strong>Methods: </strong>This retrospective review of medical charts was performed in a tertiary center experienced for maternal, fetal, and neonatal care, including 89 pregnant women with placental abruption with or without stillbirth. The results of the hemogram tests with hematological indices, including the NLR, PLR, and MPV, which are the routinely obtained parameters both at admission and 4 h postoperatively, were correlated with other clinical parameters.</p><p><strong>Results: </strong>The findings showed that although there were remarkable changes in some of the clinical features of women with placental abruption with or without stillbirth, in general, the study groups were found comparable regarding these variables. The values of NLR, PLR, and MPV in women with stillbirth presented remarkable changes when hemogram tests were used as pre-operative and post-operative laboratory examinations, although these changes did not correlate with each other meaningfully.</p><p><strong>Conclusion: </strong>Stillbirth is one of the most important complications of placental abruption requiring rapid diagnosis and regular follow-up after its surgical management. To fine-tune emergent management of placental abruption in women with stillbirth, the indices of NLR, PLR, and MPV calculated at the first admission as well as during follow-up of the patients have clinical value as easily obtainable laboratory findings like other hematological parameters.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 1","pages":"40-47"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/14/41/NCI-10-040.PMC9996653.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9096487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population.","authors":"Sule Darbas,&nbsp;Dilara Inan,&nbsp;Yahya Kilinc,&nbsp;Habibe Sema Arslan,&nbsp;Fahri Ucar,&nbsp;Ozaydin Boylubay,&nbsp;Sadi Koksoy,&nbsp;Esvet Mutlu,&nbsp;Burcu Yucel,&nbsp;Nurten Sayin Ekinci","doi":"10.14744/nci.2021.00018","DOIUrl":"https://doi.org/10.14744/nci.2021.00018","url":null,"abstract":"<p><strong>Objective: </strong>Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye.</p><p><strong>Methods: </strong>This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by sequence-based high-resolution typing.</p><p><strong>Results: </strong>Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were higher, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity, which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant.</p><p><strong>Conclusion: </strong>Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play a role in susceptibility to HIV-1 infection.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 1","pages":"67-73"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/4d/NCI-10-067.PMC9996654.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of thromboembolic prophylaxis after cesarean section in patients with hypertensive disorders.","authors":"Kubra Cakar Yilmaz,&nbsp;Gul Cakmak,&nbsp;Sunullah Soysal,&nbsp;Ayten Saracoglu","doi":"10.14744/nci.2021.68726","DOIUrl":"https://doi.org/10.14744/nci.2021.68726","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the effect of thromboembolic prophylaxis in patients diagnosed with hypertensive disorders of pregnancy undergoing cesarean section.</p><p><strong>Methods: </strong>Three hundred and eighty-six patients were included in the study. The patients were divided into groups according to the type of hypertensive disorders of pregnancy and whether thromboembolism prophylaxis was applied or not. The thromboembolic event incidence and other pregnancy outcomes were compared.</p><p><strong>Results: </strong>Nonadministration of thromboprophylaxis was recorded in 210 patients. Eleven patients had thromboembolic events (5%). Among 176 patients who received thromboprophylaxis, only two patients (1%) had a thromboembolic event (p<0.05).</p><p><strong>Conclusion: </strong>There is an increased tendency to thromboembolism in pregnancy. The incidence increases in the presence of hypertension accompanying pregnancy. In our study, the importance of thromboembolism prophylaxis on peri-postnatal complications in patients with hypertensive disorders of pregnancy was emphasized.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 2","pages":"222-227"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/93/NCI-10-222.PMC10170378.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From open wound treatment to primary soft-tissue non-Hodgkin lymphoma diagnosis; a challenging case report.","authors":"Ahmet Askar","doi":"10.14744/nci.2022.24650","DOIUrl":"https://doi.org/10.14744/nci.2022.24650","url":null,"abstract":"<p><p>Primary soft-tissue extranodal lymphomas are rare clinical entities. By their natures, they can cause significant swelling around the affected extremities, and they can be easily misdiagnosed with other conditions like sarcomas. We share an unfortunate experience of a young male patient who was admitted to another clinic with complaints of a large mass in his right thigh, the patient has been diagnosed with anaplastic pleomorphic sarcoma, and he was scheduled for surgery. The patient refused the operation and was admitted to our emergency clinic with an open wound on his right thigh. Successful open wound management was achieved with antibiotic therapy, tissue debridement, larvae therapy, and Vacuum-assisted closure. Meanwhile, the pathologic re-examination revealed diffuse large B-cell lymphoma. After an uneventful follow-up, the patient was referred to the hematology clinic. This case highlights the importance of considering alternative diagnoses before making surgical intervention decisions that may result in unpleasing consequences.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 4","pages":"527-530"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2b/60/NCI-10-527.PMC10500239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Autoimmune Syndrome Without Hypoglycemia: A Different Perspective of Method Interference","authors":"F. Yeşildal","doi":"10.14744/nci.2022.80034","DOIUrl":"https://doi.org/10.14744/nci.2022.80034","url":null,"abstract":"","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"92 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91301288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraperitoneal \"Golden Yellow\" in a pediatric patient with Burkitt lymphoma: xanthogranulomatous appendicitis","authors":"Elbrus Zarbaliyev","doi":"10.14744/nci.2022.78477","DOIUrl":"https://doi.org/10.14744/nci.2022.78477","url":null,"abstract":"","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"5 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87118111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}