Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Sule Darbas, Dilara Inan, Yahya Kilinc, Habibe Sema Arslan, Fahri Ucar, Ozaydin Boylubay, Sadi Koksoy, Esvet Mutlu, Burcu Yucel, Nurten Sayin Ekinci
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引用次数: 0

Abstract

Objective: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye.

Methods: This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by sequence-based high-resolution typing.

Results: Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were higher, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity, which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant.

Conclusion: Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play a role in susceptibility to HIV-1 infection.

土耳其人群HLA-B等位基因与HIV易感性和保护作用的关系
目的:许多人类白细胞抗原(HLA)-B等位基因与获得性免疫缺陷综合征(AIDS)和人类免疫缺陷病毒(HIV)进展的风险增加有关;然而,他们的分布在不同的种族/民族群体中有所不同。用于治疗艾滋病的阿巴卡韦显著增加HLA-B患者超敏反应的风险*57:01。本研究的目的是确定hiv相关HLA-B亚群的分布(高分辨率和低分辨率)以及HLA-B*57:01与土耳其人阿巴卡韦敏感性相关。方法:本回顾性病例对照研究包括416例(F/M:111/305) HIV阳性患者和416例(F/M:111/305)健康对照。采用基于Luminex的低分辨率方法鉴定HLA-B等位基因,并进一步采用基于序列的高分辨率分型进行亚组。结果:我们的数据显示,在HIV-1感染患者中,HLA-B*15、*35和*51等位基因频率高于对照组,HLA-B*07、*14和*55等位基因频率低于对照组。结果表明,HIV-1感染患者HLA-B*15:01、*35:01、*35:08、*51:01等位基因频率高于对照组,HLA-B*07:02、*14:01、*44:01、*55:01等位基因频率较低。HLA-B*57:01等位基因阳性在阿巴卡韦过敏中很重要,但低于对照组,差异无统计学意义。结论:HLA-B*07、*14、*55等位基因和HLA-B*07:02、*14:01、*44:01、*55:01亚群可能具有保护作用,而HLA-B*15、*35、*51等位基因和HLA-B*15:01、*35:01、*35:08、*51:01亚群可能与HIV-1感染易感性有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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