家族性地中海热患者的炎症过程与卵素抑制素样蛋白1和卵素抑制素样蛋白3相关吗?

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Huseyin Kaplan, Mustafa Calis, Cevat Yazici, Inayet Gunturk, Isa Cuce, Abdurrahman Soner Senel
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引用次数: 0

摘要

目的:卵泡抑素样蛋白1 (Follistatin-like protein 1, FSTL-1)和卵泡抑素样蛋白3 (Follistatin-like protein 3, FSTL-3)是一种与炎性细胞因子相关的糖蛋白。然而,尚不清楚它们是否对家族性地中海热(FMF)的发病机制有影响。我们的目的是检测FSTL-1和FSTL-3的水平,并确定它们与FMF患者发作状态和突变类型的关系。方法:选取56例FMF患者和22例健康对照(hc)。采用酶联免疫吸附法测定血清FSTL-1和FSTL-3水平。此外,还记录了患者的地中海热(MEFV)基因突变类型。结果:FMF患者血清FSTL-1水平显著高于hcc患者(p=0.005)。而发作期(n=26)与无发作期(n=30)患者FSTL-1水平差异无统计学意义。FMF患者与hcc患者、发作期与无发作期患者FSTL-3水平相似。MEFV突变类型和发作状态对FSTL-1和FSTL-3水平无显著影响(p>0.05)。结论:FSTL-1可能与FMF的发病机制有关,而非FSTL-3。然而,血清FSTL-1和FSTL-3似乎都不是反映炎症活性的良好标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?

Objective: Follistatin-like protein 1 (FSTL-1) and follistatin-like protein 3 (FSTL-3) are glycoproteins whose associations with inflammatory cytokines were reported in previous studies. However, it is not yet known whether they have an effect on the pathogenesis of familial Mediterranean fever (FMF). We aimed to detect the FSTL-1 and FSTL-3 levels and to determine their relationship to the attack status and mutation types in patients with FMF.

Methods: Fifty-six FMF patients and 22 healthy controls (HCs) were included in the study. Serum FSTL-1 and FSTL-3 levels were measured with the enzyme-linked immunosorbent assay method from collected serum samples. In addition, the MEditerranean FeVer (MEFV) gene mutation types of the patients were noted.

Results: Serum FSTL-1 levels were significantly higher in FMF patients than in HCs (p=0.005). However, there was no significant difference in FSTL-1 levels between patients in the attack period (n=26) and in the attack-free period (n=30). FSTL-3 levels were similar between FMF patients and HCs or patients in the attack period and in the attack-free period. Furthermore, the MEFV mutation type and attack status had no significant effect on FSTL-1 and FSTL-3 levels (p>0.05).

Conclusion: Our results suggest that FSTL-1 may be associated with the pathogenesis of FMF, rather than FSTL-3. However, neither serum FSTL-1 nor FSTL-3 seems to be good markers to reflect inflammatory activity.

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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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