New Journal of Science最新文献

Qualitative and Quantitative Determination of Phytochemical Contents of Indigenous Nigerian Softwoods 尼日利亚本土软木植物化学成分的定性和定量测定

New Journal of Science Pub Date : 2016-10-20 DOI: 10.1155/2016/5601327

C. Ezeonu, C. Ejikeme

{"title":"Qualitative and Quantitative Determination of Phytochemical Contents of Indigenous Nigerian Softwoods","authors":"C. Ezeonu, C. Ejikeme","doi":"10.1155/2016/5601327","DOIUrl":"https://doi.org/10.1155/2016/5601327","url":null,"abstract":"The phytochemical contents of some milled Nigerian softwood chips were carried out in a quest to evaluate their potentials as sources of alternative medicine as well as uses in other industrial applications. The qualitative and quantitative analysis were ascertained. Tannin was found in all the Nigerian softwoods examined with the highest quantities obtained in Sterculia oblonga (1240 mg/100 g) and Barteria nigritiana (1230 mg/100 g). Highest quantities of alkaloid were obtained in Cordia millenii (11.2%) and Sterculia oblonga (10.4%). Barteria nigritiana (14.2%) and Moringa oleifera (12.2%) recorded more flavonoid content than other individual softwoods. Saponin was more in Anogeissus leiocarpus (12.5%) and Dichrostachys cinerea (9.8%). Oxalate was found to be higher in Combretodendron macrocarpum (5.84 g/100 g) and Glyphaea brevis (3.55 g/100 g). Pentaclethra macrophylla (890 mg/100 g) and Moringa oleifera (880 mg/100 g) contained more cyanogenic glycosides. Sacoglottis gabonensis (4.68 mg/g) and Pentaclethra macrophylla (4.04 mg/g) showed the highest contents of phenol, while more lipids (8% and 7.2%) were found in Anogeissus leiocarpus and Kaempferia galanga, respectively. The results showed that these Nigerian softwoods grains could be a source for the exploitation of these phytochemicals beneficial in the pharmaceutical and alternative medicine industries.","PeriodicalId":19156,"journal":{"name":"New Journal of Science","volume":"18 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2016-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91200629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 156

Xenic Cultivation and Genotyping of Pathogenic Free-Living Amoeba from Public Water Supply Sources in Uganda 乌干达公共水源中致病性自由生活阿米巴原虫的异种培养和基因分型

New Journal of Science Pub Date : 2016-10-16 DOI: 10.1155/2016/6358315

C. Sente, J. Erume, I. Naigaga, B. Namara, J. Mulindwa, Sylvester Ochwo, Phillip Kimuda Magambo, C. Kato, A. Tamale, M. Ocaido

{"title":"Xenic Cultivation and Genotyping of Pathogenic Free-Living Amoeba from Public Water Supply Sources in Uganda","authors":"C. Sente, J. Erume, I. Naigaga, B. Namara, J. Mulindwa, Sylvester Ochwo, Phillip Kimuda Magambo, C. Kato, A. Tamale, M. Ocaido","doi":"10.1155/2016/6358315","DOIUrl":"https://doi.org/10.1155/2016/6358315","url":null,"abstract":"Studies on waterborne parasites from natural environment and domestic water sources in Uganda are very scarce and unpublished. Water dwelling free-living amoebae (FLA) of the genus Acanthamoeba, Hartmannella, and Naegleria are often responsible for causing morbidities and mortalities in individuals with recent contact with contaminated water, but their presence in Uganda’s public water supply sources is not known. We cultivated and genotyped FLA from natural and domestic water from Queen Elizabeth Protected Area (QEPA) and Kampala (KLA). The cultivated parasites were observed microscopically and recorded. The overall prevalence of FLA in QEPA (Acanthamoeba spp., 35%; Hartmannella spp., 18.9%; Naegleria spp., 13.5%) and KLA (Acanthamoeba spp., 28.3%; Naegleria spp., 16.6%; Hartmannella spp., 23.1%) were not significantly different. The highest prevalence across water sources in QEPA and KLA was observed for Acanthamoeba spp., followed by Hartmannella spp., and Naegleria spp. Overall FLA mean (±SE) and mean (±SE) across water sources were highest for Acanthamoeba spp. compared to other FLA but were not statistically significant ( > 0.05). Analysis of the FLA sequences produced 1 Cercomonas, 1 Nuclearia, 1 Bodomorpha, 2 Hartmannella, 5 Echinamoeba, and 7 Acanthamoeba partial sequences, indicating a muliplicity of water contaminants that need to be controlled by proper water treatment.","PeriodicalId":19156,"journal":{"name":"New Journal of Science","volume":"69 1-3","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2016-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91487977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Influence of an Inclined Magnetic Field and Rotation on the Peristaltic Flow of a Micropolar Fluid in an Inclined Channel 倾斜磁场和旋转对倾斜通道中微极流体蠕动流动的影响

New Journal of Science Pub Date : 2016-10-10 DOI: 10.1155/2016/5717542

A. Dar, K. Elangovan

引用次数: 15

The Chemical Featuring, Toxicity, and Antimicrobial Activity of Psidium cattleianum (Myrtaceae) Leaves 紫金桃科紫金桃叶的化学特性、毒性及抗菌活性研究

New Journal of Science Pub Date : 2016-08-17 DOI: 10.1155/2016/7538613

J. H. Faleiro, R. C. Gonçalves, Mara Núbia Guimarães dos Santos, Diego Pereira da Silva, P. Naves, G. Malafaia

{"title":"The Chemical Featuring, Toxicity, and Antimicrobial Activity of Psidium cattleianum (Myrtaceae) Leaves","authors":"J. H. Faleiro, R. C. Gonçalves, Mara Núbia Guimarães dos Santos, Diego Pereira da Silva, P. Naves, G. Malafaia","doi":"10.1155/2016/7538613","DOIUrl":"https://doi.org/10.1155/2016/7538613","url":null,"abstract":"It is known that the phytochemical identification and assessment of biological effects caused by the constituent species Psidium cattleianum, which belongs to family Myrtaceae, are poorly held in the literature. The aim of the current study is to investigate the composition of secondary metabolites, the toxicity, and the antimicrobial activity of P. cattleianum leaves. The crude ethanolic extract of the plant was obtained through maceration and fractionated with hexane, dichloromethane, and ethyl acetate. The crude ethanol extract and the fractions were subjected to phytochemical screening and tested against the microcrustacean Artemia salina for toxicological assessment. Antimicrobial tests with crude ethanol extract and the fractions were carried out through the agar diffusion method using broth microdilution against Staphylococcus aureus, S. epidermidis, Burkholderia cepacia, and Escherichia coli strains. A variety of secondary metabolite groups such as catechins, steroids, phenolic compounds, flavonoids, and saponins was detected. Regarding toxicity, hexane and dichloromethane fractions were considered nontoxic, whereas the crude ethanol extract and the ethyl acetate fraction showed low toxicity. The crude ethanol extract and the fractions, except for the hexane fraction, showed activity against the tested strains. Therefore, the composition of the secondary metabolites, the low toxicity, and the antimicrobial activity suggest that this species is promising in the search and development of new drugs.","PeriodicalId":19156,"journal":{"name":"New Journal of Science","volume":"2008 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82579203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines 几种中药的药代动力学研究综述

New Journal of Science Pub Date : 2016-01-01 DOI: 10.1155/2016/7830367

P. Mehta, V. Dhapte

{"title":"A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines","authors":"P. Mehta, V. Dhapte","doi":"10.1155/2016/7830367","DOIUrl":"https://doi.org/10.1155/2016/7830367","url":null,"abstract":"Herbal medicines are the oldest and most widely used form of treatment for welfare of mankind. Herbal medicines possess strong reputation as complementary treatment across the globe due to their easy accessibility and safety. Particularly traditional Chinese medicines (TCM) are very popular due to their desirable therapeutic effects. They already have been proven for their remarkable potential in treatment of wide range of disease ailments. The major drawback in using herbal medicines is lack of standardisation aspects due to the complexity of chemical constituents. Pharmacokinetics study of such medicines helps forecast a range of events related to efficacy, safety, and toxicity profile of them. Apart from this, pharmacokinetics studies also recommended by various regulatory agencies during diverse stages of herbal drug development. Thus it is highly essential to have knowledge about the pharmacokinetic properties of any herbal drug. Thus it was thought that it will be worthwhile to compile the pharmacokinetic data of TCM which will be helpful for the researchers involved in further research on TCM. To portray entire picture about absorption, distribution, metabolism, and excretion (ADME) of some TCM, this well-designed scientific review covers the pharmacokinetic profile of 50 TCM available from 2003 and onwards.","PeriodicalId":19156,"journal":{"name":"New Journal of Science","volume":"1 1","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84406461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

MicroRNAs as Potential Biomarkers in Acute Promyelocytic Leukaemia microrna作为急性早幼粒细胞白血病的潜在生物标志物

New Journal of Science Pub Date : 2014-12-07 DOI: 10.1155/2014/932342

Imilia Ismail, S. Sulong, R. Hassan

{"title":"MicroRNAs as Potential Biomarkers in Acute Promyelocytic Leukaemia","authors":"Imilia Ismail, S. Sulong, R. Hassan","doi":"10.1155/2014/932342","DOIUrl":"https://doi.org/10.1155/2014/932342","url":null,"abstract":"Acute promyelocytic leukaemia (APL) is an M3 subtype of acute myeloid leukaemia (AML). This classification is based on the morphology of promyelocytic cell. The clinical characteristics of APL can be recognized by haemorrhagic episodes, a differentiation block at the promyelocytic stage, and sensitivity to the differentiation response to all-trans-retinoic acid (ATRA). Cytogenetically, APL is characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the production of PML/RARα fusion protein. Recent studies reported that microRNAs (miRNAs) have also been proposed to contribute to the pathogenesis of APL. miRNAs have been associated with the pathogenesis of cancer and their involvement as oncogenic and tumour suppressor activities have been identified. They are involved in various biological processes including the cell proliferation, differentiation, growth and development, metabolism, apoptosis, and haematopoiesis. The new discovery of miRNAs as possible therapeutic markers will provide new insight for the diagnosis and therapeutic entries for the treatment of APL. This review highlights the potential of miRNAs as biomarkers in APL.","PeriodicalId":19156,"journal":{"name":"New Journal of Science","volume":"32 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2014-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75238208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cytolethal Distending Toxin: A Unique Variation on the AB Toxin Paradigm 细胞致死膨胀毒素:AB毒素范例的一种独特变异

New Journal of Science Pub Date : 2014-09-25 DOI: 10.1155/2014/249056

J. Dirienzo

引用次数: 8

Zingiber officinale (Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States 生姜在预防和治疗糖尿病及前驱糖尿病中的应用前景

New Journal of Science Pub Date : 2014-09-23 DOI: 10.1155/2014/674684

B. Roufogalis

引用次数: 40

Regulation of EPCs: The Gateway to Blood Vessel Formation 内皮祖细胞的调控:血管形成的门户

New Journal of Science Pub Date : 2014-09-22 DOI: 10.1155/2014/972043

Kate A. Parham, S. Pitson, C. Bonder

{"title":"Regulation of EPCs: The Gateway to Blood Vessel Formation","authors":"Kate A. Parham, S. Pitson, C. Bonder","doi":"10.1155/2014/972043","DOIUrl":"https://doi.org/10.1155/2014/972043","url":null,"abstract":"Endothelial progenitor cells (EPCs) are primitive endothelial precursors which are known to functionally contribute to the pathogenesis of disease. To date a number of distinct subtypes of these cells have been described, with differing maturation status, cellular phenotype, and function. Although there is much debate on which subtype constitutes the true EPC population, all subtypes have endothelial characteristics and contribute to neovascularisation. Vasculogenesis, the process by which EPCs contribute to blood vessel formation, can be dysregulated in disease with overabundant vasculogenesis in the context of solid tumours, leading to tumour growth and metastasis, and conversely insufficient vasculogenesis can be present in an ischemic environment. Importantly, it is widely known that transcription factors tightly regulate cellular phenotype and function by controlling the expression of particular target genes and in turn regulating specific signalling pathways. This suggests that transcriptional regulators may be potential therapeutic targets to control EPC function. Herein, we discuss the observed EPC subtypes described in the literature and review recent studies describing the role of a number of transcriptional families in the regulation of EPC phenotype and function in normal and pathological conditions.","PeriodicalId":19156,"journal":{"name":"New Journal of Science","volume":"35 1","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2014-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89949535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Endocrine Resistance in Breast Cancer 乳腺癌的内分泌抵抗

New Journal of Science Pub Date : 2014-09-17 DOI: 10.1155/2014/390618

J. Dixon

引用次数: 49