细胞致死膨胀毒素:AB毒素范例的一种独特变异

J. Dirienzo
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引用次数: 8

摘要

植物和细菌产生的一些最有效的毒素是一个被称为AB毒素的大家族的成员。AB毒素通常具有由以各种单体或聚合物构型排列的两条蛋白质链组成的异质复合物的特征。这个超家族中最新的一类是细胞致死膨胀毒素(Cdt)。Cdt由一组分类上不同的革兰氏阴性细菌产生的毒素亚家族代表。该亚族的成员具有相关的AB型链或亚基配置和与AB范式不同的属性。在这篇综述中,Cdt亚家族的独特结构和细胞毒性、靶细胞特异性、中毒途径、作用方式以及与AB毒素超家族的关系进行了比较和对比。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cytolethal Distending Toxin: A Unique Variation on the AB Toxin Paradigm
Some of the most potent toxins produced by plants and bacteria are members of a large family known as the AB toxins. AB toxins are generally characterized by a heterogenous complex consisting of two protein chains arranged in various monomeric or polymeric configurations. The newest class within this superfamily is the cytolethal distending toxin (Cdt). The Cdt is represented by a subfamily of toxins produced by a group of taxonomically distinct Gram negative bacteria. Members of this subfamily have a related AB-type chain or subunit configuration and properties distinctive to the AB paradigm. In this review, the unique structural and cytotoxic properties of the Cdt subfamily, target cell specificities, intoxication pathway, modes of action, and relationship to the AB toxin superfamily are compared and contrasted.
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