内皮祖细胞的调控:血管形成的门户

Kate A. Parham, S. Pitson, C. Bonder
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引用次数: 6

摘要

内皮祖细胞(EPCs)是一种原始的内皮前体细胞,在功能上参与疾病的发病机制。迄今为止,已经描述了这些细胞的许多不同亚型,具有不同的成熟状态,细胞表型和功能。尽管对于哪种亚型构成真正的EPC人群存在很多争论,但所有亚型都具有内皮特征并有助于新生血管的形成。血管生成,EPCs促进血管形成的过程,在实体瘤中血管生成过多的疾病中可能失调,导致肿瘤生长和转移,相反,在缺血环境中可能存在血管生成不足。重要的是,众所周知,转录因子通过控制特定靶基因的表达来严格调节细胞表型和功能,进而调节特定的信号通路。这表明转录调节因子可能是控制EPC功能的潜在治疗靶点。在此,我们讨论了文献中描述的观察到的EPC亚型,并回顾了最近的研究,这些研究描述了一些转录家族在正常和病理条件下调控EPC表型和功能的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulation of EPCs: The Gateway to Blood Vessel Formation
Endothelial progenitor cells (EPCs) are primitive endothelial precursors which are known to functionally contribute to the pathogenesis of disease. To date a number of distinct subtypes of these cells have been described, with differing maturation status, cellular phenotype, and function. Although there is much debate on which subtype constitutes the true EPC population, all subtypes have endothelial characteristics and contribute to neovascularisation. Vasculogenesis, the process by which EPCs contribute to blood vessel formation, can be dysregulated in disease with overabundant vasculogenesis in the context of solid tumours, leading to tumour growth and metastasis, and conversely insufficient vasculogenesis can be present in an ischemic environment. Importantly, it is widely known that transcription factors tightly regulate cellular phenotype and function by controlling the expression of particular target genes and in turn regulating specific signalling pathways. This suggests that transcriptional regulators may be potential therapeutic targets to control EPC function. Herein, we discuss the observed EPC subtypes described in the literature and review recent studies describing the role of a number of transcriptional families in the regulation of EPC phenotype and function in normal and pathological conditions.
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