Neuromodulation最新文献

{"title":"Colonic Transit Induced by Intermittent Stimulation of Sacral S2 Spinal Root in Cats with Intact or Injured Spinal Cord","authors":"Jialiang Chen MD,&nbsp;Bing Shen DVM,&nbsp;Jicheng Wang PhD,&nbsp;Alexander Ma BS,&nbsp;Jonathan Beckel PhD,&nbsp;Changfeng Tai PhD","doi":"10.1016/j.neurom.2026.06.461","DOIUrl":"10.1016/j.neurom.2026.06.461","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated whether low frequency (7 Hz) intermittent (one minute ON/OFF) stimulation of sacral S2 spinal root could induce colonic transit in anesthetized cats with intact spinal cords or complete spinal cord injury (SCI).</div></div><div><h3>Materials and Methods</h3><div>Colonic transit was directly observed by tracking the displacement of intraluminal glass marbles prepositioned in the proximal (score = 3), middle (score = 2), or distal colon (score = 1). Colonic transit is quantified by a reduction of the colon score that was calculated by summation of all marble’s score.</div></div><div><h3>Results</h3><div>In cats with intact spinal cords (N = 5), intermittent S2 root stimulation induced colonic transit during a 60-minute period, significantly (<em>p</em> &lt; 0.05) reducing the colon score from 6.4 ± 0.2 to 4.4 ± 0.7. In cats with complete SCI (<em>N</em> = 5), the 60-minute S2 root stimulation also induced colonic transit, significantly (<em>p</em> &lt; 0.05) decreasing the colon score from 5.8 ± 0.4 to 3.2 ± 0.9.</div></div><div><h3>Conclusions</h3><div>These findings show that low frequency intermittent sacral neuromodulation is effective in facilitating colonic transit in both neurologically intact and cats with SCI, providing promising preclinical evidence to develop a novel sacral neuromodulation therapy to treat chronic constipation caused by slow colonic transit.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1175-1181"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2182965 DUAL-LEAD PERCUTANEOUS PERIPHERAL NERVE STIMULATION OF THE BRACHIAL PLEXUS FOR INTRACTABLE CANCER PAIN","authors":"Ellie Tsang BS,&nbsp;Lee Nguyen MD,&nbsp;Scott Pritzlaff MD","doi":"10.1016/j.neurom.2026.06.041","DOIUrl":"10.1016/j.neurom.2026.06.041","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e26"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149093726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2181627 REAL-WORLD CLINICAL AND SAFETY OUTCOMES FROM A PROSPECTIVE, MULTICENTER DEEP BRAIN STIMULATION REGISTRY OF PATIENTS WITH ESSENTIAL TREMOR","authors":"Guenther Deuschl MD, PhD,&nbsp;Michael T. Barbe MD,&nbsp;Won Seok Chang MD,&nbsp;Frederik Clement MD,&nbsp;Marta Blazquez Estrada MD,&nbsp;Michael Fleischer MD,&nbsp;Christopher Honey MD, PhD,&nbsp;Serge Jaumà Classen MD,&nbsp;Norbert Kovacs MD,&nbsp;Jung-Il Lee MD,&nbsp;Griet Loret MD,&nbsp;Ana Oliveira MD,&nbsp;Steffen Paschen MD,&nbsp;David Pedrosa MD,&nbsp;Alfons Schnitzler MD,&nbsp;Rick Schuurman MD,&nbsp;Jens Volkmann MD, PhD,&nbsp;Rajat Shivacharan PhD","doi":"10.1016/j.neurom.2026.06.039","DOIUrl":"10.1016/j.neurom.2026.06.039","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages e24-e25"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149093881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2176134 COMPARISON OF SPINAL CORD STIMULATION WAVEFORMS AND FREQUENCY OF REPROGRAMMING ADJUSTMENTS: A RETROSPECTIVE CHART REVIEW","authors":"Jared McDonald MS,&nbsp;Saba Javed MD,&nbsp;Munfarid Zaidi MD","doi":"10.1016/j.neurom.2026.06.030","DOIUrl":"10.1016/j.neurom.2026.06.030","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e19"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2193382 DURABLE OUTCOMES OF PERCUTANEOUS 60-DAY PERIPHERAL NERVE STIMULATION FOR LOW BACK PAIN: FIVE-YEAR FOLLOW-UP SURVEY","authors":"Brandon D. Swan,&nbsp;Denise D. Lester MD, FASAM,&nbsp;Jaudat Mahmood MD,&nbsp;Sarah E. Trampota MD,&nbsp;Lawson Smith MD,&nbsp;Raheleh Rahimi MD,&nbsp;Brandon D. Swan BSE,&nbsp;Meredith J. McGee PhD,&nbsp;Joseph W. Boggs PhD","doi":"10.1016/j.neurom.2026.06.061","DOIUrl":"10.1016/j.neurom.2026.06.061","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e38"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2143034 SPINAL CORD STIMULATION IN A PATIENT WITH A CERVICAL SPINAL CORD TUMOR","authors":"Chris A. Woolley MD, D.ABA,&nbsp;Jesica Godinez Medical Student,&nbsp;Raquel Deines Physician Assistant","doi":"10.1016/j.neurom.2026.06.002","DOIUrl":"10.1016/j.neurom.2026.06.002","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e2"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Vagal Nerve Stimulation for Chronic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Mohamad Abi Nassif MD,&nbsp;Neha R. Santucci MD, MBBS, MS","doi":"10.1016/j.neurom.2026.02.005","DOIUrl":"10.1016/j.neurom.2026.02.005","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1304-1305"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacral Nerve Stimulation and Chronic Bladder Pain: Meta-Analysis","authors":"Rodwan Husein MBChB,&nbsp;Moein Tavakkoli MD,&nbsp;Sara Ahmadi Abhari MD, PhD,&nbsp;Lawrence Hutchinson MBBS,&nbsp;Suraj Shah MBBS,&nbsp;Anish Thillainathan MBBS,&nbsp;Andrew Baranowski MD","doi":"10.1016/j.neurom.2025.09.318","DOIUrl":"10.1016/j.neurom.2025.09.318","url":null,"abstract":"<div><h3>Objectives</h3><div>Chronic bladder pain syndrome (CBPS) is a debilitating condition with limited treatment efficacy. This meta-analysis evaluates the effectiveness of sacral nerve stimulation (SNS) in the management of pain, urinary symptoms, and quality of life (QoL) in patients with CBPS.</div></div><div><h3>Materials and Methods</h3><div>A systematic review was conducted across EMBASE, PubMed, and the Cochrane Library, adhering to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Studies involving adult patients with bladder pain symptoms treated with SNS and reported pain scores were included. Pain scores were the primary outcome measure of interest. Secondary outcome measures included Interstitial Cystitis Problem Index (ICPI)/Interstitial Cystitis Symptom Index (ICSI), urinary frequency, nocturia, and QoL. Risk of bias was assessed using Risk Of Bias In Non-randomized Studies—of Interventions, and pooled effect estimates were calculated using random-effects meta-analysis models.</div></div><div><h3>Results</h3><div>A total of 15 studies (<em>N</em> = 494) were included in the meta-analysis. SNS was associated with a statistically significant reduction in pain scores (mean difference: −2.27 on a 0–10 scale, 95% CI: −2.94 to −1.60, <em>p</em> &lt; 0.001), ICSI (−2.18, 95% CI: −2.99 to −1.37, <em>p</em> &lt; 0.001), urinary frequency (−1.71 voids/d, 95% CI: −2.29 to −1.12), and nocturia (−1.49 episodes/night, 95% CI: −2.35 to −0.63). Changes in ICPI and QoL were not statistically significant. Complication rates ranged from 0% to 40.6%, and explantation rates from 0% to 18%.</div></div><div><h3>Conclusions</h3><div>This meta-analysis suggests that SNS may offer clinically meaningful pain and urinary symptom relief in patients with CBPS. However, substantial methodological heterogeneity, moderate-to-high risk of bias, and the absence of randomized control trials limit the strength of conclusions. Larger, high-quality trials with standardized diagnostic criteria and outcome measures are essential to establish SNS as a validated treatment option for CBPS.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1091-1102"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Unilateral and Bilateral Sacral Nerve Stimulation on Defecation and Microbiota in Constipated Dogs","authors":"Ting Yi MD,&nbsp;Xiaojuan Guo PhD,&nbsp;Yanbin Fang MM,&nbsp;Hanwei Liang MM,&nbsp;Yang Lu PhD,&nbsp;Xiaolu Zhang MM,&nbsp;Han Cao PhD,&nbsp;Jinzhe Liu PhD,&nbsp;Qiyue Wang MM,&nbsp;Youge Qu PhD,&nbsp;Xuan Jiang MD","doi":"10.1016/j.neurom.2025.10.065","DOIUrl":"10.1016/j.neurom.2025.10.065","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to explore potential differences in therapeutic efficacy and impact on intestinal microbiota between unilateral and bilateral sacral nerve stimulation (uSNS and bSNS) in the treatment of constipation.</div></div><div><h3>Materials and Methods</h3><div>Dual-channel sacral nerve stimulators were implanted in six beagles, while constipation was induced using compound diphenoxylate and alosetron hydrochloride. Using a randomized crossover design, dogs (total n = 6) underwent uSNS and bSNS interventions sequentially, with ten-day washout periods. Data collection spanned four stages: baseline, constipation, uSNS treatment, and bSNS treatment. Measured parameters included the number of defecations, Bristol Stool Form Scale (BSFS) scores, total gastrointestinal transit time (TGTT), short-chain fatty acid concentrations (quantified via liquid chromatography–tandem mass spectrometry), and intestinal microbiota levels (assessed by 16S ribosomal RNA [rRNA] V3–V4 region sequencing).</div></div><div><h3>Results</h3><div>Compared with the baseline stage, the constipation stage showed a reduced number of defecations, lower BSFS scores, and prolonged TGTT (<em>p</em> &lt; 0.05). Sacral nerve stimulation (SNS) improved BSFS scores and shortened TGTT in constipated dogs, but only bSNS showed statistically significant changes relative to the constipation stage (<em>p</em> &lt; 0.05). Moreover, bSNS shortened TGTT significantly more than uSNS (<em>p</em> &lt; 0.05). 16S rRNA sequencing revealed that constipation altered the intestinal microbiota composition. In constipated dogs, <em>Blautia</em> abundance and the concentrations of butyrate and valerate were lower than those at baseline (<em>p</em> &lt; 0.05). After SNS treatment, these measures increased without reaching statistical significance (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>bSNS improved BSFS scores and TGTT in constipated dogs and was superior to uSNS for TGTT. SNS may also beneficially modulate intestinal microbiota, which warrants confirmation in larger studies.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1155-1165"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Short-Term Effects of Transcutaneous Auricular Vagus Nerve Stimulation in Female Patients with Functional Constipation and Myofascial Pain Syndrome: A Randomized Clinical Trial","authors":"Fariba Khosravi PhD,&nbsp;Siyavash Joukar PhD,&nbsp;Mohammad Reza Nourbakhsh PhD,&nbsp;Mahboobeh Abdolalizadeh PhD,&nbsp;Amir Massoud Arab PhD","doi":"10.1016/j.neurom.2026.05.003","DOIUrl":"10.1016/j.neurom.2026.05.003","url":null,"abstract":"<div><h3>Introduction</h3><div>The management of chronic constipation when it coexists with chronic pain syndrome is challenging because of complex pathophysiologic and constipating analgesic side effects. Transcutaneous auricular vagus nerve stimulation (taVNS) is an effective neuromodulation method to modulate gastrointestinal function and pain processing by targeting vagal pathways. Accordingly, this study evaluated the short-term effects of taVNS in patients with functional constipation (FC) comorbid with myofascial pain syndrome (MPS).</div></div><div><h3>Materials and Methods</h3><div>A total of 38 female participants with FC and MPS (aged 20–50 years) were randomly allocated (1:1) using a computer-generated randomization to either taVNS or sham-taVNS groups. Participants received the intervention for 30 minutes, five days a week for two weeks. The complete spontaneous bowel movements per week (CSBMs/week) as the primary outcome was assessed at baseline and after the treatment. Secondary outcomes were Wexner constipation scores (WCS), patient assessment of constipation quality of life (PAC-QoL) score, visual analogue scale (VAS), pressure pain threshold (PPT), and heart rate variability (HRV).</div></div><div><h3>Results</h3><div>The result of analysis of covariance (ANCOVA) showed that taVNS significantly and clinically improved CSBMs/week compared with the sham-taVNS (<em>p</em> = 0.007; Cohen <em>d</em> = 0.97, 95% CI 0.26 – 1.66). The mean increase of CSBMs/week was 1.65 times compared with the baseline and 1.37 times compared with the sham-taVNS (MCID = 1.3 times). Moreover, the taVNS group had greater reduction in WCS and VAS compared with the sham group. In the HRV analysis, the taVNS enhanced high frequency (HF) and decreased low frequency (LF) and the LF/HF ratio compared with the sham-taVNS. However, there was no substantial difference in the PPT and PAC-QoL between groups.</div></div><div><h3>Conclusions</h3><div>These promising findings provide preliminary evidence that taVNS may be an effective nonpharmacologic intervention in female patients with FC coexisting with chronic pain conditions, particularly MPS. Further large-scale studies with longer follow-up and mechanistic assessments are warranted.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1218-1228"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}