Neuromodulation最新文献

{"title":"Effects of Auricular Stimulation on Inflammatory Parameters: Results of a Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Kevin Hua MD ,&nbsp;Mike Cummings MD ,&nbsp;Miriam Bernatik MD ,&nbsp;Benno Brinkhaus MD, PhD ,&nbsp;Taras Usichenko MD, PhD ,&nbsp;Stefan N. Willich MD, PhD ,&nbsp;Carmen Scheibenbogen MD, PhD ,&nbsp;Joanna Dietzel MD","doi":"10.1016/j.neurom.2024.12.007","DOIUrl":"10.1016/j.neurom.2024.12.007","url":null,"abstract":"<div><h3>Background</h3><div>The number of randomized controlled trials (RCTs) using auricular stimulation (AS) techniques, such as transauricular vagus nerve stimulation, auricular electrostimulation, auricular acupuncture, and acupressure in experimental and clinical settings has increased markedly over the last three decades. This systematic review evaluates the effects of AS on biomarkers of inflammation and stress responses.</div></div><div><h3>Materials and Methods</h3><div>The following data bases were searched: MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ISI Web of Science, and Scopus Data base. Data collection and analysis were conducted independently by two reviewers. Quality and risk assessments of the included studies were performed, and a meta-analysis of the effects of the most frequently assessed biomarkers was conducted using RevMan statistical software.</div></div><div><h3>Results</h3><div>A total of 1122 patients and healthy volunteers from 27 RCTs were included in this systematic review; 81% of the participants were female, with a median age of 51 years. Pooled data of 18 studies showed a significant effect of AS regarding a reduction of serum C-reactive protein, tumor necrosis factor-α, interleukin (IL)-6, and IL-10. Although IL-4, IL1β, cortisol, substance P and calcitonin gene-related peptide, and adrenocorticotropic hormone did not show any changes, salivary amylase increased under AS.</div></div><div><h3>Conclusions</h3><div>The influence of inflammatory cytokines seems to be mediated by AS. More research is needed to investigate the effects of AS on the immunologic system in addition to its clinical significance in high-quality RCT.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 627-640"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoroscopy-Guided Percutaneous Placement of Peripheral Nerve Stimulator of the Cervical Medial Branches in Patients With Treatment-Refractory Occipital Neuralgia: A Case Series","authors":"Qing Zhao Ruan MD ,&nbsp;Adriano Bellotti MD, PhD ,&nbsp;Amitabh Gulati MD ,&nbsp;Lisa Gfrerer MD, PhD ,&nbsp;Daniel Pak MD ,&nbsp;David Reece DO ,&nbsp;Sean Li MD ,&nbsp;Jun Beom Ku MD ,&nbsp;Christopher L. Robinson MD, PhD ,&nbsp;Rohan Jotwani MD, MBA","doi":"10.1016/j.neurom.2025.02.004","DOIUrl":"10.1016/j.neurom.2025.02.004","url":null,"abstract":"<div><h3>Background</h3><div>Pain from occipital neuralgia (ON) stems from the compression of the greater occipital nerve, muscle hypertrophy, or spasm. C2–C3 facet joint pain also is implicated in ON, given the third occipital nerve’s innervation of the C2–C3 zygapophysial joint. Percutaneous peripheral nerve stimulation (PNS) has in recent years been popularized as a minimally invasive approach in the management of treatment-resistant ON.</div></div><div><h3>Objective</h3><div>The study seeks to summarize the various modalities used in percutaneous peripheral nerve stimulator placement for ON in the existing literature and propose a novel fluoroscopic technique for effective peripheral nerve stimulator implantation established through a retrospective institutional case series for treatment of patients with ON.</div></div><div><h3>Materials and Methods</h3><div>MEDLINE was accessed for our literature search, and the time frame of the search was set from data base inception to May 1, 2024. Our institutional retrospective chart review was performed in patients who had undergone new implantation of the SPRINT PNS system (SPR Therapeutics, Inc, Cleveland, OH) from January 2023 to May 2024. Parameters extracted from patients’ charts for analysis included patient demographics, pain presentation, prior treatments and injection-based interventions, pain intensity, and opioid medications used.</div></div><div><h3>Results</h3><div>A total of five articles meeting the inclusion criteria were obtained after screening a total of 74 studies, describing peripheral nerve stimulator placement techniques using ultrasound, fluoroscopy, and a combination of both. Five institutional subjects were assessed in our case series. During active PNS therapy, there was a clinically significant reduction in pain (≥50%) intensity as measured by visual analog scale (VAS) score in all five subjects (<em>N</em> = 5, mean 7.20 vs 1.68, 95% CI [−8.87, −2.17], <em>p</em> = 0.0102). At 60 days, pain relief improved (<em>N</em> = 5, mean 7.20 vs 1.32, 95% CI [−8.97, −2.78], <em>p</em> = 0.0062). After device removal, the VAS score trended lower without attaining significance (<em>n</em> = 4, mean 7.5 vs 3.13, 95% CI [−11.04, 2.29], <em>p</em> = 0.128).</div></div><div><h3>Conclusions</h3><div>Our fluoroscopic-guided peripheral nerve stimulator placement technique yielded pain relief from therapeutic commencement to up to 18 weeks from device placement, exhibiting an efficacy equivalent to that of existing modalities of lead placement published in literature.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 592-599"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Events Associated With Peripheral Nerve Stimulation: An Analysis of the MAUDE Data base and Implications for Pain and Spine Clinicians","authors":"Amanda N. Cooper PhD ,&nbsp;Hasan Sen MD ,&nbsp;Napatpaphan Kanjanapanang MD ,&nbsp;Kristen Saad MD ,&nbsp;Garret Wahl MD ,&nbsp;Chase Young MD, MPH ,&nbsp;Matthew Essman MD, DPT ,&nbsp;Alexandra E. Fogarty MD ,&nbsp;Taylor Burnham DO, MS ,&nbsp;Aaron M. Conger DO ,&nbsp;Zachary L. McCormick MD ,&nbsp;Allison Glinka Przybysz MD, MPH","doi":"10.1016/j.neurom.2025.02.002","DOIUrl":"10.1016/j.neurom.2025.02.002","url":null,"abstract":"<div><h3>Summary of Background Data</h3><div>The use of peripheral nerve stimulation (PNS) devices within pain and spine-related care has increased significantly in recent years. The United States Food and Drug Administration (FDA)–approved indications for PNS have expanded rapidly with technologic advances and randomized controlled trials demonstrating its efficacy. Analysis of real-world data regarding the complications associated with PNS can help inform clinical decision-making and patient counseling as the use of this neuromodulation therapy continues to evolve.</div></div><div><h3>Objectives</h3><div>This study aimed to categorize adverse events (AEs) described in medical device reports (MDRs) within the FDA Manufacturer and User Facility Device Experience (MAUDE) data base related to the use of PNS for pain and spinal indications.</div></div><div><h3>Materials and Methods</h3><div>A comprehensive search within the MAUDE data base was conducted to identify AEs related to FDA-approved PNS devices reported between January 1, 2023 and December 31, 2023, specifically to capture AEs related to current PNS technology in clinical use. AEs were manually categorized according to event descriptions.</div></div><div><h3>Results</h3><div>We identified 594 unique MDRs associated with the five PNS devices currently approved by the FDA for use in the spine. While most MDRs (77.1%) did not specify lead location, spinal lead placements were implicated in 9.1% of cases, and appendicular lead placement accounted for 13.8%. Infection (22.7%), migration (14.7%), and skin erosion (9.4%) were the most common AEs reported. Most entries were categorized as device-related (40.1%) or procedural AEs (32.7%), and the remainder as patient complaints (17.3%), serious AEs (1.0%), and “other” complications (6.1%). Most complications were managed with explantations (43.8%) rather than revisions (29.5%).</div></div><div><h3>Discussion/Conclusion</h3><div>New technologies and their applications must be regularly evaluated for safety and effectiveness. Our analysis of the MAUDE data base revealed that infection, lead migration, and skin erosion were the most commonly reported AEs associated with the use of PNS technology during 2023. Most AEs were deemed to be device- or procedure-related.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 619-626"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"41. Pre-emptive use of lidocaine patches following SCS implant to prevent postoperative pain and hypersensitivity – 6 month prospective data","authors":"M.Y. Khilji ,&nbsp;A. Ahmad ,&nbsp;A. Elyas ,&nbsp;V. Mehta ,&nbsp;K. Poply","doi":"10.1016/j.neurom.2025.03.043","DOIUrl":"10.1016/j.neurom.2025.03.043","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S21"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"58. The UK&I National Neuromodulation Registry: spinal cord stimulation improves quality of life for patients with pelvic pain","authors":"S. Martin ,&nbsp;G. Baranidharan ,&nbsp;S. Thomson ,&nbsp;A. Gulve ,&nbsp;V. Mehta ,&nbsp;S. Love-Jones ,&nbsp;R. Strachan ,&nbsp;S. Bojanić ,&nbsp;S. Eldabe ,&nbsp;J.J. FitzGerald","doi":"10.1016/j.neurom.2025.03.060","DOIUrl":"10.1016/j.neurom.2025.03.060","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S30"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"27. High-frequency spinal cord stimulation provides long-term relief from refractory pain of the trunk and limb","authors":"N. Park ,&nbsp;N. Robinson ,&nbsp;J. Camoras ,&nbsp;C. Struthers ,&nbsp;J. Dawes ,&nbsp;R. King","doi":"10.1016/j.neurom.2025.03.029","DOIUrl":"10.1016/j.neurom.2025.03.029","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S14"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"60. The UK&I National Neuromodulation Registry: trial or no trial for SCS in the real world","authors":"S. Martin ,&nbsp;G. Baranidharan ,&nbsp;A. Gulve ,&nbsp;V. Mehta ,&nbsp;S. Love-Jones ,&nbsp;R. Strachan ,&nbsp;S. Bojanić ,&nbsp;S. Eldabe ,&nbsp;J.J. FitzGerald ,&nbsp;S. Thomson","doi":"10.1016/j.neurom.2025.03.062","DOIUrl":"10.1016/j.neurom.2025.03.062","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S31"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3. A single-center experience of screening trial vs all-in-one (AIO) procedures using multi-waveform spinal cord stimulation (SCS)","authors":"C. Patel,&nbsp;D. Lowes,&nbsp;E. Yuen","doi":"10.1016/j.neurom.2025.03.005","DOIUrl":"10.1016/j.neurom.2025.03.005","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S2"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"45. Real world SCS outcome from a small district general hospital in the UK: what does this really mean in the context of social outcomes and pharmaceutical impact?","authors":"K. Fleming,&nbsp;J. Thomas,&nbsp;J. Graterol,&nbsp;N. Roberts,&nbsp;A. Doyle","doi":"10.1016/j.neurom.2025.03.047","DOIUrl":"10.1016/j.neurom.2025.03.047","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S23"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"47. Real-world data from a single-centre longitudinal cohort on restorative neurostimulation for chronic mechanical back pain","authors":"M. Zubair,&nbsp;N. Collighan,&nbsp;R. Bhadresha,&nbsp;T. Elliott,&nbsp;V. Gawler,&nbsp;R. Hyett,&nbsp;T. George,&nbsp;J. Kirkham,&nbsp;K. Turner","doi":"10.1016/j.neurom.2025.03.049","DOIUrl":"10.1016/j.neurom.2025.03.049","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S24"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}