Neuromodulation最新文献

{"title":"Sacral Neuromodulation in Pediatric Gastrointestinal Motility Disorders: An Exploratory Prospective Cohort Analysis of Clinical Outcomes Based on Different Approaches","authors":"Frederike Bieling MD,&nbsp;Annemarie Kirchgatter MD,&nbsp;Angelina Bauer,&nbsp;Christel Weiss MD,&nbsp;Hanna Müller MD,&nbsp;Klaus E. Matzel MD,&nbsp;Andreas Rowald PhD,&nbsp;Manuel Besendörfer MD,&nbsp;Sonja Diez MD","doi":"10.1016/j.neurom.2026.05.013","DOIUrl":"10.1016/j.neurom.2026.05.013","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the efficacy and safety of minimally invasive sacral neuromodulation (SNM) and noninvasive enteral neuromodulation (ENM) in children with refractory gastrointestinal motility disorders (GMD).</div></div><div><h3>Materials and Methods</h3><div>This prospective exploratory trial enrolled pediatric patients with GMD between 2019 and 2024 at a single tertiary referral center. Children with inflammatory bowel disease or mechanical causes of GMD were excluded. Participants received either SNM through an implanted device or ENM through surface electrodes. Stimulation was delivered at 14 Hz, 210 μs pulse width, with individualized intensity (median 1.0 mA for SNM; 6.0 mA for ENM). Primary outcomes were abdominal pain, fecal incontinence, defecation frequency, and stool consistency. Treatment success was defined as clinically significant improvement in at least two of these four domains. Quality of life was assessed at baseline and 12 weeks. Safety outcomes were monitored over a 12-month follow-up.</div></div><div><h3>Results</h3><div>Of 70 eligible patients, 48 completed the study (18 SNM; 30 ENM). Diagnoses included Hirschsprung disease, functional constipation, and congenital neuronal malformations. Severe comorbidities were more frequent in the SNM group (45%) than the ENM group (3%; <em>p</em> = 0.0018). Treatment success was observed in 80% (24/30) of the ENM cohort and 83% (15/18) of SNM cohort. No significant differences were found between groups for individual outcomes. No major complications occurred. Minor adverse events were comparable (ENM 27%; SNM 17%).</div></div><div><h3>Conclusions</h3><div>Both SNM and ENM are effective and safe options for treating pediatric GMD and may be considered within a multimodal therapeutic approach.</div></div><div><h3>Clinical Trial Registration</h3><div>This trial is registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> (ID NCT04713085, title “Sacral Neuromodulation in Children and Adolescents”). Web link: <span><span>https://clinicaltrials.gov/study/NCT04713085</span><svg><path></path></svg></span></div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1254-1262"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Sacral Neuromodulation for Fecal Incontinence Across Multiple Etiologies: A Single-Center Study","authors":"Peirui Wu MD,&nbsp;Tianming Ma MD, PhD,&nbsp;Qinxian Huang MD, MSc,&nbsp;Zhengyu Xian MD, PhD,&nbsp;Li Lu MD, PhD","doi":"10.1016/j.neurom.2026.05.012","DOIUrl":"10.1016/j.neurom.2026.05.012","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the clinical outcomes of sacral neuromodulation (SNM) for fecal incontinence (FI) caused by diverse etiologies.</div></div><div><h3>Materials and Methods</h3><div>This retrospective study, conducted between April 2021 and December 2024, analyzed 34 consecutive patients with FI who underwent SNM. Preoperative examinations included high-resolution anorectal manometry, magnetic resonance imaging, and endoscopy. Symptom severity was assessed using the Wexner or low anterior resection syndrome (LARS) score, and quality of life was evaluated using the Fecal Incontinence Quality of Life scores (FIQL) pre- and postoperatively.</div></div><div><h3>Results</h3><div>The cohort included 14 women and 20 men with a median age of 52 years and a median FI duration of five years. Etiologies included LARS (<em>n</em> = 11), neurogenic bowel (<em>n</em> = 9), congenital malformations (<em>n</em> = 5), idiopathic FI (<em>n</em> = 3), and trauma- or radiation-related FI (<em>n</em> = 6). After successful lead implantation, &gt;50% symptom relief was achieved in 29 patients (85.3%) during the testing phase, and 27 patients (79.4%) subsequently underwent permanent implantable pulse generator implantation. During a median follow-up of 32 months, Wexner scores decreased significantly from baseline (18.1 ± 2.3) to 6.6 ± 5.4 (testing phase), 5.3 ± 2.7 (six months), 8.8 ± 2.6 (12 months), and 8.2 ± 1.5 (24 months) (all <em>p</em> &lt; 0.001). Significant improvements also were observed in the FIQL domains for lifestyle, coping/behavior, and depression (<em>p</em> &lt; 0.05), whereas the embarrassment domain remained unchanged. Reported complications included surgical site infections (<em>n</em> = 2), delayed wound healing (<em>n</em> = 1), and one case of late efficacy that was successfully managed with device revision.</div></div><div><h3>Conclusion</h3><div>SNM provides safe, effective, and sustained relief in symptoms and improvements in quality of life for patients with FI across a spectrum of complex etiologies.</div></div><div><h3>Clinical Trial Registration</h3><div>The Chinese Clinical Trial Registry registration number for the study is ChiCTR2100054268.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1263-1268"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2186119 SUBTHRESHOLD SPINAL CORD STIMULATION IN PERSISTENT SPINAL PAIN SYNDROME: TOWARD AMPLITUDE-OPTIMIZED NEUROMODULATION—A LITERATURE REVIEW","authors":"Tishawn Ross MD,&nbsp;Roberto Andrade MD,&nbsp;Panayotis Jusakos MD","doi":"10.1016/j.neurom.2026.06.048","DOIUrl":"10.1016/j.neurom.2026.06.048","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e30"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2182562 ANALYSIS OF DYNAMIC FUNCTIONAL MAGNETIC RESONANCE IMAGING CONNECTIVITY WITH DEEP LEARNING TO GUIDE AROUSAL NEUROMODULATION IN EPILEPSY","authors":"Derek J. Doss PhD,&nbsp;Ghassan Makhoul BS,&nbsp;Graham Johnson MD, PhD,&nbsp;Anas Reda BA,&nbsp;Bruno Hidalgo BS,&nbsp;Addison Cavendar BS,&nbsp;Emily Liao BE,&nbsp;Kate Wang BS,&nbsp;Sameer Sundrani BS,&nbsp;Haatef Pourmotabbed BS,&nbsp;Sarah Goodale PhD,&nbsp;Douglas Terry PhD,&nbsp;Hakmook Kang PhD,&nbsp;Kevin Haas MD, PhD,&nbsp;Martin Gallagher MD, PhD,&nbsp;Victoria Morgan PhD,&nbsp;Catie Chang PhD,&nbsp;Dario Englot MD, PhD","doi":"10.1016/j.neurom.2026.06.040","DOIUrl":"10.1016/j.neurom.2026.06.040","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages e25-e26"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2171344 SOLIS RANDOMIZED CONTROLLED TRIAL: TWO-YEAR OUTCOMES OF SPINAL CORD STIMULATION VS MEDICAL MANAGEMENT IN PATIENTS WITH BACK PAIN WHO WERE SURGERY-NAÏVE","authors":"Drew Trainor DO,&nbsp;Magdalena Anitescu MD, PhD,&nbsp;Joseph Atallah MD,&nbsp;Aaron Calodney MD,&nbsp;John Chatas MD,&nbsp;Anne Christopher MD,&nbsp;Mitchell Engle MD,&nbsp;Maged Guirguis MD,&nbsp;Suneil Jolly MD,&nbsp;Daniel Kloster MD,&nbsp;Tim Leier MD,&nbsp;Eric Loudermilk MD,&nbsp;Zachary McCormick MD,&nbsp;John Noles MD,&nbsp;James North MD,&nbsp;Julio Paez MD,&nbsp;Daniel Pak MD,&nbsp;Jeffrey Peacock MD,&nbsp;Gregory Philiips MD,&nbsp;Steve Rosen MD,&nbsp;Michael Yang MD","doi":"10.1016/j.neurom.2026.06.023","DOIUrl":"10.1016/j.neurom.2026.06.023","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages e15-e16"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2187956 PERIPHERAL NERVE STIMULATION COST SAVINGS COMPARISON: A SYSTEMATIC REVIEW OF THE CURRENT LITERATURE","authors":"Vladislav Zhitny Medical Doctor,&nbsp;Vladislav Zhitny MD,&nbsp;Michelle Zhu BS,&nbsp;Rakshita Giri BS,&nbsp;Michael J. Wajda MD,&nbsp;Alon Mogilner MD, PhD,&nbsp;Jake P. Young BS,&nbsp;John J. Michalisin MD,&nbsp;Nathanael Leo MD,&nbsp;Shengping Zou MD,&nbsp;Adlai Pappy MD,&nbsp;Mohammed Issa MD","doi":"10.1016/j.neurom.2026.06.052","DOIUrl":"10.1016/j.neurom.2026.06.052","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages e32-e33"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2176900 BRAIN VOLUME CHANGES AFTER RADIATION THERAPY AND THEIR ASSOCIATION WITH QUALITY OF LIFE","authors":"Seung Ho Yang","doi":"10.1016/j.neurom.2026.06.033","DOIUrl":"10.1016/j.neurom.2026.06.033","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e21"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page for Abstracts from the 29th Annual Meeting of the North American Neuromodulation Society (NANS)","authors":"","doi":"10.1016/S1094-7159(26)01370-X","DOIUrl":"10.1016/S1094-7159(26)01370-X","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e1"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selecting the Right Patient for Gastric Electrical Stimulation: Using Blinded Temporary Stimulation Trials in Children and Adolescents","authors":"Andrea Geleni Gongora BS,&nbsp;Christel Gharby MD,&nbsp;Madison Wnuk MD,&nbsp;Thomas Abell MD,&nbsp;Saleem Islam MD, MPH","doi":"10.1016/j.neurom.2025.12.004","DOIUrl":"10.1016/j.neurom.2025.12.004","url":null,"abstract":"<div><h3>Background</h3><div>Gastric electrical stimulation (GES) has been shown to relieve symptoms in children with gastroparesis (GP). Currently, trials with temporary gastric stimulation (tGES) guide selection for permanent implantation; however, there remain several nonresponders and early failures requiring early device explant. This study reports our experience with patient selection with “blinding” during their tGES trial.</div></div><div><h3>Materials and Methods</h3><div>A cohort study was conducted in patients aged four to 26 years who underwent blinded (B) and nonblinded (NB) tGES for GP from January 2014 to April 2022. B cases began the trial as either ON or OFF and then crossed over. Gastroparesis Cardinal Symptom Index (GCSI), nutritional intake, and permanent stimulator implant outcomes were measured and compared between the groups using Fisher exact test.</div></div><div><h3>Results</h3><div>A total of 84 patients underwent tGES, of whom 57 were NB and 27 B. Of the NB, 55 (96.5%) had improved GCSI, of whom 49 (86%) underwent permanent implantation. In the B group, 14 (51.9%) showed improvement when ON and worsened when OFF (concordant), whereas the others had either discordant or no response to the ON/OFF phase; 12 of 27 B cases (44.4%) were implanted. Early failures were noted in one of 12 B vs nine of 49 in NB cases (<em>p</em> = 0.67).</div></div><div><h3>Conclusions</h3><div>Overall, GES remains an effective therapy for severe GP in children and adolescents. Blinded tGES trials appeared to allow improved patient selection for those with concordant responses with lower implant rates and fewer early failures. Long-term outcomes of patients who were blinded and received a permanent implant need to be further studied.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1242-1248"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the Dots in Neuromodulation: Introducing the European International Neuromodulation Society 2027 Brussels Grand Challenges","authors":"Maarten Moens MD, PhD, MBA,&nbsp;Lisa Goudman PhD, MSc, MBA","doi":"10.1016/j.neurom.2026.07.648","DOIUrl":"10.1016/j.neurom.2026.07.648","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1300-1303"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}