Neuromodulation最新文献

{"title":"IS091 DECIPHERING VAGAL ANATOMY AND BRAIN-BODY SIGNALING TO OPTIMIZE NEUROMODULATION THERAPIES","authors":"Theodoros Zanos PhD","doi":"10.1016/j.neurom.2024.09.100","DOIUrl":"10.1016/j.neurom.2024.09.100","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Page S48"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IS038 IS THERE ANY INDICATION FOR SPINAL CORD STIMULATION (SCS) AND DORSAL ROOT GANGLION (DRG) IN REFRACTORY BRACHIAL PLEXUS PAIN?","authors":"Jan Vesper MD","doi":"10.1016/j.neurom.2024.09.047","DOIUrl":"10.1016/j.neurom.2024.09.047","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Page S20"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O003 SPATIO-DIRECTIONAL TUNING OF EVOKED RESONANT NEURAL ACTIVITY WITH DEEP BRAIN STIMULATION IN PARKINSON’S DISEASE","authors":"Kara Johnson PhD , Jackson Cagle PhD , Justin Hilliard MD , Kelly Foote MD , Coralie De Hemptinne PhD","doi":"10.1016/j.neurom.2024.09.104","DOIUrl":"10.1016/j.neurom.2024.09.104","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Pages S51-S52"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IS016 POTENTIAL MECHANISMS OF NOVEL NEUROMODULATION TECHNOLOGIES / THERAPY","authors":"Andrei Sdrulla PhD","doi":"10.1016/j.neurom.2024.09.025","DOIUrl":"10.1016/j.neurom.2024.09.025","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Page S9"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IS001 TRANSCRANIAL DIRECT CURRENT STIMULATION FOR INFLAMMATORY AND POST-INFECTION DISORDERS","authors":"Giuseppina Pilloni PhD, Leigh Charvet PhD","doi":"10.1016/j.neurom.2024.09.010","DOIUrl":"10.1016/j.neurom.2024.09.010","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Page S1"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IS052 INTRATHECAL DRUG DELIVERY (ITDD) SHALL REMAIN AN RCT FREE ZONE: THE CHALLENGES OF RESEARCH IN ITDD – ITDD DAY","authors":"Sam Eldabe FRCA","doi":"10.1016/j.neurom.2024.09.061","DOIUrl":"10.1016/j.neurom.2024.09.061","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Page S28"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Working Mechanism of Transcranial Direct Current Stimulation","authors":"Emma Lescrauwaet MSc ,&nbsp;Mathieu Sprengers MD, PhD ,&nbsp;Evelien Carrette PhD ,&nbsp;Chloé Algoet MD ,&nbsp;Ann Mertens MD, PhD ,&nbsp;Debby Klooster PhD ,&nbsp;Steven Beumer MSc ,&nbsp;Rob Mestrom PhD ,&nbsp;Robrecht Raedt PhD ,&nbsp;Paul Boon MD, PhD ,&nbsp;Kristl Vonck MD, PhD","doi":"10.1016/j.neurom.2024.05.002","DOIUrl":"10.1016/j.neurom.2024.05.002","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial direct current stimulation (tDCS) is used to modulate neuronal activity, but the exact mechanism of action (MOA) is unclear. This study investigates tDCS-induced modulation of the corticospinal excitability and the underlying MOA. By anesthetizing the scalp before applying tDCS and by stimulating the cheeks, we investigated whether stimulation of peripheral and/or cranial nerves contributes to the effects of tDCS on corticospinal excitability.</div></div><div><h3>Materials and Methods</h3><div>In a randomized cross-over study, four experimental conditions with anodal direct current stimulation were compared in 19 healthy volunteers: 1) tDCS over the motor cortex (tDCS-MI), 2) tDCS over the motor cortex with a locally applied topical anesthetic (TA) on the scalp (tDCS-MI + TA), 3) DCS over the cheek region (DCS-C), and 4) sham tDCS over the motor cortex(sham). tDCS was applied for 20 minutes at 1 mA. Motor evoked potentials (MEPs) were measured before tDCS and immediately, 15, 30, 45, and 60 minutes after tDCS. A questionnaire was used to assess the tolerability of tDCS.</div></div><div><h3>Results</h3><div>A significant MEP amplitude increase compared with baseline was found 30 minutes after tDCS-MI, an effect still observed 60 minutes later; no time∗condition interaction effect was detected. In the other three conditions (tDCS-MI + TA, DCS-C, sham), no significant MEP modulation was found. The questionnaire indicated that side effects are significantly lower when the local anesthetic was applied before stimulation than in the other three conditions.</div></div><div><h3>Conclusions</h3><div>The significant MEP amplitude increase observed from 30 minutes on after tDCS-MI supports the modulatory effect of tDCS on corticospinal neurotransmission. This effect lasted one hour after stimulation. The absence of a significant modulation when a local anesthetic was applied suggests that effects of tDCS are not solely established through direct cortical stimulation but that stimulation of peripheral and/or cranial nerves also might contribute to tDCS-induced modulation.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Pages 68-75"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive Transcutaneous Spinal Cord Stimulation Programming Recommendations for the Treatment of Upper Extremity Impairment in Tetraplegia","authors":"Kristen Gelenitis PhD ,&nbsp;Andrea Santamaria MD, MBA ,&nbsp;Jared Pradarelli DPT ,&nbsp;Markus Rieger PT, PhD ,&nbsp;Fatma Inanici MD, PhD ,&nbsp;Candace Tefertiller DPT, PhD ,&nbsp;Edelle Field-Fote PT, PhD ,&nbsp;James Guest MD, PhD ,&nbsp;Jenny Suggitt MSc, OT ,&nbsp;Amanda Turner BSc ,&nbsp;Jessica M. D’Amico PhD ,&nbsp;Chet Moritz PhD","doi":"10.1016/j.neurom.2024.05.005","DOIUrl":"10.1016/j.neurom.2024.05.005","url":null,"abstract":"<div><h3>Objectives</h3><div>This study analyzes the stimulation parameters implemented during two successful trials that used non-invasive transcutaneous spinal cord stimulation (tSCS) to effectively improve upper extremity function after chronic spinal cord injury (SCI). It proposes a framework to guide stimulation programming decisions for the successful translation of these techniques into the clinic.</div></div><div><h3>Materials and Methods</h3><div>Programming data from 60 participants who completed the Up-LIFT trial and from 17 participants who subsequently completed the LIFT Home trial were analyzed. All observations of stimulation amplitudes, frequencies, waveforms, and electrode configurations were examined. The incidence of adverse events and relatedness to stimulation parameters is reported. A comparison of parameter usage across the American Spinal Injury Association Impairment Scale (AIS) subgroups was conducted to evaluate stimulation strategies across participants with varying degrees of sensorimotor preservation.</div></div><div><h3>Results</h3><div>Active (cathodal) electrodes were typically placed between the C3/C4 and C6/C7 spinous processes. Most sessions featured return (anodal) electrodes positioned bilaterally over the anterior superior iliac spine, although clavicular placement was frequently used by 12 participants. Stimulation was delivered with a 10-kHz carrier frequency and typically a 30-Hz burst frequency. Biphasic waveforms were used in 83% of sessions. Average stimulation amplitudes were higher for biphasic waveforms. The AIS B subgroup required significantly higher amplitudes than did the AIS C and D subgroups. Device-related adverse events were infrequent, and not correlated with specific waveforms or amplitudes. Within the home setting, participants maintained their current amplitudes within 1% of the preset values. The suggested stimulation programming framework dictates the following hierarchical order of parameter adjustments: current amplitude, waveform type, active/return electrode positioning, and burst frequency, guided by clinical observations as required.</div></div><div><h3>Conclusions</h3><div>This analysis summarizes effective stimulation parameters from the trials and provides a decision-making framework for clinical implementation of tSCS for upper extremity functional restoration after SCI. The parameters are aligned with existing literature and proved safe and well tolerated by participants.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Pages 162-173"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IS015 MECHANISM OF PERIPHERAL NERVE STIMULATION (PNS), SPINAL CORD STIMULATION (SCS): SUPRASPINAL MECHANISMS AND MECHANISMS OF ACTION (MOA)","authors":"Eellan Sivanesan MD","doi":"10.1016/j.neurom.2024.09.024","DOIUrl":"10.1016/j.neurom.2024.09.024","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Page S8"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IS047 POSTSURGICAL MORBIDITY AND MORTALITY FAVORABLY INFORMS DEEP BRAIN STIMULATION FOR NEW INDICATIONS INCLUDING SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDER","authors":"Judith Gault PhD ,&nbsp;Patrick Hosokawa MSc ,&nbsp;Daniel Kramer MD ,&nbsp;Elyn Saks PhD ,&nbsp;Paul Appelbaum MD ,&nbsp;John Thompson PhD ,&nbsp;Ann Olincy MD ,&nbsp;Nicola Cascella MD ,&nbsp;Akira Sawa MD ,&nbsp;Wayne Goodman MD ,&nbsp;Nidal Moukaddam MD ,&nbsp;Sameer A. Sheth MD ,&nbsp;William Anderson MD ,&nbsp;Rachel A. Davis MD","doi":"10.1016/j.neurom.2024.09.056","DOIUrl":"10.1016/j.neurom.2024.09.056","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 1","pages":"Page S25"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}