Neuromodulation最新文献

{"title":"48 Real-world outcomes, implant and programming details, and user satisfaction of SCS for treatment of PSPS-2: results from a European Clinical Survey","authors":"F.J. Castro Seoane , J.C. de la Pinta García , S. Du Four , L. Elzinga , J.M. López Millán , L. Nader Navarro , F.J. Sánchez Montero , I. Smet , J.M. Trinidad Martín-Arroyo , C. Simonelli , H. Hanbli , R. Buschman","doi":"10.1016/j.neurom.2025.03.050","DOIUrl":"10.1016/j.neurom.2025.03.050","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S25"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"32. Multi-centre prospective cohort of intractable chronic low back pain patients treated with restorative neurostimulation – outcomes from 5-year data","authors":"A. Gulve, ReActiv8-B trial investigators","doi":"10.1016/j.neurom.2025.03.034","DOIUrl":"10.1016/j.neurom.2025.03.034","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S17"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerative Effects of Transcutaneous Electrical Acustimulation on Postoperative Recovery After Thoracolumbar Vertebral Fracture Associated With Suppressed Sympathetic Activity and Interleukin-6","authors":"Ying Kang MD ,&nbsp;Feng Xu MD ,&nbsp;Yang Wang MD ,&nbsp;Xiangyue Gao MD ,&nbsp;Weixin Dong MD ,&nbsp;Liansong Lu MD ,&nbsp;Fei Li MD ,&nbsp;Lin Lin PhD ,&nbsp;Jiande D.Z. Chen PhD","doi":"10.1016/j.neurom.2024.11.011","DOIUrl":"10.1016/j.neurom.2024.11.011","url":null,"abstract":"<div><h3>Objectives</h3><div>Gastrointestinal (GI) disturbance is a frequent complication in patients with thoracolumbar vertebral fracture (TVF). Transcutaneous electrical acustimulation (TEA) has been reported to effectively accelerate postoperative GI function recovery after abdominal surgery. This study aimed to investigate the effects of TEA on postoperative recovery and the associated mechanisms.</div></div><div><h3>Materials and Methods</h3><div>A total of 81 patients with TVF who underwent elective posterior pedicle screw fixation surgery were randomized to receive TEA or sham-TEA. TEA at ST36 or sham-TEA at nonacupoints was performed for one hour twice daily, from 24 hours before surgery to postoperative day (POD) 3. The effects were then assessed in the form of a diary at different time points.</div></div><div><h3>Results</h3><div>Compared with sham-TEA, TEA attenuated postoperative impairments associated with lower GI motility, including a reduction in time to defecation by 27.2% (<em>p</em> = 0.002 vs sham-TEA), time to first flatus by 17.2% (<em>p</em> = 0.027), an increase in the Bristol stool score (<em>p</em> = 0.014), and the number of spontaneous bowel movement (<em>p</em> = 0.009). TEA also relieved other GI symptoms including abdominal bloating on POD1 and POD4 (<em>p</em> &lt; 0.001 and <em>p</em> = 0.001, respectively), straining during defecation (<em>p</em> &lt; 0.001), and sensation of anorectal blockage during defecation (<em>p</em> = 0.02). Moreover, TEA reduced the visual analog scale wound pain score on POD1 (<em>p</em> = 0.026), POD2 (<em>p</em> &lt; 0.001), and POD3 (<em>p</em> &lt; 0.001), increased vagal activity, and decreased sympathetic activity (<em>p</em> &lt; 0.001), in addition to suppressing the serum level of norepinephrine on both POD1 (<em>p</em> = 0.047) and POD4 (<em>p</em> = 0.036). TEA caused a higher decrease from POD1 to POD4 in serum interleukin-6 (<em>p</em> = 0.011, vs sham-TEA). The use of TEA was an independent predictor of shortened time to first defecation.</div></div><div><h3>Conclusion</h3><div>Noninvasive TEA at ST36, in comparison with sham-TEA, is effective in promoting postoperative recovery in patients with TVF by enhancing vagal and suppressing sympathetic activities.</div></div><div><h3>Clinical Trial Registration</h3><div>The study was retrospectively registered on <span><span>www.chictr.org.cn</span><svg><path></path></svg></span> (Chinese Clinical Trial Registry ChiCTR2300078195).</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 690-699"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tonic and Event-Related Phasic Transcutaneous Auricular Vagus Nerve Stimulation Alters Pupil Responses in the Change-Detection Task","authors":"Jingxin Chen MD ,&nbsp;Yufeng Ke PhD ,&nbsp;Guangjian Ni PhD ,&nbsp;Shuang Liu PhD ,&nbsp;Dong Ming PhD","doi":"10.1016/j.neurom.2025.01.003","DOIUrl":"10.1016/j.neurom.2025.01.003","url":null,"abstract":"<div><h3>Background</h3><div>Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a potential modulator of cognitive behavior by activating the locus ceruleus-noradrenaline (LC-NA) system. Previous studies explored both phasic and tonic taVNS by investigating their impact on LC-NA markers such as pupil dilation and heart rate variability (HRV).</div></div><div><h3>Objective</h3><div>Inconsistencies persist in the identification of reliable markers for assessing the effects of taVNS on noradrenergic activity. Furthermore, it remains unclear whether the effects of taVNS extend beyond pure vagal nerve responses, particularly in specific cognitive domains such as working memory. In the present study, we investigated the effects of taVNS on working memory capacity and LC-NA markers using a change-detection task.</div></div><div><h3>Materials and Methods</h3><div>Twenty-two healthy, right-handed university students participated in a sham-controlled, randomized cross-over experiment with four sessions. We applied two types of phasic and event-related stimulation (Pre-event and Event-synchronous), tonic stimulation (Pre-task), and sham stimulation across different sessions. Pupil size and electrocardiogram data were recorded during the tasks.</div></div><div><h3>Results</h3><div>taVNS did not significantly modulate behavioral performance on the change-detection task, specifically working memory capacity. However, both tonic and event-related phasic taVNS significantly influenced the pupillary response during the task. In addition, the Pre-task condition of the taVNS affected the low-frequency parameter of HRV.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that tonic and event-related phasic taVNS may modulate noradrenergic activity, as evidenced by pupil responses and HRV changes during the change-detection task. This study provides new evidence regarding the impact of taVNS on cognitive tasks, thus supporting the development of noninvasive neuromodulation interventions.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 652-662"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Anesthetic Effect on the Subthalamic Nucleus in Microelectrode Recording and Local Field Potential of Parkinson’s Disease","authors":"Cinira Diogo PhD ,&nbsp;Christopher R. Conner MD, PhD","doi":"10.1016/j.neurom.2025.03.066","DOIUrl":"10.1016/j.neurom.2025.03.066","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 705-706"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Letter to the Editor Regarding: “Anesthetic Effect on the Subthalamic Nucleus in Microelectrode Recording and Local Field Potential of Parkinson’s Disease”","authors":"Shin-Yuan Chen MD ,&nbsp;Sheng-Huang Lin MD","doi":"10.1016/j.neurom.2025.03.067","DOIUrl":"10.1016/j.neurom.2025.03.067","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 707-708"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"28. Holistic composite assessments, arithmetic gymnastics to make sense of a complex outcome","authors":"J. Graterol,&nbsp;K. Fleming,&nbsp;J. Thomas,&nbsp;N. Roberts,&nbsp;A. Doyle","doi":"10.1016/j.neurom.2025.03.030","DOIUrl":"10.1016/j.neurom.2025.03.030","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S15"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"42. Prospective trial investigating interactable nonsurgical neuropathic lower lumbar pain (PSPS type1) using mixed waveform SCS therapy: 2 years clinical data","authors":"K. Poply,&nbsp;A. Ahmad,&nbsp;R. Taylor,&nbsp;T. Lambe,&nbsp;S. Vaidya,&nbsp;G. Bajaj,&nbsp;V. Mehta","doi":"10.1016/j.neurom.2025.03.044","DOIUrl":"10.1016/j.neurom.2025.03.044","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S22"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"36. Occipital nerve stimulation for primary headache disorders","authors":"I. Wilkinson,&nbsp;J. Robinson,&nbsp;S. Copley,&nbsp;A. Gulve","doi":"10.1016/j.neurom.2025.03.038","DOIUrl":"10.1016/j.neurom.2025.03.038","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S19"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title page","authors":"","doi":"10.1016/S1094-7159(25)00183-7","DOIUrl":"10.1016/S1094-7159(25)00183-7","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page A1"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}