Ying Kang, Feng Xu, Yang Wang, Xiangyue Gao, Weixin Dong, Liansong Lu, Fei Li, Lin Lin, Jiande D Z Chen
{"title":"经皮电刺激对胸腰椎骨折术后恢复的促进作用与交感神经活动和白细胞介素-6抑制相关。","authors":"Ying Kang, Feng Xu, Yang Wang, Xiangyue Gao, Weixin Dong, Liansong Lu, Fei Li, Lin Lin, Jiande D Z Chen","doi":"10.1016/j.neurom.2024.11.011","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Gastrointestinal (GI) disturbance is a frequent complication in patients with thoracolumbar vertebral fracture (TVF). Transcutaneous electrical acustimulation (TEA) has been reported to effectively accelerate postoperative GI function recovery after abdominal surgery. This study aimed to investigate the effects of TEA on postoperative recovery and the associated mechanisms.</p><p><strong>Materials and methods: </strong>A total of 81 patients with TVF who underwent elective posterior pedicle screw fixation surgery were randomized to receive TEA or sham-TEA. TEA at ST36 or sham-TEA at nonacupoints was performed for one hour twice daily, from 24 hours before surgery to postoperative day (POD) 3. The effects were then assessed in the form of a diary at different time points.</p><p><strong>Results: </strong>Compared with sham-TEA, TEA attenuated postoperative impairments associated with lower GI motility, including a reduction in time to defecation by 27.2% (p = 0.002 vs sham-TEA), time to first flatus by 17.2% (p = 0.027), an increase in the Bristol stool score (p = 0.014), and the number of spontaneous bowel movement (p = 0.009). TEA also relieved other GI symptoms including abdominal bloating on POD1 and POD4 (p < 0.001 and p = 0.001, respectively), straining during defecation (p < 0.001), and sensation of anorectal blockage during defecation (p = 0.02). Moreover, TEA reduced the visual analog scale wound pain score on POD1 (p = 0.026), POD2 (p < 0.001), and POD3 (p < 0.001), increased vagal activity, and decreased sympathetic activity (p < 0.001), in addition to suppressing the serum level of norepinephrine on both POD1 (p = 0.047) and POD4 (p = 0.036). TEA caused a higher decrease from POD1 to POD4 in serum interleukin-6 (p = 0.011, vs sham-TEA). The use of TEA was an independent predictor of shortened time to first defecation.</p><p><strong>Conclusion: </strong>Noninvasive TEA at ST36, in comparison with sham-TEA, is effective in promoting postoperative recovery in patients with TVF by enhancing vagal and suppressing sympathetic activities.</p><p><strong>Clinical trial registration: </strong>The study was retrospectively registered on www.chictr.org.cn (Chinese Clinical Trial Registry ChiCTR2300078195).</p>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Accelerative Effects of Transcutaneous Electrical Acustimulation on Postoperative Recovery After Thoracolumbar Vertebral Fracture Associated With Suppressed Sympathetic Activity and Interleukin-6.\",\"authors\":\"Ying Kang, Feng Xu, Yang Wang, Xiangyue Gao, Weixin Dong, Liansong Lu, Fei Li, Lin Lin, Jiande D Z Chen\",\"doi\":\"10.1016/j.neurom.2024.11.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Gastrointestinal (GI) disturbance is a frequent complication in patients with thoracolumbar vertebral fracture (TVF). Transcutaneous electrical acustimulation (TEA) has been reported to effectively accelerate postoperative GI function recovery after abdominal surgery. This study aimed to investigate the effects of TEA on postoperative recovery and the associated mechanisms.</p><p><strong>Materials and methods: </strong>A total of 81 patients with TVF who underwent elective posterior pedicle screw fixation surgery were randomized to receive TEA or sham-TEA. TEA at ST36 or sham-TEA at nonacupoints was performed for one hour twice daily, from 24 hours before surgery to postoperative day (POD) 3. The effects were then assessed in the form of a diary at different time points.</p><p><strong>Results: </strong>Compared with sham-TEA, TEA attenuated postoperative impairments associated with lower GI motility, including a reduction in time to defecation by 27.2% (p = 0.002 vs sham-TEA), time to first flatus by 17.2% (p = 0.027), an increase in the Bristol stool score (p = 0.014), and the number of spontaneous bowel movement (p = 0.009). TEA also relieved other GI symptoms including abdominal bloating on POD1 and POD4 (p < 0.001 and p = 0.001, respectively), straining during defecation (p < 0.001), and sensation of anorectal blockage during defecation (p = 0.02). Moreover, TEA reduced the visual analog scale wound pain score on POD1 (p = 0.026), POD2 (p < 0.001), and POD3 (p < 0.001), increased vagal activity, and decreased sympathetic activity (p < 0.001), in addition to suppressing the serum level of norepinephrine on both POD1 (p = 0.047) and POD4 (p = 0.036). 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Accelerative Effects of Transcutaneous Electrical Acustimulation on Postoperative Recovery After Thoracolumbar Vertebral Fracture Associated With Suppressed Sympathetic Activity and Interleukin-6.
Objectives: Gastrointestinal (GI) disturbance is a frequent complication in patients with thoracolumbar vertebral fracture (TVF). Transcutaneous electrical acustimulation (TEA) has been reported to effectively accelerate postoperative GI function recovery after abdominal surgery. This study aimed to investigate the effects of TEA on postoperative recovery and the associated mechanisms.
Materials and methods: A total of 81 patients with TVF who underwent elective posterior pedicle screw fixation surgery were randomized to receive TEA or sham-TEA. TEA at ST36 or sham-TEA at nonacupoints was performed for one hour twice daily, from 24 hours before surgery to postoperative day (POD) 3. The effects were then assessed in the form of a diary at different time points.
Results: Compared with sham-TEA, TEA attenuated postoperative impairments associated with lower GI motility, including a reduction in time to defecation by 27.2% (p = 0.002 vs sham-TEA), time to first flatus by 17.2% (p = 0.027), an increase in the Bristol stool score (p = 0.014), and the number of spontaneous bowel movement (p = 0.009). TEA also relieved other GI symptoms including abdominal bloating on POD1 and POD4 (p < 0.001 and p = 0.001, respectively), straining during defecation (p < 0.001), and sensation of anorectal blockage during defecation (p = 0.02). Moreover, TEA reduced the visual analog scale wound pain score on POD1 (p = 0.026), POD2 (p < 0.001), and POD3 (p < 0.001), increased vagal activity, and decreased sympathetic activity (p < 0.001), in addition to suppressing the serum level of norepinephrine on both POD1 (p = 0.047) and POD4 (p = 0.036). TEA caused a higher decrease from POD1 to POD4 in serum interleukin-6 (p = 0.011, vs sham-TEA). The use of TEA was an independent predictor of shortened time to first defecation.
Conclusion: Noninvasive TEA at ST36, in comparison with sham-TEA, is effective in promoting postoperative recovery in patients with TVF by enhancing vagal and suppressing sympathetic activities.
Clinical trial registration: The study was retrospectively registered on www.chictr.org.cn (Chinese Clinical Trial Registry ChiCTR2300078195).
期刊介绍：
Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.
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