Neurointervention最新文献

{"title":"Woven EndoBridge Device Migration and Microsnare Retrieval Strategy: Single Institutional Case Reports with Technical Video Demonstration.","authors":"Brandon A Santhumayor, Timothy G White, Cassidy Werner, Kevin Shah, Henry H Woo","doi":"10.5469/neuroint.2023.00136","DOIUrl":"10.5469/neuroint.2023.00136","url":null,"abstract":"<p><p>The Woven EndoBridge (WEB) (MicroVention/Terumo) device is a treatment option for wideneck bifurcation aneurysms. An uncommon adverse effect is WEB device migration. While certain bailout strategies for WEB recovery have been described, there is still a paucity of information on optimal strategies to maximize both short and long-term post-operative outcomes. We add 2 cases at our institution to the existing literature of WEBectomy in the setting of complicated intracranial aneurysm treatment. We discuss the long-term imaging outcomes with additional fluoroscopy video demonstrating our technique. Our findings reflect a clear benefit for the use of the Amplatz GooseneckTM microsnare (Medtronic) device as a means of WEB recovery, coupled with potential stent-assisted WEB embolization to remove the aneurysm from the parent circulation, while minimizing recurrence and thromboembolic complications.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 2","pages":"129-134"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/93/neuroint-2023-00136.PMC10318226.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical Thrombectomy in a 12-Month-Old Infant with Acute Ischemic Stroke Possibly due to Internal Carotid Artery Dissection: A Case Report.","authors":"Leila Afshar Hezarkhani,&nbsp;Saeed Abdollahifard,&nbsp;Mohammad Hossein Mirbolouk,&nbsp;Shohre Hooshmand,&nbsp;Ashkan Mowla,&nbsp;Humain Baharvahdat","doi":"10.5469/neuroint.2023.00045","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00045","url":null,"abstract":"<p><p>Stroke in children is a rare but devastating disease. Although endovascular treatment has been reported to be safe and effective in the treatment of stroke with large vessel occlusion in this population, there are still limitations and controversies. In this case report, we describe a 12-month-old girl who was admitted to the hospital with acute onset of left-sided hemiplegia and confusion, which turned out to be due to a large infarct in the right middle cerebral artery territory, possibly caused by dissection of the right cervical internal carotid artery. Aspiration thrombectomy was successfully performed, and the patient was able to walk a few steps and raise her left upper extremity at the 12-month follow-up. The aspiration-only technique in thrombectomy may be safe and technically feasible to treat acute ischemic stroke with large vessel occlusion in children as young as 12 months, although large-volume prospective studies are needed.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 2","pages":"140-144"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/f6/neuroint-2023-00045.PMC10318220.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous Congestive Myelopathy Caused by Spinal Vascular Malformation.","authors":"Dae Chul Suh","doi":"10.5469/neuroint.2023.00262","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00262","url":null,"abstract":"Vascular myelopathy can be result from either extrinsic or intrinsic spinal cord lesions. Extrinsic pathology results from spinal cord compression and/or injury associated with mass effect. Intrinsic pathology results from spinal cord infarction, hemorrhage and venous congestion. Among intrinsic spinal cord pathology, spinal cord infarction and hemorrhage develop symptoms rather suddenly, whereas venous congestion develops various symptoms gradually. Although spinal vascular malformation is a rare neurovascular disease, it is related to all three intrinsic and even extrinsic pathologies by compressing the spinal cord due to dilated arterial aneurysm or veins. Venous congestion tends to be neglected at the time of diagnosis because of its insidious and vague symptom onset. When spinal dural arteriovenous fistula (SDAVF) develops symptoms, abnormal T2-wighted image or fluid attenuated inversion recovery signal intensity appears on magnetic resonance imaging in the midline scan along the spinal cord.","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 2","pages":"77-79"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/95/neuroint-2023-00262.PMC10318227.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9810985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Arterial Thrombolysis to Improve Final Thrombolysis in Cerebral Infarction Score after Thrombectomy: A Case-Series Analysis.","authors":"Antonio De Mase,&nbsp;Paolo Candelaresi,&nbsp;Emanuele Spina,&nbsp;Flavio Giordano,&nbsp;Stefano Barbato,&nbsp;Giovanna Servillo,&nbsp;Elio Prestipino,&nbsp;Alessandra Fasolino,&nbsp;Gianluigi Guarnieri,&nbsp;Giuseppe Leone,&nbsp;Massimo Muto,&nbsp;Mario Muto,&nbsp;Vincenzo Andreone","doi":"10.5469/neuroint.2023.00052","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00052","url":null,"abstract":"<p><p>Endovascular thrombectomy is the standard treatment in selected patients with acute ischemic stroke and large vessel occlusion, but continuous improvement in angiographic and clinical outcome is still needed. Intra-arterial thrombolysis has been tested as a possible rescue tool in unsuccessful thrombectomy, or as an adjuvant therapy after the endovascular procedure, to pursue complete recanalization. Here we present a case series analysis of intra-arterial alteplase administration (5 mg bolus, repeated up to 15 mg if Thrombolysis in Cerebral Infarction (TICI) scale ≥2c is not achieved) in 15 consecutive anterior circulation stroke patients after unsuccessful thrombectomy, defined as TICI score ≤2b after at least 3 passes or if unsuitable for further endovascular attempts, with the aim of improving recanalization. An improvement of final TICI score was achieved in 10 of 15 patients (66.7%). TICI score ≥2c was achieved after 5 mg intra-arterial tissue plasminogen activator (iaTPA) in 4 patients, and after 10 mg iaTPA in 5 cases. Six of 15 patients received 15 mg iaTPA: 1 of 6 showed angiographical improvement. A major effect of intra-arterial alteplase was observed for distally migrated emboli. None of the patients experienced any symptomatic hemorrhagic transformation or other major bleeding. Our report shows, in a very small cohort, a high rate of final TICI score improvement, encouraging the development of randomized controlled trials of rescue intra-arterial thrombolysis in patients with suboptimal angiographic results after mechanical thrombectomy.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 2","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/ec/neuroint-2023-00052.PMC10318223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9836089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Endovascular Treatment for Posterior Circulation Strokes.","authors":"Sung Hyun Baik,&nbsp;Jun Yup Kim,&nbsp;Cheolkyu Jung","doi":"10.5469/neuroint.2023.00213","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00213","url":null,"abstract":"<p><p>Mechanical thrombectomy for acute posterior circulation strokes (PCSs) is recommended based on evidence from anterior circulation strokes (ACSs). Two recent randomized controlled trials showed that endovascular treatment (EVT) leads to better functional outcomes than those of the best medical care. However, many studies have shown that patients undergoing PC-EVT have a higher rate of futile recanalization than those undergoing AC-EVT. The characteristics and outcomes of PC-EVT may differ according to the pathological mechanisms, including cardioembolism, intracranial atherosclerosis, and tandem vertebrobasilar occlusion. We reviewed PC-EVT outcomes reported in recent studies and discussed technical considerations for maximizing treatment efficacy according to the etiology of a PCS.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 2","pages":"90-106"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/09/neuroint-2023-00213.PMC10318221.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current Limitations and Advanced Analysis of Hemodynamic Study of Cerebral Aneurysms.","authors":"Kwang-Chun Cho","doi":"10.5469/neuroint.2023.00164","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00164","url":null,"abstract":"<p><p>Among the various perspectives on cerebrovascular diseases, hemodynamic analysis-which has recently garnered interest-is of great help in understanding cerebrovascular diseases. Computational fluid dynamics (CFD) analysis has been the primary hemodynamic analysis method, and studies on cerebral aneurysms have been actively conducted. However, owing to the intrinsic limitations of the analysis method, the role of wall shear stress (WSS), the most representative parameter, remains controversial. High WSS affects the formation of cerebral aneurysms; however, no consensus has been reached on the role of WSS in the growth and rupture of cerebral aneurysms. Therefore, this review aimed to briefly introduce the up-to-date results and limitations made through CFD analysis and to inform the need for a new hemodynamic analysis method.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 2","pages":"107-113"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/bb/neuroint-2023-00164.PMC10318229.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Adult Unruptured Brain Arteriovenous Malformations: An Updated Network Meta-Analysis.","authors":"Adam A Dmytriw,&nbsp;Jerry Ku,&nbsp;Sherief Ghozy,&nbsp;Sahibjot Grewal,&nbsp;Nicole M Cancelliere,&nbsp;Ahmed Y Azzam,&nbsp;Robert W Regenhardt,&nbsp;James D Rabinov,&nbsp;Christopher J Stapleton,&nbsp;Krunal Patel,&nbsp;Aman B Patel,&nbsp;Vitor Mendes Pereira,&nbsp;Michael Tymianski","doi":"10.5469/neuroint.2023.00171","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00171","url":null,"abstract":"<p><p>The management of unruptured brain arteriovenous malformations (ubAVMs) is a complex challenge to neurovascular practitioners. This meta-analysis aimed to identify the optimal management of ubAVMs comparing conservative management, embolization, radiosurgery, microsurgical resection, and multimodality. The search strategy was developed a priori according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched the Ovid Medline, Embase, Web of Science, and Cochrane Library databases to identify relevant papers. Using R version 4.1.1., a frequentist network meta-analysis was conducted to compare different management modalities for the ubAVMs. Overall, the conservative group had the lowest risk of rupture (P-score=0.77), and the lowest rate of complications was found in the conservative group (P-score=1). Among different interventions, the multimodality group had the highest rupture risk (P-score=0.34), the lowest overall complications (P-score=0.75), the best functional improvement (P-score=0.65), and the lowest overall mortality (P-score=0.8). However, multimodality treatment showed a significantly higher risk of rupture (odds ratio [OR]=2.13; 95% confidence interval [95% CI]=1.18-3.86) and overall complication rate (OR=5.56; 95% CI=3.37-9.15) compared to conservative management; nevertheless, there were no significant differences in overall mortality or functional independence when considered independently. Conservative management is associated with the lowest rupture risk and complication rate overall. A multimodal approach is the best option when considering mortality rates and functional improvement in the context of existing morbidity/symptoms. Microsurgery, embolization, and radiosurgery alone are similar to the natural history in terms of functional improvement and mortality, but have higher complication rates.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 2","pages":"80-89"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/28/neuroint-2023-00171.PMC10318219.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Puncture of the Superficial Temporal Artery in Embolization of a Scalp Arteriovenous Fistula: A Case Report.","authors":"Gregory B Walker,&nbsp;Alick P Wang,&nbsp;Jeremiah Hadwen,&nbsp;Undrakh-Erdene Erdenebold,&nbsp;Razmik Bebedjian,&nbsp;Patrick Sullivan,&nbsp;Marlise P Santos,&nbsp;Chad Chenier,&nbsp;Stephen Karwaski,&nbsp;Katie Caron,&nbsp;Gabriella Varga,&nbsp;Jennifer Lyon,&nbsp;Howard J Lesiuk,&nbsp;Navraj Heran,&nbsp;Manraj Heran,&nbsp;Aiman Quateen,&nbsp;Brian J Drake,&nbsp;Eduardo Portela De Oliveira,&nbsp;Mario Kontolemos,&nbsp;Robert Fahed","doi":"10.5469/neuroint.2022.00465","DOIUrl":"https://doi.org/10.5469/neuroint.2022.00465","url":null,"abstract":"<p><p>We describe a minimally invasive endovascular approach to treat an arteriovenous fistula of the scalp. We performed a direct puncture of the lesion through the patient's scalp for liquid embolic agent injection along with external compression of the superficial temporal artery to perform a \"manual pressure-cooker technique.\" The combination of these minimally invasive techniques resulted in an excellent clinical and radiographic outcome.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 1","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/f1/neuroint-2022-00465.PMC9986351.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10858839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Experience Using the New pHLO 0.072-inch Large-Bore Catheter for Direct Aspiration Thrombectomy in Acute Ischemic Stroke.","authors":"Giuseppe Leone,&nbsp;Massimo Muto,&nbsp;Flavio Giordano,&nbsp;Gianluigi Guarnieri,&nbsp;Antonio Di Donna,&nbsp;Camilla Russo,&nbsp;Daniele Giuseppe Romano,&nbsp;Paolo Candelaresi,&nbsp;Giovanna Servillo,&nbsp;Emanuele Spina,&nbsp;Antonio De Mase,&nbsp;Vincenzo Andreone,&nbsp;Mario Muto","doi":"10.5469/neuroint.2022.00479","DOIUrl":"https://doi.org/10.5469/neuroint.2022.00479","url":null,"abstract":"<p><strong>Purpose: </strong>A direct aspiration, first pass technique (ADAPT) has been introduced as a rapid and safe thrombectomy strategy in patients with intracranial large vessel occlusion (LVO). The aim of the study is to determine the technical feasibility, safety, and functional outcome of ADAPT using the newly released large bore pHLO 0.072-inch aspiration catheter (AC; Phenox).</p><p><strong>Materials and methods: </strong>We performed a retrospective analysis of data collected prospectively (October 2019-November 2021) from 2 comprehensive stroke centers. Accessibility of the thrombus, vascular recanalization, time to recanalization, and procedure-related complications were evaluated. National Institutes of Health stroke scale scores at presentation and discharge and the modified Rankin scale (mRS) score at 90 days post-procedure were recorded.</p><p><strong>Results: </strong>Twenty-five patients (14 female, 11 male) with occlusions of the anterior circulation were treated. In 84% of cases, ADAPT led to successful recanalization with a median procedure time of 28 minutes. In the remaining cases, successful recanalization required (to a total of 96%; modified thrombolysis in cerebral infarction score 2b/3) the use of stent retrievers. No AC-related complications were reported. Other complications included distal migration of the thrombus, requiring a stent-retriever, and symptomatic PH2 hemorrhage in 16% and 4%, respectively. After 3 months, 52% of the patients had mRS scores of 0-2 with an overall mortality rate of 20%.</p><p><strong>Conclusion: </strong>Results from our retrospective case series revealed that thrombectomy of LVOs with pHLO AC is safe and effective in cases of large-vessel ischemic stroke. Rates of complete or near-complete recanalization after the first pass with this method might be used as a new benchmark in future trials.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 1","pages":"30-37"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0d/6a/neuroint-2022-00479.PMC9986350.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9320759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow Diverter Treatment for Non-Ruptured Carotid Aneurysms: Efficacy and Safety.","authors":"Orlando López-Callejas,&nbsp;Andres F Ortiz-Giraldo,&nbsp;Daniela D Vera,&nbsp;Diego A Ramirez-Rojas,&nbsp;Ana B Villamizar-Barahona,&nbsp;Carlos A Ferreira-Prada,&nbsp;Melquizidel Galvis,&nbsp;Oliverio Vargas-Pérez,&nbsp;Sergio Serrano-Gómez,&nbsp;Adriana Reyes-Gonzalez,&nbsp;Daniel Mantilla","doi":"10.5469/neuroint.2022.00458","DOIUrl":"https://doi.org/10.5469/neuroint.2022.00458","url":null,"abstract":"<p><strong>Purpose: </strong>Internal carotid artery (ICA) aneurysm treatment with a flow diverter (FD) has shown an adequate efficacy and safety profile, presenting high complete occlusion or near occlusion rates with low complications during follow-up. The purpose of this study was to evaluate the efficacy and safety of FD treatment in non-ruptured internal carotid aneurysms.</p><p><strong>Materials and methods: </strong>This is a retrospective, single-center, observational study evaluating patients diagnosed with unruptured ICA aneurysms treated with an FD between January 1, 2014, and January 1, 2020. We analyzed an anonymized database. The primary effectiveness endpoint was complete occlusion (O'Kelly-Marotta D, OKM-D) of the target aneurysm through 1-year follow-up. The safety endpoint was the evaluation of modified Rankin Scale (mRS) 90 days after treatment, considering a favorable outcome an mRS 0-2.</p><p><strong>Results: </strong>A total of 106 patients were treated with an FD, 91.5% were women; the mean follow- up was 427.2±144.8 days. Technical success was achieved in 105 cases (99.1%). All patients included had 1-year follow-up digital subtraction angiography control; 78 patients (73.6%) completed the primary efficacy endpoint by achieving total occlusion (OKM-D). Giant aneurysms had a higher risk of not achieving complete occlusion (risk ratio, 3.07; 95% confidence interval, 1.70 - 5.54]). The safety endpoint of mRS 0-2 at 90 days was accomplished in 103 patients (97.2%).</p><p><strong>Conclusion: </strong>Treatment of unruptured ICA aneurysms with an FD showed high 1-year total occlusion results, with very low morbidity and mortality complications.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":"18 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/fa/neuroint-2022-00458.PMC9986347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10856165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}