Neurointervention最新文献

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Rescue Endovascular Treatment to Prevent Neurological Deterioration in Acute Symptomatic Bilateral Vertebral Artery Occlusion. 抢救血管内治疗预防急性症状性双侧椎动脉闭塞的神经系统恶化。
Neurointervention Pub Date : 2023-11-01 Epub Date: 2023-10-24 DOI: 10.5469/neuroint.2023.00381
Byoung Wook Hwang, Min A Lee, Sang Woo Ha, Jae Ho Kim, Hak Sung Kim, Seong Hwan Ahn
{"title":"Rescue Endovascular Treatment to Prevent Neurological Deterioration in Acute Symptomatic Bilateral Vertebral Artery Occlusion.","authors":"Byoung Wook Hwang,&nbsp;Min A Lee,&nbsp;Sang Woo Ha,&nbsp;Jae Ho Kim,&nbsp;Hak Sung Kim,&nbsp;Seong Hwan Ahn","doi":"10.5469/neuroint.2023.00381","DOIUrl":"10.5469/neuroint.2023.00381","url":null,"abstract":"<p><p>Bilateral vertebral artery occlusive disease has been considered as a favorable condition with good collaterals. However, the prognosis of acute ischemic stroke secondary to symptomatic bilateral vertebral artery occlusion (BVAO) and endovascular treatment (EVT) has rarely been reported. We retrospectively selected patients with acute ischemic stroke admitted for symptomatic BVAO between January 2020 and February 2023. All patients with ischemic stroke were evaluated for ischemic lesion and arterial status using brain imaging and angiography. The prognosis of acute stroke with symptomatic BVAO was compared between EVT and conventional treatment. Outcomes were evaluated using modified Rankin Scale (mRS) score at 3 months follow-up. Within the study period, 17 of 2,655 acute ischemic stroke patients were diagnosed with ischemic stroke with symptomatic BVAO. The median age of these patients was 70 (interquartile range 44-89) years, and 13 (76%) were male. Seven patients received emergent EVT with stenting and 10 patients received conventional medical treatment only. Nine of 10 patients with conventional treatment had in-hospital stroke progression and developed new ischemic lesions in the pons and midbrain. Five patients with fetal and hypoplastic posterior communicating artery presented bilateral cerebral peduncular lesions. At 3 months follow-up, 6 patients (35%) had favorable outcomes (mRS 0-2), of which 5 were treated with vertebral artery stenting and 1 received conventional treatment. Ischemic stroke in patients with acute symptomatic BVAO is uncommon. However, stroke progression is common, and the prognosis of most patients is poor. Rescue management such as EVT might be considered for symptomatic BVAO.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adoption of Artificial Intelligence, Preprints, Open Peer Review, Model Text Recycling Policies, Best Practice in Scholarly Publishing: Comment. 人工智能的采用,预印本,开放同行评审,模型文本回收政策,学术出版的最佳实践:评论。
Neurointervention Pub Date : 2023-07-01 DOI: 10.5469/neuroint.2023.00087
Amnuay Kleebayoon, Viroj Wiwanitkit
{"title":"Adoption of Artificial Intelligence, Preprints, Open Peer Review, Model Text Recycling Policies, Best Practice in Scholarly Publishing: Comment.","authors":"Amnuay Kleebayoon,&nbsp;Viroj Wiwanitkit","doi":"10.5469/neuroint.2023.00087","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00087","url":null,"abstract":"","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/78/neuroint-2023-00087.PMC10318228.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9809960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to the Comment on Adoption of Artificial Intelligence, Preprints, Open Peer Review, Model Text Recycling Policies, Best Practice in Scholarly Publishing: Comment. 关于采用人工智能、预印本、开放同行评审、模型文本回收政策、学术出版最佳实践的评论回复:评论。
Neurointervention Pub Date : 2023-07-01 DOI: 10.5469/neuroint.2023.00115
Sun Huh
{"title":"Reply to the Comment on Adoption of Artificial Intelligence, Preprints, Open Peer Review, Model Text Recycling Policies, Best Practice in Scholarly Publishing: Comment.","authors":"Sun Huh","doi":"10.5469/neuroint.2023.00115","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00115","url":null,"abstract":"","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/51/neuroint-2023-00115.PMC10318224.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9809965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Safety and Diagnostic Efficacy of Iohexol 240 mgI/mL, Iopamidol 250 mgI/mL, and Iodixanol 270 mgI/mL in Cerebral Angiography: A Prospective, Multicenter Study. 比较碘海醇 240 毫克碘/毫升、碘帕米醇 250 毫克碘/毫升和碘克沙醇 270 毫克碘/毫升在脑血管造影中的安全性和诊断效果:一项前瞻性多中心研究。
IF 1.2
Neurointervention Pub Date : 2023-07-01 Epub Date: 2024-06-05 DOI: 10.5469/neuroint.2024.00129
Jinwook Baek, Hae Woong Jeong, Young Jin Heo, Suyoung Yun, Myongjin Kang, Byungjun Kim, Eui Jong Kim, Soo Mee Lim, Boeun Lee
{"title":"Comparison of Safety and Diagnostic Efficacy of Iohexol 240 mgI/mL, Iopamidol 250 mgI/mL, and Iodixanol 270 mgI/mL in Cerebral Angiography: A Prospective, Multicenter Study.","authors":"Jinwook Baek, Hae Woong Jeong, Young Jin Heo, Suyoung Yun, Myongjin Kang, Byungjun Kim, Eui Jong Kim, Soo Mee Lim, Boeun Lee","doi":"10.5469/neuroint.2024.00129","DOIUrl":"10.5469/neuroint.2024.00129","url":null,"abstract":"<p><strong>Purpose: </strong>This multicenter prospective study aimed to evaluate the quality and diagnostic effectiveness of cerebral angiography images obtained using low-concentration iodinated contrast agents (iohexol 240 mgI/mL, iopamidol 250 mgI/mL, and iodixanol 270 mgI/mL) and to assess the safety thereof. The study addresses the need for safer contrast agent alternatives without compromising the diagnostic quality of identifying cerebrovascular disease.</p><p><strong>Materials and methods: </strong>Conducted in 5 medical centers in South Korea, we enrolled patients aged 19 years or older who were referred for diagnostic cerebral angiography under non-emergency conditions, excluding those with specific health conditions and sensitivities. The study design included a prospective, observational approach with a 1-way analysis of variance (ANOVA) for sample size calculation, aiming for a total sample of 231 participants for adequate power. Image quality was evaluated using a 4-level scale by 2 independent, blinded radiologists, and adverse reactions were monitored both immediately and up to 7 days post-procedure. Statistical analysis involved 1-way ANOVA and Kruskal-Wallis tests to assess the image quality and safety profiles of the contrast agents.</p><p><strong>Results: </strong>Among 266 patients screened, 243 were included in the final analysis. The evaluation revealed no statistically significant differences in image quality among the 3 types of low-concentration contrast agents. Adverse events were observed in 28.8% of patients, with 27.2% experiencing acute reactions, primarily mild reactions, and 3.3% experiencing delayed reactions. The overall safety profile showed no significant changes in vital signs or electrocardiogram readings before and after contrast agent injection.</p><p><strong>Conclusion: </strong>Using low-concentration iodinated contrast agents for cerebral angiography provides image quality comparable to that of conventional high-concentration agents, with no significant increase in adverse events, suggesting a safer alternative for patients.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obscured Segments of Ruptured Brain Arteriovenous Malformations: Insights from Their Visualization during Emergency Transarterial Embolization. 脑动静脉畸形破裂的模糊片段:急诊经动脉栓塞时的可视化观察。
Neurointervention Pub Date : 2023-07-01 DOI: 10.5469/neuroint.2023.00150
Jieun Roh, Seung Kug Baik, Jeong A Yeom, Sang-Won Lee
{"title":"Obscured Segments of Ruptured Brain Arteriovenous Malformations: Insights from Their Visualization during Emergency Transarterial Embolization.","authors":"Jieun Roh,&nbsp;Seung Kug Baik,&nbsp;Jeong A Yeom,&nbsp;Sang-Won Lee","doi":"10.5469/neuroint.2023.00150","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00150","url":null,"abstract":"<p><p>A ruptured brain arteriovenous malformation (bAVM) presenting with a hematoma may have unseen parts of the shunts in diagnostic angiography in the acute phase, which may lead to innate incomplete evaluation for the whole angioarchitecture of the bAVM. Even though it is generally accepted that the nidus of a ruptured bAVM may be underestimated in angiography during the acute phase due to hematoma compression, documentation of the underestimated parts has not been described in the literature. The authors report 2 cases of ruptured bAVMs in which the obscured segments were cast with liquid embolic material, which suggests a potential presence of obscured segments in bAVMs.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/7c/neuroint-2023-00150.PMC10318225.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9754887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flow Diverter Treatment Using a Flow Re-Direction Endoluminal Device for Unruptured Intracranial Vertebral Artery Dissecting Aneurysm: Single-Center Case Series and Technical Considerations. 使用流量重定向腔内装置分流治疗未破裂的颅内椎动脉夹层动脉瘤:单中心病例系列和技术考虑。
Neurointervention Pub Date : 2023-07-01 DOI: 10.5469/neuroint.2023.00199
Dae Chul Suh, Yunsun Song, Sang Ik Park, Boseong Kwon
{"title":"Flow Diverter Treatment Using a Flow Re-Direction Endoluminal Device for Unruptured Intracranial Vertebral Artery Dissecting Aneurysm: Single-Center Case Series and Technical Considerations.","authors":"Dae Chul Suh,&nbsp;Yunsun Song,&nbsp;Sang Ik Park,&nbsp;Boseong Kwon","doi":"10.5469/neuroint.2023.00199","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00199","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effectiveness, safety, and technical considerations of flow diverter (FD) treatment using a Flow Re-direction Endoluminal Device (FRED) for unruptured intracranial vertebral artery dissecting aneurysms (VADAs).</p><p><strong>Materials and methods: </strong>We conducted a retrospective study of 23 patients with unruptured intracranial VADAs who underwent FD treatment using a FRED between June 2017 and August 2021. Symptoms, imaging findings, treatment strategies, and angiographic and clinical outcomes were evaluated. Dissections were categorized according to the dominance of the VA in which they occurred: dominant VA, co-dominant VA, and non-dominant VA.</p><p><strong>Results: </strong>All patients successfully underwent FD treatment with either a FRED (n=11) or FRED Jr. (n=12). Complete occlusion rates were 78.3% at 6-month follow-up magnetic resonance angiography and 91.3% at 12-month. There were no instances of complications, recurrence, or retreatment during a median follow-up of 20 months. Dissections occurred in the dominant VA in 3 cases (13.0%), the co-dominant VA in 13 cases (56.5%), and the non-dominant VA in 7 cases (30.4%). Intimal flap and true lumen stenosis were observed in 39.1% and 30.4% of cases, respectively. Four cases required a bilateral VA approach due to technical difficulties, all in the non-dominant VA.</p><p><strong>Conclusion: </strong>Flow diversion treatment using a FRED for unruptured intracranial VADAs proved feasible and safe, yielding satisfactory occlusion rates. Technical challenges were more likely in lesions involving non-dominant VAs in the acute or subacute stage, mainly due to associated intraluminal lesions compromising the arterial lumen.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/88/neuroint-2023-00199.PMC10318222.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanical Thrombectomy in a 12-Month-Old Infant with Acute Ischemic Stroke Possibly due to Internal Carotid Artery Dissection: A Case Report. 机械取栓术治疗可能因颈内动脉夹层引起的12月龄婴儿急性缺血性脑卒中1例。
Neurointervention Pub Date : 2023-07-01 DOI: 10.5469/neuroint.2023.00045
Leila Afshar Hezarkhani, Saeed Abdollahifard, Mohammad Hossein Mirbolouk, Shohre Hooshmand, Ashkan Mowla, Humain Baharvahdat
{"title":"Mechanical Thrombectomy in a 12-Month-Old Infant with Acute Ischemic Stroke Possibly due to Internal Carotid Artery Dissection: A Case Report.","authors":"Leila Afshar Hezarkhani,&nbsp;Saeed Abdollahifard,&nbsp;Mohammad Hossein Mirbolouk,&nbsp;Shohre Hooshmand,&nbsp;Ashkan Mowla,&nbsp;Humain Baharvahdat","doi":"10.5469/neuroint.2023.00045","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00045","url":null,"abstract":"<p><p>Stroke in children is a rare but devastating disease. Although endovascular treatment has been reported to be safe and effective in the treatment of stroke with large vessel occlusion in this population, there are still limitations and controversies. In this case report, we describe a 12-month-old girl who was admitted to the hospital with acute onset of left-sided hemiplegia and confusion, which turned out to be due to a large infarct in the right middle cerebral artery territory, possibly caused by dissection of the right cervical internal carotid artery. Aspiration thrombectomy was successfully performed, and the patient was able to walk a few steps and raise her left upper extremity at the 12-month follow-up. The aspiration-only technique in thrombectomy may be safe and technically feasible to treat acute ischemic stroke with large vessel occlusion in children as young as 12 months, although large-volume prospective studies are needed.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/f6/neuroint-2023-00045.PMC10318220.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venous Congestive Myelopathy Caused by Spinal Vascular Malformation. 由脊髓血管畸形引起的静脉充血性脊髓病。
Neurointervention Pub Date : 2023-07-01 DOI: 10.5469/neuroint.2023.00262
Dae Chul Suh
{"title":"Venous Congestive Myelopathy Caused by Spinal Vascular Malformation.","authors":"Dae Chul Suh","doi":"10.5469/neuroint.2023.00262","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00262","url":null,"abstract":"Vascular myelopathy can be result from either extrinsic or intrinsic spinal cord lesions. Extrinsic pathology results from spinal cord compression and/or injury associated with mass effect. Intrinsic pathology results from spinal cord infarction, hemorrhage and venous congestion. Among intrinsic spinal cord pathology, spinal cord infarction and hemorrhage develop symptoms rather suddenly, whereas venous congestion develops various symptoms gradually. Although spinal vascular malformation is a rare neurovascular disease, it is related to all three intrinsic and even extrinsic pathologies by compressing the spinal cord due to dilated arterial aneurysm or veins. Venous congestion tends to be neglected at the time of diagnosis because of its insidious and vague symptom onset. When spinal dural arteriovenous fistula (SDAVF) develops symptoms, abnormal T2-wighted image or fluid attenuated inversion recovery signal intensity appears on magnetic resonance imaging in the midline scan along the spinal cord.","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/95/neuroint-2023-00262.PMC10318227.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9810985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Woven EndoBridge Device Migration and Microsnare Retrieval Strategy: Single Institutional Case Reports with Technical Video Demonstration. 编织 EndoBridge 装置迁移和微针回收策略:单个机构病例报告及技术视频演示。
IF 1.2
Neurointervention Pub Date : 2023-07-01 Epub Date: 2023-05-03 DOI: 10.5469/neuroint.2023.00136
Brandon A Santhumayor, Timothy G White, Cassidy Werner, Kevin Shah, Henry H Woo
{"title":"Woven EndoBridge Device Migration and Microsnare Retrieval Strategy: Single Institutional Case Reports with Technical Video Demonstration.","authors":"Brandon A Santhumayor, Timothy G White, Cassidy Werner, Kevin Shah, Henry H Woo","doi":"10.5469/neuroint.2023.00136","DOIUrl":"10.5469/neuroint.2023.00136","url":null,"abstract":"<p><p>The Woven EndoBridge (WEB) (MicroVention/Terumo) device is a treatment option for wideneck bifurcation aneurysms. An uncommon adverse effect is WEB device migration. While certain bailout strategies for WEB recovery have been described, there is still a paucity of information on optimal strategies to maximize both short and long-term post-operative outcomes. We add 2 cases at our institution to the existing literature of WEBectomy in the setting of complicated intracranial aneurysm treatment. We discuss the long-term imaging outcomes with additional fluoroscopy video demonstrating our technique. Our findings reflect a clear benefit for the use of the Amplatz GooseneckTM microsnare (Medtronic) device as a means of WEB recovery, coupled with potential stent-assisted WEB embolization to remove the aneurysm from the parent circulation, while minimizing recurrence and thromboembolic complications.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/93/neuroint-2023-00136.PMC10318226.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-Arterial Thrombolysis to Improve Final Thrombolysis in Cerebral Infarction Score after Thrombectomy: A Case-Series Analysis. 动脉溶栓提高取栓后脑梗死评分的最终溶栓率:一项病例系列分析。
Neurointervention Pub Date : 2023-07-01 DOI: 10.5469/neuroint.2023.00052
Antonio De Mase, Paolo Candelaresi, Emanuele Spina, Flavio Giordano, Stefano Barbato, Giovanna Servillo, Elio Prestipino, Alessandra Fasolino, Gianluigi Guarnieri, Giuseppe Leone, Massimo Muto, Mario Muto, Vincenzo Andreone
{"title":"Intra-Arterial Thrombolysis to Improve Final Thrombolysis in Cerebral Infarction Score after Thrombectomy: A Case-Series Analysis.","authors":"Antonio De Mase,&nbsp;Paolo Candelaresi,&nbsp;Emanuele Spina,&nbsp;Flavio Giordano,&nbsp;Stefano Barbato,&nbsp;Giovanna Servillo,&nbsp;Elio Prestipino,&nbsp;Alessandra Fasolino,&nbsp;Gianluigi Guarnieri,&nbsp;Giuseppe Leone,&nbsp;Massimo Muto,&nbsp;Mario Muto,&nbsp;Vincenzo Andreone","doi":"10.5469/neuroint.2023.00052","DOIUrl":"https://doi.org/10.5469/neuroint.2023.00052","url":null,"abstract":"<p><p>Endovascular thrombectomy is the standard treatment in selected patients with acute ischemic stroke and large vessel occlusion, but continuous improvement in angiographic and clinical outcome is still needed. Intra-arterial thrombolysis has been tested as a possible rescue tool in unsuccessful thrombectomy, or as an adjuvant therapy after the endovascular procedure, to pursue complete recanalization. Here we present a case series analysis of intra-arterial alteplase administration (5 mg bolus, repeated up to 15 mg if Thrombolysis in Cerebral Infarction (TICI) scale ≥2c is not achieved) in 15 consecutive anterior circulation stroke patients after unsuccessful thrombectomy, defined as TICI score ≤2b after at least 3 passes or if unsuitable for further endovascular attempts, with the aim of improving recanalization. An improvement of final TICI score was achieved in 10 of 15 patients (66.7%). TICI score ≥2c was achieved after 5 mg intra-arterial tissue plasminogen activator (iaTPA) in 4 patients, and after 10 mg iaTPA in 5 cases. Six of 15 patients received 15 mg iaTPA: 1 of 6 showed angiographical improvement. A major effect of intra-arterial alteplase was observed for distally migrated emboli. None of the patients experienced any symptomatic hemorrhagic transformation or other major bleeding. Our report shows, in a very small cohort, a high rate of final TICI score improvement, encouraging the development of randomized controlled trials of rescue intra-arterial thrombolysis in patients with suboptimal angiographic results after mechanical thrombectomy.</p>","PeriodicalId":19140,"journal":{"name":"Neurointervention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/ec/neuroint-2023-00052.PMC10318223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9836089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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