Neurology International最新文献_第9页

Adult Case of Pontocerebellar Hypoplasia without the Claustrum. 无胼胝体的桥小脑发育不全成人病例

IF 3.2

Neurology International Pub Date : 2024-10-07 DOI: 10.3390/neurolint16050085

Koji Hayashi, Shiho Mitsuhashi, Ei Kawahara, Asuka Suzuki, Yuka Nakaya, Mamiko Sato, Yasutaka Kobayashi

{"title":"Adult Case of Pontocerebellar Hypoplasia without the Claustrum.","authors":"Koji Hayashi, Shiho Mitsuhashi, Ei Kawahara, Asuka Suzuki, Yuka Nakaya, Mamiko Sato, Yasutaka Kobayashi","doi":"10.3390/neurolint16050085","DOIUrl":"https://doi.org/10.3390/neurolint16050085","url":null,"abstract":"We describe the case of a 63-year-old man with pontocerebellar hypoplasia without the claustrum (CL). The patient had a history of cerebral palsy, intelligent disability, cerebellar atrophy, and seizures since birth. At age 61, brain computed tomography (CT) revealed significant cerebellar and brainstem atrophy. At age 63, he was admitted to our hospital for aspiration pneumonia. Although he was treated with medications, including antibiotics, he died one month after admission. The autopsy revealed a total brain weight of 815 g, with the small-sized frontal lobe, cerebellum, and pons. The cross-section of the fourth ventricle had a slit-like appearance, rather than the typical diamond shape. In addition, bilateral CLs were not observed. Apart from CL, no other missing brain tissue or cells could be identified. Microscopic examinations disclosed neurofibrillary tangles in the hippocampus but not in the cortex; however, neither senile plaques nor Lewy bodies were detected. No acquired lesions, including cerebral infarction, hemorrhage, or necrosis, were noted. We pathologically diagnosed the patient with pontocerebellar hypoplasia without CL. As there have been no prior reports of pontocerebellar hypoplasia lacking CL in adults, this case may represent a new subtype. Congenital CL deficiency is likely associated with abnormalities in brain development. CL may play a role in seizure activity, and the loss of bilateral CLs does not necessarily result in immediate death. Further studies are needed to clarify the functions of CL.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1132-1142"},"PeriodicalIF":3.2,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging Processes of Working Memory in Different Modalities. 不同模式下工作记忆的衰老过程

IF 3.2

Neurology International Pub Date : 2024-09-30 DOI: 10.3390/neurolint16050084

Ohad Levi, Eyal Heled

{"title":"Aging Processes of Working Memory in Different Modalities.","authors":"Ohad Levi, Eyal Heled","doi":"10.3390/neurolint16050084","DOIUrl":"https://doi.org/10.3390/neurolint16050084","url":null,"abstract":"Background: Working memory (WM) involves temporarily storing and manipulating information. Research on the impact of aging on WM has shown inconsistent results regarding the decline in visual and verbal WM, with a lack of studies on tactile WM. This study aimed to assess the effects of aging on WM across verbal, visuospatial, and tactile modalities using span tasks of forward (storage) and backward (manipulation) stages. Methods: A total of 130 participants, divided into four age groups of 20-29, 60-69, 70-79, and 80-89, completed the Digit, Visuospatial, and Tactual Spans. Performance was analyzed using a 3 (Task) × 4 (Group) × 2 (Stage) mixed design repeated measures ANOVA. Results: The analysis revealed significant main effects for modality (p < 0.001, ηp2 = 0.15), age (p < 0.001, ηp2 = 0.48), and stage (p < 0.001, ηp2 = 0.30). Digit Span outperformed the other modalities, while Tactual Span showed the worst performance. Additionally, task performance declined with age, and the forward stage was superior to the backward stage. Interaction effects indicated that Digit Span was less affected by aging compared to the Visuospatial and Tactual Spans (p = 0.004, ηp2 = 0.07). Post hoc analyses further revealed that the Digit Span consistently outperformed the other modalities in both stages, with more pronounced differences observed in the forward stage. Conclusions: Verbal WM is more resilient to aging compared to the other modalities while tactile WM declines with age in a manner similar to verbal and visuospatial WM, suggesting a modality-specific impact of aging on WM.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1122-1131"},"PeriodicalIF":3.2,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Froin's Syndrome: A Comprehensive Review of the Literature and the Addition of Two New Cases. 弗罗因综合征：文献综述及两例新病例。

IF 3.2

Neurology International Pub Date : 2024-09-29 DOI: 10.3390/neurolint16050083

Lucas Jacobs, Bertil Delsaut, Marta Lamartine S Monteiro, Audrey Cambier, Ibrahim Alcan, Evelyne Maillart, Maxime Taghavi

{"title":"Froin's Syndrome: A Comprehensive Review of the Literature and the Addition of Two New Cases.","authors":"Lucas Jacobs, Bertil Delsaut, Marta Lamartine S Monteiro, Audrey Cambier, Ibrahim Alcan, Evelyne Maillart, Maxime Taghavi","doi":"10.3390/neurolint16050083","DOIUrl":"https://doi.org/10.3390/neurolint16050083","url":null,"abstract":"Background: Froin's syndrome (FS) is a rare entity with uncertain prevalence and prognosis, defined by a pathognomonic triad: cerebrospinal fluid (CSF) xanthochromia, elevated protein levels in the CSF, and hypercoagulated CSF, usually obtained through lumbar puncturing below the level of a partial or complete spinal block.Methods: We conducted a comprehensive review of the literature on FS from its first description in 1903 to December 2023, utilizing PubMed and Google Scholar, and included two new cases from our clinical practice.Results: We describe two patients who suffered from Froin's syndrome secondary to spinal abscesses. According to our review, FS is caused by neoplasia in 33% of cases, non-malignant mechanical causes in 27%, infections in 27%, non-infectious inflammatory processes in 6%, and vascular in 6%. The most prevalent symptoms are paraplegia/paraparesis (64%), back pain (38%), altered mental state and/or confusion (23%), sciatica (17%), headaches (17%), leg sensory defects (17%), and urinary retention (14%), and are thought to be linked with the underlying causes rather than the CSF characteristics. FS holds a poor prognosis: only 22% recuperate fully after treatment, 22% die due to the cause leading to FS, and 14% retain sequelae.Conclusions: Xanthochromia and proteinorachia >500 mg/dL are not specific to any single pathological condition, but indicate defective CSF recirculation and spinal block, causing diffusive and/or inflammatory processes resulting in the hyperproteinosis and coagulation of the CSF. We reviewed the pathophysiology, etiologies, symptoms, outcomes, and workups of Froin's syndrome according to the existing medical literature.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1112-1121"},"PeriodicalIF":3.2,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Properties of Rutin Hydrate against Scopolamine-Induced Deficits in BDNF/TrkB/ERK/CREB/Bcl2 Pathways. 芦丁水合物对东莨菪碱诱导的 BDNF/TrkB/ERK/CREB/Bcl2 通路缺陷的神经保护特性

IF 3.2

Neurology International Pub Date : 2024-09-27 DOI: 10.3390/neurolint16050082

Inturu Sreelatha, Ga-Young Choi, In-Seo Lee, Omkaram Inturu, Hyun-Sook Lee, Yea-Na Park, Cheol-Won Lee, Inkyou Yang, Sungho Maeng, Ji-Ho Park

{"title":"Neuroprotective Properties of Rutin Hydrate against Scopolamine-Induced Deficits in BDNF/TrkB/ERK/CREB/Bcl2 Pathways.","authors":"Inturu Sreelatha, Ga-Young Choi, In-Seo Lee, Omkaram Inturu, Hyun-Sook Lee, Yea-Na Park, Cheol-Won Lee, Inkyou Yang, Sungho Maeng, Ji-Ho Park","doi":"10.3390/neurolint16050082","DOIUrl":"https://doi.org/10.3390/neurolint16050082","url":null,"abstract":"Background/Objectives: Alzheimer's disease (AD) is an age-related degenerative brain disorder characterized by a progressive decline in cognitive function and memory. This study aimed to evaluate whether rutin hydrate (RH) has neuroprotective effects in an AD-like learning and memory impairment rat model induced by scopolamine (SCO). Methods: The rats were administered with RH (100 mg/kg) and SCO (1.5 mg/kg) and underwent behavioral tests, including the Morris water maze test, Y-maze test, and passive avoidance test, to evaluate their learning and memory abilities. Additionally, long-term potentiation (LTP) was induced to observe changes in the field excitatory postsynaptic potential (fEPSP) activity. Results: RH treatment attenuated the SCO-induced shortening of step-through latency in the passive avoidance (PA) test, increased the percentage of alternation in the Y-maze, and increased the time spent in the target zone in the Morris water maze (MWM). Moreover, RH increased the total activity of fEPSP following theta burst stimulation and attenuated the SCO-induced blockade of fEPSP. RH also ameliorated the SCO-induced decrease in the expression levels of the BDNF, TrkB, ERK, CREB, and Bcl-2 proteins and the increase in the Bax protein level in the rat hippocampus. This demonstrates that RH has beneficial neuroprotective effects in the brain, improving learning, memory, and synaptic plasticity in rats. Conclusions: Our results highlight the molecular and cellular mechanisms through which RH exerts its neuroprotective effects in the prevention and treatment of learning and memory deficit disorders. RH could potentially be used as a therapeutic strategy for the restoration of learning and memory function and the prevention of the progression of AD.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1094-1111"},"PeriodicalIF":3.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity and Reliability of the Japanese Version of the Frontal Assessment Battery in Patients with Stroke. 脑卒中患者额叶评估测验日文版的有效性和可靠性

IF 3.2

Neurology International Pub Date : 2024-09-25 DOI: 10.3390/neurolint16050081

Katsuya Sakai, Yuichiro Hosoi, Yusuke Harada, Kenji Morikawa, Yuichi Kato

{"title":"Validity and Reliability of the Japanese Version of the Frontal Assessment Battery in Patients with Stroke.","authors":"Katsuya Sakai, Yuichiro Hosoi, Yusuke Harada, Kenji Morikawa, Yuichi Kato","doi":"10.3390/neurolint16050081","DOIUrl":"https://doi.org/10.3390/neurolint16050081","url":null,"abstract":"Background: The Frontal Assessment Battery (FAB), which is used to assess executive function, has been translated into several languages and shown to be valid and reliable. However, the validity and reliability of the Japanese version in patients with stroke are unknown. This study aimed to investigate the validity and reliability of the Japanese version of the FAB in patients with stroke.Methods: The Japanese version of the FAB for dementia was modified and evaluated in 52 patients with stroke. FAB measurements were obtained twice over a 10-day period. Convergent validity was assessed using the Stroop Color Word Test (SCWT) and the Trail Making Test (TMT) part B. Internal consistency was measured using Cronbach's alpha (Cα). Test-retest evaluations were performed using intraclass correlation coefficient [ICC (2.1)] measurements, and limits of agreement (LOA) were calculated using the total FAB score.Results: The mean total FAB score was 13.4 ± 2.8 points, the ICC (2.1) was 0.856, and Cα was 0.92. The total FAB score was correlated with SCWT scores for parts I through IV (r = 0.70 to 0.77) and the TMT score for part B (ρ = -0.53). The LOA were -1.7 to 2.9 points.Conclusions: The Japanese version of the FAB had higher validity and reliability in patients with stroke.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1086-1093"},"PeriodicalIF":3.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contrasting Effects of an Atherogenic Diet and High-Protein/Unsaturated Fatty Acids Diet on the Accelerated Aging Mouse Model SAMP8 Phenotype. 致动脉粥样硬化饮食和高蛋白/不饱和脂肪酸饮食对加速衰老模型 SAMP8 表型的不同影响

IF 3.2

Neurology International Pub Date : 2024-09-23 DOI: 10.3390/neurolint16050080

Jesús Llanquinao, Claudia Jara, Daniela Cortés-Díaz, Bredford Kerr, Cheril Tapia-Rojas

{"title":"Contrasting Effects of an Atherogenic Diet and High-Protein/Unsaturated Fatty Acids Diet on the Accelerated Aging Mouse Model SAMP8 Phenotype.","authors":"Jesús Llanquinao, Claudia Jara, Daniela Cortés-Díaz, Bredford Kerr, Cheril Tapia-Rojas","doi":"10.3390/neurolint16050080","DOIUrl":"https://doi.org/10.3390/neurolint16050080","url":null,"abstract":"Background/Objectives: Aging has been extensively studied, with a growing interest in memory impairment by a neurobiological approach. Mitochondrial dysfunction is a hallmark of aging, contributing to the aging phenotype; therefore, mitochondrial interventions seem fundamental. The diet is a physiological approximation for modifying mitochondria, which could impact the age-related phenotype. Methods: We studied two diets with low-carbohydrate and high-fat compositions, differing in the amount of protein and the fat type disposable-the atherogenic diet Cocoa (high protein/high saturated fat/high cholesterol) and the South Beach diet (very high-protein/high-unsaturated fat)-on oxidative stress, mitochondrial state, and hippocampus-dependent memory in 3-month-old Senescence-Accelerated Mouse Model (SAMP8) seed over 3 months to determine their pro- or anti-aging effects. Results: Despite its bad reputation, the Cocoa diet reduces the reactive oxygen species (ROS) content without impacting the energy state and hippocampus-dependent spatial acuity. In contrast to the beneficial impact proposed for the South Beach diet, it induced a pro-aging phenotype, increasing oxidative damage and the levels of NR2B subunit of the NMDA, impairing energy and spatial acuity. Surprisingly, despite the negative changes observed with both diets, this led to subtle memory impairment, suggesting the activation of compensatory mechanisms preventing more severe cognitive decline. Conclusions: Our results demonstrated that diets usually considered good could be detrimental to the onset of aging. Also, probably due to the brain plasticity of non-aged animals, they compensate for the damage, preventing a more aggravated phenotype. Nevertheless, these silent changes could predispose or increase the risk of suffering pathologies at advanced age.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1066-1085"},"PeriodicalIF":3.2,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts. 散发性克雅氏病的系统回顾：发病机制、诊断和治疗尝试。

IF 3.2

Neurology International Pub Date : 2024-09-20 DOI: 10.3390/neurolint16050079

Maria Carolina Jurcau, Anamaria Jurcau, Razvan Gabriel Diaconu, Vlad Octavian Hogea, Vharoon Sharma Nunkoo

引用次数: 0

Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve. 通过弥散张量成像 (DTI) 预测正中神经外伤患者的预后。

IF 3.2

Neurology International Pub Date : 2024-09-19 DOI: 10.3390/neurolint16050078

Théa Voser, Manuel Martin, Issiaka Muriset, Michaela Winkler, Jean-Baptiste Ledoux, Yasser Alemán-Gómez, Sébastien Durand

{"title":"Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve.","authors":"Théa Voser, Manuel Martin, Issiaka Muriset, Michaela Winkler, Jean-Baptiste Ledoux, Yasser Alemán-Gómez, Sébastien Durand","doi":"10.3390/neurolint16050078","DOIUrl":"10.3390/neurolint16050078","url":null,"abstract":"Background/Objectives: The accurate quantification of peripheral nerve axonal regeneration after injury is critically important. Current strategies are limited to detecting early reinnervation. DTI is an MRI modality permitting the assessment of fractional anisotropy, which increases with axonal regeneration. The aim of this pilot study is to evaluate DTI as a potential predictive factor of clinical outcome after median nerve section and microsurgical repair. Methods: We included 10 patients with a complete section of the median nerve, who underwent microsurgical repair up to 7 days after injury. The follow-up period was 1 year, including the current strategy with clinical visits, the Rosén-Lundborg score and electroneuromyography. Additionally, DTI MRI of the injured wrist was planned 1, 3 and 12 months post-operatively and once for the contralateral wrist. Results: The interobserver reliability of DTI measures was almost perfect (ICC 0.802). We report an early statistically significant increase in the fractional anisotropy value after median nerve repair, especially in the region located distal to the suture. Meanwhile, Rosén-Lundborg score gradually increased between the third and sixth month, and continued to increase between the sixth and twelfth month. Conclusions: DTI outcomes three months post-operation could offer greater predictability compared to current strategies. This would enable faster decision-making regarding the need for a potential re-operation in cases of inadequate early reinnervation.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1026-1038"},"PeriodicalIF":3.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterograde Intramedullary Nailing without Bone Grafting for Humeral Shaft Nonunion Associated with Early Exploration of Secondary Radial Nerve Palsy: A Case Report. 无需植骨的前行髓内钉治疗伴有继发性桡神经麻痹的肱骨轴不连：病例报告。

IF 3.2

Neurology International Pub Date : 2024-09-15 DOI: 10.3390/neurolint16050077

Dan Viorel Nistor, Răzvan Marian Melinte, Romana von Mengershausen

{"title":"Anterograde Intramedullary Nailing without Bone Grafting for Humeral Shaft Nonunion Associated with Early Exploration of Secondary Radial Nerve Palsy: A Case Report.","authors":"Dan Viorel Nistor, Răzvan Marian Melinte, Romana von Mengershausen","doi":"10.3390/neurolint16050077","DOIUrl":"10.3390/neurolint16050077","url":null,"abstract":"Background: Humeral shaft fractures are relatively common. Complications associated with this type of fracture and its treatment include nonunion and radial nerve palsy. Plate osteosynthesis with autologous bone grafting is considered the gold standard for treating nonunion. However, bone grafts might not always be necessary in cases of hypertrophic nonunion, and treatment should be tailored to the specific type and characteristics of the nonunion. The treatment of radial nerve palsy is debated, with some favoring expectant management based on the nerve's ability to regenerate, and others preferring early surgical exploration to prevent possible lasting nerve damage.Methods: We present the case of a 46-year-old male patient with a six-year-old humeral shaft fracture resulting in hypertrophic nonunion. We treated the nonunion with anterograde intramedullary nailing without bone grafting. Postoperatively, the patient developed severe radial nerve palsy. After repeated electrophysiological studies, a decision was made to surgically explore the nerve 10 days after the nonunion surgery. The nerve was subsequently found to be intact and treated with neurolysis.Results: Bony union was shown at six months after nonunion surgery. Four months after the nonunion surgery, the patient started to show clinical signs of nerve recovery, and at 12 months he achieved nearly full clinical recovery of radial nerve function.Conclusions: Anterograde intramedullary nailing without autologous bone grafting may be considered an option for treating hypertrophic nonunion. The management of radial nerve palsy requires effective cooperation and communication between patient and physician. Further research is necessary to be able to better predict nerve recovery.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1014-1025"},"PeriodicalIF":3.2,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Romanian Translation and Cultural Adaptation of the Seizure Severity Questionnaire. 癫痫发作严重程度问卷的罗马尼亚语翻译和文化适应。

IF 3.2

Neurology International Pub Date : 2024-09-13 DOI: 10.3390/neurolint16050076

Ionut-Horia Cioriceanu, Dan-Alexandru Constantin, Bianca Zamfirescu, Petru Cezar Podasca, Luigi Geo Marceanu, Liliana Rogozea

{"title":"Romanian Translation and Cultural Adaptation of the Seizure Severity Questionnaire.","authors":"Ionut-Horia Cioriceanu, Dan-Alexandru Constantin, Bianca Zamfirescu, Petru Cezar Podasca, Luigi Geo Marceanu, Liliana Rogozea","doi":"10.3390/neurolint16050076","DOIUrl":"10.3390/neurolint16050076","url":null,"abstract":"The aim of this study was to report the translation into Romanian of the Seizure Severity Questionnaire (SSQ), an instrument for the evaluation of the frequency and severity of epileptic seizures, and the results of applying it to a group of patients with epilepsy evaluated at a hospital in Romania.Methods: Four translators were involved in obtaining conceptual analogies and the cultural importance of the translated notions. The final version was obtained for the Romanian population, with the same appearance as the original instrument. Sixty-seven patients with epilepsy completed the SSQ and the Patient-Weighted Quality of Life in Epilepsy Inventory-QOLIE-31-P.Results: Females had a lower mean SSQ total score (TS) and perceived seizures less seriously than men. Patients with epilepsy with aura had a higher mean SSQ TS, with a more severe seizure perception, compared to those without aura. According to the frequency of seizures, patients with epilepsy with rare seizures had the lowest mean SSQ total score (TS) compared to those with frequent seizures. Patients who were on monotherapy had a less severe perception of epileptic seizures compared to those who were treated with two or more antiepileptic drugs. All QOLIE-31-P domains and TS correlated statistically significantly with the SSQ TS.Conclusions: This study explored SSQ translation, evaluated preliminary results, and showed the correlation between seizure frequency and severity, clinical factors, and quality of life. This tool could be useful for measuring seizure severity in Romanian patients with epilepsy and conducting comparative studies.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 5","pages":"1005-1013"},"PeriodicalIF":3.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0