Neurology International最新文献

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Idiopathic Normal-Pressure Hydrocephalus Revealed by Systemic Infection: Clinical Observations of Two Cases. 全身感染引起的特发性常压脑积水2例临床观察。
IF 3.2
Neurology International Pub Date : 2025-05-30 DOI: 10.3390/neurolint17060086
Shinya Watanabe, Yasushi Shibata, Kosuke Baba, Yuhei Kuriyama, Eiichi Ishikawa
{"title":"Idiopathic Normal-Pressure Hydrocephalus Revealed by Systemic Infection: Clinical Observations of Two Cases.","authors":"Shinya Watanabe, Yasushi Shibata, Kosuke Baba, Yuhei Kuriyama, Eiichi Ishikawa","doi":"10.3390/neurolint17060086","DOIUrl":"10.3390/neurolint17060086","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Idiopathic normal-pressure hydrocephalus (iNPH) is a potentially reversible neurological disorder characterized by gait disturbance, cognitive impairment, and urinary incontinence. Its pathophysiology involves impaired cerebrospinal fluid (CSF) absorption, and recent research has highlighted the role of the glymphatic and meningeal lymphatic systems in this process. However, the factors that trigger the clinical manifestations of iNPH in subclinical cases remain poorly understood. <b>Case Presentation</b>: Herein, we report two rare cases of iNPH in which clinical symptoms only became apparent following systemic infections. An 82-year-old man presented with transient neurological deficits during a course of sepsis caused by <i>Klebsiella pneumoniae</i>. Neuroimaging revealed periventricular changes and mild ventricular enlargement. Shunting and a tap test led to significant improvements to both his gait and cognition. An 80-year-old man with a history of progressive gait disturbance and cognitive decline developed worsening urinary incontinence and acute cerebral infarction caused by <i>Staphylococcus haemolyticus</i> bacteremia. Magnetic resonance imaging revealed a ventriculomegaly with features of disproportionally enlarged subarachnoid space hydrocephalus and a corona radiata infarct. Clinical improvement was achieved after a ventriculoperitoneal shunt was placed. <b>Conclusions</b>: Our two present cases suggest that systemic inflammatory states may act as catalysts for the manifestation of iNPH in patients with predisposing cerebral ischemia or subclinical abnormalities in CSF flow, highlighting the need for higher clinical awareness of iNPH in older patients who present with neurological deterioration during systemic infections. Early diagnosis and timely shunting after appropriate infection control may facilitate significant functional recovery in such patients.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment-Associated Neuroplastic Changes in People with Stroke-Associated Ataxia-An fMRI Study. 脑卒中相关性共济失调患者治疗相关的神经可塑性改变——一项fMRI研究
IF 3.2
Neurology International Pub Date : 2025-05-29 DOI: 10.3390/neurolint17060084
Patricia Meier, Christian Siedentopf, Lukas Mayer-Suess, Michael Knoflach, Stefan Kiechl, Gudrun Sylvest Schönherr, Astrid E Grams, Elke R Gizewski, Claudia Lamina, Malik Galijasevic, Ruth Steiger
{"title":"Treatment-Associated Neuroplastic Changes in People with Stroke-Associated Ataxia-An fMRI Study.","authors":"Patricia Meier, Christian Siedentopf, Lukas Mayer-Suess, Michael Knoflach, Stefan Kiechl, Gudrun Sylvest Schönherr, Astrid E Grams, Elke R Gizewski, Claudia Lamina, Malik Galijasevic, Ruth Steiger","doi":"10.3390/neurolint17060084","DOIUrl":"10.3390/neurolint17060084","url":null,"abstract":"<p><p><b>Background/Objectives</b>: In consideration of the significance of the pursuit of training-induced neuroplastic changes in the stroke population, who are reliant on neurorehabilitation treatment for the restoration of neuronal function, the objectives of this trial were to investigate fMRI paradigms for acute stroke patients with ataxic symptoms, to follow up on changes in motor function and balance due to recovery and rehabilitation, and to investigate the different effects of two treatment methods on neuronal plasticity. <b>Methods</b>: Therefore, fMRI-paradigms foot tapping and the motor imagery (MI) of a balancing task (tandem walking) were employed. <b>Results</b>: The paradigms investigated were suitable for ataxic stroke patients to monitor changes in neuroplasticity while revealing increased activity in the primary motor cortex (M1) and the cerebellum over 3 months of treatment. Furthermore, analysis of the more complex balance task revealed augmented activation of association areas due to training. Coordination exercises, constituting a specific treatment of ataxic symptoms, indicate more consolidated brain activations, corresponding to a faster motor learning process. Activation within Brodmann Area 7 has been prominent among all paradigms, indicating a special importance of this region for coordinative functions. <b>Conclusions</b>: Further studies are needed to confirm our results in larger patient groups. <b>Clinical Trial Registration</b>: German Clinical Trials Registry (drks.de). Identifier: DRKS00020825. Registered 16.07.2020.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Differences in Obstructive Sleep Apnea: A Preliminary Clinical and Polysomnographic Investigation. 阻塞性睡眠呼吸暂停的性别差异:初步临床和多导睡眠图调查。
IF 3.2
Neurology International Pub Date : 2025-05-29 DOI: 10.3390/neurolint17060085
Alessandra Castelnuovo, Sara Marelli, Salvatore Mazzeo, Francesca Casoni, Paola Proserpio, Alessandro Oldani, Alessandro Bombaci, Elisa Bortolin, Giulia Bruschi, Federica Agosta, Massimo Filippi, Luigi Ferini-Strambi, Maria Salsone
{"title":"Gender Differences in Obstructive Sleep Apnea: A Preliminary Clinical and Polysomnographic Investigation.","authors":"Alessandra Castelnuovo, Sara Marelli, Salvatore Mazzeo, Francesca Casoni, Paola Proserpio, Alessandro Oldani, Alessandro Bombaci, Elisa Bortolin, Giulia Bruschi, Federica Agosta, Massimo Filippi, Luigi Ferini-Strambi, Maria Salsone","doi":"10.3390/neurolint17060085","DOIUrl":"10.3390/neurolint17060085","url":null,"abstract":"<p><strong>Background/objectives: </strong>Gender differences influence the clinical manifestations, progression, and treatment response in obstructive sleep apnea (OSA) syndrome, suggesting the existence of distinct gender-related phenotypes potentially driven by anatomical, physiological, and hormonal factors. However, the impact of gender on OSA-related cognitive profiles remains unknown. This study aimed to investigate the neuropsychological and polysomnographic (PSG) differences between OSA females and males in order to detect the impact of gender on clinical manifestation and PSG features.</p><p><strong>Methods: </strong>Data were collected from 28 OSA patients (14 females and 14 males matched for age, education, and disease severity). All patients performed a complete neuropsychological evaluation, Epworth sleepiness scale, and whole-night PSG. To evaluate the relationship between specific sleep profiles and cognitive performance, PSG parameters were correlated to scores obtained on neuropsychological tests.</p><p><strong>Results: </strong>Both male and female groups performed within the normal range across all administered neuropsychological tests, according to Italian normative values. Compared with OSA males, female patients showed significantly lower values on the Rey-Osterrieth Complex Figure (ROCF) Recall Test. By contrast, no significant statistical clinical difference emerged between the two OSA groups in terms of clinical manifestation and sleep parameters.</p><p><strong>Conclusions: </strong>This study improves the knowledge on gender-related cognitive impairment in OSA patients. Our preliminary findings demonstrate that the ROCF Recall Test may be altered in OSA females, but not in males. Further longitudinal studies are needed to investigate whether OSA female patients will develop a frank dementia over time.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12195948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketamine in Status Epilepticus: How Soon Is Now? 氯胺酮治疗癫痫持续状态:现在多久?
IF 3.2
Neurology International Pub Date : 2025-05-28 DOI: 10.3390/neurolint17060083
Giuseppe Magro
{"title":"Ketamine in Status Epilepticus: How Soon Is Now?","authors":"Giuseppe Magro","doi":"10.3390/neurolint17060083","DOIUrl":"10.3390/neurolint17060083","url":null,"abstract":"<p><p>Status epilepticus (SE) is a neurological emergency. Current evidence dictates a step-by-step approach with a first line of therapy consisting of benzodiazepines (BDZs). In many situations, the currently approved approach does not terminate a BDZ-resistant SE. This happens in Stage 1 Plus, a framework designed by the author to recognize cases of probable benzodiazepine-resistant status epilepticus even before treatment initiation. These cases include Prolonged SE (SE lasting > 10 min), the absence of prominent motor phenomena, and acute etiology (primary central nervous system etiologies most of all). BDZ-refractory SE cases (Stage 1 Plus) might require a different approach, one targeting the unresponsive GABA signaling state mediated by NMDA/AMPA receptors, such as combined polytherapy with Ketamine from the start. These considerations stem from the receptor trafficking hypotheses: in prolonged seizure activity and primary central nervous system etiologies, GABA receptors get internalized and move away from synapses, and therefore, SE becomes resistant to BDZ. A rational polytherapy that might restore the unresponsiveness to BDZ in SE should include NMDA antagonists, such as Ketamine. Ketamine has proven effective in many experimental models of status epilepticus, and much evidence is gathering supporting its use in humans, especially in refractory and super-refractory SE. We lack studies evaluating combined polytherapy in SE, especially in the early phases. The author suggests here that Ketamine should be used along with first-line BDZ in the early SE stage falling in the category of Stage 1 Plus and as a first-line anesthetic infusion drug in refractory SE, especially in cases progressing from Stage 1 Plus, eventually adding continuous midazolam/propofol infusion in later phases. This systematic review's objective is to summarize the presently available evidence of the early use of combined polytherapy that includes Ketamine, along with the currently available evidence of Ketamine use in early, established, and refractory SE. Nine studies were included. Boluses of Ketamine and Midazolam are effective in pediatric convulsive Stage 1 Plus SE. The results show that earlier Ketamine administration (especially within 12 h of SE onset) was significantly associated with improved seizure control, with a more favorable safety profile than Midazolam in refractory SE. Notably, a dosage of less than 0.9 mg/kg/h proves ineffective in terminating SE. Ketamine has the advantage of preventing intubation, possibly shortening the length of stay in the intensive care unit.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12195624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Hypertension and Related Risk Factors on the Onset and Resolution Rates of Benign Paroxysmal Positional Vertigo Recurrence: A 6-Year Retrospective Study. 高血压及相关危险因素对良性阵发性体位性眩晕复发的发病和消退率的影响:一项6年回顾性研究。
IF 3.2
Neurology International Pub Date : 2025-05-25 DOI: 10.3390/neurolint17060082
Alessandro Micarelli, Ivan Granito, Riccardo Xavier Micarelli, Marco Alessandrini
{"title":"The Impact of Hypertension and Related Risk Factors on the Onset and Resolution Rates of Benign Paroxysmal Positional Vertigo Recurrence: A 6-Year Retrospective Study.","authors":"Alessandro Micarelli, Ivan Granito, Riccardo Xavier Micarelli, Marco Alessandrini","doi":"10.3390/neurolint17060082","DOIUrl":"10.3390/neurolint17060082","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Due to conflicting results about hypertension and the involvement of associated risk factors in the presentation of idiopathic benign paroxysmal positional vertigo recurrence (R-BPPV), this study aimed to explore possible associations between the resolution rate (RR) and recurrence onset (RO) of R-BPPV, as well as hypertension classification and stages and demographic characteristics. <b>Methods:</b> A total of 1201 medical records from patients collected over a 6-year span who first presented with R-BPPV were retrospectively evaluated regarding blood pressure (BP) presentation and associated risk factors. R-BPPV included patients treated with necessary canalith repositioning procedures (CRPs) and followed up with for 12 months. The RO and RR were evaluated when comparing patients sub-grouped by current classification and staging. The association between the RO and RR and many prognostic factors, including the presence of cardio- and neuro-vascular risks, was examined via multiple regression analysis. <b>Results:</b> Among the 857 included patients with R-BPPV, 211 presented with an optimal/normal BP, 210 were found to have a high-normal BP, 222 were classified with Grade 1 hypertension, and 214 were found to have Grade 2 hypertension. Significant (<i>p</i> < 0.05) progressive earlier presentations and increases in needed CRPs were found with the respective increase in BP subgroups. For the RO, the correlation was statistically significant for age and gender, while for the RR, the correlation was statistically significant for age and hypertension stage. <b>Conclusions:</b> This study demonstrates for the first time that clinical consequences of R-BPPV are strongly associated with cardio-, neuro-vascular, and socio-demographic risk factors, which are commonly involved in R-BPPV occurrence.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reciprocal Interactions Between Periodontal Disease and Alzheimer's Disease: Implications for Mutual Triggering, Exacerbation, and Treatment Interventions-A Comprehensive Review of the Literature. 牙周病和阿尔茨海默病之间的相互作用:相互触发、加剧和治疗干预的含义——文献综述
IF 3.2
Neurology International Pub Date : 2025-05-24 DOI: 10.3390/neurolint17060081
Shatha Gharaibeh, Alameen Alsabbah, Ahmad Alloubani, Abeer Gharaibeh
{"title":"Reciprocal Interactions Between Periodontal Disease and Alzheimer's Disease: Implications for Mutual Triggering, Exacerbation, and Treatment Interventions-A Comprehensive Review of the Literature.","authors":"Shatha Gharaibeh, Alameen Alsabbah, Ahmad Alloubani, Abeer Gharaibeh","doi":"10.3390/neurolint17060081","DOIUrl":"10.3390/neurolint17060081","url":null,"abstract":"<p><p>Periodontal health is connected to many systemic diseases, such as cardiovascular, diabetes mellitus, and neurodegenerative diseases. The oral-brain axis has gained increasing interest in the pathogenesis of diseases. Emerging studies have highlighted the potential role of periodontal disease in the development and progression of Alzheimer's disease. However, Alzheimer's disease also affects periodontal disease and oral health. In this review, we address the correlation between the two diseases and the mechanisms by which one contributes to the other. Exploring the correlation between Alzheimer's disease and periodontal disease will assist in better understanding the pathophysiology of diseases and pave the way for the development of therapeutic and preventive strategies.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying Clinical Measures Related to Falls in Ambulatory Patients with Spinal and Bulbar Muscular Atrophy. 确定与脊髓和球性肌萎缩症门诊患者跌倒相关的临床措施。
IF 3.2
Neurology International Pub Date : 2025-05-23 DOI: 10.3390/neurolint17060080
Joseph A Shrader, Allison C Niemic, Rafael Jiménez-Silva, Joshua G Woolstenhulme, Galen O Joe, Uma Jacobs, Ashwini Sansare, Angela Kokkinis, Kenneth Fischbeck, Chris Grunseich, Cris Zampieri
{"title":"Identifying Clinical Measures Related to Falls in Ambulatory Patients with Spinal and Bulbar Muscular Atrophy.","authors":"Joseph A Shrader, Allison C Niemic, Rafael Jiménez-Silva, Joshua G Woolstenhulme, Galen O Joe, Uma Jacobs, Ashwini Sansare, Angela Kokkinis, Kenneth Fischbeck, Chris Grunseich, Cris Zampieri","doi":"10.3390/neurolint17060080","DOIUrl":"10.3390/neurolint17060080","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal and bulbar muscular atrophy (SBMA) is an adult-onset, X-linked, progressive neuromuscular disease caused by abnormal CAG trinucleotide expansion in the androgen receptor gene. Patients with SBMA report difficulty with falls on self-reported activities of daily living scales. To our knowledge, no study has examined the relationship between falls and common clinical measures of strength, balance, mobility, and disease biomarkers. We performed a cross-sectional analysis of an SBMA cohort.</p><p><strong>Objectives: </strong>The objectives of this study are as follows: (1) compare demographics, clinical measures, and biomarkers between patients who did and did not fall; (2) determine which measures best discriminate fallers from non-fallers; and (3) identify cutoff scores to detect patients with a higher fall risk.</p><p><strong>Design: </strong>Cross-sectional analysis was used.</p><p><strong>Outcome measures: </strong>Disease biomarkers included blood serum creatinine, and clinical measures included the Timed Up and Go (TUG), the Adult Myopathy Assessment Tool (AMAT), and posturography, including the Modified Clinical Test of Sensory Interaction on Balance and the Motor Control Test. The Maximal Voluntary Isometric Contractions (MVICs) of four lower extremity muscles were captured via fixed-frame dynamometry.</p><p><strong>Results: </strong>We identified three clinical measures that help detect fall risk in people with SBMA. A post hoc receiver operating characteristic curve analysis helped identify cut scores for each test. Impairments of mobility (TUG > 8 s), muscle endurance (AMAT endurance subscale < 14), and muscle strength (ankle plantar flexion MVIC < 45% of predicted) were different between fallers and non-fallers, via independent <i>t</i>-tests.</p><p><strong>Conclusions: </strong>These three clinical tests can help detect fall risk that may help clinicians implement gait aid use or other fall prevention strategies before catastrophic falls occur.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12195735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Sensory and Motor Function in Spinal and Bulbar Muscular Atrophy Using Quiet Stance and Reactive Postural Control. 用安静姿势和反应性姿势控制评价脊髓和球性肌萎缩的感觉和运动功能。
IF 3.2
Neurology International Pub Date : 2025-05-22 DOI: 10.3390/neurolint17060079
Joseph A Shrader, Ashwini Sansare, Allison C Niemic, Rafael Jiménez-Silva, Joshua G Woolstenhulme, Galen O Joe, Uma Jacobs, Angela Kokkinis, Kenneth Fischbeck, Chris Grunseich, Cris Zampieri
{"title":"Evaluation of Sensory and Motor Function in Spinal and Bulbar Muscular Atrophy Using Quiet Stance and Reactive Postural Control.","authors":"Joseph A Shrader, Ashwini Sansare, Allison C Niemic, Rafael Jiménez-Silva, Joshua G Woolstenhulme, Galen O Joe, Uma Jacobs, Angela Kokkinis, Kenneth Fischbeck, Chris Grunseich, Cris Zampieri","doi":"10.3390/neurolint17060079","DOIUrl":"10.3390/neurolint17060079","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal and bulbar muscular atrophy (SBMA) is an X-linked neuromuscular disorder characterized by progressive muscle weakness, along with muscle cramps, tremors, and sensory neuropathy. Previous research has shown that patients with SBMA have difficulty with dynamic balance and sensory postural control during quiet stance. There have been no reports on automatic postural reactions in SBMA.</p><p><strong>Objectives: </strong>In this study, we aimed (1) to augment previous findings of sensory postural control, (2) to investigate automatic postural reactions in SBMA, and (3) to explore the relationship between strength and balance.</p><p><strong>Design: </strong>A cross-sectional design was used for the analysis.</p><p><strong>Participants: </strong>The participants were fifty male individuals with a confirmed diagnosis of SBMA.</p><p><strong>Outcome measures: </strong>Balance testing included the NeuroCom modified Clinical Test of Sensory Interaction on Balance (mCTSIB), which measures sway velocity during quiet stance, and the NeuroCom Motor Control Test (MCT), which measures the latency and strength of postural reactions following sudden perturbations. Strength testing included maximal voluntary isometric contractions measured via fixed-frame dynamometry.</p><p><strong>Results: </strong>Forty-seven out of fifty participants were able to complete the mCTSIB test, but only thirty-eight completed the MCT test. Patients who were unable to complete the MCT were significantly weaker in all lower extremity muscles compared to those who were able to complete testing. Compared to normative data, participants showed significantly higher sway velocity during quiet stance across all conditions of the mCTSIB, except when standing on foam with eyes open. They also exhibited significantly slower postural reactions in response to sudden shifts of the force plate on the MCT. Plantarflexor weakness was significantly correlated with poor postural control on the mCTSIB and MCT.</p><p><strong>Conclusions: </strong>This study confirms previously reported abnormalities of sensory postural control in SBMA and highlights patients' heavy reliance on visual inputs for postural control. Additionally, this study shows that automatic postural corrections are slower than normal in SBMA and provides a unique approach for measuring the combined sensory and motor components of the disease. Both the sensory and automatic balance abnormalities were found to be associated with plantarflexor weakness and may contribute to a higher risk of falls under challenging situations. Therefore, addressing this weakness may be an important step toward fall prevention in this population.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Novel Method of Spinal Electrophysiological Assessment via Intrathecal Administration at Analgesic Doses. 鞘内镇痛剂量脊髓电生理评估新方法的发展。
IF 3.2
Neurology International Pub Date : 2025-05-21 DOI: 10.3390/neurolint17050078
Daisuke Uta, Takuya Yamane, Sosuke Yoneda, Erika Kasai, Toshiaki Kume
{"title":"Development of a Novel Method of Spinal Electrophysiological Assessment via Intrathecal Administration at Analgesic Doses.","authors":"Daisuke Uta, Takuya Yamane, Sosuke Yoneda, Erika Kasai, Toshiaki Kume","doi":"10.3390/neurolint17050078","DOIUrl":"10.3390/neurolint17050078","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Chronic pain is a significant global health challenge and is associated with diverse conditions, such as diabetic neuropathic pain and spinal stenosis. Understanding the mechanisms of pain transmission is crucial, for both the peripheral and central pathways. However, there are limitations in spinal electrophysiological techniques in terms of the injection method. Traditional methods such as spinal injections may differ in the distributions and concentrations of drugs compared with intrathecal administration during the behavior test. So, we developed a new intrathecal administration method for electrophysiological recordings. <b>Methods</b>: Sprague-Dawley rats were injected with lidocaine intrathecally, and the analgesic effect was evaluated by the von Frey test. In vivo extracellular single-unit recordings of the superficial dorsal horn neurons were performed following a newly developed technique. Lidocaine was intrathecally injected into the arachnoid membrane after laminectomy. After that, the neural responses in the superficial dorsal horn were measured. <b>Results</b>: Newly developed intrathecally administered dye reached the spinal cord and the cauda equina. Intrathecally administrated lidocaine increased the paw withdrawal threshold and suppressed spinal neuronal firing. This suppression correlated with increases in paw withdrawal thresholds. <b>Conclusions</b>: This innovative method provides insights into the central effects of analgesics, which will help the development of therapies for chronic pain.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"17 5","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12114472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medications for Managing Central Neuropathic Pain as a Result of Underlying Conditions-A Systematic Review. 治疗中枢神经性疼痛的药物作为潜在条件的结果-系统综述。
IF 3.2
Neurology International Pub Date : 2025-05-20 DOI: 10.3390/neurolint17050077
Bjarke Kaae Houlind, Henrik Boye Jensen
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