Neurobiology of Stress最新文献_第2页

Stress reactivity moderates the association between early experiences of unpredictability and emotional problems in adolescents 应激反应缓和了青少年早期不可预测性经历与情绪问题之间的联系。

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2024.100706

J.L. Buthmann , C. Antonacci , J.P. Uy , L.R. Borchers , J.G. Miller , I.H. Gotlib

{"title":"Stress reactivity moderates the association between early experiences of unpredictability and emotional problems in adolescents","authors":"J.L. Buthmann , C. Antonacci , J.P. Uy , L.R. Borchers , J.G. Miller , I.H. Gotlib","doi":"10.1016/j.ynstr.2024.100706","DOIUrl":"10.1016/j.ynstr.2024.100706","url":null,"abstract":"<div><div>Researchers have documented that exposure to different kinds of psychosocial stressors can lead to emotional difficulties and, further, that heightened reactivity to stress can moderate these associations. Recently, investigators have distinguished among threat, deprivation, and unpredictability as different dimensions of early life stress (ELS). It is not clear, however, whether reactivity in specific stress response systems functions as a diathesis to lead to emotional difficulties following exposure to these dimensions of ELS. In this study (N = 154) we examined whether stress reactivity, assessed across different psychobiological systems during the Trier Social Stress Test, is a unitary or multidimensional construct, and if reactivity differentially moderates the associations between ELS dimensions and adolescents’ susceptibility to emotional and behavioral problems two years later. A factor analysis conducted on stress reactivity measures yielded two factors: one composed of reactivity in heart rate, heart rate variability, and cortisol, and one composed of reactivity in skin conductance and self-reported mood. These two factors independently moderated the associations between early unpredictability and subsequent emotional problems. For each factor, the combination of higher unpredictability and higher stress reactivity predicted higher emotional problems; stress reactivity factors were not significant moderators of the effects of threat and deprivation. Our findings suggest that increased stress reactivity, assessed across several domains of functioning, functions as a diathesis that interacts with ELS characterized by unpredictability to predict subsequent mental health difficulties in adolescents and, further, that low stress reactivity buffers against mental health difficulties in adolescents who have experienced unpredictability early in life.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100706"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrotransposons and the brain: Exploring a complex relationship between mobile elements, stress, and neurological health

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2025.100709

Amelia Cuarenta

{"title":"Retrotransposons and the brain: Exploring a complex relationship between mobile elements, stress, and neurological health","authors":"Amelia Cuarenta","doi":"10.1016/j.ynstr.2025.100709","DOIUrl":"10.1016/j.ynstr.2025.100709","url":null,"abstract":"<div><div>Environmental experiences during early life, including stress, can significantly impact brain development and behavior. Early life stress (ELS) is linked to an increased risk for various psychiatric disorders including anxiety, depression, and substance use disorders. Epigenetic mechanisms have increasingly been of interest to understand how environmental factors contribute to reprogramming the brain and alter risk and resilience to developing psychiatric disorders. However, we know very little about mobile elements or the regulation of mobile elements and their contribution to psychiatric disorders. Recently, advances in genomics have contributed to our understanding of mobile elements, including the retrotransposon LINE-1 (L1) and their potential role in mediating environmental experiences. Yet we still do not understand how these elements may contribute to psychiatric disorders. Future research leveraging cutting-edge technologies will deepen our understanding of these mobile elements. By elucidating their role in development and how stress may impact them, we may unlock new avenues for therapeutic and diagnostic innovations.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100709"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative approaches to studying sleep, stress, and related disorders

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2024.100700

Thomas C. Neylan, Gina R. Poe, Victoria B. Risbrough

引用次数: 0

Neuroanatomical prediction of individual anxiety problems level using machine learning models: A population-based cohort study of young adults 使用机器学习模型的个体焦虑问题水平的神经解剖学预测：一项基于人群的年轻人队列研究。

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2024.100705

Hui Xu , Jing Xu , Dandong Li

{"title":"Neuroanatomical prediction of individual anxiety problems level using machine learning models: A population-based cohort study of young adults","authors":"Hui Xu , Jing Xu , Dandong Li","doi":"10.1016/j.ynstr.2024.100705","DOIUrl":"10.1016/j.ynstr.2024.100705","url":null,"abstract":"<div><div>Anxiety, a mental state in healthy individuals, is characterized by apprehension of potential future threats. Though the neurobiological basis of anxiety has been investigated widely in the clinical populations, the underly mechanism of neuroanatomical correlates with anxiety level in healthy young adults is still unclear. In this study, 1080 young adults were enrolled from the Human Connectome Project Young Adult dataset, and machine learning-based elastic net regression models with cross validation, together with linear mix effects (LME) models were adopted to investigate whether the neuroanatomical profiles of structural magnetic resonance imaging indicators associated with anxiety level in healthy young adults. We found multi-region neuroanatomical profiles predicted anxiety problems level and it was still robust in an out-of-sample. The neuroanatomical profiles had widespread brain nodes, including the dorsal lateral prefrontal cortex, supramarginal gyrus, and entorhinal cortex, which implicated in the default mode network and frontoparietal network. This finding was further supported by LME models, which showed significant univariate associations between brain nodes with anxiety. In sum, it's a large sample size study with multivariate analysis methodology to provide evidence that individual anxiety problems level can be predicted by machine learning-based models in healthy young adults. The neuroanatomical signature including hub nodes involved theoretically relevant brain networks robustly predicts anxiety, which could aid the assessment of potential high-risk of anxiety individuals.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100705"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain receptor dynamics in early and adult life stress: Gateways to maladaptive coping strategies

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2025.100707

Sora Shin

{"title":"Brain receptor dynamics in early and adult life stress: Gateways to maladaptive coping strategies","authors":"Sora Shin","doi":"10.1016/j.ynstr.2025.100707","DOIUrl":"10.1016/j.ynstr.2025.100707","url":null,"abstract":"<div><div>Stress plays a significant role in the onset of numerous psychiatric disorders. Depending on individual resilience or stressor's nature, long-term changes to stress in the brain can lead to a wide range of behavioral symptoms, including social withdrawal, feelings of helplessness, and emotional overeating. The brain receptor molecules are key mediators of these processes, translating neuromodulatory signals into neuronal responses or circuit activity changes that ultimately shape behavioral outcomes. Here, I highlight several of my previous studies that reveal the pivotal role of receptor molecules in critical brain regions such as the nucleus accumbens, lateral hypothalamus, and lateral septum. I identified how mGluR5 signaling in the nucleus accumbens promotes stress resilience through pathways involving ΔFosB and SRF, while leptin receptor or glucocorticoid receptor signaling within lateral hypothalamic circuits contributes to stress eating. Additionally, I uncovered the role of dopamine receptor 3 signaling in the lateral septum in mediating the impact of early life stress on social behaviors. These findings underscore the functional relevance of brain receptor molecules in transducing stress—from early life through adulthood—into maladaptive coping behaviors. As druggable targets, these receptor-mediated pathways provide a critical foundation for developing targeted interventions to alleviate stress-related psychiatric symptoms.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100707"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats 升高的gaba能神经传递可防止慢性间歇乙醇诱导的雌性大鼠腹侧下背内外输入的高兴奋性。

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2024.100696

Eva C. Bach, Jeff L. Weiner

{"title":"Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats","authors":"Eva C. Bach, Jeff L. Weiner","doi":"10.1016/j.ynstr.2024.100696","DOIUrl":"10.1016/j.ynstr.2024.100696","url":null,"abstract":"<div><div>With the recent rise in the rate of alcohol use disorder (AUD) in women, the historical gap between men and women living with this condition is narrowing. While there are many commonalities in how men and women are impacted by AUD, an accumulating body of evidence is revealing sex-dependent adaptations that may require distinct therapeutic approaches. Preclinical rodent studies are beginning to shed light on sex differences in the effects of chronic alcohol exposure on synaptic activity in a number of brain regions. Prior studies from our laboratory revealed that, while withdrawal from chronic intermittent ethanol (CIE), a commonly used model of AUD, increased excitability in the ventral hippocampus (vHC) of male rats, this same treatment had the opposite effect in females. A follow-up study not only expanded on the synaptic mechanisms of these findings in male rats, but also established a CIE-dependent increase in the excitatory-inhibitory (E-I) balance of a glutamatergic projection from the basolateral amygdala to vHC (BLA-vHC). This pathway modulates anxiety-like behavior and could help explain the comorbid occurrence of anxiety disorders in individuals suffering from AUD. The present study sought to conduct a similar analysis of CIE effects on both synaptic mechanisms in the vHC and adaptations in the BLA-vHC pathway of female rats. Our findings indicate that CIE increases the strength of inhibitory neurotransmission in the vHC and that this sex-specific adaptation blocks, or at least delays, the increases in intrinsic vHC excitability and BLA-vHC synaptic transmission observed in males. Our findings establish the BLA-vHC pathway and the vHC as important circuitry to consider for future studies directed at identifying sex-dependent therapeutic approaches to AUD.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100696"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11722943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing 硫醇标记的 RNA 测序揭示急性和慢性应激下小鼠杏仁核转录组的动态变化

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100688

Dan Zhao , Lu Zhang , Yang Yang

{"title":"Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing","authors":"Dan Zhao , Lu Zhang , Yang Yang","doi":"10.1016/j.ynstr.2024.100688","DOIUrl":"10.1016/j.ynstr.2024.100688","url":null,"abstract":"<div><div>Both acute and chronic stress have significant impact on brain functions. The amygdala is essential in mediating stress responses, but how its transcriptomic dynamics change under stress remains elusive. To overcome the difficulties in detecting subtle stress-induced changes by evaluating total RNA using classic RNA sequencing, we conducted thiol-labeled RNA sequencing (SLAM-seq). We injected 4-thiouridine (4sU) into mouse amygdala followed by SLAM-seq to detect nascent mRNA induced by acute and chronic restraint stress, and found that SLAM-seq could label actively transcribed genes in the major neuronal and glial subtypes. Using SLAM-seq, we found that chronic stress led to higher turnover of a group of genes associated with myelination, and this finding is confirmed by immunostaining which showed increased myelination in the chronically stressed amygdala. Additionally, genes detected by SLAM-seq and RNA-seq only partially overlapped, suggesting that SLAM-seq and RNA-seq are complementary in identifying stress-responsive genes. By applying SLAM-seq <em>in vivo</em>, we obtained a rich dataset of genes with higher turnover in the amygdala under stress.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100688"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols 小鼠对慢性失败压力的行为应对：当前方案的系统回顾

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100689

Alina Díez-Solinska , Zurine De Miguel , Garikoitz Azkona , Oscar Vegas

{"title":"Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols","authors":"Alina Díez-Solinska , Zurine De Miguel , Garikoitz Azkona , Oscar Vegas","doi":"10.1016/j.ynstr.2024.100689","DOIUrl":"10.1016/j.ynstr.2024.100689","url":null,"abstract":"<div><div>Social stress is the most significant source of chronic stress in humans and is commonly associated with health impairment. Individual differences in the behavioral coping responses to stress have been proposed to mediate the negative effects of stress on physical, behavioral and mental health. Animal models, particularly mice, offer valuable insights into the physiological and neurobiological correlates of behavioral coping strategies in response to chronic social stress. Here we aim to identify differences and similarities among stress protocols in mice, with particular attention to how neuroendocrine and/or behavioral responses vary according to different coping strategies, while highlighting the need for standardized approaches in future research. A systematic review was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA statement). A total of 213 references were identified by electronic search, and after the screening, 18 articles were found to meet all the established criteria. We analyzed differences in the stress protocol, the characterization and classification of coping strategies and the physiological and behavioral differences according to coping. The results show that differences in behavioural expression under chronic social stress (coping) may also be associated with physiological differences and differential susceptibility to disease. However, this review also underlines the importance of a cautious interpretation of the results obtained. The lack of consistency in the nomenclature and procedures associated with the study of coping strategies for social stress, as well as the absence of a uniform classification, highlight the importance of using a common language when approaching the study of coping strategies. Thereby, this review encourages the development of a more defined method and criteria for assessing coping strategies, based on both behavioral and biological indicators.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100689"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withdrawal notice to: “Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats” [Neurobiol. Stress 32 (2024) 100665] 撤回通知：“升高的gaba能神经传递可防止慢性间歇乙醇诱导的雌性大鼠腹侧下背内在和外在输入的高兴奋性”[神经生物学]。压力32 (2024)100665]

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100693

Eva C. Bach, Jeff L. Weiner

引用次数: 0

Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets 神经元周围网络对压力、疼痛和酒精相关行为的调节作用

IF 4.3 2区医学

Neurobiology of Stress Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100692

Jhoan S. Aguilar , Amy W. Lasek

{"title":"Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets","authors":"Jhoan S. Aguilar , Amy W. Lasek","doi":"10.1016/j.ynstr.2024.100692","DOIUrl":"10.1016/j.ynstr.2024.100692","url":null,"abstract":"<div><div>Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity. Most PNNs in the brain surround parvalbumin-expressing inhibitory interneurons, which tightly regulate excitatory/inhibitory balance and brain activity associated with optimal cognitive functioning. Alterations in PNNs have been observed in neurological diseases and psychiatric disorders, suggesting that they may be key contributors to the neuropathological progression and behavioral changes in these diseases. Alcohol use disorder (AUD), major depressive disorder (MDD), and chronic pain are highly comorbid conditions, and changes in PNNs have been observed in animal models of these disorders, as well as postmortem tissue from individuals diagnosed with AUD and MDD. This review focuses on the literature describing stress-, alcohol-, and pain-induced adaptations in PNNs, potential cellular contributors to altered PNNs, and the role of PNNs in behaviors related to these disorders. Medicines that can restore PNNs to a non-pathological state may be a novel therapeutic approach to treating chronic pain, AUD, and MDD.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100692"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0