Neurobiology of Stress最新文献

{"title":"Acute stress selectively blunts reward anticipation but not consumption: An ERP study","authors":"Wei Yi ,&nbsp;Yantao Chen ,&nbsp;Linlin Yan ,&nbsp;Nils Kohn ,&nbsp;Jianhui Wu","doi":"10.1016/j.ynstr.2023.100583","DOIUrl":"https://doi.org/10.1016/j.ynstr.2023.100583","url":null,"abstract":"<div><p>Stress-induced dysfunction of reward processing is documented to be a critical factor associated with mental illness. Although many studies have attempted to clarify the relationship between stress and reward, few studies have investigated the effect of acute stress on the temporal dynamics of reward processing. The present study applied event-related potentials (ERP) to examine how acute stress differently influences reward anticipation and consumption. In this study, seventy-eight undergraduates completed a two-door reward task following a Trier Social Stress Task (TSST) or a placebo task. The TSST group showed higher cortisol levels, perceived stress, anxiety, and negative affect than the control group. For the control group, a higher magnitude of reward elicited a reduced cue-N2 but increased stimulus-preceding negativity (SPN), suggesting that controls were sensitive to reward magnitude. In contrast, these effects were absent in the stress group, suggesting that acute stress reduces sensitivity to reward magnitude during the anticipatory phase. However, the reward positivity (RewP) and P3 of both groups showed similar patterns, which suggests that acute stress has no impact on reward responsiveness during the consummatory phase. These findings suggest that acute stress selectively blunts sensitivity to reward magnitude during the anticipatory rather than the consummatory phase.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100583"},"PeriodicalIF":5.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352289523000711/pdfft?md5=c85d53b17bd67afd5e53bd423c3cfc77&pid=1-s2.0-S2352289523000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92099723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The double-edged sword of the hippocampus-ventromedial prefrontal cortex resting-state connectivity in stress susceptibility and resilience: A prospective study","authors":"Jingjing Chang ,&nbsp;Di Song ,&nbsp;Rongjun Yu","doi":"10.1016/j.ynstr.2023.100584","DOIUrl":"https://doi.org/10.1016/j.ynstr.2023.100584","url":null,"abstract":"<div><p>The hippocampus has long been considered a pivotal region implicated in both stress susceptibility and resilience. A wealth of evidence from animal and human studies underscores the significance of hippocampal functional connectivity with the ventromedial prefrontal cortex (vmPFC) in these stress-related processes. However, there remains a scarcity of research that explores and contrasts the roles of hippocampus-vmPFC connectivity in stress susceptibility and resilience when facing a real-life traumatic event from a prospective standpoint. In the present study, we investigated the contributions of undirected and directed connectivity between the hippocampus and vmPFC to stress susceptibility and resilience within the context of the COVID-19 pandemic. Our findings revealed that the left hippocampus-left vmPFC connectivity prior to the pandemic exhibited a negative correlation with both stress susceptibility and resilience. Specifically, individuals with stronger left hippocampus-left vmPFC connectivity reported experiencing fewer stress-related feelings during the outbreak period of the epidemic but displayed lower levels of stress resilience five months later. Our application of spectral dynamic causal modeling unveiled an additional inhibitory connectivity pathway from the left hippocampus to the left vmPFC in the context of stress susceptibility, which was notably absent in stress resilience. Furthermore, we observed a noteworthy positive association between self-inhibition of the vmPFC and stress susceptibility, with this effect proving substantial enough to predict an individual's susceptibility to stress; conversely, these patterns did not manifest in the realm of stress resilience. These findings enrich our comprehension of stress susceptibility and stress resilience and might have implications for innovative approaches to managing stress-related disorders.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100584"},"PeriodicalIF":5.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352289523000723/pdfft?md5=a4883c1c0bdf0cdf5fb0f37358420291&pid=1-s2.0-S2352289523000723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92043715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling intrusive thoughts of future fears under stress","authors":"Stephanie M. Ashton ,&nbsp;Tom Smeets ,&nbsp;Conny W.E.M. Quaedflieg","doi":"10.1016/j.ynstr.2023.100582","DOIUrl":"https://doi.org/10.1016/j.ynstr.2023.100582","url":null,"abstract":"<div><p>Negative outlooks of our future may foster unwanted and intrusive thoughts. To some extent, individuals have control over their ability to suppress intrusions and downregulate their frequency. Acute stress impairs intentional suppression, leading to an increased frequency of intrusions. The aim of this study was to gain insight into the mechanism underlying stress-induced impairments in intentional suppression of intrusions by investigating the combined and independent roles of the two major stress hormones, noradrenaline and cortisol. Healthy participants (<em>N</em> = 181) were administered propranolol (to block the noradrenergic response), metyrapone (to block the cortisol response), or a placebo before being exposed to the Maastricht Acute Stress Test. Intrusive thoughts of autobiographical future fears were then measured via the Imagine/No-Imagine task. Results demonstrated that the stress response was successfully altered because of the drug and stress manipulations. In all groups, repeated suppression of future fears reduced intrusions. Across the sample, an enhanced decrease over time was associated with greater attenuation of anxiety towards the related fears. The groups did not differ in the total frequency of intrusions. Though, trait anxiety increased the total number of intrusions. Our findings show that stress hormones did not influence the ability to suppress intrusions. However, our results do add support to previous research linking anxiety to memory control deficits. When using autobiographical content, future research should focus on the quality and characteristics of the individual memories to explain more of the variation observed in intentional memory control.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100582"},"PeriodicalIF":5.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235228952300070X/pdfft?md5=3660a876f99a5d2ddca1e43b5acaf2b0&pid=1-s2.0-S235228952300070X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92099722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats","authors":"Cyprien G.J. Guerrin ,&nbsp;Kavya Prasad ,&nbsp;Daniel A. Vazquez-Matias ,&nbsp;Jing Zheng ,&nbsp;Maria Franquesa-Mullerat ,&nbsp;Lara Barazzuol ,&nbsp;Janine Doorduin ,&nbsp;Erik F.J. de Vries","doi":"10.1016/j.ynstr.2023.100580","DOIUrl":"https://doi.org/10.1016/j.ynstr.2023.100580","url":null,"abstract":"<div><p>Maternal infection during pregnancy and childhood social trauma have been associated with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum disorders, bipolar disorder and depression. These disorders are characterized by changes in microglial cells, which play a notable role in synaptic pruning, and synaptic deficits. Here, we investigated the effect of prenatal infection and social adversity during adolescence – either alone or in combination – on behavior, microglia, and synaptic density. Male offspring of pregnant rats injected with poly I:C, mimicking prenatal infection, were exposed to repeated social defeat during adolescence. We found that maternal infection during pregnancy prevented the reduction in social behavior and increase in anxiety induced by social adversity during adolescence. Furthermore, maternal infection and social adversity, alone or in combination, induced hyperlocomotion in adulthood. Longitudinal in vivo imaging with [¹¹C]PBR28 positron emission tomography revealed that prenatal infection alone and social adversity during adolescence alone induced a transient increase in translocator protein TSPO density, an indicator of glial reactivity, whereas their combination induced a long-lasting increase that remained until adulthood. Furthermore, only the combination of prenatal infection and social adversity during adolescence induced an increase in microglial cell density in the frontal cortex. Prenatal infection increased proinflammatory cytokine IL-1β protein levels in hippocampus and social adversity reduced anti-inflammatory cytokine IL-10 protein levels in hippocampus during adulthood. This reduction in IL-10 was prevented if rats were previously exposed to prenatal infection. Adult offspring exposed to prenatal infection or adolescent social adversity had a higher synaptic density in the frontal cortex, but not hippocampus, as evaluated by synaptophysin density. Interestingly, such an increase in synaptic density was not observed in rats exposed to the combination of prenatal infection and social adversity, perhaps due to the long-lasting increase in microglial density, which may lead to an increase in microglial synaptic pruning. These findings suggest that changes in microglia activity and cytokine release induced by prenatal infection and social adversity during adolescence may be related to a reduced synaptic pruning, resulting in a higher synaptic density and behavioral changes in adulthood.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100580"},"PeriodicalIF":5.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High emotional reactivity is associated with activation of a molecularly distinct hippocampal-amygdala circuit modulated by the glucocorticoid receptor","authors":"Qiang Wei ,&nbsp;Vivek Kumar ,&nbsp;Shannon Moore,&nbsp;Fei Li,&nbsp;Geoffrey G. Murphy,&nbsp;Stanley J. Watson ,&nbsp;Huda Akil","doi":"10.1016/j.ynstr.2023.100581","DOIUrl":"https://doi.org/10.1016/j.ynstr.2023.100581","url":null,"abstract":"<div><p>Emotions are characterized not only by their valence but also by whether they are stable or labile. Yet, we do not understand the molecular or circuit mechanisms that control the dynamic nature of emotional responses. We have shown that glucocorticoid receptor overexpression in the forebrain (GRov) leads to a highly reactive mouse with increased anxiety behavior coupled with greater swings in emotional responses. This phenotype is established early in development and persists into adulthood. However, the neural circuitry mediating this lifelong emotional lability remains unknown. In the present study, optogenetic stimulation in ventral dentate gyrus (vDG) of GRov mice led to a greater range and a prolonged duration of anxiety behavior. cFos expression analysis showed that the amplified behavioral response to vDG activation in GRov mice is coupled to increased neuronal activity in specific brain regions. Relative to wild type mice, GRov mice displayed glutamatergic/GABAergic activation imbalance in ventral CA1 (vCA1) and selectively increased glutamatergic activation in the basal posterior amygdaloid complex. Moreover, forebrain GR overexpression led to increased activation of molecularly distinct subpopulations of neurons within the hippocampus and the posterior basolateral amygdala (pBLA) as evident from the increased cFos co-labeling in the calbindin1⁺ glutamatergic neurons in vCA1 and in the DARPP-32/Ppp1r1b⁺ glutamatergic neurons in pBLA. We propose that a molecularly distinct hippocampal-amygdala circuit is shaped by stress early in life and tunes the dynamics of emotional responses.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100581"},"PeriodicalIF":5.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders","authors":"John M. Felt ,&nbsp;Natan Yusupov ,&nbsp;Karra D. Harrington ,&nbsp;Julia Fietz ,&nbsp;Zhenyu “Zach” Zhang ,&nbsp;Martin J. Sliwinski ,&nbsp;Nilam Ram ,&nbsp;Kieran J. O'Donnell ,&nbsp;BeCOME Working Group ,&nbsp;Michael J. Meaney ,&nbsp;Frank W. Putnam ,&nbsp;Jennie G. Noll ,&nbsp;Elisabeth B. Binder ,&nbsp;Chad E. Shenk","doi":"10.1016/j.ynstr.2023.100577","DOIUrl":"https://doi.org/10.1016/j.ynstr.2023.100577","url":null,"abstract":"<div><h3>Background</h3><p>Early life adversity and psychiatric disorders are associated with earlier declines in neurocognitive abilities during adulthood. These declines may be preceded by changes in biological aging, specifically epigenetic age acceleration, providing an opportunity to uncover genome-wide biomarkers that identify individuals most likely to benefit from early screening and prevention.</p></div><div><h3>Methods</h3><p>Five unique epigenetic age acceleration clocks derived from peripheral blood were examined in relation to latent variables of general and speeded cognitive abilities across two independent cohorts: 1) the Female Growth and Development Study (FGDS; <em>n</em> = 86), a 30-year prospective cohort study of substantiated child sexual abuse and non-abused controls, and 2) the Biological Classification of Mental Disorders study (BeCOME; <em>n</em> = 313), an adult community cohort established based on psychiatric disorders.</p></div><div><h3>Results</h3><p>A faster pace of biological aging (DunedinPoAm) was associated with lower general cognitive abilities in both cohorts and slower speeded abilities in the BeCOME cohort. Acceleration in the Horvath clock was significantly associated with slower speeded abilities in the BeCOME cohort but not the FGDS. Acceleration in the Hannum clock and the GrimAge clock were not significantly associated with either cognitive ability. Accelerated PhenoAge was associated with slower speeded abilities in the FGDS but not the BeCOME cohort.</p></div><div><h3>Conclusions</h3><p>The present results suggest that epigenetic age acceleration has the potential to serve as a biomarker for neurocognitive decline in adults with a history of early life adversity or psychiatric disorders. Estimates of epigenetic aging may identify adults at risk of cognitive decline that could benefit from early neurocognitive screening.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100577"},"PeriodicalIF":5.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49819106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?","authors":"Danique La Torre ,&nbsp;Lukas Van Oudenhove ,&nbsp;Tim Vanuytsel ,&nbsp;Kristin Verbeke","doi":"10.1016/j.ynstr.2023.100579","DOIUrl":"10.1016/j.ynstr.2023.100579","url":null,"abstract":"<div><p>An impaired intestinal barrier function can be detrimental to the host as it may allow the translocation of luminal antigens and toxins into the subepithelial tissue and bloodstream. In turn, this may cause local and systemic immune responses and lead to the development of pathologies. In vitro and animal studies strongly suggest that psychosocial stress is one of the factors that can increase intestinal permeability via mast-cell dependent mechanisms. Remarkably, studies have not been able to yield unequivocal evidence that such relation between stress and intestinal permeability also exists in (healthy) humans. In the current Review, we discuss the mechanisms that are involved in stress-induced intestinal permeability changes and postulate factors that influence these alterations and that may explain the translational difficulties from in vitro and animal to human studies. As human research differs highly from animal research in the extent to which stress can be applied and intestinal permeability can be measured, it remains difficult to draw conclusions about the presence of a relation between stress and intestinal permeability in (healthy) humans. Future studies should bear in mind these difficulties, and more research into <em>in vivo</em> methods to assess intestinal permeability are warranted.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100579"},"PeriodicalIF":5.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/b5/main.PMC10569989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic","authors":"Qingyuan Li ,&nbsp;Xun Zhang ,&nbsp;Xun Yang ,&nbsp;Nanfang Pan ,&nbsp;Xiao Li ,&nbsp;Graham J. Kemp ,&nbsp;Song Wang ,&nbsp;Qiyong Gong","doi":"10.1016/j.ynstr.2023.100578","DOIUrl":"10.1016/j.ynstr.2023.100578","url":null,"abstract":"<div><h3>Background</h3><p>Social anxiety (SA) is a negative emotional response that can lead to mental health issues, which some have experienced during the coronavirus disease 2019 (COVID-19) pandemic. Little attention has been given to the neurobiological mechanisms underlying inter-individual differences in SA alterations related to COVID-19. This study aims to identify neurofunctional markers of COVID-specific SA development.</p></div><div><h3>Methods</h3><p>110 healthy participants underwent resting-state magnetic resonance imaging and behavioral tests before the pandemic (T1, October 2019 to January 2020) and completed follow-up behavioral measurements during the pandemic (T2, February to May 2020). We constructed individual functional networks and used graph theoretical analysis to estimate their global and nodal topological properties, then used Pearson correlation and partial least squares correlations examine their associations with COVID-specific SA alterations.</p></div><div><h3>Results</h3><p>In terms of global network parameters, SA alterations (T2-T1) were negatively related to pre-pandemic brain small-worldness and normalized clustering coefficient. In terms of nodal network parameters, SA alterations were positively linked to a pronounced degree centrality pattern, encompassing both the high-level cognitive networks (dorsal attention network, cingulo-opercular task control network, default mode network, memory retrieval network, fronto-parietal task control network, and subcortical network) and low-level perceptual networks (sensory/somatomotor network, auditory network, and visual network). These findings were robust after controlling for pre-pandemic general anxiety, other stressful life events, and family socioeconomic status, as well as by treating SA alterations as categorical variables.</p></div><div><h3>Conclusions</h3><p>The individual functional network associated with SA alterations showed a disrupted topological organization with a more random state, which may shed light on the neurobiological basis of COVID-related SA changes at the network level.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100578"},"PeriodicalIF":5.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/83/main.PMC10570707.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater maltreatment severity is associated with smaller brain volume with implication for intellectual ability in young children","authors":"Judith Joseph ,&nbsp;Claudia Buss ,&nbsp;Andrea Knop ,&nbsp;Karin de Punder ,&nbsp;Sibylle M. Winter ,&nbsp;Birgit Spors ,&nbsp;Elisabeth Binder ,&nbsp;John-Dylan Haynes ,&nbsp;Christine Heim","doi":"10.1016/j.ynstr.2023.100576","DOIUrl":"10.1016/j.ynstr.2023.100576","url":null,"abstract":"<div><h3>Background</h3><p>Childhood maltreatment profoundly alters trajectories of brain development, promoting markedly increased long-term health risks and impaired intellectual development. However, the immediate impact of maltreatment on brain development in children and the extent to which altered global brain volume contributes to intellectual development in children with maltreatment experience is currently unknown. We here utilized MRI data obtained from children within 6 months after the exposure to maltreatment to assess the association of maltreatment severity with global brain volume changes. We further assessed the association between maltreatment severity and intellectual development and tested for the mediating effect of brain volume on this association.</p></div><div><h3>Method</h3><p>We used structural MRI (3T) in a sample of 49 children aged 3–5 years with maltreatment exposure, i.e. emotional and physical abuse and/or neglect within 6 months, to characterize intracranial and tissue-specific volumes. Maltreatment severity was coded using the Maternal Interview for the Classification of Maltreatment. IQ was tested at study entry and after one year using the Snijders Oomen Nonverbal Test.</p></div><div><h3>Results</h3><p>Higher maltreatment severity was significantly correlated with smaller intracranial volume (<em>r</em> = -.393, <em>p</em> = .008), which was mainly driven by lower total brain volume (<em>r</em> = -.393, <em>p</em> = .008), which in turn was primarily due to smaller gray matter volume (<em>r</em> = -.454, <em>p</em> = .002). Furthermore, smaller gray matter volume was associated with lower IQ at study entry (r = -.548, <em>p</em> &lt; .001) and predicted IQ one year later (r = -.493, <em>p</em> = .004). The observed associations were independent of potential confounding variables, including height, socioeconomic status, age and sex.</p></div><div><h3>Importance</h3><p>We provide evidence that greater maltreatment severity in early childhood is related to smaller brain size at a very young age with significant consequences for intellectual ability, likely setting a path for far-reaching long-term disadvantages. Insights into the molecular and neural processes that underlie the impact of maltreatment on brain structure and function are urgently needed to derive mechanism-driven targets for early intervention.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100576"},"PeriodicalIF":5.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/05/main.PMC10558820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41129005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic stress promotes basal ganglia disinhibition by increasing the excitatory drive of direct-pathway neurons","authors":"Diana Rodrigues ,&nbsp;Patricia Monteiro","doi":"10.1016/j.ynstr.2023.100571","DOIUrl":"10.1016/j.ynstr.2023.100571","url":null,"abstract":"<div><p>Chronic stress (CS) is a well-recognized triggering factor in obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS), two neuropsychiatric disorders characterized by the presence of stereotypic motor symptoms. Planning and execution of motor actions are controlled by the dorsal striatum, a brain region that promotes or suppresses motor movement by activating striatal neurons from the direct- or indirect-pathway, respectively. Despite the dorsal striatum being affected in motor disorders and by CS exposure, how CS affects the two opposing pathways is not fully understood. Here, we report that CS in mice selectively potentiates the direct-pathway, while sparing the indirect-pathway. Specifically, we show that CS both increases excitation and reduces inhibition over direct-pathway neurons in the dorsomedial striatum (DMS). Furthermore, inhibitory interneurons located in the DMS also display reduced excitatory drive after chronic stress, thus amplifying striatal disinhibition. Altogether, we propose a model where both increased excitatory drive and decreased inhibitory drive in the striatum causes disinhibition of basal ganglia's motor direct pathway - a mechanism that might explain the emergence of motor stereotypies and tic disorders under stress.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"27 ","pages":"Article 100571"},"PeriodicalIF":5.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}