Neural Plasticity最新文献_第9页

Research on Recognition of Motor Imagination Based on Connectivity Features of Brain Functional Network. 基于大脑功能网络连接特征的运动想象识别研究。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-12 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6655430

Zhizeng Luo, Ronghang Jin, Hongfei Shi, Xianju Lu

{"title":"Research on Recognition of Motor Imagination Based on Connectivity Features of Brain Functional Network.","authors":"Zhizeng Luo, Ronghang Jin, Hongfei Shi, Xianju Lu","doi":"10.1155/2021/6655430","DOIUrl":"10.1155/2021/6655430","url":null,"abstract":"Feature extraction is essential for classifying different motor imagery (MI) tasks in a brain-computer interface. To improve classification accuracy, we propose a novel feature extraction method in which the connectivity increment rate (CIR) of the brain function network (BFN) is extracted. First, the BFN is constructed on the basis of the threshold matrix of the Pearson correlation coefficient of the mu rhythm among the channels. In addition, a weighted BFN is constructed and expressed by the sum of the existing edge weights to characterize the cerebral cortex activation degree in different movement patterns. Then, on the basis of the topological structures of seven mental tasks, three regional networks centered on the C3, C4, and Cz channels are constructed, which are consistent with correspondence between limb movement patterns and cerebral cortex in neurophysiology. Furthermore, the CIR of each regional functional network is calculated to form three-dimensional vectors. Finally, we use the support vector machine to learn a classifier for multiclass MI tasks. Experimental results show a significant improvement and demonstrate the success of the extracted feature CIR in dealing with MI classification. Specifically, the average classification performance reaches 88.67% which is higher than other competing methods, indicating that the extracted CIR is effective for MI classification.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6655430"},"PeriodicalIF":3.1,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Histone Modifications of Neuronal Plasticity. 神经元可塑性的组蛋白修饰。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-11 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6690523

Huixia Geng, Hongyang Chen, Haiying Wang, Lai Wang

引用次数: 11

Impaired Limb Functional Outcome of Peripheral Nerve Regeneration Is Marked by Incomplete Recovery of Paw Muscle Atrophy and Brain Functional Connectivity in a Rat Forearm Nerve Repair Model. 在大鼠前臂神经修复模型中，周围神经再生的肢体功能受损结果以爪肌萎缩和脑功能连接的不完全恢复为标志。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-11 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6689476

Qiyuan Bao, Qi Liu, Jun Wang, Yuhui Shen, Weibin Zhang

{"title":"Impaired Limb Functional Outcome of Peripheral Nerve Regeneration Is Marked by Incomplete Recovery of Paw Muscle Atrophy and Brain Functional Connectivity in a Rat Forearm Nerve Repair Model.","authors":"Qiyuan Bao, Qi Liu, Jun Wang, Yuhui Shen, Weibin Zhang","doi":"10.1155/2021/6689476","DOIUrl":"https://doi.org/10.1155/2021/6689476","url":null,"abstract":"Skilled sensorimotor deficit is an unsolved problem of peripheral nerve injury (PNI) led by limb trauma or malignancies, despite the improvements in surgical techniques of peripheral nerve anastomosis. It is now accepted that successful functional recovery of PNI relies tremendously on the multilevel neural plasticity from the muscle to the brain. However, animal models that recapitulate these processes are still lacking. In this report, we developed a rat model of PNI to longitudinally assess peripheral muscle reinnervation and brain functional reorganization using noninvasive imaging technology. Based on such model, we compared the longitudinal changes of the rat forepaw intrinsic muscle volume and the seed-based functional connectivity of the sensorimotor cortex after nerve repair. We found that the improvement of skilled limb function and the recovery of paw intrinsic muscle following nerve regeneration are incomplete, which correlated with the functional connectivity between the primary motor cortex and dorsal striatum. Our results were highly relevant to the clinical observations and provided a framework for future investigations that aim to study the peripheral central sensorimotor circuitry underlying skilled limb function recovery after PNI.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6689476"},"PeriodicalIF":3.1,"publicationDate":"2021-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Motor Sequence Learning across Multiple Sessions Is Not Facilitated by Targeting Consolidation with Posttraining tDCS in Patients with Progressive Multiple Sclerosis. 进行性多发性硬化症患者训练后tDCS的目标巩固不能促进多期运动序列学习。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-09 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6696341

Harald Seelmann-Eggebert, Muriel Stoppe, Florian Then Bergh, Joseph Classen, Jost-Julian Rumpf

{"title":"Motor Sequence Learning across Multiple Sessions Is Not Facilitated by Targeting Consolidation with Posttraining tDCS in Patients with Progressive Multiple Sclerosis.","authors":"Harald Seelmann-Eggebert, Muriel Stoppe, Florian Then Bergh, Joseph Classen, Jost-Julian Rumpf","doi":"10.1155/2021/6696341","DOIUrl":"https://doi.org/10.1155/2021/6696341","url":null,"abstract":"Compared to relapsing-remitting multiple sclerosis (MS), progressive MS is characterized by a lack of spontaneous recovery and a poor response to pharmaceutical immunomodulatory treatment. These patients may, therefore, particularly benefit from interventions that augment training-induced plasticity of the central nervous system. In this cross-sectional double-blind cross-over pilot study, effects of transcranial direct current stimulation (tDCS) on motor sequence learning were examined across four sessions on days 1, 3, 5, and 8 in 16 patients with progressive MS. Active or sham anodal tDCS of the primary motor cortex was applied immediately after each training session. Participants took part in two experiments separated by at least four weeks, which differed with respect to the type of posttraining tDCS (active or sham). While task performance across blocks of training and across sessions improved significantly in both the active and sham tDCS experiment, neither online nor offline motor learning was modulated by the type of tDCS. Accordingly, the primary endpoint (task performance on day 8) did not differ between stimulation conditions. In sum, patients with progressive MS are able to improve performance in an ecologically valid motor sequence learning task through training. However, even multisession posttraining tDCS fails to promote motor learning in progressive MS.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6696341"},"PeriodicalIF":3.1,"publicationDate":"2021-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25535815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of BDNF-mTORC1 Signaling Pathway in Female Depression. BDNF-mTORC1信号通路在女性抑郁症中的作用

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-09 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6619515

Xianquan An, Xiaoxiao Yao, Bingjin Li, Wei Yang, Ranji Cui, Guoqing Zhao, Yang Jin

{"title":"Role of BDNF-mTORC1 Signaling Pathway in Female Depression.","authors":"Xianquan An, Xiaoxiao Yao, Bingjin Li, Wei Yang, Ranji Cui, Guoqing Zhao, Yang Jin","doi":"10.1155/2021/6619515","DOIUrl":"https://doi.org/10.1155/2021/6619515","url":null,"abstract":"Depression is a common psychological and mental disorder, characterized by low mood, slow thinking and low will, and even suicidal tendencies in severe cases. It imposes a huge mental and economic burden on patients and their families, and its prevention and treatment have become an urgent public health problem. It is worth noting that there is a significant gender difference in the incidence of depression. Studies have shown that females are far more likely to suffer from depression than males, confirming a close relationship between estrogen and the onset of depression. Moreover, recent studies suggest that the brain-derived neurotrophic factor- (BDNF-) mammalian target of rapamycin complex-1 (mTORC1) signaling pathway is a crucial target pathway for improving depression and mediates the rapid antidepressant-like effects of various antidepressants. However, it is not clear whether the BDNF-mTORC1 signaling pathway mediates the regulation of female depression and how to regulate female depression. Hence, we focused on the modulation of estrogen-BDNF-mTORC1 signaling in depression and its possible mechanisms in recent years.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6619515"},"PeriodicalIF":3.1,"publicationDate":"2021-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Connectivity Analysis during Rubber Hand Illusion-A Pilot TMS-EEG Study in a Patient with SCI. 橡胶手错觉的连通性分析——脊髓损伤患者的TMS-EEG先导研究。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6695530

Vanessa N Frey, Aljoscha Thomschewski, Patrick B Langthaler, Alexander B Kunz, Yvonne Höller, Eugen Trinka, Raffaele Nardone

{"title":"Connectivity Analysis during Rubber Hand Illusion-A Pilot TMS-EEG Study in a Patient with SCI.","authors":"Vanessa N Frey, Aljoscha Thomschewski, Patrick B Langthaler, Alexander B Kunz, Yvonne Höller, Eugen Trinka, Raffaele Nardone","doi":"10.1155/2021/6695530","DOIUrl":"https://doi.org/10.1155/2021/6695530","url":null,"abstract":"Background: Bodily self-perception is an important concept for several neurological disorders, including spinal cord injury (SCI). Changing one's bodily self-perception, e.g., via rubber hand illusion (RHI), induces alterations of bottom-up and top-down pathways and with this the connectivity between involved brain areas. We aim to examine whether (1) this process can be manipulated by changing cortical excitability, (2) connectivity between relevant brain areas differ when the RHI cannot be evoked, and (3) how this projection differs in a patient with SCI.Method: We applied RHI and facilitatory theta burst stimulation (TBS) on the right primary somatosensory cortex (S1) of 18 healthy participants and one patient with incomplete, cervical SCI. During RHI, we recorded high-density electroencephalography (HD-EEG) and extracted directed and nondirected connectivity measures.Results: There is no difference in connectivity between sham and real TBS or in the effectivity of RHI. We observed a higher laterality in the patient, i.e., higher connectivity of the right and lower of the left hemisphere. Besides this, connectivity patterns do not differ between healthy participants and the patient.Conclusion: This connectivity pattern might represent a neuroplastic response in the attempt to overcome the functional impairment of the patient resulting in a similar overall connectivity pattern to the healthy participants, yet with a higher sensitivity towards RHI and a higher laterality. The cortico-cortical communication was not altered depending on whether the illusion was provoked or not; hence, the perceptory illusion could not be observed in the EEG analysis.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6695530"},"PeriodicalIF":3.1,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secretagogin Mediates the Regulatory Effect of Electroacupuncture on Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Surgical Trauma. 分泌素介导电针对外科创伤下丘脑-垂体-肾上腺轴功能障碍的调节作用。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-04 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8881136

Mizhen Zhang, Jingxian Sun, Yu Wang, Zhanzhuang Tian

{"title":"Secretagogin Mediates the Regulatory Effect of Electroacupuncture on Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Surgical Trauma.","authors":"Mizhen Zhang, Jingxian Sun, Yu Wang, Zhanzhuang Tian","doi":"10.1155/2021/8881136","DOIUrl":"https://doi.org/10.1155/2021/8881136","url":null,"abstract":"Electroacupuncture (EA) improves hypothalamic-pituitary-adrenal (HPA) axis disorder by reducing corticotropin-releasing hormone (CRH) synthesis and release in the paraventricular nucleus (PVN). However, the potential mechanism underlying CRH regulation remains unclear. Secretagogin (SCGN) is closely related to stress and is involved in regulating the release of CRH. We hypothesized that SCGN in the PVN might trigger the HPA system and be involved in EA-mediated modulation of HPA dysfunction caused by surgical trauma. Serum CRH and adrenocorticotropic hormone (ACTH) and plasma corticosterone (CORT) levels at 6 h and 24 h after hepatectomy were determined by radioimmunoassay. CRH and SCGN protein levels in the PVN were detected by western blot and immunofluorescence, and CRH and SCGN mRNA levels in the PVN were determined by means of real-time polymerase chain reaction (RT-PCR) and in situ hybridization (ISH). Our studies showed that serum CRH, ACTH, and CORT levels and PVN CRH expression were significantly increased at 6 h and 24 h after hepatectomy in the hepatectomy group compared with the control group, and those in the EA+hepatectomy group were decreased compared with those in the hepatectomy group. The protein and mRNA levels of SCGN in the PVN were also increased after hepatectomy, and their expression in the EA+hepatectomy group was decreased compared with that in the hepatectomy group. When SCGN expression in the PVN was functionally knocked down by a constructed CsCI virus, we found that SCGN knockdown decreased the serum CRH, ACTH, and CORT levels in the SCGN shRNA+hepatectomy group compared with the hepatectomy group, and it also attenuated CRH expression in the PVN. In summary, our findings illustrated that EA normalized HPA axis dysfunction after surgical trauma by decreasing the transcription and synthesis of SCGN.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"8881136"},"PeriodicalIF":3.1,"publicationDate":"2021-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review. 生物反馈和神经反馈干预治疗抑郁症的证据水平:叙述性回顾。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-04 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8878857

Mikhail Ye Melnikov

{"title":"The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review.","authors":"Mikhail Ye Melnikov","doi":"10.1155/2021/8878857","DOIUrl":"https://doi.org/10.1155/2021/8878857","url":null,"abstract":"This article is aimed at showing the current level of evidence for the usage of biofeedback and neurofeedback to treat depression along with a detailed review of the studies in the field and a discussion of rationale for utilizing each protocol. La Vaque et al. criteria endorsed by the Association for Applied Psychophysiology and Biofeedback and International Society for Neuroregulation & Research were accepted as a means of study evaluation. Heart rate variability (HRV) biofeedback was found to be moderately supportable as a treatment of MDD while outcome measure was a subjective questionnaire like Beck Depression Inventory (level 3/5, \"probably efficacious\"). Electroencephalographic (EEG) neurofeedback protocols, namely, alpha-theta, alpha, and sensorimotor rhythm upregulation, all qualify for level 2/5, \"possibly efficacious.\" Frontal alpha asymmetry protocol also received limited evidence of effect in depression (level 2/5, \"possibly efficacious\"). Finally, the two most influential real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback protocols targeting the amygdala and the frontal cortices both demonstrate some effectiveness, though lack replications (level 2/5, \"possibly efficacious\"). Thus, neurofeedback specifically targeting depression is moderately supported by existing studies (all fit level 2/5, \"possibly efficacious\"). The greatest complication preventing certain protocols from reaching higher evidence levels is a relatively high number of uncontrolled studies and an absence of accurate replications arising from the heterogeneity in protocol details, course lengths, measures of improvement, control conditions, and sample characteristics.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"8878857"},"PeriodicalIF":3.1,"publicationDate":"2021-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25390707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

A Synchronization Criterion for Two Hindmarsh-Rose Neurons with Linear and Nonlinear Coupling Functions Based on the Laplace Transform Method. 基于拉普拉斯变换的两个具有线性和非线性耦合函数的Hindmarsh-Rose神经元的同步判据。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-02 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6692132

Chunlin Su, Bin Zhen, Zigen Song

{"title":"A Synchronization Criterion for Two Hindmarsh-Rose Neurons with Linear and Nonlinear Coupling Functions Based on the Laplace Transform Method.","authors":"Chunlin Su, Bin Zhen, Zigen Song","doi":"10.1155/2021/6692132","DOIUrl":"https://doi.org/10.1155/2021/6692132","url":null,"abstract":"In this paper, an analytical criterion is proposed to investigate the synchronization between two Hindmarsh-Rose neurons with linear and nonlinear coupling functions based on the Laplace transform method. Different from previous works, the synchronization error system is expressed in its integral form, which is more convenient to analyze. The synchronization problem of two HR coupled neurons is ultimately converted into the stability problem of roots to a nonlinear algebraic equation. Then, an analytical criterion for synchronization between the two HR neurons can be given by using the Routh-Hurwitz criterion. Numerical simulations show that the synchronization criterion derived in this paper is valid, regardless of the periodic spikes or burst-spike chaotic behavior of the two HR neurons. Furthermore, the analytical results have almost the same accuracy as the conditional Lyapunov method. In addition, the calculation quantities always are small no matter the linear and nonlinear coupling functions, which show that the approach presented in this paper is easy to be developed to study synchronization between a large number of HR neurons.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6692132"},"PeriodicalIF":3.1,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25382882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparing Two Different Modes of Task Practice during Lower Limb Constraint-Induced Movement Therapy in People with Stroke: A Randomized Clinical Trial. 在脑卒中患者下肢约束诱导运动治疗中比较两种不同任务练习模式:一项随机临床试验。

IF 3.1 4区医学

Neural Plasticity Pub Date : 2021-02-01 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6664058

Auwal Abdullahi, Naima Umar Aliyu, Ushotanefe Useh, Muhammad Aliyu Abba, Mukadas Oyeniran Akindele, Steven Truijen, Wim Saeys

{"title":"Comparing Two Different Modes of Task Practice during Lower Limb Constraint-Induced Movement Therapy in People with Stroke: A Randomized Clinical Trial.","authors":"Auwal Abdullahi, Naima Umar Aliyu, Ushotanefe Useh, Muhammad Aliyu Abba, Mukadas Oyeniran Akindele, Steven Truijen, Wim Saeys","doi":"10.1155/2021/6664058","DOIUrl":"https://doi.org/10.1155/2021/6664058","url":null,"abstract":"Background: Constraint-induced movement therapy (CIMT) is used for the rehabilitation of motor function after stroke.Objectives: The aim of this study was to compare the effects of lower limb CIMT that uses number of repetition of tasks with the one that uses number of hours of practice.Method: The study was a randomized clinical trial approved by the Ethics Committee of Kano State Ministry of Health. Fifty-eight people with stroke participated in the study. Groups 1 and 2 performed daily 600 repetitions and 3 hours of task practice, respectively, 5 times weekly for 4 weeks. Motor impairment (primary outcome), balance, functional mobility, knee extensor spasticity, walking speed and endurance, and exertion before and after commencement of activities were assessed at baseline and postintervention. The data was analyzed using Friedmann and Mann-Whitney U tests.Result: The results showed that there was only significant difference (p < 0.05) in knee extensor spasticity (group 1 (median = 0(0), mean rank = 27.50); group 2 (median = 0(0), mean rank = 31.64)), exertion before commencement of activities (group 1 (median = 0(0.5), mean rank = 21.90); group 2 (median = 1(0.5), mean rank = 37.64)), and exertion after commencement of activities (group 1 (median = 1(1), mean rank = 20.07); group 2 (median = 1(0), mean rank = 39.61) postintervention in favour of the experimental group (group 1)).Conclusion: The group 1 protocol is more effective at improving outcomes after stroke.","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6664058"},"PeriodicalIF":3.1,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25382881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13