Neural Plasticity最新文献

{"title":"Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE₂ Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model.","authors":"Wei Wang, Yunhao Wang, Tengfei Lou, Mingqian Ding, Juehong Li, Hao Xiong, Zhixiao Yao, Yingying Ma, Huajiang Chen, Shenghe Liu","doi":"10.1155/2021/6684176","DOIUrl":"10.1155/2021/6684176","url":null,"abstract":"<p><p>To date, failed back surgery syndrome (FBSS) remains a therapy-refractory clinical condition after spinal surgery. The antiadhesion membrane is applied to prevent FBSS by isolating fibrosis; however, the inflammation stimulated by the foreign body and surgical trauma needs to be further resolved simultaneously. Therefore, we developed new electrospun polycaprolactone (PCL) fibrous membranes loaded with celecoxib (CEL) to prevent fibrosis and inflammation associated with FBSS. The CEL-loaded PCL fibers were randomly distributed, and the drug was released over two weeks. Fluorescence micrographs revealed that the fibroblasts proliferated less on the PCL-CEL fibrous membranes than in the PCL group and the blank control. In the rat laminectomy model after 4 weeks, magnetic resonance imaging of epidural fibrosis was least in the PCL-CEL group. Expression of COX-2 and PGE₂ was lower in the PCL-CEL group. It concluded that the CEL-loaded PCL membrane could reduce fibrosis and inflammation in a rat model of FBSS via COX-2/PGE₂ signaling pathways.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6684176"},"PeriodicalIF":3.1,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25444115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of a Large-Scale Spiking Neural Network with Quadratic Integrate-and-Fire Neurons.","authors":"Weijie Ye","doi":"10.1155/2021/6623926","DOIUrl":"10.1155/2021/6623926","url":null,"abstract":"<p><p>Since the high dimension and complexity of the large-scale spiking neural network, it is difficult to research the network dynamics. In recent decades, the mean-field approximation has been a useful method to reduce the dimension of the network. In this study, we construct a large-scale spiking neural network with quadratic integrate-and-fire neurons and reduce it to a mean-field model to research the network dynamics. We find that the activity of the mean-field model is consistent with the network activity. Based on this agreement, a two-parameter bifurcation analysis is performed on the mean-field model to understand the network dynamics. The bifurcation scenario indicates that the network model has the quiescence state, the steady state with a relatively high firing rate, and the synchronization state which correspond to the stable node, stable focus, and stable limit cycle of the system, respectively. There exist several stable limit cycles with different periods, so we can observe the synchronization states with different periods. Additionally, the model shows bistability in some regions of the bifurcation diagram which suggests that two different activities coexist in the network. The mechanisms that how these states switch are also indicated by the bifurcation curves.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6623926"},"PeriodicalIF":3.1,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25444113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review.","authors":"Xia-Qing Wang,&nbsp;Tahmineh Mokhtari,&nbsp;Yu-Xuan Zeng,&nbsp;Lu-Peng Yue,&nbsp;Li Hu","doi":"10.1155/2021/6682275","DOIUrl":"https://doi.org/10.1155/2021/6682275","url":null,"abstract":"<p><p>Chronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. Opioids are the most common analgesics prescribed for the management of moderate to severe pain. However, chronic exposure to these drugs can result in opioid tolerance and opioid-induced hyperalgesia. On pain modulation strategies, exploiting the multitarget drugs with the ability of the superadditive or synergistic interactions attracts more attention. In the present report, we have reviewed the analgesic effects of different dopamine receptors, particularly D1 and D2 receptors, in different regions of the central nervous system, including the spinal cord, striatum, nucleus accumbens (NAc), and periaqueductal gray (PAG). According to the evidence, these regions are not only involved in pain modulation but also express a high density of DA receptors. The findings can be categorized as follows: (1) D2-like receptors may exert a higher analgesic potency, but D1-like receptors act in different manners across several mechanisms in the mentioned regions; (2) in the spinal cord and striatum, antinociception of DA is mainly mediated by D2-like receptors, while in the NAc and PAG, both D1- and D2-like receptors are involved as analgesic targets; and (3) D2-like receptor agonists can act as adjuvants of <i>μ</i>-opioid receptor agonists to potentiate analgesic effects and provide a better approach to pain relief.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6682275"},"PeriodicalIF":3.1,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25467366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Upcoming Events Occurring in the Space Surrounding the Hand.","authors":"Maria L Rangel,&nbsp;Lidiane Souza,&nbsp;Erika C Rodrigues,&nbsp;José M Oliveira,&nbsp;Michelle F Miranda,&nbsp;Antonio Galves,&nbsp;Claudia D Vargas","doi":"10.1155/2021/6649135","DOIUrl":"https://doi.org/10.1155/2021/6649135","url":null,"abstract":"<p><p>Predicting upcoming sensorimotor events means creating forward estimates of the body and the surrounding world. This ability is a fundamental aspect of skilled motor behavior and requires an accurate and constantly updated representation of the body and the environment. To test whether these prediction mechanisms could be affected by a peripheral injury, we employed an action observation and electroencephalogram (EEG) paradigm to assess the occurrence of prediction markers in anticipation of observed sensorimotor events in healthy and brachial plexus injury (BPI) participants. Nine healthy subjects and six BPI patients watched a series of video clips showing an actor's hand and a colored ball in an egocentric perspective. The color of the ball indicated whether the hand would grasp it (hand movement), or the ball would roll toward the hand and touch it (ball movement), or no event would occur (no movement). In healthy participants, we expected to find distinct electroencephalographic activation patterns (EEG signatures) specific to the prediction of the occurrence of each of these situations. Cluster analysis from EEG signals recorded from electrodes placed over the sensorimotor cortex of control participants showed that predicting either an upcoming hand movement or the occurrence of a tactile event yielded specific neural signatures. In BPI participants, the EEG signals from the sensorimotor cortex contralateral to the dominant hand in the hand movement condition were different compared to the other conditions. Furthermore, there were no differences between ball movement and no movement conditions in the sensorimotor cortex contralateral to the dominant hand, suggesting that BPI blurred specifically the ability to predict upcoming tactile events for the dominant hand. These results highlight the role of the sensorimotor cortex in creating estimates of both actions and tactile interactions in the space around the body and suggest plastic effects on prediction coding following peripheral sensorimotor loss.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6649135"},"PeriodicalIF":3.1,"publicationDate":"2021-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25451779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Study of Pain after Spinal Cord Injury.","authors":"Yi-Zu Wang,&nbsp;Cheng-Cheng Wu,&nbsp;Xue-Qiang Wang","doi":"10.1155/2021/6634644","DOIUrl":"https://doi.org/10.1155/2021/6634644","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of comorbid pain after spinal cord injury (SCI) is relatively high in clinical observations and has continued to increase over time. Neuropathic pain (70.14%) is the most popular subject in academic journals after SCI. However, studies that used the bibliometric method to analyze comorbid pain after SCI are still lacking. This study is aimed at combining and integrating acquired information to analyze the global trends of research on the comorbidity of pain after SCI in the last three decades (1990-2019).</p><p><strong>Methods: </strong>Systematic works of literature published from 1990 to 2019 were obtained from the Web of Science Core Collection. CiteSpace software was used to analyze the relationship of publication year with the country, institution, journals, authors, references, and keywords. The regression analysis is used to evaluate the percentage of the category increase or decrease over time significantly. IBM SPSS Statistics was used in the statistical analysis.</p><p><strong>Results: </strong>A total of 730 publications were included in the analysis. A remarkable increase in the number of publications was observed in the study period (<i>P</i> < 0.05). A total of 202 academic journals focused on the categories of clinical neurology, neurosciences, and rehabilitation, and the annual growth rate of articles in these three categories was statistically significant (<i>P</i> < 0.05). The USA (356, 48.77%) and the University of Miami (64, 8.77%) were the country and institution with the highest number of publications, respectively. <i>Spinal Cord</i>, which was the main journal for research on pain after SCI, had the most publications (88, 12.05%). Burst keywords showed that the individual, inflammation, and central sensitization with pain after SCI are the research development trends and focus in this research field.</p><p><strong>Conclusions: </strong>Overall, this study provides the latest research direction for pain after SCI. This historical overview of research into pain after SCI will be a useful basis for further research into development trends, focus issues, cooperators, and cooperative institutions.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6634644"},"PeriodicalIF":3.1,"publicationDate":"2021-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25451778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Representations of Transversus Abdominis and Multifidus Muscles Were Discrete in Patients with Chronic Low Back Pain: Evidence Elicited by TMS.","authors":"Xin Li,&nbsp;Howe Liu,&nbsp;Le Ge,&nbsp;Yifeng Yan,&nbsp;Wai Leung Ambrose Lo,&nbsp;Le Li,&nbsp;Chuhuai Wang","doi":"10.1155/2021/6666024","DOIUrl":"https://doi.org/10.1155/2021/6666024","url":null,"abstract":"<p><strong>Introduction: </strong>The transversus abdominis (TVA) and multifidus (MF) muscles are the main segmental spinal stabilizers that are controlled by the primary motor cortex of the brain. However, relocations of the muscle representation in the motor cortex may occur after chronic lower back pain (cLBP); it still needs more evidence to be proven. The current study was aimed at applying transcranial magnetic stimulation (TMS) to investigate the changes of representation of TVA and MF muscles at the cortical network in individuals with cLBP.</p><p><strong>Methods: </strong>Twenty-four patients with cLBP and 12 age-matched healthy individuals were recruited. Responses of TVA and MF to TMS during muscle contraction were monitored and mapped over the contralateral cortex using a standardized grid cap. Maps of the center of gravity (CoG), area, volume, and latency were analyzed, and the asymmetry index was also computed and compared.</p><p><strong>Results: </strong>The locations of MF CoG in cLBP individuals were posterior and lateral to the CoG locations in healthy individuals. In the healthy group, the locations of TVA and MF CoG were closed to each other in both the left and right hemispheres. In the cLBP group, these two locations were next to each other in the right hemisphere but discrete in the left hemisphere. In the cLBP group, the cortical motor map of TVA and MF were mutually symmetric in five out of eleven (45.5%) subjects and leftward asymmetric in four out of ten (40.0%) subjects.</p><p><strong>Conclusions: </strong>Neural representations of TVA and MF muscles were closely organized in both the right and left motor cortices in the healthy group but were discretely organized in the left motor cortex in the cLBP group. This provides strong support for the neural basis of pathokinesiology and clinical treatment of cLBP.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6666024"},"PeriodicalIF":3.1,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25444114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Recognition of Motor Imagination Based on Connectivity Features of Brain Functional Network.","authors":"Zhizeng Luo, Ronghang Jin, Hongfei Shi, Xianju Lu","doi":"10.1155/2021/6655430","DOIUrl":"10.1155/2021/6655430","url":null,"abstract":"<p><p>Feature extraction is essential for classifying different motor imagery (MI) tasks in a brain-computer interface. To improve classification accuracy, we propose a novel feature extraction method in which the connectivity increment rate (CIR) of the brain function network (BFN) is extracted. First, the BFN is constructed on the basis of the threshold matrix of the Pearson correlation coefficient of the mu rhythm among the channels. In addition, a weighted BFN is constructed and expressed by the sum of the existing edge weights to characterize the cerebral cortex activation degree in different movement patterns. Then, on the basis of the topological structures of seven mental tasks, three regional networks centered on the C3, C4, and Cz channels are constructed, which are consistent with correspondence between limb movement patterns and cerebral cortex in neurophysiology. Furthermore, the CIR of each regional functional network is calculated to form three-dimensional vectors. Finally, we use the support vector machine to learn a classifier for multiclass MI tasks. Experimental results show a significant improvement and demonstrate the success of the extracted feature CIR in dealing with MI classification. Specifically, the average classification performance reaches 88.67% which is higher than other competing methods, indicating that the extracted CIR is effective for MI classification.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6655430"},"PeriodicalIF":3.1,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Histone Modifications of Neuronal Plasticity.","authors":"Huixia Geng,&nbsp;Hongyang Chen,&nbsp;Haiying Wang,&nbsp;Lai Wang","doi":"10.1155/2021/6690523","DOIUrl":"https://doi.org/10.1155/2021/6690523","url":null,"abstract":"<p><p>Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dimensional structure of chromosomes and affect gene expression. Therefore, the combination of different states of histone modifications modulates gene expression is called histone code. The formation of learning and memory is one of the most important mechanisms for animals to adapt to environmental changes. A large number of studies have shown that histone codes are involved in the formation and consolidation of learning and memory. Here, we review the most recent literature of histone modification in regulating neurogenesis, dendritic spine dynamic, synapse formation, and synaptic plasticity.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6690523"},"PeriodicalIF":3.1,"publicationDate":"2021-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Limb Functional Outcome of Peripheral Nerve Regeneration Is Marked by Incomplete Recovery of Paw Muscle Atrophy and Brain Functional Connectivity in a Rat Forearm Nerve Repair Model.","authors":"Qiyuan Bao,&nbsp;Qi Liu,&nbsp;Jun Wang,&nbsp;Yuhui Shen,&nbsp;Weibin Zhang","doi":"10.1155/2021/6689476","DOIUrl":"https://doi.org/10.1155/2021/6689476","url":null,"abstract":"<p><p>Skilled sensorimotor deficit is an unsolved problem of peripheral nerve injury (PNI) led by limb trauma or malignancies, despite the improvements in surgical techniques of peripheral nerve anastomosis. It is now accepted that successful functional recovery of PNI relies tremendously on the multilevel neural plasticity from the muscle to the brain. However, animal models that recapitulate these processes are still lacking. In this report, we developed a rat model of PNI to longitudinally assess peripheral muscle reinnervation and brain functional reorganization using noninvasive imaging technology. Based on such model, we compared the longitudinal changes of the rat forepaw intrinsic muscle volume and the seed-based functional connectivity of the sensorimotor cortex after nerve repair. We found that the improvement of skilled limb function and the recovery of paw intrinsic muscle following nerve regeneration are incomplete, which correlated with the functional connectivity between the primary motor cortex and dorsal striatum. Our results were highly relevant to the clinical observations and provided a framework for future investigations that aim to study the peripheral central sensorimotor circuitry underlying skilled limb function recovery after PNI.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6689476"},"PeriodicalIF":3.1,"publicationDate":"2021-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor Sequence Learning across Multiple Sessions Is Not Facilitated by Targeting Consolidation with Posttraining tDCS in Patients with Progressive Multiple Sclerosis.","authors":"Harald Seelmann-Eggebert,&nbsp;Muriel Stoppe,&nbsp;Florian Then Bergh,&nbsp;Joseph Classen,&nbsp;Jost-Julian Rumpf","doi":"10.1155/2021/6696341","DOIUrl":"https://doi.org/10.1155/2021/6696341","url":null,"abstract":"<p><p>Compared to relapsing-remitting multiple sclerosis (MS), progressive MS is characterized by a lack of spontaneous recovery and a poor response to pharmaceutical immunomodulatory treatment. These patients may, therefore, particularly benefit from interventions that augment training-induced plasticity of the central nervous system. In this cross-sectional double-blind cross-over pilot study, effects of transcranial direct current stimulation (tDCS) on motor sequence learning were examined across four sessions on days 1, 3, 5, and 8 in 16 patients with progressive MS. Active or sham anodal tDCS of the primary motor cortex was applied immediately after each training session. Participants took part in two experiments separated by at least four weeks, which differed with respect to the type of posttraining tDCS (active or sham). While task performance across blocks of training and across sessions improved significantly in both the active and sham tDCS experiment, neither online nor offline motor learning was modulated by the type of tDCS. Accordingly, the primary endpoint (task performance on day 8) did not differ between stimulation conditions. In sum, patients with progressive MS are able to improve performance in an ecologically valid motor sequence learning task through training. However, even multisession posttraining tDCS fails to promote motor learning in progressive MS.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6696341"},"PeriodicalIF":3.1,"publicationDate":"2021-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25535815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}