Neural Plasticity最新文献

{"title":"Focal Vibration Alters Human Digital Sensory Nerve Action Potentials: A Pilot Study.","authors":"Dong Qing Zhu,&nbsp;Fang Liu,&nbsp;Yu Zhu,&nbsp;Duan Lei,&nbsp;Xiang Jin,&nbsp;Lan Xu,&nbsp;Chao Jun Zheng,&nbsp;Robert Weber,&nbsp;Xiang Jun Chen","doi":"10.1155/2021/8819169","DOIUrl":"https://doi.org/10.1155/2021/8819169","url":null,"abstract":"<p><strong>Introduction: </strong>We studied the impact of vibratory stimulation on the electrophysiological features of digital sensory nerve action potential (SNAP).</p><p><strong>Methods: </strong>The antidromic digit 3 SNAP was recorded in 19 healthy adults before, during, and after applying a vibration to either 3rd or 5th metacarpal phalangeal joint (MCPJ) at 60 Hz and amplitude of 2 mm. 100% supramaximal stimulus intensity was performed in 5 subjects (randomly selected from the 19 subjects) where the SNAP sizes were recorded.</p><p><strong>Results: </strong>The amplitude of digit 3 SNAP declined to 58.9 ± 8.6% when a vibration was applied to MCPJ digit 3. These impacts did not change by increasing the electrical stimulus intensity. The SNAP regained its baseline value immediately after the cessation of vibration stimulation. The magnitude of size reduction of digit 3 SNAP was less when vibration was moved to from MCPJ of digit 3 to MCPJ of digit 5. <i>Discussion</i>. The marked drop of the SNAP size during vibratory stimulation reflects the decreased responsiveness of A<i>β</i> afferents to electrical stimulation, which deserve further investigation in the study of focal vibration in neurorehabilitation.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"8819169"},"PeriodicalIF":3.1,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25514032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy.","authors":"Chieh-Hsin Wu, Ming-Kung Wu, Chun-Ching Lu, Hung-Pei Tsai, Ying-Yi Lu, Chih-Lung Lin","doi":"10.1155/2021/8854461","DOIUrl":"10.1155/2021/8854461","url":null,"abstract":"<p><p>Resiniferatoxin is an ultrapotent capsaicin analog that mediates nociceptive processing; treatment with resiniferatoxin can cause an inflammatory response and, ultimately, neuropathic pain. Hepatoma-derived growth factor, a growth factor related to normal development, is associated with neurotransmitters surrounding neurons and glial cells. Therefore, the study aims to investigate how blocking hepatoma-derived growth factor affects the inflammatory response in neuropathic pain. Serum hepatoma-derived growth factor protein expression was measured via ELISA. Resiniferatoxin was administrated intraperitoneally to induce neuropathic pain in 36 male Sprague-Dawley rats which were divided into three groups (resiniferatoxin+recombinant hepatoma-derived growth factor antibody group, resiniferatoxin group, and control group) (<i>n</i> = 12/group). The mechanical threshold response was tested with calibration forceps. Cell apoptosis was measured by TUNEL assay. Immunofluorescence staining was performed to detect apoptosis of neuron cells and proliferation of astrocytes in the spinal cord dorsal horn. RT-PCR technique and western blot were used to measure detect inflammatory factors and protein expressions. Serum hepatoma-derived growth factor protein expression was higher in the patients with sciatica compared to controls. In resiniferatoxin-group rats, protein expression of hepatoma-derived growth factor was higher than controls. Blocking hepatoma-derived growth factor improved the mechanical threshold response in rats. In dorsal root ganglion, blocking hepatoma-derived growth factor inhibited inflammatory cytokines. In the spinal cord dorsal horn, blocking hepatoma-derived growth factor inhibited proliferation of astrocyte, apoptosis of neuron cells, and attenuated expressions of pain-associated proteins. The experiment showed that blocking hepatoma-derived growth factor can prevent neuropathic pain and may be a useful alternative to conventional analgesics.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"8854461"},"PeriodicalIF":3.1,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25485320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Network Pharmacology for Traditional Chinese Medicine Liangxue Tongyu Formula in Acute Intracerebral Hemorrhagic Stroke.","authors":"Yang Chen,&nbsp;Ju Dong,&nbsp;Dongqing Yang,&nbsp;Qin Qian,&nbsp;Pengcheng Wang,&nbsp;Xiaojuan Yang,&nbsp;Wei Li,&nbsp;Guochun Li,&nbsp;Xu Shen,&nbsp;Fushun Wang","doi":"10.1155/2021/8874296","DOIUrl":"https://doi.org/10.1155/2021/8874296","url":null,"abstract":"<p><strong>Background: </strong>Nowadays, acute intracerebral hemorrhage stroke (AICH) still causes higher mortality. Liangxue Tongyu Formula (LXTYF), originating from a traditional Chinese medicine (TCM) prescription, is widely used as auxiliary treatment for AICH.</p><p><strong>Objective: </strong>To dig into the multicomponent, multitarget, and multipathway mechanism of LXTYF on treating AICH via network pharmacology and RNA-seq.</p><p><strong>Methods: </strong>Network pharmacology analysis was used by ingredient collection, target exploration and prediction, network construction, and Gene Ontology (GO) and KEGG analysis, with the Cytoscape software and ClusterProfiler package in R. The RNA-seq data of the AICH-rats were analyzed for differential expression and functional enrichments. Herb-Compound-Target-Pathway (H-C-T-P) network was shown to clarify the mechanism of LXTYF for AICH.</p><p><strong>Results: </strong>76 active ingredients (quercetin, Alanine, kaempferol, etc.) of LXTYF and 376 putative targets to alleviate AICH (PTGS2, PTGS1, ESR1, etc.) were successfully identified. The protein-protein interaction (PPI) network indicated the important role of STAT3. The functional enrichment of GO and KEGG pathway showed that LXTYF is most likely to influence MAPK and PI3K-Akt signaling pathways for AICH treatment. From the RNA-seq of AICH-rats, 583 differential mRNAs were identified and 14 of them were consistent with the putative targets of LXTYF for AICH treatment. The KEGG pathway enrichment also implied that the MAPK signaling pathway was the most correlated one among all the related signaling pathways. Many important targets with expression changes of LXTYF for AICH treatment and their related pathways are great markers of antioxidation, anti-inflammatory, antiapoptosis, and lowering blood pressure, which indicated that LXTYF may play mutiroles in the mechanisms for AICH treatment.</p><p><strong>Conclusion: </strong>The LXTYF attenuates AICH partially by antioxidation, anti-inflammatory, and antiapoptosis and lowers blood pressure roles through regulating the targets involved MAPK, calcium, apoptosis, and TNF signaling pathway, which provide notable clues for further experimental validation.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"8874296"},"PeriodicalIF":3.1,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25495745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway.","authors":"Chao Ma,&nbsp;Yan Wu,&nbsp;Xinyao Liu,&nbsp;Yi He,&nbsp;Yuan Jia,&nbsp;Pei Chen,&nbsp;Dongqing Yin,&nbsp;Yanzhe Ning,&nbsp;Guoqiang Xing,&nbsp;Zuoli Sun,&nbsp;Hongxiao Jia","doi":"10.1155/2021/8812362","DOIUrl":"https://doi.org/10.1155/2021/8812362","url":null,"abstract":"<p><p>Shi-Zhen-An-Shen decoction (SZASD), a Chinese herbal medicine that is a liquor extracted from plants by boiling, has been reported to be effective in treating schizophrenia. However, the mechanism is unclear. Abnormal demyelination has been implicated in schizophrenia. The aim of this study was to investigate the effect of SZASD on myelin in demyelinated mice exhibiting schizophrenia-like behaviors. Sixty male C57BL/6 mice were randomly divided into six groups (<i>n</i> = 10 per group): (1) control group, (2) cuprizone (CPZ, a copper chelator that induced demyelination, 0.2% <i>w</i>/<i>w</i>)+saline, (3) CPZ+low-dose SZASD (8.65 g·kg^-1·d^-1), (4) CPZ+medium-dose SZASD (17.29 g·kg^-1·d^-1), (5) CPZ+high-dose SZASD (25.94 g·kg^-1·d^-1), and (6) CPZ+quetiapine (QTP, an atypical antipsychotic that served as a positive treatment control, 10 mg·kg^-1·d^-1). Mice in groups 2-6 were treated with CPZ added to rodent chow for six weeks to induce demyelination. During the last two weeks, these mice were given an oral gavage of sterile saline, SZASD, or quetiapine. Behavioral tests and brain analyses were conducted after the last treatment. The brain expression of myelin basic protein (MBP) and neuregulin-1 (NRG-1) was assessed using immunohistochemistry and Western blots. CPZ induced significant schizophrenia-like behaviors in the mice, including reduced nest-building activity and sensory gating deficits. Hyperlocomotor activity was accompanied by significant reductions in MBP expression in the corpus callosum, hippocampus, and cerebral cortex. However, both QTP and SZASD significantly reversed the schizophrenia-like behaviors and demyelination in CPZ-fed mice. The QTP and medium-dose SZASD resulted in better therapeutic effects compared to the low and high SZASD doses. Reduced NRG-1 expression was observed in CPZ-fed mice compared with controls, but neither QTP nor SZASD showed significant influence on NRG-1 expression in the hippocampus. Together, SZASD showed a therapeutic effect on demyelinated mice, and the improvement of demyelination might not be through the NRG-1 pathway.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"8812362"},"PeriodicalIF":3.1,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25468571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE₂ Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model.","authors":"Wei Wang, Yunhao Wang, Tengfei Lou, Mingqian Ding, Juehong Li, Hao Xiong, Zhixiao Yao, Yingying Ma, Huajiang Chen, Shenghe Liu","doi":"10.1155/2021/6684176","DOIUrl":"10.1155/2021/6684176","url":null,"abstract":"<p><p>To date, failed back surgery syndrome (FBSS) remains a therapy-refractory clinical condition after spinal surgery. The antiadhesion membrane is applied to prevent FBSS by isolating fibrosis; however, the inflammation stimulated by the foreign body and surgical trauma needs to be further resolved simultaneously. Therefore, we developed new electrospun polycaprolactone (PCL) fibrous membranes loaded with celecoxib (CEL) to prevent fibrosis and inflammation associated with FBSS. The CEL-loaded PCL fibers were randomly distributed, and the drug was released over two weeks. Fluorescence micrographs revealed that the fibroblasts proliferated less on the PCL-CEL fibrous membranes than in the PCL group and the blank control. In the rat laminectomy model after 4 weeks, magnetic resonance imaging of epidural fibrosis was least in the PCL-CEL group. Expression of COX-2 and PGE₂ was lower in the PCL-CEL group. It concluded that the CEL-loaded PCL membrane could reduce fibrosis and inflammation in a rat model of FBSS via COX-2/PGE₂ signaling pathways.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6684176"},"PeriodicalIF":3.1,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25444115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of a Large-Scale Spiking Neural Network with Quadratic Integrate-and-Fire Neurons.","authors":"Weijie Ye","doi":"10.1155/2021/6623926","DOIUrl":"10.1155/2021/6623926","url":null,"abstract":"<p><p>Since the high dimension and complexity of the large-scale spiking neural network, it is difficult to research the network dynamics. In recent decades, the mean-field approximation has been a useful method to reduce the dimension of the network. In this study, we construct a large-scale spiking neural network with quadratic integrate-and-fire neurons and reduce it to a mean-field model to research the network dynamics. We find that the activity of the mean-field model is consistent with the network activity. Based on this agreement, a two-parameter bifurcation analysis is performed on the mean-field model to understand the network dynamics. The bifurcation scenario indicates that the network model has the quiescence state, the steady state with a relatively high firing rate, and the synchronization state which correspond to the stable node, stable focus, and stable limit cycle of the system, respectively. There exist several stable limit cycles with different periods, so we can observe the synchronization states with different periods. Additionally, the model shows bistability in some regions of the bifurcation diagram which suggests that two different activities coexist in the network. The mechanisms that how these states switch are also indicated by the bifurcation curves.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6623926"},"PeriodicalIF":3.1,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25444113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review.","authors":"Xia-Qing Wang,&nbsp;Tahmineh Mokhtari,&nbsp;Yu-Xuan Zeng,&nbsp;Lu-Peng Yue,&nbsp;Li Hu","doi":"10.1155/2021/6682275","DOIUrl":"https://doi.org/10.1155/2021/6682275","url":null,"abstract":"<p><p>Chronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. Opioids are the most common analgesics prescribed for the management of moderate to severe pain. However, chronic exposure to these drugs can result in opioid tolerance and opioid-induced hyperalgesia. On pain modulation strategies, exploiting the multitarget drugs with the ability of the superadditive or synergistic interactions attracts more attention. In the present report, we have reviewed the analgesic effects of different dopamine receptors, particularly D1 and D2 receptors, in different regions of the central nervous system, including the spinal cord, striatum, nucleus accumbens (NAc), and periaqueductal gray (PAG). According to the evidence, these regions are not only involved in pain modulation but also express a high density of DA receptors. The findings can be categorized as follows: (1) D2-like receptors may exert a higher analgesic potency, but D1-like receptors act in different manners across several mechanisms in the mentioned regions; (2) in the spinal cord and striatum, antinociception of DA is mainly mediated by D2-like receptors, while in the NAc and PAG, both D1- and D2-like receptors are involved as analgesic targets; and (3) D2-like receptor agonists can act as adjuvants of <i>μ</i>-opioid receptor agonists to potentiate analgesic effects and provide a better approach to pain relief.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6682275"},"PeriodicalIF":3.1,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25467366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Upcoming Events Occurring in the Space Surrounding the Hand.","authors":"Maria L Rangel,&nbsp;Lidiane Souza,&nbsp;Erika C Rodrigues,&nbsp;José M Oliveira,&nbsp;Michelle F Miranda,&nbsp;Antonio Galves,&nbsp;Claudia D Vargas","doi":"10.1155/2021/6649135","DOIUrl":"https://doi.org/10.1155/2021/6649135","url":null,"abstract":"<p><p>Predicting upcoming sensorimotor events means creating forward estimates of the body and the surrounding world. This ability is a fundamental aspect of skilled motor behavior and requires an accurate and constantly updated representation of the body and the environment. To test whether these prediction mechanisms could be affected by a peripheral injury, we employed an action observation and electroencephalogram (EEG) paradigm to assess the occurrence of prediction markers in anticipation of observed sensorimotor events in healthy and brachial plexus injury (BPI) participants. Nine healthy subjects and six BPI patients watched a series of video clips showing an actor's hand and a colored ball in an egocentric perspective. The color of the ball indicated whether the hand would grasp it (hand movement), or the ball would roll toward the hand and touch it (ball movement), or no event would occur (no movement). In healthy participants, we expected to find distinct electroencephalographic activation patterns (EEG signatures) specific to the prediction of the occurrence of each of these situations. Cluster analysis from EEG signals recorded from electrodes placed over the sensorimotor cortex of control participants showed that predicting either an upcoming hand movement or the occurrence of a tactile event yielded specific neural signatures. In BPI participants, the EEG signals from the sensorimotor cortex contralateral to the dominant hand in the hand movement condition were different compared to the other conditions. Furthermore, there were no differences between ball movement and no movement conditions in the sensorimotor cortex contralateral to the dominant hand, suggesting that BPI blurred specifically the ability to predict upcoming tactile events for the dominant hand. These results highlight the role of the sensorimotor cortex in creating estimates of both actions and tactile interactions in the space around the body and suggest plastic effects on prediction coding following peripheral sensorimotor loss.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6649135"},"PeriodicalIF":3.1,"publicationDate":"2021-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25451779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Study of Pain after Spinal Cord Injury.","authors":"Yi-Zu Wang,&nbsp;Cheng-Cheng Wu,&nbsp;Xue-Qiang Wang","doi":"10.1155/2021/6634644","DOIUrl":"https://doi.org/10.1155/2021/6634644","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of comorbid pain after spinal cord injury (SCI) is relatively high in clinical observations and has continued to increase over time. Neuropathic pain (70.14%) is the most popular subject in academic journals after SCI. However, studies that used the bibliometric method to analyze comorbid pain after SCI are still lacking. This study is aimed at combining and integrating acquired information to analyze the global trends of research on the comorbidity of pain after SCI in the last three decades (1990-2019).</p><p><strong>Methods: </strong>Systematic works of literature published from 1990 to 2019 were obtained from the Web of Science Core Collection. CiteSpace software was used to analyze the relationship of publication year with the country, institution, journals, authors, references, and keywords. The regression analysis is used to evaluate the percentage of the category increase or decrease over time significantly. IBM SPSS Statistics was used in the statistical analysis.</p><p><strong>Results: </strong>A total of 730 publications were included in the analysis. A remarkable increase in the number of publications was observed in the study period (<i>P</i> < 0.05). A total of 202 academic journals focused on the categories of clinical neurology, neurosciences, and rehabilitation, and the annual growth rate of articles in these three categories was statistically significant (<i>P</i> < 0.05). The USA (356, 48.77%) and the University of Miami (64, 8.77%) were the country and institution with the highest number of publications, respectively. <i>Spinal Cord</i>, which was the main journal for research on pain after SCI, had the most publications (88, 12.05%). Burst keywords showed that the individual, inflammation, and central sensitization with pain after SCI are the research development trends and focus in this research field.</p><p><strong>Conclusions: </strong>Overall, this study provides the latest research direction for pain after SCI. This historical overview of research into pain after SCI will be a useful basis for further research into development trends, focus issues, cooperators, and cooperative institutions.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6634644"},"PeriodicalIF":3.1,"publicationDate":"2021-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25451778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Representations of Transversus Abdominis and Multifidus Muscles Were Discrete in Patients with Chronic Low Back Pain: Evidence Elicited by TMS.","authors":"Xin Li,&nbsp;Howe Liu,&nbsp;Le Ge,&nbsp;Yifeng Yan,&nbsp;Wai Leung Ambrose Lo,&nbsp;Le Li,&nbsp;Chuhuai Wang","doi":"10.1155/2021/6666024","DOIUrl":"https://doi.org/10.1155/2021/6666024","url":null,"abstract":"<p><strong>Introduction: </strong>The transversus abdominis (TVA) and multifidus (MF) muscles are the main segmental spinal stabilizers that are controlled by the primary motor cortex of the brain. However, relocations of the muscle representation in the motor cortex may occur after chronic lower back pain (cLBP); it still needs more evidence to be proven. The current study was aimed at applying transcranial magnetic stimulation (TMS) to investigate the changes of representation of TVA and MF muscles at the cortical network in individuals with cLBP.</p><p><strong>Methods: </strong>Twenty-four patients with cLBP and 12 age-matched healthy individuals were recruited. Responses of TVA and MF to TMS during muscle contraction were monitored and mapped over the contralateral cortex using a standardized grid cap. Maps of the center of gravity (CoG), area, volume, and latency were analyzed, and the asymmetry index was also computed and compared.</p><p><strong>Results: </strong>The locations of MF CoG in cLBP individuals were posterior and lateral to the CoG locations in healthy individuals. In the healthy group, the locations of TVA and MF CoG were closed to each other in both the left and right hemispheres. In the cLBP group, these two locations were next to each other in the right hemisphere but discrete in the left hemisphere. In the cLBP group, the cortical motor map of TVA and MF were mutually symmetric in five out of eleven (45.5%) subjects and leftward asymmetric in four out of ten (40.0%) subjects.</p><p><strong>Conclusions: </strong>Neural representations of TVA and MF muscles were closely organized in both the right and left motor cortices in the healthy group but were discretely organized in the left motor cortex in the cLBP group. This provides strong support for the neural basis of pathokinesiology and clinical treatment of cLBP.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2021 ","pages":"6666024"},"PeriodicalIF":3.1,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25444114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}