Neural Plasticity最新文献

{"title":"Environmental Enrichment Enhances Visual Function in Adult Amblyopia: Association With miR-132/HDAC3 Regulation.","authors":"Suzhen Ding, Yong Li, Yutong Zhang, Tingyu Zhang, Lan Li","doi":"10.1155/np/6559412","DOIUrl":"10.1155/np/6559412","url":null,"abstract":"<p><p>Amblyopia is a neurodevelopmental disorder for which effective treatments in adults are limited due to reduced cortical plasticity. Environmental enrichment (EE) can partially restore this plasticity, but the underlying molecular mechanisms remain unclear. This study investigated whether the miR-132/HDAC3 pathway is associated with EE-induced visual recovery in adult amblyopic mice. An adult amblyopia model (n = 64) was established via monocular deprivation (MD). Amblyopic mice were assigned to untreated, standard housing (SH), or EE groups, with normal mice as controls. Visual function was assessed using flash visual evoked potentials (fVEP), and molecular analyses of miR-132 and HDAC3 in the primary visual cortex (V1) were performed. In vitro studies included a dual-luciferase assay to verify miR-132-HDAC3 targeting and evaluated the effects of miR-132/HDAC3 overexpression on cortical neurons. Compared to SH, EE-reared amblyopic mice showed (1) increased N1-P2 wave amplitude in fVEP and (2) upregulated miR-132 and downregulated HDAC3 in V1. In vitro, HDAC3 was confirmed as a direct miR-132 target, and miR-132 overexpression suppressed HDAC3 while promoting structural remodeling in visual cortical neurons. These findings suggest that the miR-132/HDAC3 pathway potentially contributes to EE-induced visual restoration in adult amblyopia.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e6559412"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Effects of Electroacupuncture at Governor Vessel Acupoints on Neurotrophin-3 in Rats with Experimental Spinal Cord Injury.","authors":"Neural Plasticity","doi":"10.1155/np/9845020","DOIUrl":"10.1155/np/9845020","url":null,"abstract":"","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13686129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-Assisted Upper-Limb Rehabilitation After Stroke: A Systematic Review and Meta-Analysis of Cortical Reorganization and Neuroplasticity Biomarkers.","authors":"Rocco Salvatore Calabrò, Andrea Calderone, Lilla Bonanno, Angelo Quartarone, Antonino Naro, Alessandro Marco De Nunzio, Serena Filoni","doi":"10.1155/np/9282578","DOIUrl":"10.1155/np/9282578","url":null,"abstract":"<p><strong>Background: </strong>Robot-assisted upper-limb rehabilitation is widely used after stroke, but links to neuroplasticity biomarkers remain uncertain.</p><p><strong>Objective: </strong>To synthesize biomarker evidence after robot-assisted upper-limb training and quantify post-intervention effects versus non-robot comparators.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science, Embase, Cochrane Library, EBSCOhost, and Scopus from inception to December 31, 2025. Randomized controlled trials (RCTs) and nonrandomized intervention studies enrolling adults with stroke were eligible if they reported at least one neuroplasticity biomarker. Prespecified comparison classes were used; only the primary contrast (robot-assisted training vs. non-robot control) was pooled at post using DerSimonian-Laird random-effects models. Effects were expressed as standardized mean differences (SMDs; Hedges' g) or mean differences (MDs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Fifty-five studies, including 24 RCTs, were included. Four RCTs contributed to the primary quantitative synthesis, and each pooled endpoint included two or three trials. Robot-assisted training was associated with improved ipsilesional resting motor threshold (RMT; SMD 1.77, 95% CI: 0.46-3.08; k = 2) and upper-limb impairment (Fugl-Meyer assessment-upper extremity [FMA-UE]; MD 4.48 points, 95% CI: 0.33-8.62; k = 3). Effects were uncertain for ipsilesional motor-evoked potential (MEP) amplitude (SMD 0.52, 95% CI: -0.31-1.34; k = 2) and activities of daily living (ADL). Heterogeneity was moderate to substantial, prediction intervals crossed the null, and certainty was low or very low.</p><p><strong>Conclusions: </strong>Robot-assisted training may improve impairment and corticospinal excitability, but randomized biomarker evidence remains sparse and heterogeneous. Biomarkers should be interpreted as exploratory observations, not validated surrogates or causal evidence of cortical restitution.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e9282578"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise for Non-Motor Symptoms of Parkinson's Disease: An Evidence-Based Review of Clinical Trials, Dosing Considerations, and Mechanistic Insights.","authors":"Shuang Hu, Jing Lei, Hao-Jun You","doi":"10.1155/np/7191029","DOIUrl":"10.1155/np/7191029","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder characterised primarily by motor symptoms. However, non-motor symptoms (NMS) also substantially affect patients' quality of life. In recent years, exercise therapy has attracted increasing attention as a complementary treatment for PD and is regarded as a promising strategy for alleviating neuropsychiatric symptoms. A substantial body of evidence suggests that exercise improves multiple NMS domains in PD, and this effect may be achieved through several mechanisms. Despite the growing recognition of its benefits, the evidence base is limited by small sample sizes, heterogeneous interventions and inconsistent outcome measures. This underscores the necessity for further research to be conducted into the distinct effects of various forms of exercise. The present review synthesises the clinical evidence relating the impact of different exercise modalities on mood symptoms (anxiety and depression), cognitive dysfunction, sleep disturbances, pain and autonomic dysfunction in PD. It also discusses how exercise parameters such as intensity and duration can regulate NMS, exploring their potential mechanisms and clinical applications. These insights may inform new approaches to the comprehensive management of PD and future therapeutic strategies targeting NMS.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e7191029"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Primary Motor Cortex Astrocyte Calcium Signaling With Motor Learning.","authors":"Ragunathan Padmashri, Anna Dunaevsky","doi":"10.1155/np/5571169","DOIUrl":"10.1155/np/5571169","url":null,"abstract":"<p><p>Astrocytes form an integral part of the nervous system and are proposed to modulate neuronal circuits and behavior. The motor cortex plays a key role in the planning and execution of voluntary movements and makes key contributions to motor skill learning. However, whether motor skill learning modulates astrocytic Ca²⁺ signaling in the primary motor cortex (M1) is not known. To understand the role of astrocytes in the M1, we first characterized the Ca²⁺ signaling properties in astrocyte subcompartments in awake mice. We found that the subcompartments exhibited different Ca²⁺ event properties during the no movement periods and locomotion. We then asked whether astrocytic Ca²⁺ signaling in M1 is modulated with the acquisition of a skilled forelimb reaching task. Astrocytes exhibited altered Ca²⁺ event properties at different stages of learning a forelimb reaching task, with early and transient increases in Ca²⁺ event amplitude being the most prominent. These results demonstrate for the first time that, in addition to previously described synaptic plasticity, astrocytic Ca²⁺ signaling is also modified with motor skill learning.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2025 ","pages":"5571169"},"PeriodicalIF":3.7,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Fluoxetine Administration Restores Hippocampal Function in a Juvenile Global Cerebral Ischemia Mouse Model in a Sex-Specific Manner.","authors":"April Fineberg, Tanner McVey, Jamie Henry, Erika Tiemeyer, James E Orfila, Robert M Dietz","doi":"10.1155/np/8841616","DOIUrl":"10.1155/np/8841616","url":null,"abstract":"<p><p>Global cerebral ischemia (GCI) during childhood is a leading cause of long-term cognitive impairment, yet no therapies currently exist to promote recovery in survivors. We previously demonstrated that juvenile mice exhibit transient hippocampal synaptic dysfunction after GCI, associated with reduced brain-derived neurotrophic factor (BDNF) expression and partial endogenous recovery over time. In this study, we tested whether delayed treatment with fluoxetine (FLX)-a selective serotonin reuptake inhibitor (SSRI) known to enhance BDNF-TrkB signaling-could accelerate synaptic recovery. Juvenile mice underwent cardiac arrest and cardiopulmonary resuscitation, followed by in vivo FLX or vehicle administration from postinjury days 10-13. Electrophysiological recordings on day 14 revealed that FLX restored hippocampal long-term potentiation (LTP) in males but not females. This effect was paralleled by an increase in hippocampal BDNF expression in FLX-treated males, whereas no change was observed in females. Paired ex vivo experiments further confirmed that acute FLX exposure rescued LTP in GCI-injured male slices. These findings suggest that FLX promotes synaptic recovery through BDNF-TrkB signaling in males, while recovery in females may proceed via alternate, hormone-dependent mechanisms. Together, these results identify a novel therapeutic window for enhancing neuroplasticity after juvenile GCI and underscore the importance of developmental stage and biological sex in shaping responses to treatment.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2025 ","pages":"8841616"},"PeriodicalIF":3.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of tDCS Concurrent With VR-Based Robotic Intervention on Hemiplegic Upper Limb Function After Subacute Ischemic Stroke: A Randomized Controlled Study.","authors":"Chuan Guo, Ayan Geng, Youxin Sui, Shizhe Zhu, Qinglei Wang, Chaojie Kan, Sheng Xu, Ren Zhuang, Tong Wang, Ying Shen","doi":"10.1155/np/8425060","DOIUrl":"10.1155/np/8425060","url":null,"abstract":"<p><strong>Background: </strong>Upper limb hemiplegia faces the challenge of slow and difficult recovery. A \"closed-loop method\" based on brain plasticity has been proposed, combining central and peripheral interventions to enhance the upper limb function. Based on the theory, we aimed to investigate the effect of transcranial direct current stimulation (tDCS) concurrent with virtual reality (VR)-based robotic intervention on upper limb recovery and cortical excitability.</p><p><strong>Methods: </strong>In this single-blinded, randomized, controlled trial, 40 patients with subacute ischemic stroke were recruited and randomized to experimental (tDCS concurrent with VR-based robotic intervention) and control (sham tDCS concurrent with VR-based robotic intervention) groups. All patients received 15 sessions (20 min per day, 5 sessions per week). Outcome measures included the Fugl-Meyer Assessment Upper Limb Scale (FMA-UL), the Action Research Arm Test (ARAT), the Modified Barthel Index (MBI), and functional near-infrared spectroscopy (fNIRS).</p><p><strong>Results: </strong>All 40 patients completed the intervention, with 34 included in the fNIRS analysis. FMA-UL (<i>F</i> = 22.239, <i>p</i> < 0.001) and ARAT (<i>F</i> = 10.984, <i>p</i>=0.002) scores showed significant time-by-group interaction effects. Greater improvements were observed in the experimental group compared to the control group for both FMA-UL (<i>p</i> < 0.001) and ARAT (<i>p</i>=0.001). MBI scores increased significantly in both groups over time (<i>F</i> = 55.415, <i>p</i> < 0.001), but the change scores did not differ significantly between groups (<i>p</i>=0.369). fNIRS analysis revealed a significant time-by-group interaction effect in the ipsilesional primary motor cortex (M1) (<i>F</i> = 4.762, <i>p</i>=0.037) and contralesional prefrontal cortex (PFC) (<i>F</i> = 10.881, <i>p</i>=0.002). Greater increases in activation were found in the experimental group for both ipsilesional M1 (<i>p</i>=0.025) and contralesional PFC (<i>p</i>=0.002).</p><p><strong>Conclusions: </strong>Compared with sham tDCS concurrent with VR-based robotic intervention, tDCS concurrent with VR-based robotic intervention can effectively enhance upper limb function and promote activation of ipsilesional M1 and contralesional PFC in subacute ischemic patients with stroke. However, there was no obvious advantage in improving activities of daily life (ADL). <b>Trial Registration:</b> Chinese Clinical Trial Registry: ChiCTR2100047442.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2025 ","pages":"8425060"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Gait Training With Functional Electrical Stimulation Enhances Corticospinal Excitability of Paretic Ankle Muscles in Individuals Post-Stroke.","authors":"Vyoma Parikh, Anjali Sivaramakrishnan, Justin Liu, Jiang Xu, Catherine F Mason, Trisha M Kesar","doi":"10.1155/np/5529427","DOIUrl":"10.1155/np/5529427","url":null,"abstract":"<p><strong>Introduction: </strong>High-intensity readmill training (FAST) and functional electrical stimulation (FES) are both evidence-supported interventions that improve gait function post-stroke, but their neural mechanisms are unclear. Here, we tested the hypothesis that FAST-FES training, which incorporates task-specific sensorimotor stimulation to paretic ankle muscles, would induce greater upregulation of lesioned corticospinal tract (CST) excitability compared to dose-matched training without FES in individuals post-stroke.</p><p><strong>Methods: </strong>In this repeated-measures crossover study, 11 participants >6 months post-stroke (66.25 ± 8.15 years, six females) received FAST-FES or FAST gait training protocols (comprising three training sessions) in a randomized order, with an intervening >3-week washout period. FES was applied to the paretic dorsi- and plantar-flexor muscles during the paretic swing and terminal stance phases of gait, respectively. CST excitability was measured before and after each training protocol from bilateral tibialis anterior and soleus muscles in three different test positions: sit-rest, sit-active, and quiet standing.</p><p><strong>Results: </strong>We found a significant main effect of intervention on training-induced change in motor evoked potential (MEP) amplitude (<i>p</i>=0.02). Post hoc comparisons revealed that FAST-FES caused a larger training-induced increase in MEPs than FAST training (<i>p</i>=0.01). FAST-FES did not affect CST excitability of the nonlesioned hemisphere, with no significant changes in MEP amplitude of the nonparetic ankle muscles.</p><p><strong>Conclusions: </strong>FAST-FES training increased corticospinal excitability in paretic ankle muscles without upregulating nonparetic ankle corticospinal drive, suggesting preferential induction of neuroplasticity in the lesioned CST.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2025 ","pages":"5529427"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-Wave Music: A Personalized Approach to Improving Anxiety Resistance.","authors":"Haohan Yang, Yan Li, Haoyu Bian, Chenxi Qiu, Xinjian Su, Jiaxian Chen, Roberto Rodriguez-Labrada, Jing Lu, Dezhong Yao","doi":"10.1155/np/3500022","DOIUrl":"10.1155/np/3500022","url":null,"abstract":"<p><strong>Introduction: </strong>Music has long been recognized for its potential to modulate anxiety resistance at the population level. However, there is a lack of an auditory method that performs general and effective in enhancing anxiety resistance. Here we investigate the impact of a specific music that directly reflects brain activity (brain-wave music [BWM]) on anxiety resistance and its underlying neural mechanisms.</p><p><strong>Method: </strong>A two-phase experimental protocol was designed utilizing the ToS anxiety induction paradigm to examine the efficacy of BWM in enhancing anxiety resistance. In Phase 1, resting-state EEG recordings were initially collected from 70 participants, followed by a standardized anxiety induction procedure involving auditory cues, to validate the effectiveness of the anxiety induction paradigm and establish baseline anxiety resistance for each participant. Phase 2, designed based on Phase 1 and conducted 24 h later, further investigated the neural mechanisms underlying anxiety regulation through brain-music intervention. Participants were randomly allocated into three groups: BWM (<i>n</i> = 30) group exposed to personalized EEG generated music, Preferred Music Control (PMC, <i>n</i> = 20) group to self-selected music, and silent control (SC, <i>n</i> = 20) to no auditory input. The anxiety induction procedure was then repeated in all groups. Anxiety levels were assessed through the state anxiety inventory (SAI) in both phases.</p><p><strong>Results: </strong>Compared to Phase 1 resting-state baseline, the BWM group exhibited significantly reduced SAI scores in Phase 2, accompanied by enhanced prefrontal theta oscillations and functional connectivity between the prefrontal cortex, parietal lobe, and auditory cortex. No significant changes were observed in the other groups.</p><p><strong>Discussion: </strong>These findings suggest that BWM effectively promotes anxiety resistance by facilitating network connectivity between the prefrontal and multisensory regions. Moreover, this study highlights BWM as a novel and promising method for emotional regulation.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2025 ","pages":"3500022"},"PeriodicalIF":3.7,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Receptor Potential Vanilloid 4 Antagonist Eliminated Age-Related Spatial Memory Deficit in Female Sprague Dawley Rats.","authors":"Narongrit Thongon, Tanida Treerattanakulporn, Phossawee Kongkaew, Pongsakorn Lapchock, Nattida Kampuang, Siriporn Chamniansawat","doi":"10.1155/np/6405980","DOIUrl":"10.1155/np/6405980","url":null,"abstract":"<p><p>The expression of transient receptor potential vanilloid 4 (TRPV4) channels in the brains of normal-aging individuals significantly increases. However, the involvement of TRPV4 activity in age-related memory impairment remains unknown. This study aimed to investigate the role of TRPV4 in spatial memory tasks, hippocampal inflammation, and hippocampal autophagy in adolescent, adult, and aged female rats. Rats of different ages were used: 5, 10, 19, and 19 months treated with a TRPV4 inhibitor. Memory performance was assessed using the Morris water maze (MWM). Molecular changes were evaluated through western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). The hippocampal TRPV4 expression was significantly increased in the aged rats. Furthermore, aged rats exhibited spatial memory decline, which was normalized with TRPV4 antagonist GSK2193874 (GSK219) injection. The senescence-associated β-galactosidase (SA-β-Gal) activity and hippocampal inflammatory cytokine and microglial activation marker levels in the hippocampus of aged rats were significantly increased. Similarly, the phosphoprotein marker levels of autophagy in the hippocampus of aged rats were significantly increased. GSK219 treatment effectively normalized hippocampal SA-β-Gal activity, inflammation, and autophagy in aged rats. TRPV4 hyperactivity was found to induce hippocampal inflammation and neuronal death, leading to spatial memory impairment in normal aging.</p>","PeriodicalId":19122,"journal":{"name":"Neural Plasticity","volume":"2025 ","pages":"6405980"},"PeriodicalIF":3.7,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12672063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}