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Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression 抑郁症、癫痫和癫痫伴抑郁症患者血清中的细胞外小泡水平升高
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-12-01 DOI: 10.1134/s1819712423040244
{"title":"Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression","authors":"","doi":"10.1134/s1819712423040244","DOIUrl":"https://doi.org/10.1134/s1819712423040244","url":null,"abstract":"<p><strong>Abstract</strong>—Characteristics of small extracellular vesicles (sEVs) and sEVs composition are far from being well-studied for now, especially in the context of mental disorders. To elucidate the role of sEVs in disease we performed a quantitative analysis of the blood sEV in patients with focal epilepsy and patients with focal epilepsy with depression, psychogenic non-epileptic seizures with depression, pure depression, and bipolar affective disorder with the current depressive episode (cDE). Small EVs were isolated from the serum by gel filtration or PEG precipitation, and both methods showed very similar results. Subsequently, we precipitated neuronal sEVs and quantified it with several methods. Activity of lysosomal enzymes was determined in the sEVs fraction. The concentration of the blood sEVs in patients with depression, focal epilepsy, or depression with focal epilepsy was higher than in healthy controls. No difference was found between patients and controls in terms of neuronal sEVs concentration. Another finding of our study is that sEVs in the serum of patients contains various lysosomal enzymes. We suppose that the concentration of the blood sEVs in patients with depression or epilepsy is higher due to the sEVs secretion by the immune cells. Finding sEVs in the blood of patients with depression and focal epilepsy grants validity for future attempts to use sEVs as diagnostic tools for these disorders.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats 产前缺氧导致成年大鼠和老龄大鼠海马中缺氧诱导因子 HIF1α 的含量和转录活性增加
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-12-01 DOI: 10.1134/s1819712423330012
{"title":"Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats","authors":"","doi":"10.1134/s1819712423330012","DOIUrl":"https://doi.org/10.1134/s1819712423330012","url":null,"abstract":"<span> <h3> <strong>Abstract</strong>—</h3> <p>Using Western blotting, we conducted a study investigating the expression levels of the regulatory alpha subunit of hypoxia-inducible factor 1 (HIF1α) in the hippocampus of adult and aging rats, whose mothers were exposed to severe damaging hypoxia during days 14-16 of pregnancy. Furthermore, we assessed the relative abundance of mRNA for HIF1-regulated genes (<em>hk1, ldha, mct4, pdk1</em>) using quantitative real-time PCR in adult rats. Our findings indicate that prenatal hypoxia induces a sustained increase in HIF1α expression in the hippocampus. Additionally, we observed an accompanying elevation in the mRNA levels of the investigated HIF1-regulated genes. These results suggest that prenatal hypoxia exerts a lasting impact on hippocampal metabolism. Consequently, these metabolic disruptions may persist throughout life.</p> </span>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity and Depression. Some Neurochemical and Molecular Links 肥胖症与抑郁症。一些神经化学和分子联系
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-12-01 DOI: 10.1134/s1819712423040050
{"title":"Obesity and Depression. Some Neurochemical and Molecular Links","authors":"","doi":"10.1134/s1819712423040050","DOIUrl":"https://doi.org/10.1134/s1819712423040050","url":null,"abstract":"<span> <h3>Abstract</h3> <p>In recent decades, the fast-paced nature of life and increased social and professional competition have led to a notable rise in depression rates. This condition profoundly impacts individuals’ quality of life and overall well-being. Simultaneously, the characteristics of modern society, along with numerous environmental stressors and dietary habits, have contributed to the escalating prevalence of obesity and other metabolic disorders. Obesity and depression, two pressing issues in modern medicine, may initially appear unrelated as one is a metabolic condition and the other a mental health disorder. However, they are intricately intertwined: evidence suggests that individuals with obesity are more susceptible to experiencing depression, and vice versa. This review highlights the link between obesity and depression on a molecular and neurochemical level.</p> </span>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor 利用神经生长因子诱导小鼠神经母细胞瘤细胞的胆碱能表型
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-12-01 DOI: 10.1134/s181971242304013x
{"title":"Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor","authors":"","doi":"10.1134/s181971242304013x","DOIUrl":"https://doi.org/10.1134/s181971242304013x","url":null,"abstract":"<p><strong>Abstract</strong>—Nerve growth factor (NGF) is a factor which determines neuronal differentiation. NGF plays an important role in growth and differentiation of sensory and sympathetic neurons in the peripheral nervous system. In the mature brain, NGF is involved in the maintenance of the cholinergic neuronal phenotype. Here, we studied a possibility to induce the cholinergic phenotype in mouse neuroblastoma cells, which are often used to model various physiological and pathological processes occurring in the nervous system. Cells of NB41A3 and Neuro2a neuroblastoma lines are most frequently used to study the properties of cholinergic neurons. In the cells of these lines, the expression of TrkA and p75NGFR receptors, which is specific for the forebrain cholinergic nuclei, was revealed. Differentiation of the cells was induced by application of NGF or 8-Br-cAMP. NGF did not induce neuronal differentiation. Moreover, we did not find any changes in the content of choline acetyltransferase and vesicular acetylcholine transporter mRNA and protein, which were used as markers of the cholinergic phenotype. Thus, NB41A3 and Neuro2a cell lines cannot be advised as a model of cholinergic neurons in vitro because they do not differentiate and/or exhibit signs of the cholinergic phenotype in response to NGF stimulation.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T-Cell Aspects of Some Neurological Diseases 某些神经系统疾病的 T 细胞因素
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-12-01 DOI: 10.1134/s1819712423040153
{"title":"T-Cell Aspects of Some Neurological Diseases","authors":"","doi":"10.1134/s1819712423040153","DOIUrl":"https://doi.org/10.1134/s1819712423040153","url":null,"abstract":"<p><strong>Abstract</strong>—Polyneuropathies are a heterogeneous group of immune-mediated diseases, among which Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy are the most frequent. On the contrary, amyotrophic lateral sclerosis is most often considered as a disease, whose development is practically not associated with changes in the function of the immune system. This review summarizes the latest data on changes in the T-lymphocyte subpopulations and their function in the blood and cerebrospinal fluid in the aforementioned diseases. These data suggest that regulatory T cells and NKT cells may play an important role in the development of the discussed pathologies. We stress the necessity of accumulation and analysis of data on T-cell subpopulations, as well as the sequence of T-cell receptors, HLA, and CD1 in patients for the development of approaches to the diagnosis and possible therapy of these diseases.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain IQ-1S JNK (c-Jun n -末端激酶)抑制剂抑制OXYS大鼠脑早衰
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030212
A. A. Zhdankina, A. Osipenko, D. I. Tikhonov, S. Logvinov, M. Plotnikov, A. Khlebnikov, N. G. Kolosova
{"title":"The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain","authors":"A. A. Zhdankina, A. Osipenko, D. I. Tikhonov, S. Logvinov, M. Plotnikov, A. Khlebnikov, N. G. Kolosova","doi":"10.1134/S1819712423030212","DOIUrl":"https://doi.org/10.1134/S1819712423030212","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45466503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy 机械取栓后急性缺血性脑卒中患者血栓物质中的微生物特征
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030194
L. B. Yadav, Shivam Tiwari, M. Vajpeyee, A. Vajpeyee
{"title":"Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy","authors":"L. B. Yadav, Shivam Tiwari, M. Vajpeyee, A. Vajpeyee","doi":"10.1134/S1819712423030194","DOIUrl":"https://doi.org/10.1134/S1819712423030194","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45584125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Effect of In Vitro Culture and Embryo Transfer on Neuronal Density and Neurogenesis in the Brains of C57BL/6J Mice 体外培养和胚胎移植对C57BL/6J小鼠脑内神经元密度和神经发生的影响
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030066
E. Brusentsev, T. Igonina, I. N. Rozhkova, S. Okotrub, D. A. Lebedeva, E. V. Vladimirova, V. S. Kozeneva, S. Amstislavsky
{"title":"The Effect of In Vitro Culture and Embryo Transfer on Neuronal Density and Neurogenesis in the Brains of C57BL/6J Mice","authors":"E. Brusentsev, T. Igonina, I. N. Rozhkova, S. Okotrub, D. A. Lebedeva, E. V. Vladimirova, V. S. Kozeneva, S. Amstislavsky","doi":"10.1134/S1819712423030066","DOIUrl":"https://doi.org/10.1134/S1819712423030066","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44114434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease 营养药品:阿尔茨海默病管理的补充方法
4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/s1819712423030030
None Keshav Bansal, Samiksha Mishra, Vanshita Singh, Meenakshi Bajpai
{"title":"Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease","authors":"None Keshav Bansal, Samiksha Mishra, Vanshita Singh, Meenakshi Bajpai","doi":"10.1134/s1819712423030030","DOIUrl":"https://doi.org/10.1134/s1819712423030030","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136142227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains 两品系雄性小鼠下丘脑基因表达的反复经历
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030169
A. A. Sapronova, P. Kisaretova, R. Salman, N. Bondar
{"title":"Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains","authors":"A. A. Sapronova, P. Kisaretova, R. Salman, N. Bondar","doi":"10.1134/S1819712423030169","DOIUrl":"https://doi.org/10.1134/S1819712423030169","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46151794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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