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Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor 利用神经生长因子诱导小鼠神经母细胞瘤细胞的胆碱能表型
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-12-01 DOI: 10.1134/s181971242304013x
{"title":"Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor","authors":"","doi":"10.1134/s181971242304013x","DOIUrl":"https://doi.org/10.1134/s181971242304013x","url":null,"abstract":"<p><strong>Abstract</strong>—Nerve growth factor (NGF) is a factor which determines neuronal differentiation. NGF plays an important role in growth and differentiation of sensory and sympathetic neurons in the peripheral nervous system. In the mature brain, NGF is involved in the maintenance of the cholinergic neuronal phenotype. Here, we studied a possibility to induce the cholinergic phenotype in mouse neuroblastoma cells, which are often used to model various physiological and pathological processes occurring in the nervous system. Cells of NB41A3 and Neuro2a neuroblastoma lines are most frequently used to study the properties of cholinergic neurons. In the cells of these lines, the expression of TrkA and p75NGFR receptors, which is specific for the forebrain cholinergic nuclei, was revealed. Differentiation of the cells was induced by application of NGF or 8-Br-cAMP. NGF did not induce neuronal differentiation. Moreover, we did not find any changes in the content of choline acetyltransferase and vesicular acetylcholine transporter mRNA and protein, which were used as markers of the cholinergic phenotype. Thus, NB41A3 and Neuro2a cell lines cannot be advised as a model of cholinergic neurons in vitro because they do not differentiate and/or exhibit signs of the cholinergic phenotype in response to NGF stimulation.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"5 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T-Cell Aspects of Some Neurological Diseases 某些神经系统疾病的 T 细胞因素
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-12-01 DOI: 10.1134/s1819712423040153
{"title":"T-Cell Aspects of Some Neurological Diseases","authors":"","doi":"10.1134/s1819712423040153","DOIUrl":"https://doi.org/10.1134/s1819712423040153","url":null,"abstract":"<p><strong>Abstract</strong>—Polyneuropathies are a heterogeneous group of immune-mediated diseases, among which Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy are the most frequent. On the contrary, amyotrophic lateral sclerosis is most often considered as a disease, whose development is practically not associated with changes in the function of the immune system. This review summarizes the latest data on changes in the T-lymphocyte subpopulations and their function in the blood and cerebrospinal fluid in the aforementioned diseases. These data suggest that regulatory T cells and NKT cells may play an important role in the development of the discussed pathologies. We stress the necessity of accumulation and analysis of data on T-cell subpopulations, as well as the sequence of T-cell receptors, HLA, and CD1 in patients for the development of approaches to the diagnosis and possible therapy of these diseases.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"178 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain IQ-1S JNK (c-Jun n -末端激酶)抑制剂抑制OXYS大鼠脑早衰
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030212
A. A. Zhdankina, A. Osipenko, D. I. Tikhonov, S. Logvinov, M. Plotnikov, A. Khlebnikov, N. G. Kolosova
{"title":"The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain","authors":"A. A. Zhdankina, A. Osipenko, D. I. Tikhonov, S. Logvinov, M. Plotnikov, A. Khlebnikov, N. G. Kolosova","doi":"10.1134/S1819712423030212","DOIUrl":"https://doi.org/10.1134/S1819712423030212","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"17 1","pages":"369 - 379"},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45466503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of In Vitro Culture and Embryo Transfer on Neuronal Density and Neurogenesis in the Brains of C57BL/6J Mice 体外培养和胚胎移植对C57BL/6J小鼠脑内神经元密度和神经发生的影响
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030066
E. Brusentsev, T. Igonina, I. N. Rozhkova, S. Okotrub, D. A. Lebedeva, E. V. Vladimirova, V. S. Kozeneva, S. Amstislavsky
{"title":"The Effect of In Vitro Culture and Embryo Transfer on Neuronal Density and Neurogenesis in the Brains of C57BL/6J Mice","authors":"E. Brusentsev, T. Igonina, I. N. Rozhkova, S. Okotrub, D. A. Lebedeva, E. V. Vladimirova, V. S. Kozeneva, S. Amstislavsky","doi":"10.1134/S1819712423030066","DOIUrl":"https://doi.org/10.1134/S1819712423030066","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"17 1","pages":"349 - 358"},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44114434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy 机械取栓后急性缺血性脑卒中患者血栓物质中的微生物特征
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030194
L. B. Yadav, Shivam Tiwari, M. Vajpeyee, A. Vajpeyee
{"title":"Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy","authors":"L. B. Yadav, Shivam Tiwari, M. Vajpeyee, A. Vajpeyee","doi":"10.1134/S1819712423030194","DOIUrl":"https://doi.org/10.1134/S1819712423030194","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"17 1","pages":"482 - 491"},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45584125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease 营养药品:阿尔茨海默病管理的补充方法
4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/s1819712423030030
None Keshav Bansal, Samiksha Mishra, Vanshita Singh, Meenakshi Bajpai
{"title":"Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease","authors":"None Keshav Bansal, Samiksha Mishra, Vanshita Singh, Meenakshi Bajpai","doi":"10.1134/s1819712423030030","DOIUrl":"https://doi.org/10.1134/s1819712423030030","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136142227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region TNF-α、TNFRSF1A和CD40基因多态性在托木斯克地区多发性硬化症中的作用
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423020150
M. Titova, V. Alifirova, N. Musina, T. Nikolaeva
{"title":"The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region","authors":"M. Titova, V. Alifirova, N. Musina, T. Nikolaeva","doi":"10.1134/S1819712423020150","DOIUrl":"https://doi.org/10.1134/S1819712423020150","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"17 1","pages":"412 - 417"},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48251110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains 两品系雄性小鼠下丘脑基因表达的反复经历
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030169
A. A. Sapronova, P. Kisaretova, R. Salman, N. Bondar
{"title":"Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains","authors":"A. A. Sapronova, P. Kisaretova, R. Salman, N. Bondar","doi":"10.1134/S1819712423030169","DOIUrl":"https://doi.org/10.1134/S1819712423030169","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"17 1","pages":"359 - 368"},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46151794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective Effect of Curcumin on the Rat Model of Parkinson’s Disease Induced by Rotenone via Modulating Tyrosine Hydroxylase and Dopa Decarboxylase Expression Levels 姜黄素通过调节酪氨酸羟化酶和多巴脱羧酶表达水平对鱼藤酮诱导的帕金森病大鼠模型的神经保护作用
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030091
A. Essawy, Cecil Matta, Basant Nabil, Heba-Tallah Abd, Elrahim Abd Elkader, R. Alhasani, A. Soffar
{"title":"Neuroprotective Effect of Curcumin on the Rat Model of Parkinson’s Disease Induced by Rotenone via Modulating Tyrosine Hydroxylase and Dopa Decarboxylase Expression Levels","authors":"A. Essawy, Cecil Matta, Basant Nabil, Heba-Tallah Abd, Elrahim Abd Elkader, R. Alhasani, A. Soffar","doi":"10.1134/S1819712423030091","DOIUrl":"https://doi.org/10.1134/S1819712423030091","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"17 1","pages":"457 - 466"},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63920333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies 外源性热休克蛋白(HSP 27和HSP 70)在职业性神经系统病变患者中的变化特征
IF 0.5 4区 医学
Neurochemical Journal Pub Date : 2023-08-30 DOI: 10.1134/S1819712423030054
G. Bodienkova, E. Boklazhenko
{"title":"Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies","authors":"G. Bodienkova, E. Boklazhenko","doi":"10.1134/S1819712423030054","DOIUrl":"https://doi.org/10.1134/S1819712423030054","url":null,"abstract":"","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"17 1","pages":"418 - 422"},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43939431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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