Neurobehavioral toxicology and teratology最新文献_第2页

Sulfolane effects on audiogenic, pentylenetetrazol and afterdischarge seizure activity. 磺胺对听原性、戊四氮和放电后癫痫活动的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-11-01

L J Burdette, R S Dyer

引用次数: 0

The effects of diisopropyl phosphorofluoridate (DFP) on inter-response time and circadian patterns of lever-pressing in rats. 氟化磷酸二异丙酯(DFP)对大鼠杠杆按压间反应时间和昼夜节律模式的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-11-01

T G Raslear, J R Leu, L Simmons

{"title":"The effects of diisopropyl phosphorofluoridate (DFP) on inter-response time and circadian patterns of lever-pressing in rats.","authors":"T G Raslear, J R Leu, L Simmons","doi":"","DOIUrl":"","url":null,"abstract":"Rats were injected with saline, 1.0 mg/kg or 2.6 mg/kg of diisopropyl phosphorofluoridate (DFP). Three days later the animals were placed in cages in which they could press a lever to obtain their entire daily ration of food. The time of day at which responses occurred and the time between successive responses were recorded over a six day period to determine the circadian pattern of lever-pressing and the distribution of inter-response times (IRTs). The saline injected rats exhibited a normal nocturnal pattern of feeding, while both DFP treated groups exhibited a significantly greater tendency to eat during the day. Analysis of the IRT distributions of the three groups showed a different pattern of results. The saline and 1.0 mg/kg DFP groups produced nearly identical IRT distributions, while the 2.6 mg/kg group produced an IRT distribution which was marked by significant increases in the interquartile range and median IRT. Since the 1.0 mg/kg dose of DFP produced a circadian disruption but did not affect the IRT distribution, it appears that the disruption of circadian activity by DFP which was reported by Raslear and Kaufman cannot be solely explained by simple changes in the motor response.","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 6","pages":"655-8"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14926412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of single exposure to toluene on shock avoidance and time estimation in rats. 单次接触甲苯对大鼠休克避免和时间估计的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-11-01

H Wada, T Hosokawa, K Saito

引用次数: 0

Duration and intensity of behavioral change after sublethal exposure to soman in rats. 大鼠亚致死暴露于人体后行为改变的持续时间和强度。

Neurobehavioral toxicology and teratology Pub Date : 1986-11-01

G C Haggerty, P J Kurtz, R D Armstrong

{"title":"Duration and intensity of behavioral change after sublethal exposure to soman in rats.","authors":"G C Haggerty, P J Kurtz, R D Armstrong","doi":"","DOIUrl":"","url":null,"abstract":"The behavioral effects produced by acute exposure to sublethal doses of pinacolyl methylphosphonofluoridate (soman) were examined in the Sprague Dawley rat. Two hours after exposure to soman (100-150 micrograms/kg IM), dose-related decreases in spontaneous motor activity (SMA), fore- and hindlimb grip strength, thermal sensitivity, and rectal temperature were observed. In addition, acoustic startle response amplitude decreased, while response latency increased. Soman also depressed the percentage of conditioned avoidance and escape responses and increased response latency. In both the 103 and 116 micrograms/kg dose groups, effects on hindlimb grip strength persisted up to 14 days after exposure, while effects on hot plate response lasted for 7 days. A biphasic change in motor activity was seen in the 103 and 116 mg/kg soman groups: Initial SMA depression during the first 24 hours after exposure was followed by SMA increases which persisted up to 21 days. Animals that showed delayed hyperactivity often exhibited seizures and increased excitability when handled. The results of these studies demonstrate that sublethal doses of soman can cause marked and often long-lasting changes in behavior in the rat.","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 6","pages":"695-702"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14925314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal ethanol exposure alters rat brain morphology but does not affect amygdaloid kindling. 产前乙醇暴露改变大鼠脑形态，但不影响杏仁核点燃。

Neurobehavioral toxicology and teratology Pub Date : 1986-11-01

E Viirre, D P Cain, K P Ossenkopp

引用次数: 0

Behavioral effects of chronic manganese administration in rats: locomotor activity studies. 长期服用锰对大鼠行为的影响:运动活动研究。

Neurobehavioral toxicology and teratology Pub Date : 1986-11-01

J P Nachtman, R E Tubben, R L Commissaris

{"title":"Behavioral effects of chronic manganese administration in rats: locomotor activity studies.","authors":"J P Nachtman, R E Tubben, R L Commissaris","doi":"","DOIUrl":"","url":null,"abstract":"Manganese (Mn) is an industrially important metal which, when given in excess, produces lesions in the basal ganglia of rats and humans. Humans poisoned with Mn often exhibit an initial hyperactivity (\"manganese madness\") followed by a parkinsonian-like syndrome. The present studies examined the effects of chronic Mn exposure on locomotor activity in rats maintained on 0.0 or 1.0 mg Mn(Cl)2 X 4H2O/ml drinking water. No differences in mean body weights were observed from 0-65 weeks of treatment. Locomotor activity was tested in 15 min sessions at weekly intervals (Weeks 1-13), then at 4 or 14 week intervals thereafter. Mn treatment produced a significant increase in activity on weeks 5-7 before returning to control values at 8 weeks. Habituation measured within a test session was not affected at any time. At 14 and, to a lesser extent, 29 weeks, Mn animals were found to be more responsive to the effects of 1.25 mg/kg d-amphetamine (d-A) than controls. This increased responsiveness was gone at Weeks 41 and 65. Consistent with clinical reports, these results suggest that Mn may produce a transient increase in dopaminergic function, as measured by both spontaneous and d-A-stimulated locomotor activity.","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 6","pages":"711-5"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14926215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of prenatal retinoic acid on the viability and behavior of the offspring. 产前维甲酸对后代生存能力和行为的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-11-01

G A Nolen

{"title":"The effects of prenatal retinoic acid on the viability and behavior of the offspring.","authors":"G A Nolen","doi":"","DOIUrl":"","url":null,"abstract":"Three experiments were done in Charles River rats to assess the effects of various doses of retinoic acid given at different periods of pregnancy on the postnatal function of the offspring. In the first study doses of 5 mg/kg of body weight were given on days 8-10, 11-13, or 14-16. In the second study, doses of 2.5 or 5 mg/kg were given on days 11-13 or 14-16. In the third study, doses of 2, 4 or 6 mg/kg were given on days 14-16. Five mg/kg given on days 11-13 resulted in significant postnatal mortality, while the viability at all other doses and periods was not affected. The weights of the pups at birth and weaning were normal except in the first study when the pups from dams given 5 mg/kg on days 14-16 were smaller than controls at weaning. The pups from dams treated with 4, 5 or 6 mg/kg consistently showed a delayed response to negative geotropism and auditory startle was delayed in two of the studies at 6 mg/kg. Hyperactivity in preweaning rats tested in photo-cell cages was seen only in the first study, but open-field hyperactivity occurred in all three studies at doses of 4 mg/kg or above. The M-maze performance of the rats from groups dosed with 4, 5 or 6 mg/kg on days 8-10 or 14-16 and the ones dosed with 2.5 mg/kg on days 11-13 was poorer than controls. No differences were seen in either photo-cell or open-field activity at 42 days, but in the final experiment, the rats from the 6 mg/kg group were hyperactive at 100+ days in running wheels. The rats in the 6 mg/kg group performed more poorly at active avoidance and were hypoactive after an amphetamine challenge. These studies show that retinoic acid given prenatally induced functional deficits in the offspring at doses below the \"no-effect\" level for producing morphological defects and suggests that retinoic acid may be a good model compound for such studies.","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 6","pages":"643-54"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14926411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of trichloroethylene on male sexual behavior: possible opioid role. 三氯乙烯对男性性行为的影响:可能的阿片作用。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

J L Nelson, H Zenick

引用次数: 0

Effects of inhaled carbon disulfide on sensory-evoked potentials of Long-Evans rats. 吸入二硫化碳对龙-埃文斯大鼠感觉诱发电位的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

C S Rebert, E Becker

引用次数: 0

Testing strategies in behavioral teratology: I. Testing battery approach. 行为畸形学的测试策略:1 .测试电池方法。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

K E Suter, H Schön

引用次数: 0