Neuro endocrinology letters最新文献

{"title":"Behavioral and Neurochemical Changes in Rats with Recurrent Depression induced by chronic unpredictable stress.","authors":"Cheng Hong,&nbsp;Libing Chen,&nbsp;Weiyue Kong,&nbsp;Danni Zhang,&nbsp;Lingfeng Wang,&nbsp;Jinkai Zhao,&nbsp;Xiaoming Zhong,&nbsp;Guangji Zhang,&nbsp;Zhen Huang,&nbsp;Fengmei Qiu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The mechanism of recurrent depression remains unclear. This study aimed to evaluate the behavioural and neurochemical patterns of rats with recurrent depression.</p><p><strong>Materials and methods: </strong>An animal model of recurrent depression was established using chronic unpredictable stress and imipramine hydrochloride. The behaviour of the rats was tested during the first onset and recurrence periods of depression. The levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT), and cyclic adenosine monophosphate (cAMP) in serum were detected by ELISA. The protein expressions of brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) in the hippocampal dentate gyrus (DG) area of rats were detected by western blotting.</p><p><strong>Results: </strong>The weight and sugar preference of the rats with recurrent depression were significantly decreased, and the immobility time of tail suspension was significantly increased during the first onset and recurrence periods. The modelling time of rats was shortened by one week in the recurrence period compared with that in the first onset. The model rats with recurrent depression had significantly increased ACTH and CORT and significantly decreased cAMP, CREB, and BDNF levels.</p><p><strong>Conclusion: </strong>Rats with recurrent depression are highly susceptible to stress and exhibit depression-like behaviours such as weight loss, increased immobility time in tail suspension test, and reduced sucrose preference index. Moreover, the modelling time was shortened by one week, indicating an obvious susceptibility to recurrent depression. The significantly up-regulated neuroendocrine in the HPA and the significantly inhibited BDNF and protein expression factors in related signalling pathways may be involved in the increased susceptibility to recurrent depression.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39573285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between sex hormone-binding globulin level and blood glucose in middle-aged and elder males of Uygur ethnic group.","authors":"Li Quan,&nbsp;Lin Hu,&nbsp;Jing Wang,&nbsp;Binya Yuwen,&nbsp;Jun Zhu,&nbsp;Sheng Jiang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between sex hormone-binding globulin (SHBG) and blood glucose in elder men of Uygur ethnic group.</p><p><strong>Methods: </strong>A total of 467 males of ugyur ethnic group resident in Urumqi, Tuokesun County, and Turpan were included by cluster sampling, classified by ages and SHBG level, and compared the metabolic index to define the risk factors by regression.</p><p><strong>Results: </strong>BMI, waist circumference (WC), glycosylated hemoglobin (GH), fasting insulin level (FIL), SHBG, testosterone, free testosteroneindex (FAI), and HOMA-IR were statistically different in different age groups (P<0.05); the differences in the age, BMI, WC, fasting blood glucose (FBG), OGTT 2-hr blood glucose, HOMA-IR, FIL, GH, testosterone, and F among the study subjects grouped according to SHBG level were statistically significant (P<0.05); the logistic regression analysis revealed that FIL and testosterone were the independent factors that will affect SHBG in the models using FIL, HOMA-IR, and other indexes with statistical significance as the continuous variables and the interquartile grouping of SHBG as the independent variables.</p><p><strong>Conclusions: </strong>Among middle-aged and elder males, there are differences in the sex hormone and SHBG levels. The independent influencing factors of SHBG are HOMA-IR, testosterone, and FIL.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39661585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid cancer risk assessment indicators: A correlation between preoperative and postoperative criteria.","authors":"Noora Al Moosa,&nbsp;Mai Abdulla Nasser,&nbsp;Mohamed Alshehabi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>To differentiate preoperatively between benign nodule and thyroid cancer (TC) is highly important. Therefore, we investigated the risk assessment indicators that correlate preoperative clinical, radiological, and pathological features with post-operative TC characteristics.</p><p><strong>Methods: </strong>An observational retrospective study was performed in Bahrain Defense Force (BDF) hospital for all patients suspected of having thyroid cancer from January 2016 to October 2020. All the medical records, including clinical, laboratory, radiological, and pathological assessments of these patients, were retrieved and analyzed for association using binary and multivariate logistic regression analysis to estimate significance, odds ratio (OR), and 95% confidence interval.</p><p><strong>Results: </strong>A total of 87 patients were included in the study with a mean age of 40 ± 12.5 years old. The histopathology revealed that 27 patients had TC with a mean age of 38.1±10.8 years (p>0.05 vs. benign conditions). Furthermore, the TC frequencies within gender were 29.9% and 36.4% for females and males, respectively. Besides, most patients (85.2%) had papillary TC cancer, whereas 7.4% had follicular cancer, and 3.7% had either medullary TC or minimally invasive follicular TC. The correlation results between demographic, clinical characteristic evaluations, laboratory findings of the study patients, and TC as reported by the histopathology were all not significant except for ultrasound features including solitary nodule (p<0.05), lymph node involvement, and consistency (p<0.01). The sensitivity and specificity values of FNAC for detection of TC were 77.8% and 86.3%, respectively. Multivariate analysis revealed that only solid consistency of the tumor (OR = 9.88) and lymph node involvement (OR = 14.78) were correlated with TC detection. On the other hand, gender, symptoms of hypothyroidism, hyperthyroidism, or compression, family history of TC, abnormal thyroid function tests, neck swelling, and ultrasounds imaging with regards to vascularization and microcalcification were not correlated with the detection of TC.</p><p><strong>Conclusion: </strong>Preoperative nodule and FNAC assessments need further research and development to approach higher sensitivity in detecting TC.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39661586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotoxic side effects of acyclovir: two case reports.","authors":"Zoltan Paluch,&nbsp;Milan Trojánek,&nbsp;Zuzana Velíšková,&nbsp;Jana Mlíchová,&nbsp;Pavel Chrbolka,&nbsp;Jana Gregorová,&nbsp;Emanuel Marques,&nbsp;Dagmar Kalatova,&nbsp;Dušan Pícha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acyclovir is an antiviral drug frequently used in clinical practice. It is indicated for the treatment of infections caused by herpes simplex virus and varicella zoster virus. The drug has a good safety profile; however, severe side effects may rarely occur during therapy. These include renal failure as a major risk factor for neurotoxic side effects potentially developing within 24-48 hours of therapy initiation. The paper presents the cases of two patients developing neurotoxic side effects while treated for herpes zoster. The aim of the authors is to highlight the potential for developing neurotoxic side effects in high-risk groups such as the elderly, patients with impaired renal function or multiple comorbidities on polypharmacy, or those using nephrotoxic drugs. Acyclovir use could lead to renal impairment and an increase in its plasma and CNS concentrations with severe neuropsychiatric side effects. The neurotoxic side effects are reversible after therapy withdrawal. Thus, in patients developing mental impairment or showing other neurological symptoms during acyclovir therapy, the patient should be promptly assessed for potential drug neurotoxicity, their therapy should be discontinued and drug elimination with forced diuresis or hemodialysis considered. Early recognition of acyclovir neurotoxic side effects can significantly improve a patient's prognosis.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39661584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"X-linked adrenoleukodystrophy: phenotype-genotype correlation in hemizygous males and heterozygous females with ABCD1 mutations.","authors":"Marketa Zemanova, Petr Chrastina, Lenka Dvorakova, Martin Reboun, Hana Vlaskova, Helena Jahnova, Nabil El-Lababidi, Jana Cepova, Tomas Honzik, Jiri Zeman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>X-linked adrenoleukodystrophy (X-ALD) causes cerebral adrenoleukodystrophy (cALD), myelopathy and/or adrenal insufficiency in males, and myelopathy/peripheral neuropathy in females. These distinct phenotypes are scarcely linked to a specific mutations. The objective herein was to find a link between the phenotype with the genotype mutation, serum very long-chain fatty acids (VLCFA), and the diet with Lorenzo´s and GTO oils in hemizygous males and heterozygous females.</p><p><strong>Methods: </strong>A retrospective study design with follow-up of 45 hemizygous males and 50 heterozygous females carrying mutations in ABCD1 from 35 unrelated families with X-ALD. Mutation analysis was performed by Sanger sequencing of PCR and/or RT-PCR and the severity of missense mutations was evaluated using GERP++ score and CADD score.</p><p><strong>Results: </strong>Twenty-five described and eight novel ABCD1 mutations were identified. Fifteen males and 23 females had severe mutations while 30 males and 27 females had less detrimental ones. cALD developed in 25 males (56%) including nine boys with severe mutations, 10 boys with less detrimental mutations and 6 adults with adrenomyelopathy. Myelopathy and/or adrenal insufficiency developed in 14 males (31%), six were asymptomatic. Adrenal insufficiency developed in two of five boys treated with hematopoietic stem cell transplantation (HSCT). Myelopathy/peripheral neuropathy developed in 26% of females. No correlation was found between the disease severity and the genotype, GERP++ and CADD scores, presence/absence of aberrant ALDP protein or X-inactivation. VLCFA were higher in males than heterozygous females and decreased during Lorenzo´s and GTO oils diet without a clear clinical impact on the disease.</p><p><strong>Conclusion: </strong>The prognosis was unfavourable in most males and significant part of females. Therapy with early HSCT is effective. Thus, the need for early diagnosis with the neonatal screening is crucial.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39403731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between DVH parameters and lung function changes before and after radiotherapy and the occurrence of radiation induced lung injury (RILI).","authors":"Sha Sha, Jigang Dong, Maoyu Wang, Ziyu Chen, Peng Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the correlation between dose volume histogram (DVH) parameters and lung function changes before and after radiotherapy and the occurrence of radiation-induced lung injury (RILI), and to evaluate its value in predicting the risk of RILI.</p><p><strong>Methods: </strong>120 patients with advanced non-small cell lung cancer diagnosed in Jiaozhou Central Hospital of Qingdao City in the past three years and received chest conformal (intensity modulated) radiation therapy were selected. Before radiotherapy, irradiation of 45-50 Gy, and 1 month after radiotherapy, the patients were tested for lung function. The evaluation of radiation lung injury was based on the RTOG acute radiation lung injury classification standard, and the observation end point was ≥2 grade RILI.</p><p><strong>Results: </strong>There are 34 patients with ≥2 grade RILI among all enrolled patients, including 23 cases of grade 2 and 11 cases of grade 3. The difference between FVC, FEV1, FEV1 / FVC, DLCO, V5, V10, V15 before radiotherapy, 45-50 Gy, and 1 month after radiotherapy were statistically significant (P <0.05). The lung function, V5, V10, and V15 before radiotherapy were related factors for RILI (P <0.05). And the risk of RILI was 1.855 times that of patients with higher FEV1 / FVC before radiation therapy (OR = 1.855 (1.199-1.946)), patients with V10 ≥50% were 3.673 times higher than patients with V10 <50% (OR = 3.673(1.548-7.582)).</p><p><strong>Conclusions: </strong>V10≥50% and FEV1 / FVC are high-risk factors for RILI before radiotherapy, which has certain value in predicting the risk of RILI.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39403801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical growth and brain MRI predict the neurodevelopmental outcomes in very low birth weight infants at 2-year-old.","authors":"Juan Gui, Yumei Liu, Yifei Wang, Youqun Zou, Xin Sun, Chaoying Zhang, Chen Chen, Bi Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the current study was to determine the predictive effect of physical growth and brain magnetic resonance imaging (MRI) on neurodevelopmental outcomes in very low birth weight infants (VLBW) infants.</p><p><strong>Materials and methods: </strong>A total of 85 VLBW infants were included in the current study. They were cared according to the guideline of preterm management during hospitalization, and to planned follow-up rules after discharged strictly. All patients enrolled in the present study had undergone measurement of weight, length and head circumference and reported on the infants' weight-for-age z-score (WAZ), height-for-age Z-score (HAZ), head circumference-for-age Z-score (HCZ), and weight-for-height Z score (WHZ).</p><p><strong>Results: </strong>At 29.38 ± 1.70 weeks old, the birth weight was 1240.06 ± 249.46g. MDI decreased gradually with the increase of corrective age (p<0.001), and MDI at 18 months of age decreased significantly compared to normal infants and young children of the same age (p<0.05), while at 24 months of age there was no significant difference between MDI and normal peers. Correcting PDI in 3, 6, 12, 18 and 24 months was significantly lower than that of normal infants and young children of the same age (p<0.05) and did not show a trend that changed with the correction of monthly age. WHZ gradually approaches normal as the age of the month increases (p<0.05), while HCZ decreases gradually with the correction of the age of the month (p<0.05).</p><p><strong>Conclusion: </strong>VLBW has obvious motor development disorders, and there is no difference between intellectual development and healthy young children. MDI rises early and then gradually declines, eventually becoming 2 years old similar to that of healthy young children. PDI has consistently shown a significant decrease in infants and young children of the same age, and has not shown a trend that changes with the correction of monthly age. There is a great correlation between infancy physical development and long-term neurodevelopment, MRI at 12 months old is a valuable prediction method.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39403300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine replacement therapy in surgical patients.","authors":"Marcela Kanova, Katerina Tejkalova, Jan Neiser, Roman Kula","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aims: </strong>The effect in smokers of nicotine withdrawal following surgery may contribute to the development of postoperative delirium. Nicotine is known to increase myocardial oxygen demand, coronary vasoconstriction, and may cause platelet activation leading to thrombosis. All of this can negatively impact postoperative recovery. The aim of this study was to determine whether nicotine replacement therapy can overweigh its negative effects, reduce the incidence of delirium, reduce the need for sedatives/analgesics, and/or shorten the duration of artificial pulmonary ventilation.</p><p><strong>Methods: </strong>This prospective randomized single-blind study was performed in a 21-bed ICU. Fifty-two patients (26 intervention/ 26 control) met the inclusion criteria. Patients in the intervention group received a 21mg nicotine patch daily until discharged from the ICU (up to 7 days), patients in the control group received a placebo patch. The incidence of delirium was monitored with the CAM-ICU test. Sedatives/analgesics used in the ICU, and the duration of both artificial ventilation as well as total ICU stay were recorded for both groups.</p><p><strong>Results: </strong>Nicotine replacement in smokers did not reduce the incidence of delirium in patients who had undergone surgery. Neither did it statistically significantly affect the length of hospitalization, sedation, analgesia, or vasopressors.</p><p><strong>Conclusion: </strong>This study did not confirm the effect of nicotine replacement therapy in reducing the incidence of delirium, it did not shorten the total duration of ICU stay or artificial ventilation and there was no reduced sedation requirement. We therefore saw no beneficial effect in patients receiving nicotine replacement therapy following elective surgery.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39403298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased antibody reactivity against insulin receptor-A and insulin like growth factor 1 receptor and their ligands in cerebrospinal fluid and serum of patients with schizophrenia or related psychosis.","authors":"Kristina Melkersson, Sophie Bensing","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence has accumulated that an autoimmune-mediated process in the central nervous system may underlie the development of schizophrenia. Various antibodies have also previously been detected in serum of patients with schizophrenia. Therefore, the aim of this study was to analyze antibody reactivity against proteins, selected based on potential schizophrenia disease relevance, in both cerebrospinal fluid and serum of patients with schizophrenia.</p><p><strong>Material and methods: </strong>Cerebrospinal fluid and serum from 17 patients with schizophrenia or related psychosis and 12 controls were analyzed regarding antibody reactivity, using bead-based antigen arrays of protein fragments or peptides of 21 selected proteins. Additionally, the patients were accessed for clinical symptoms with the Positive and Negative Syndrome Scale (PANSS) for schizophrenia.</p><p><strong>Results: </strong>Increased antibody reactivity was found in patients compared to controls against the insulin receptor (INSR), PAGE2B;2;5 and heat shock proteins (HSPs) in both cerebrospinal fluid and serum, and against the insulin like growth factor 1 receptor (IGF1R), insulin (INS), insulin like growth factor 1 (IGF1), cadherin 5 (CDH5), nerve growth factor (NGF) and vascular endothelial growth factor A (VEGFA) in serum alone. Moreover, patients' antibody reactivity in serum against PAGE2B;2;5, IGF1R or NGF correlated positively to their PANSS scores.</p><p><strong>Conclusions: </strong>Taken together, these results point to that an autoimmune-mediated process underlies the development of a core group of schizophrenia cases and that the INSR and IGF1R, their ligands (INS and IGF1) and related inter- and intracellular proteins (CDH5, PAGE2B;2;5, HSPs, NGF and VEGFA) may constitute antigen targets.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39403730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of endocrinopathy manifestations in 136 Chinese patients with POEMS syndrome.","authors":"Yi Shao, Chao Zhang, Xianling Wang, Qinghua Gu, Jianming Ba, Zhaohui Lv, Jingtao Dou, Yiming Mu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>POEMS syndrome is a rare multisystemic disease, with a wide spectrum of clinical endocrinopathies. Patients with POEMS syndrome may present with one or more hormone disorders during the disease course, but such phenomenon has usually been underestimated. In this report, we analyzed the prevalence and clinical characteristics of endocrine abnormalities in a large Chinese cohort with POEMS syndrome.</p><p><strong>Methods: </strong>This retrospective review was performed in patients with a definite diagnosis of POEMS syndrome who were hospitalized in our hospital between January 2000 and January 2020. The clinical data about endocrine abnormalities were extracted from their medical records and analyzed.</p><p><strong>Results: </strong>This study comprised 136 patients (95 male, 41 female) with a median age of 48(40-56) years old. Endocrine abnormalities were frequent (127 cases, 93.38%) in patients with POEMS syndrome. The prevalence of single endocrinopathy and multiple endocrinopathies were 12.60% (16/127 cases) and 87.40% (111/127), respectively. The most frequent endocrinopathy was hypogonadism (98/136, 72.06%), followed by hypothyroidism (83/136, 61.03%), hypocalcemia (50/136, 36.76%), hyperprolactinemia (47/136, 34.56%), abnormal glucose metabolism (41/136, 30.15%) and adrenal insufficiency (41/136, 30.15%). In patients with multiple endocrinopathies, the prevalence of 2, 3, 4, 5, and 6 kinds of endocrine axes involved were 29.92% (38/127), 30.71% (39/127), 17.32% (22/127), 7.09% (9/127) and 2.36% (3/127), respectively. Such hormone disorders cause complex clinical presentations, including overt or subclinical situations.</p><p><strong>Conclusion: </strong>Endocrinopathy manifestations in POEMS syndrome are more frequent, and its clinical complicacy should be emphasized in differential diagnosis. For patients with a definite diagnosis of POEMS syndrome, an early and thorough endocrine evaluation should be performed.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39403800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}