Juan Gui, Yumei Liu, Yifei Wang, Youqun Zou, Xin Sun, Chaoying Zhang, Chen Chen, Bi Wang
{"title":"体格生长和脑部核磁共振成像可预测极低出生体重儿 2 岁时的神经发育结果。","authors":"Juan Gui, Yumei Liu, Yifei Wang, Youqun Zou, Xin Sun, Chaoying Zhang, Chen Chen, Bi Wang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the current study was to determine the predictive effect of physical growth and brain magnetic resonance imaging (MRI) on neurodevelopmental outcomes in very low birth weight infants (VLBW) infants.</p><p><strong>Materials and methods: </strong>A total of 85 VLBW infants were included in the current study. They were cared according to the guideline of preterm management during hospitalization, and to planned follow-up rules after discharged strictly. All patients enrolled in the present study had undergone measurement of weight, length and head circumference and reported on the infants' weight-for-age z-score (WAZ), height-for-age Z-score (HAZ), head circumference-for-age Z-score (HCZ), and weight-for-height Z score (WHZ).</p><p><strong>Results: </strong>At 29.38 ± 1.70 weeks old, the birth weight was 1240.06 ± 249.46g. MDI decreased gradually with the increase of corrective age (p<0.001), and MDI at 18 months of age decreased significantly compared to normal infants and young children of the same age (p<0.05), while at 24 months of age there was no significant difference between MDI and normal peers. Correcting PDI in 3, 6, 12, 18 and 24 months was significantly lower than that of normal infants and young children of the same age (p<0.05) and did not show a trend that changed with the correction of monthly age. WHZ gradually approaches normal as the age of the month increases (p<0.05), while HCZ decreases gradually with the correction of the age of the month (p<0.05).</p><p><strong>Conclusion: </strong>VLBW has obvious motor development disorders, and there is no difference between intellectual development and healthy young children. MDI rises early and then gradually declines, eventually becoming 2 years old similar to that of healthy young children. PDI has consistently shown a significant decrease in infants and young children of the same age, and has not shown a trend that changes with the correction of monthly age. There is a great correlation between infancy physical development and long-term neurodevelopment, MRI at 12 months old is a valuable prediction method.</p>","PeriodicalId":19098,"journal":{"name":"Neuro endocrinology letters","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Physical growth and brain MRI predict the neurodevelopmental outcomes in very low birth weight infants at 2-year-old.\",\"authors\":\"Juan Gui, Yumei Liu, Yifei Wang, Youqun Zou, Xin Sun, Chaoying Zhang, Chen Chen, Bi Wang\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The purpose of the current study was to determine the predictive effect of physical growth and brain magnetic resonance imaging (MRI) on neurodevelopmental outcomes in very low birth weight infants (VLBW) infants.</p><p><strong>Materials and methods: </strong>A total of 85 VLBW infants were included in the current study. They were cared according to the guideline of preterm management during hospitalization, and to planned follow-up rules after discharged strictly. All patients enrolled in the present study had undergone measurement of weight, length and head circumference and reported on the infants' weight-for-age z-score (WAZ), height-for-age Z-score (HAZ), head circumference-for-age Z-score (HCZ), and weight-for-height Z score (WHZ).</p><p><strong>Results: </strong>At 29.38 ± 1.70 weeks old, the birth weight was 1240.06 ± 249.46g. MDI decreased gradually with the increase of corrective age (p<0.001), and MDI at 18 months of age decreased significantly compared to normal infants and young children of the same age (p<0.05), while at 24 months of age there was no significant difference between MDI and normal peers. Correcting PDI in 3, 6, 12, 18 and 24 months was significantly lower than that of normal infants and young children of the same age (p<0.05) and did not show a trend that changed with the correction of monthly age. WHZ gradually approaches normal as the age of the month increases (p<0.05), while HCZ decreases gradually with the correction of the age of the month (p<0.05).</p><p><strong>Conclusion: </strong>VLBW has obvious motor development disorders, and there is no difference between intellectual development and healthy young children. MDI rises early and then gradually declines, eventually becoming 2 years old similar to that of healthy young children. PDI has consistently shown a significant decrease in infants and young children of the same age, and has not shown a trend that changes with the correction of monthly age. There is a great correlation between infancy physical development and long-term neurodevelopment, MRI at 12 months old is a valuable prediction method.</p>\",\"PeriodicalId\":19098,\"journal\":{\"name\":\"Neuro endocrinology letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2021-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuro endocrinology letters\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuro endocrinology letters","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Physical growth and brain MRI predict the neurodevelopmental outcomes in very low birth weight infants at 2-year-old.
Objective: The purpose of the current study was to determine the predictive effect of physical growth and brain magnetic resonance imaging (MRI) on neurodevelopmental outcomes in very low birth weight infants (VLBW) infants.
Materials and methods: A total of 85 VLBW infants were included in the current study. They were cared according to the guideline of preterm management during hospitalization, and to planned follow-up rules after discharged strictly. All patients enrolled in the present study had undergone measurement of weight, length and head circumference and reported on the infants' weight-for-age z-score (WAZ), height-for-age Z-score (HAZ), head circumference-for-age Z-score (HCZ), and weight-for-height Z score (WHZ).
Results: At 29.38 ± 1.70 weeks old, the birth weight was 1240.06 ± 249.46g. MDI decreased gradually with the increase of corrective age (p<0.001), and MDI at 18 months of age decreased significantly compared to normal infants and young children of the same age (p<0.05), while at 24 months of age there was no significant difference between MDI and normal peers. Correcting PDI in 3, 6, 12, 18 and 24 months was significantly lower than that of normal infants and young children of the same age (p<0.05) and did not show a trend that changed with the correction of monthly age. WHZ gradually approaches normal as the age of the month increases (p<0.05), while HCZ decreases gradually with the correction of the age of the month (p<0.05).
Conclusion: VLBW has obvious motor development disorders, and there is no difference between intellectual development and healthy young children. MDI rises early and then gradually declines, eventually becoming 2 years old similar to that of healthy young children. PDI has consistently shown a significant decrease in infants and young children of the same age, and has not shown a trend that changes with the correction of monthly age. There is a great correlation between infancy physical development and long-term neurodevelopment, MRI at 12 months old is a valuable prediction method.
期刊介绍：
Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology
Letters.
Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered.
The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.
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