Relationship between sex hormone-binding globulin level and blood glucose in middle-aged and elder males of Uygur ethnic group.

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Neuro endocrinology letters Pub Date : 2021-10-01

Li Quan, Lin Hu, Jing Wang, Binya Yuwen, Jun Zhu, Sheng Jiang

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Abstract

Objective: To investigate the relationship between sex hormone-binding globulin (SHBG) and blood glucose in elder men of Uygur ethnic group.

Methods: A total of 467 males of ugyur ethnic group resident in Urumqi, Tuokesun County, and Turpan were included by cluster sampling, classified by ages and SHBG level, and compared the metabolic index to define the risk factors by regression.

Results: BMI, waist circumference (WC), glycosylated hemoglobin (GH), fasting insulin level (FIL), SHBG, testosterone, free testosteroneindex (FAI), and HOMA-IR were statistically different in different age groups (P<0.05); the differences in the age, BMI, WC, fasting blood glucose (FBG), OGTT 2-hr blood glucose, HOMA-IR, FIL, GH, testosterone, and F among the study subjects grouped according to SHBG level were statistically significant (P<0.05); the logistic regression analysis revealed that FIL and testosterone were the independent factors that will affect SHBG in the models using FIL, HOMA-IR, and other indexes with statistical significance as the continuous variables and the interquartile grouping of SHBG as the independent variables.

Conclusions: Among middle-aged and elder males, there are differences in the sex hormone and SHBG levels. The independent influencing factors of SHBG are HOMA-IR, testosterone, and FIL.

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维吾尔族中老年男性性激素结合球蛋白水平与血糖的关系

目的:探讨维吾尔族老年男性性激素结合球蛋白(SHBG)与血糖的关系。方法:采用整群抽样的方法，对居住在乌鲁木齐、托克孙县和吐鲁番地区的维吾尔族男性467人，按年龄和SHBG水平进行分类，比较代谢指标，通过回归分析确定危险因素。结果:不同年龄组的BMI、腰围(WC)、糖化血红蛋白(GH)、空腹胰岛素水平(FIL)、SHBG、睾酮、游离睾酮指数(FAI)、HOMA-IR差异均有统计学意义(p)。结论:中老年男性性激素、SHBG水平存在差异。SHBG的独立影响因素是HOMA-IR、睾酮和FIL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.