Thyroid cancer risk assessment indicators: A correlation between preoperative and postoperative criteria.

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Neuro endocrinology letters Pub Date : 2021-10-01

Noora Al Moosa, Mai Abdulla Nasser, Mohamed Alshehabi

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引用次数: 0

Abstract

Background and objectives: To differentiate preoperatively between benign nodule and thyroid cancer (TC) is highly important. Therefore, we investigated the risk assessment indicators that correlate preoperative clinical, radiological, and pathological features with post-operative TC characteristics.

Methods: An observational retrospective study was performed in Bahrain Defense Force (BDF) hospital for all patients suspected of having thyroid cancer from January 2016 to October 2020. All the medical records, including clinical, laboratory, radiological, and pathological assessments of these patients, were retrieved and analyzed for association using binary and multivariate logistic regression analysis to estimate significance, odds ratio (OR), and 95% confidence interval.

Results: A total of 87 patients were included in the study with a mean age of 40 ± 12.5 years old. The histopathology revealed that 27 patients had TC with a mean age of 38.1±10.8 years (p>0.05 vs. benign conditions). Furthermore, the TC frequencies within gender were 29.9% and 36.4% for females and males, respectively. Besides, most patients (85.2%) had papillary TC cancer, whereas 7.4% had follicular cancer, and 3.7% had either medullary TC or minimally invasive follicular TC. The correlation results between demographic, clinical characteristic evaluations, laboratory findings of the study patients, and TC as reported by the histopathology were all not significant except for ultrasound features including solitary nodule (p<0.05), lymph node involvement, and consistency (p<0.01). The sensitivity and specificity values of FNAC for detection of TC were 77.8% and 86.3%, respectively. Multivariate analysis revealed that only solid consistency of the tumor (OR = 9.88) and lymph node involvement (OR = 14.78) were correlated with TC detection. On the other hand, gender, symptoms of hypothyroidism, hyperthyroidism, or compression, family history of TC, abnormal thyroid function tests, neck swelling, and ultrasounds imaging with regards to vascularization and microcalcification were not correlated with the detection of TC.

Conclusion: Preoperative nodule and FNAC assessments need further research and development to approach higher sensitivity in detecting TC.

本刊更多论文

甲状腺癌风险评估指标:术前和术后标准的相关性。

背景与目的:术前鉴别良性结节与甲状腺癌(TC)非常重要。因此，我们研究了术前临床、影像学和病理特征与术后TC特征相关的风险评估指标。方法:对2016年1月至2020年10月在巴林国防军(BDF)医院所有疑似甲状腺癌患者进行观察性回顾性研究。检索所有病历，包括这些患者的临床、实验室、放射学和病理评估，并使用二元和多变量logistic回归分析来估计显著性、优势比(OR)和95%置信区间。结果:共纳入87例患者，平均年龄40±12.5岁。组织病理学显示27例患者发生TC，平均年龄38.1±10.8岁(与良性对照p>0.05)。性别间的TC频率分别为29.9%和36.4%。乳头状TC癌占85.2%，滤泡性TC癌占7.4%，髓样TC和微创滤泡性TC占3.7%。研究患者的人口学、临床特征评价、实验室检查结果与组织病理学报告的TC之间的相关性均不显著，但超声特征包括孤立结节(p)。结论:术前结节和FNAC评估需要进一步研究和发展，以获得更高的TC检测灵敏度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.