Paediatric respiratory epidemiology最新文献_第7页

Does asthma treatment still vary by sex in Switzerland? 在瑞士，哮喘治疗仍然因性别而异吗?

Paediatric respiratory epidemiology Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1046

Rebeca Mozún Torrico, C. Ardura-Garcia, M. Goutaki, F. Singer, P. Latzin, A. Moeller, C. Kuehni

{"title":"Does asthma treatment still vary by sex in Switzerland?","authors":"Rebeca Mozún Torrico, C. Ardura-Garcia, M. Goutaki, F. Singer, P. Latzin, A. Moeller, C. Kuehni","doi":"10.1183/13993003.congress-2019.pa1046","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1046","url":null,"abstract":"Introduction: Studies done in the 1990s in Eastern Switzerland found that girls received less often treatment for asthma symptoms than boys despite similar symptoms. We reviewed this question in a recent survey. Methods: The Luftibus study collected information on respiratory symptoms by parent completed questionnaires in unselected school-aged children from the canton of Zurich, 2013-16. We investigated whether wheeze prevalence and asthma medication differed between girls and boys. Results: 3148 children participated, 1587 girls and 1561 boys, with median age of 12 years (IQR 10-14, range 6-16). 253 (8%) children reported current wheeze. The proportion decreased with age from 11% in 6-9 year olds to 8% in 13-16 year olds in boys while it increased with age from 5% (6-9year olds) to 9% (13-16year olds) in girls. 78 children (3%) had frequent wheeze (≥4 attacks/year). In the past year, among children who wheezed, 129 (51%), 52% girls and 51% boys, had used short-acting beta 2 agonists (SABA) and 94 (37%), 39% girls and 36% boys, were treated with inhaled corticosteroids (ICS). Among children with frequent wheeze only 45 (58%) and 27 (35%) used SABA and ICS respectively. Adjusting for frequency of attacks and number of asthma symptoms, there was no difference between boys and girls in the use of SABA (OR 0.95, 95%CI 0.54-1.7) and ICS (OR 0.93, 95%CI 0.53-1.7) overall. Among 6-9-year olds, boys received ICS less often than girls (OR 0.22, 95%CI 0.067-0.73). Conclusion: A significant proportion of schoolchildren with frequent wheeze did not use asthma medication in the past year. We found no evidence that girls received less treatment than boys. Funding: Lung League Zurich. SNSF (320030_162628)","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131674470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact on Adherence to the 2012 Evaluation and Management of Pediatric Community Acquired Pneumonia Philippine Academy of Pediatric Pulmonologist (PAPP) Update 对2012年儿童社区获得性肺炎评估和管理的影响菲律宾儿科肺病学家学会(PAPP)更新

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA1348

Lorraine Sharon Salvana

{"title":"Impact on Adherence to the 2012 Evaluation and Management of Pediatric Community Acquired Pneumonia Philippine Academy of Pediatric Pulmonologist (PAPP) Update","authors":"Lorraine Sharon Salvana","doi":"10.1183/13993003.CONGRESS-2018.PA1348","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA1348","url":null,"abstract":"Background: Pneumonia is the third leading cause of death worldwide and in countries with low per capita income. We aimed to review the impact of adherence of clinicians as to severity and site of care, diagnostic aids, treatments and the clinical outcomes (length of stay, antibiotic use, use of mechanical ventilator)of patients managed according to the 2012 PAPP Update in the Evaluation and Management of Pediatric Community Acquired Pneumonia (pCAP). Methodology: This is a cross sectional study conducted in the Philippine Heart Center from April 2013 to June 2016. Hospital records of all pediatric patients aged 2 months to 19 years admitted with the diagnosis of pCAP were retrieved and reviewed. Subjects were grouped into adherent and non adherent. Adherence was defined as those subjects who were able to comply to ALL the recommendation as to the classification, site of care, diagnostics aids and treatment set by the PAPP guidelines. Non- adherence was defined as those who did not comply to ONE of the recommendations. This was then compared to the length of hospital stay, presence of clinical improvement, use of antibiotics and use of mechanical ventilation. Results: Adherence to PAPP guidelines was high in terms of severity and site of care, diagnostic aid and treatment. Diagnostics collected and antibiotics used were also adherent but showed no statistical significance. Most commonly used antibiotics were Cefuroxime and Clarithromycin. Length of hospital stay and signs of clinical improvement was shorter for adherent group, except those admitted to the ICU. Conclusion: The present data supports the recommendation of these guidelines.","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127678547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early childhood growth patterns and lung function and asthma at 10 years 儿童早期生长模式和肺功能以及10岁时的哮喘

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.OA3308

Maribel Casas Sanahuja, H. Dekker, Claudia J. Kruithof, I. Reiss, M. Vrijheid, J. Sunyer, J. C. Jongste, V. Jaddoe, L. Duijts

{"title":"Early childhood growth patterns and lung function and asthma at 10 years","authors":"Maribel Casas Sanahuja, H. Dekker, Claudia J. Kruithof, I. Reiss, M. Vrijheid, J. Sunyer, J. C. Jongste, V. Jaddoe, L. Duijts","doi":"10.1183/13993003.CONGRESS-2018.OA3308","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.OA3308","url":null,"abstract":"Greater infant weight gain is associated with lower lung function and increased risk of childhood asthma. Detailed individual childhood growth patterns might be better predictors of childhood respiratory morbidity than the difference in two measurements of weight and height. We assessed the associations of early childhood growth patterns with lung function and asthma at the age of 10 years and whether child’s current body mass index (BMI) influenced any association. In 4,435 children from the Generation R birth cohort study in Rotterdam, the Netherlands, we derived peak height and weight growth velocity, body mass index at adiposity peak, and age at adiposity peak from longitudinally measured growth data in the first 3 years of life. At 10 years, spirometry was performed including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC. Current asthma was assessed by questionnaires. Per standard deviation score, greater peak weight velocity was associated with higher FVC (z-score 0.03 [95% CI, 0.02 to 0.05]) but lower FEV1/FVC (-0.05 [95% CI, -0.07 to -0.04]). Greater body mass index at adiposity peak was associated with higher FVC (0.14 [0.10 to 0.18]) and FEV1 (0.06 [0.02 to 0.10]) but lower FEV1/FVC (-0.15 [-0.19 to -0.11]). Child’s current BMI partly explained the associations of PWV and FEV1/FVC and of BMIAP with FVC and FEV1/FVC. Peak height velocity and age at adiposity peak were not consistently associated with impaired lung function or asthma. Peak weight velocity and body mass index at adiposity peak were associated with lower lung function measures at age 10 years, not asthma, independently of child’s current weight status.","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133269746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neonatal manifestations in Primary Ciliary Dyskinesia: a multinational cohort study 原发性纤毛运动障碍的新生儿表现:一项多国队列研究

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA5021

M. Goutaki, F. Halbeisen, Agatha Wisse, I. Amirav, A. Barbato, C. Casaulta, S. Crowley, E. Haarman, R. Hirst, B. Karadag, J. Lucas, L. Morgan, U. Ozcelik, Santiago Ucrós, P. Yiallouros, Z. Zivković, P. Latzin, C. Kuehni

{"title":"Neonatal manifestations in Primary Ciliary Dyskinesia: a multinational cohort study","authors":"M. Goutaki, F. Halbeisen, Agatha Wisse, I. Amirav, A. Barbato, C. Casaulta, S. Crowley, E. Haarman, R. Hirst, B. Karadag, J. Lucas, L. Morgan, U. Ozcelik, Santiago Ucrós, P. Yiallouros, Z. Zivković, P. Latzin, C. Kuehni","doi":"10.1183/13993003.CONGRESS-2018.PA5021","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA5021","url":null,"abstract":"Background: Neonatal respiratory distress (NRDS) and other neonatal manifestations are reported commonly in patients with Primary Ciliary Dyskinesia (PCD): Despite this, most patients remain undiagnosed until much later in life. We calculated the prevalence of neonatal manifestations in a large multinational dataset and assessed if they were associated with earlier PCD diagnosis. Methods: We included 13 datasets from the international PCD (iPCD) cohort, with almost complete information on the neonatal period. We calculated the prevalence of reported NRDS and separately the prevalence of any reported neonatal manifestation (including any of the following: NRDS, rhinitis, cough, pneumonia, admission to NICU, mechanical ventilation, need of oxygen, hydrocephalus). Further, we compared age of diagnosis in patients with and without neonatal manifestations using poisson regression models. Results: We included 1175 patients with information on NRDS and 1053 with information on any neonatal manifestation. Prevalence of NRDS was 40% (469/1175) and of any neonatal manifestation 66% (696/1053). After adjusting for sex and laterality, mean age of diagnosis was lower in patients who reported neonatal symptoms (12 versus 14 years, p Conclusion: PCD patients who reported neonatal manifestations were diagnosed younger, however age of diagnosis was still high. Increased awareness and close collaboration with neonatologists is needed to diagnose PCD earlier in patients with early life symptoms. Funding: FP7 grant 305404, SNF 320030_173044, COST BM1407","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"11 33","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132746699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of conventional chest physiotherapy and vibratory positive pressure treatment system method in diagnosis of primary ciliary dyskinesia 常规胸部物理治疗与振动正压治疗系统诊断原发性纤毛运动障碍的比较

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa4671

Ibrahim Bingol, P. Ergenekon, E. Atag, N. Ikizoglu, Y. Gokdemir, E. E. Eralp, Ayca Evkaya, Kardelen Gencer, E. Saygı, B. Karadag

引用次数: 0

Prenatal exposure to organochlorine compounds and lung function until early adulthood 产前暴露于有机氯化合物和肺功能直到成年早期

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA5015

M. Casas, A. Abellan, Raquel García, M. Torrent, C. Roda, M. Gascon, A. Ferrero, M. Lopez-Espinosa, Carlos Zabaleta, M. Basterrechea, J. Grimalt, J. Garcia-Aymerich, M. Vrijheid, J. Sunyer

引用次数: 1

GST genotypes modify the association between paracetamol use in early life and lung function at 18 years GST基因型改变了生命早期使用扑热息痛与18岁时肺功能之间的关系

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.OA3309

Xin Dai, S. Dharmage, M. Abramson, A. Lowe, J. Perret, B. Erbas, Nilakshi Waidyatilake, C. Lodge

{"title":"GST genotypes modify the association between paracetamol use in early life and lung function at 18 years","authors":"Xin Dai, S. Dharmage, M. Abramson, A. Lowe, J. Perret, B. Erbas, Nilakshi Waidyatilake, C. Lodge","doi":"10.1183/13993003.CONGRESS-2018.OA3309","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.OA3309","url":null,"abstract":"Background: While the impact of paracetamol use in early life on asthma risk is still debated, its potential interaction with antioxidative Glutathione S-Transferase (GST) genes, and possible impact on lung function, have not been widely investigated. Aims and objectives: To investigate associations between early life paracetamol use and adolescent asthma and lung function and to assess if these associations are modified by GST gene polymorphisms. Methods: The Melbourne Atopy Cohort Study included 620 children followed from birth to 18 years, with paracetamol use and indications documented 18 times up to 2 years. Participants were genotyped for GST polymorphisms (GSTT1, GSTM1 & GSTP1). Asthma was assessed and spirometry (GLI reference equations) was measured at 18 years. Regression models tested associations/confounders and interactions were assessed using likelihood ratio tests. Results: After adjustment for frequency of early life respiratory infection, doubling of days of paracetamol use was associated with a reduction in pre- and post-bronchodilator FEV1 (-1.47%, 95%CI -2.85, -0.10 of predicted; -1.41, 95%CI -2.70, -0.12 respectively) at 18 years. In those with GSTM1 null genotype, each doubling of days of use of paracetamol for non-respiratory reasons was associated with a reduction in FEV1 of 1.81% (95%CI -3.08, -0.54) at 18 years. This was not seen in those with GSTM1 present. No associations or interactions were found for asthma. Conclusions: We found evidence of association between early life paracetamol use and decreased lung function in adolescence, especially in individuals with GSTM1 null genotypes. Further investigation is needed to confirm this important findings.","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117178361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Relation of serum IGF-1 and IGFBP3 levels with acute exacerbation in cystic fibrosis 血清IGF-1和IGFBP3水平与囊性纤维化急性加重的关系

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa1350

F. Eser, P. Ergenekon, E. Atag, N. Ikizoglu, E. E. Eralp, Y. Gokdemir, S. Turan, A. Bereket, B. Karadag

引用次数: 0

Reduced first trimester fetal size and asthma outcomes to age 29 years – results from a “virtual” birth cohort 从一个“虚拟”的出生队列中得出的结果，减少了前三个月胎儿的大小和29岁时的哮喘结果

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa5012

S. Turner, L. Aucott

引用次数: 0

Accuracy of high-speed video microscopy to diagnose primary ciliary dyskinesia 高速视频显微镜诊断原发性纤毛运动障碍的准确性

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA5022

B. Rubbo, I. Reading, A. Shoemark, C. Jackson, R. Hirst, James Thompson, Joseph Hayes, E. Frost, F. Copeland, C. O’Callaghan, C. Hogg, J. Lucas

{"title":"Accuracy of high-speed video microscopy to diagnose primary ciliary dyskinesia","authors":"B. Rubbo, I. Reading, A. Shoemark, C. Jackson, R. Hirst, James Thompson, Joseph Hayes, E. Frost, F. Copeland, C. O’Callaghan, C. Hogg, J. Lucas","doi":"10.1183/13993003.CONGRESS-2018.PA5022","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA5022","url":null,"abstract":"Background: Primary ciliary dyskinesia (PCD) is a rare genetic disease that impairs motility of cilia. Diagnosis relies on a combination of tests and final decision by multidisciplinary team (MDT). High-speed video microscopy (HSVM) is an important contribution to diagnostic testing, and is the only test that examines cilia motility on the day of patients’ appointment. No study has assessed the accuracy of HSVM. We hypothesised that scientists experienced in cilia assessment by HSVM would accurately diagnose PCD using HSVM alone compared to MDT diagnosis. Methods: We used 720 archived videos from 120 patients referred to three UK PCD diagnostic services in 2015-17. One scientist from each PCD centre reviewed videos, blinded to diagnostic and clinical data, and scored them for final diagnosis using a standardised proforma. We compared the final scoring for each scientist to: a) a report containing final diagnosis from the MDT decision, and b) diagnostic criteria provided in the 2017 ERS PCD diagnostic guidelines. Results: Sensitivity and specificity were: a) 96.1% and 100% respectively when compared to MDT decision, and b) 95.7% and 100% respectively when compared to ERS guidelines criteria. Inter-rater reliability between the three scientists was substantial (k=0.7) for ‘PCD positive’, and moderate (k=0.44) for ‘PCD highly unlikely’. Conclusions: Specialist scientists accurately diagnosed PCD using HSVM analysis, with high inter-observer agreement. HSVM can be used to reliably counsel patients on their likely diagnosis on the same day as clinic appointment and inform clinicians on initiation of treatment while confirmatory investigations are conducted. Funding: NIHR Research for Patient Benefit grant","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129331607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0