Nature biotechnology最新文献_第3页

Chronic silencing is a critical barrier to breaking the cycle of bullying in academia and industry 长期的沉默是打破学术界和工业界欺凌循环的关键障碍

IF 41.7 1区生物学

Nature biotechnology Pub Date : 2025-09-15 DOI: 10.1038/s41587-025-02803-9

Alison E. Vogelaar, Morteza Mahmoudi

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Intellectual property rights in the cultivated meat industry: opportunities and challenges 养殖肉类行业的知识产权：机遇与挑战

IF 41.7 1区生物学

Nature biotechnology Pub Date : 2025-09-15 DOI: 10.1038/s41587-025-02798-3

Garam Baek, Sukhyun Chung, Peter Yu, Yooheon Park

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Biotech news from around the world 来自世界各地的生物技术新闻

IF 41.7 1区生物学

Nature biotechnology Pub Date : 2025-09-15 DOI: 10.1038/s41587-025-02817-3

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Boosted mitochondria reverse cognitive impairment in mice 增强线粒体逆转小鼠认知障碍

IF 41.7 1区生物学

Nature biotechnology Pub Date : 2025-09-15 DOI: 10.1038/s41587-025-02823-5

Iris Marchal

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MicroRNAs

IF 41.7 1区生物学

Nature biotechnology Pub Date : 2025-09-15 DOI: 10.1038/s41587-025-02800-y

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Forum: Bao and Rogers 论坛：鲍和罗杰斯

IF 41.7 1区生物学

Nature biotechnology Pub Date : 2025-09-15 DOI: 10.1038/s41587-025-02784-9

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Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome 通过土壤宏基因组的太碱基级长读测序发现的生物活性分子

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-09-12 DOI: 10.1038/s41587-025-02810-w

Ján Burian, Robert E. Boer, Yozen Hernandez, Adrian Morales-Amador, Linhai Jiang, Abir Bhattacharjee, Cecilia Panfil, Melinda A. Ternei, Sean F. Brady

{"title":"Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome","authors":"Ján Burian, Robert E. Boer, Yozen Hernandez, Adrian Morales-Amador, Linhai Jiang, Abir Bhattacharjee, Cecilia Panfil, Melinda A. Ternei, Sean F. Brady","doi":"10.1038/s41587-025-02810-w","DOIUrl":"https://doi.org/10.1038/s41587-025-02810-w","url":null,"abstract":"<p>Metagenomics provides access to the genetic diversity of uncultured bacteria through analysis of DNA extracted from whole microbial communities. Long-read sequencing is advancing metagenomic discovery by generating larger DNA assemblies than previously possible. However, harnessing the potential of long-read sequencing to access the vast diversity within soil microbiomes is hampered by the challenge of isolating high-quality DNA. Here we introduce a method that can liberate large, high-quality metagenomic DNA fragments from soil bacteria and pair them with optimized nanopore long-read sequencing to generate megabase-sized assemblies. Using this method, we uncover hundreds of complete circular metagenomic genomes from a single soil sample. Through a combination of bioinformatic prediction and chemical synthesis, we convert nonribosomal peptide biosynthetic gene clusters directly into bioactive molecules, identifying antibiotics with rare modes of action and activity against multidrug-resistant pathogens. Our approach advances metagenomic access to the vast genetic diversity of the uncultured bacterial majority and provides a means to convert it to bioactive molecules.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"51 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Efficient sequence alignment against millions of prokaryotic genomes with LexicMap 利用LexicMap对数百万原核生物基因组进行高效序列比对

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-09-10 DOI: 10.1038/s41587-025-02812-8

Wei Shen, John A. Lees, Zamin Iqbal

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A phenotypic screen enables high-throughput target-first discovery of molecular glue degraders 表型筛选使高通量的目标优先发现分子胶水降解剂

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-09-10 DOI: 10.1038/s41587-025-02794-7

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A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2 诱导接近降解物的快速成像筛选鉴定出致癌蛋白SKP2的有效降解物

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-09-10 DOI: 10.1038/s41587-025-02793-8

Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen, Huiling Fang, Pinyu Huang, Yueru Xie, Chi Sun, Yun Chen, Baoding Zhang, Li Li, Hongchen Mu, Ding Song, Wentao Cheng, Chao Wang, Wei Jiang, Xiaolan Xu, Zhengjin He, Shuo Chen, Mingxian Liu, Jingchuan Ma, Man Yang, Jiaqi Cao, Jing Gao, Jiali Shen, Lulu Zhang, Yu Bai, Zheyi Liu, Jingyao Chen, Siqi Dai, Yi Arial Zeng, Yun Zhao, Hu Zhou, Chong Chen, Huanwei Ru, Li Tan, Ximin Chi, Fangjun Wang, Daming Gao, Moubin Lin, Xianming Deng, Hai Jiang

{"title":"A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2","authors":"Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen, Huiling Fang, Pinyu Huang, Yueru Xie, Chi Sun, Yun Chen, Baoding Zhang, Li Li, Hongchen Mu, Ding Song, Wentao Cheng, Chao Wang, Wei Jiang, Xiaolan Xu, Zhengjin He, Shuo Chen, Mingxian Liu, Jingchuan Ma, Man Yang, Jiaqi Cao, Jing Gao, Jiali Shen, Lulu Zhang, Yu Bai, Zheyi Liu, Jingyao Chen, Siqi Dai, Yi Arial Zeng, Yun Zhao, Hu Zhou, Chong Chen, Huanwei Ru, Li Tan, Ximin Chi, Fangjun Wang, Daming Gao, Moubin Lin, Xianming Deng, Hai Jiang","doi":"10.1038/s41587-025-02793-8","DOIUrl":"https://doi.org/10.1038/s41587-025-02793-8","url":null,"abstract":"<p>Targeted protein degraders hold potential as therapeutic agents to target conventionally ‘undruggable’ proteins. Here, we develop a high-throughput screen, DEath FUSion Escaper (DEFUSE), to identify small-molecule protein degraders. By conjugating the protein of interest to a fast-acting triggerable death protein, this approach translates target protein degradation into a cell survival phenotype to illustrate the presence of degraders. Using this method, we discovered a small molecule (SKPer1) that triggers degradation of the oncoprotein SKP2 and specifically kills SKP2-expressing cancer cells. Mechanistically, SKPer1 acts as an induced-proximity degrader by inducing interaction between SKP2 and an E3 ligase, STUB1, resulting in SKP2 ubiquitination and degradation. SKPer1 exhibits substantial tumour suppression with good safety profiles in vivo. We further show that a sequence of ten amino acids from SKP2 can serve as a versatile degradation tag.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"49 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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