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Beyond the blood: expanding CAR T cell therapy to solid tumors 超越血液：将 CAR T 细胞疗法扩展到实体瘤
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02446-2
Ugur Uslu, Carl H. June
{"title":"Beyond the blood: expanding CAR T cell therapy to solid tumors","authors":"Ugur Uslu, Carl H. June","doi":"10.1038/s41587-024-02446-2","DOIUrl":"https://doi.org/10.1038/s41587-024-02446-2","url":null,"abstract":"<p>Chimeric antigen receptor (CAR) T cell therapy stands as a transformative advancement in immunotherapy, triumphing against hematological malignancies and, increasingly, autoimmune disorders. After a decade of relatively modest results for solid tumors, recent clinical trials and patient reports have also started to yield promising outcomes in glioblastoma and other challenging solid tumor entities. This Perspective seeks to explore the reasons behind these latest achievements and discusses how they can be sustained and expanded through different strategies involving CAR engineering and synthetic biology. Furthermore, we critically analyze how these breakthroughs can be leveraged to maintain momentum and broaden the therapeutic impact of CAR T cells across a variety of solid tumor landscapes.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"10 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
People 人
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02464-0
{"title":"People","authors":"","doi":"10.1038/s41587-024-02464-0","DOIUrl":"10.1038/s41587-024-02464-0","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1754-1754"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal scanning of genetic variants with base and prime editing 利用碱基和质点编辑对基因变异进行多模式扫描
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02439-1
Olivier Belli, Kyriaki Karava, Rick Farouni, Randall J. Platt
{"title":"Multimodal scanning of genetic variants with base and prime editing","authors":"Olivier Belli, Kyriaki Karava, Rick Farouni, Randall J. Platt","doi":"10.1038/s41587-024-02439-1","DOIUrl":"https://doi.org/10.1038/s41587-024-02439-1","url":null,"abstract":"<p>Mutational scanning connects genetic variants to phenotype, enabling the interrogation of protein functions, interactions and variant pathogenicity. However, current methodologies cannot efficiently engineer customizable sets of diverse genetic variants in endogenous loci across cellular contexts in high throughput. Here, we combine cytosine and adenine base editors and a prime editor to assess the pathogenicity of a broad spectrum of variants in the epithelial growth factor receptor gene (<i>EGFR</i>). Using pooled base editing and prime editing guide RNA libraries, we install tens of thousands of variants spanning the full coding sequence of <i>EGFR</i> in multiple cell lines and assess the role of these variants in tumorigenesis and resistance to tyrosine kinase inhibitors. Our <i>EGFR</i> variant scan identifies important hits, supporting the robustness of the approach and revealing underappreciated routes to EGFR activation and drug response. We anticipate that multimodal precision mutational scanning can be applied broadly to characterize genetic variation in any genetic element of interest at high and single-nucleotide resolution.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"22 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucose-responsive insulin for diabetes 治疗糖尿病的葡萄糖反应性胰岛素
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02477-9
Iris Marchal
{"title":"Glucose-responsive insulin for diabetes","authors":"Iris Marchal","doi":"10.1038/s41587-024-02477-9","DOIUrl":"10.1038/s41587-024-02477-9","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1650-1650"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shot in the arm for biotech fuels 为生物技术燃料注入一剂强心针
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02484-w
{"title":"Shot in the arm for biotech fuels","authors":"","doi":"10.1038/s41587-024-02484-w","DOIUrl":"10.1038/s41587-024-02484-w","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1628-1628"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LucaProt reveals the diverse global RNA virome LucaProt 揭示了多样化的全球 RNA 病毒群
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02476-w
Iris Marchal
{"title":"LucaProt reveals the diverse global RNA virome","authors":"Iris Marchal","doi":"10.1038/s41587-024-02476-w","DOIUrl":"10.1038/s41587-024-02476-w","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1650-1650"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wasp gut microbes yield beer with extra tang 黄蜂肠道微生物酿造出口感更佳的啤酒
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02473-z
Claire Turrell
{"title":"Wasp gut microbes yield beer with extra tang","authors":"Claire Turrell","doi":"10.1038/s41587-024-02473-z","DOIUrl":"10.1038/s41587-024-02473-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1631-1631"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Bench to Podcast: Ali Shaib 从工作台到播客阿里-沙伊布
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02438-2
{"title":"From Bench to Podcast: Ali Shaib","authors":"","doi":"10.1038/s41587-024-02438-2","DOIUrl":"10.1038/s41587-024-02438-2","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1653-1653"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotech news from around the world 全球生物技术新闻
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02474-y
{"title":"Biotech news from around the world","authors":"","doi":"10.1038/s41587-024-02474-y","DOIUrl":"10.1038/s41587-024-02474-y","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1632-1632"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer cases in bluebird’s gene therapy trials 蓝鸟基因治疗试验中的癌症病例
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-11-12 DOI: 10.1038/s41587-024-02482-y
{"title":"Cancer cases in bluebird’s gene therapy trials","authors":"","doi":"10.1038/s41587-024-02482-y","DOIUrl":"10.1038/s41587-024-02482-y","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 11","pages":"1626-1626"},"PeriodicalIF":33.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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