Engineering non-viral protein nanoparticles to deliver nucleic acids and proteins to cells

IF 33.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nature biotechnology Pub Date : 2025-05-16 DOI:10.1038/s41587-025-02665-1

引用次数: 0

Abstract

Protein materials are promising drug delivery vehicles, but their use for intracellular protein and nucleic acid cargo delivery has been limited. We have developed self-assembling elastin-like polypeptide (ELP)-based protein nanoparticles that are functionalized to enable complexation and intracellular delivery of biomacromolecular cargo, including gene editors in the form of mRNA, plasmid DNA and ribonucleoproteins.

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设计非病毒蛋白质纳米颗粒，将核酸和蛋白质输送到细胞

蛋白质材料是很有前途的药物递送载体，但它们在细胞内蛋白质和核酸货物递送中的应用受到限制。我们已经开发了基于自组装弹性蛋白样多肽（ELP）的蛋白质纳米颗粒，这些纳米颗粒被功能化，可以实现生物大分子货物的络合和细胞内递送，包括mRNA、质粒DNA和核糖核蛋白形式的基因编辑器。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature biotechnology 工程技术-生物工程与应用微生物

CiteScore

63.00

自引率

1.70%

发文量

382

审稿时长

3 months

期刊介绍： Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.