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Nature Reviews. Drug Discovery最新文献

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Chinese innovative drug R&D trends in 2024 2024 年中国创新药物研发趋势
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-31 DOI: 10.1038/d41573-024-00120-5
Zimeng Chen,  Hui Zhong,  Hongxi Hu,  Fanpu Kong,  Wannian Liang,  Guanqiao Li
{"title":"Chinese innovative drug R&D trends in 2024","authors":"Zimeng Chen, \u0000 Hui Zhong, \u0000 Hongxi Hu, \u0000 Fanpu Kong, \u0000 Wannian Liang, \u0000 Guanqiao Li","doi":"10.1038/d41573-024-00120-5","DOIUrl":"10.1038/d41573-024-00120-5","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscarinic drugs breathe new life into schizophrenia pipeline 毒蕈碱类药物为精神分裂症的治疗注入了新的活力。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-30 DOI: 10.1038/d41573-024-00129-w
Katie Kingwell
{"title":"Muscarinic drugs breathe new life into schizophrenia pipeline","authors":"Katie Kingwell","doi":"10.1038/d41573-024-00129-w","DOIUrl":"10.1038/d41573-024-00129-w","url":null,"abstract":"Karuna and Bristol Myers Squibb’s muscarinic agonist KarXT looks set to offer the first new drug mechanism for patients with schizophrenia in over 70 years. Karuna and Bristol Myers Squibb’s muscarinic agonist KarXT looks set to offer the first new drug mechanism for patients with schizophrenia in over 70 years.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TCR-boosted T cell therapy yields proof-of-principle clinical data in solid cancer TCR 增强型 T 细胞疗法在实体瘤治疗中获得原则性临床数据。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-29 DOI: 10.1038/d41573-024-00121-4
Asher Mullard
{"title":"TCR-boosted T cell therapy yields proof-of-principle clinical data in solid cancer","authors":"Asher Mullard","doi":"10.1038/d41573-024-00121-4","DOIUrl":"10.1038/d41573-024-00121-4","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral miniproteins treat IBD 口服小蛋白治疗 IBD。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00126-z
Sarah Crunkhorn
{"title":"Oral miniproteins treat IBD","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00126-z","DOIUrl":"10.1038/d41573-024-00126-z","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteogenomics identifies anticancer targets 蛋白质基因组学确定抗癌目标。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00127-y
Sarah Crunkhorn
{"title":"Proteogenomics identifies anticancer targets","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00127-y","DOIUrl":"10.1038/d41573-024-00127-y","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid antidote gets a boost 阿片类药物解毒剂得到加强。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00125-0
Sarah Crunkhorn
{"title":"Opioid antidote gets a boost","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00125-0","DOIUrl":"10.1038/d41573-024-00125-0","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic editor silences prion protein 表观遗传编辑器使朊病毒蛋白沉默。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00128-x
Sarah Crunkhorn
{"title":"Epigenetic editor silences prion protein","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00128-x","DOIUrl":"10.1038/d41573-024-00128-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibody sniffs out tau 抗体能嗅出 tau。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-23 DOI: 10.1038/d41573-024-00123-2
Katie Kingwell
{"title":"Antibody sniffs out tau","authors":"Katie Kingwell","doi":"10.1038/d41573-024-00123-2","DOIUrl":"10.1038/d41573-024-00123-2","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI reverse-engineers antibodies 人工智能逆向设计抗体
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-23 DOI: 10.1038/d41573-024-00124-1
Katie Kingwell
{"title":"AI reverse-engineers antibodies","authors":"Katie Kingwell","doi":"10.1038/d41573-024-00124-1","DOIUrl":"10.1038/d41573-024-00124-1","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular glue degrader for sickle cell disease 镰状细胞病分子胶降解剂。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-23 DOI: 10.1038/d41573-024-00122-3
Katie Kingwell
{"title":"Molecular glue degrader for sickle cell disease","authors":"Katie Kingwell","doi":"10.1038/d41573-024-00122-3","DOIUrl":"10.1038/d41573-024-00122-3","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":null,"pages":null},"PeriodicalIF":122.7,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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