Nature Reviews. Drug Discovery最新文献_第5页

Author Correction: Antimalarial drug discovery: progress and approaches 作者更正：抗疟药物的发现：进展与方法。

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-13 DOI: 10.1038/s41573-024-01045-9

Jair L. Siqueira-Neto, Kathryn J. Wicht, Kelly Chibale, Jeremy N. Burrows, David A. Fidock, Elizabeth A. Winzeler

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Targeting cytokine networks in neuroinflammatory diseases 针对神经炎性疾病中的细胞因子网络

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-11 DOI: 10.1038/s41573-024-01026-y

Burkhard Becher, Tobias Derfuss, Roland Liblau

{"title":"Targeting cytokine networks in neuroinflammatory diseases","authors":"Burkhard Becher, Tobias Derfuss, Roland Liblau","doi":"10.1038/s41573-024-01026-y","DOIUrl":"10.1038/s41573-024-01026-y","url":null,"abstract":"In neuroinflammatory diseases, systemic (blood-borne) leukocytes invade the central nervous system (CNS) and lead to tissue damage. A causal relationship between neuroinflammatory diseases and dysregulated cytokine networks is well established across several preclinical models. Cytokine dysregulation is also observed as an inadvertent effect of cancer immunotherapy, where it often leads to neuroinflammation. Neuroinflammatory diseases can be separated into those in which a pathogen is at the centre of the immune response and those of largely unknown aetiology. Here, we discuss the pathophysiology, cytokine networks and therapeutic landscape of ‘sterile’ neuroinflammatory diseases such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), neurosarcoidosis and immune effector cell-associated neurotoxicity syndrome (ICANS) triggered by cancer immunotherapy. Despite successes in targeting cytokine networks in preclinical models of neuroinflammation, the clinical translation of targeting cytokines and their receptors has shown mixed and often paradoxical responses. Dysregulated cytokine networks are important in the pathogenesis of neuroinflammation. This Review discusses targeting cytokines and their receptors in non-infectious central nervous system inflammatory diseases such as multiple sclerosis and neurosarcoidosis, as well as in the neurotoxic adverse events that can be triggered by cancer immunotherapy.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 11","pages":"862-879"},"PeriodicalIF":122.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142166599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Upcoming market catalysts in Q4 2024 2024 年第四季度即将出现的市场催化剂

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-10 DOI: 10.1038/d41573-024-00148-7

Sarina Harper

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Neurons give metastatic cells a push 神经元为转移细胞提供动力

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00144-x

M. Teresa Villanueva

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Splice-switching ASO curtails brain calcification 剪接转换 ASO 可抑制大脑钙化

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00147-8

Katie Kingwell

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PPAR agonists provide new treatment options for inflammatory liver disease PPAR 激动剂为炎症性肝病提供了新的治疗方案

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00145-w

Asher Mullard

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RIPTACs expand anticancer target space RIPTACs 拓展了抗癌靶点空间

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00146-9

Katie Kingwell

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Organoids identify a role for IL-7 in coeliac disease 器官组织确定了 IL-7 在乳糜泻中的作用

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00143-y

Yvonne Bordon

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Apolipoprotein L2 inhibitor mitigates fibrosis 载脂蛋白 L2 抑制剂可减轻纤维化

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-06 DOI: 10.1038/d41573-024-00139-8

Sarah Crunkhorn

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Targeting the peripheral neural-tumour microenvironment for cancer therapy 针对外周神经-肿瘤微环境的癌症疗法

IF 122.7 1区医学

Nature Reviews. Drug Discovery Pub Date : 2024-09-06 DOI: 10.1038/s41573-024-01017-z

Dan Yaniv, Brandi Mattson, Sebastien Talbot, Frederico O. Gleber-Netto, Moran Amit

{"title":"Targeting the peripheral neural-tumour microenvironment for cancer therapy","authors":"Dan Yaniv, Brandi Mattson, Sebastien Talbot, Frederico O. Gleber-Netto, Moran Amit","doi":"10.1038/s41573-024-01017-z","DOIUrl":"10.1038/s41573-024-01017-z","url":null,"abstract":"As the field of cancer neuroscience expands, the strategic targeting of interactions between neurons, cancer cells and other elements in the tumour microenvironment represents a potential paradigm shift in cancer treatment, comparable to the advent of our current understanding of tumour immunology. Cancer cells actively release growth factors that stimulate tumour neo-neurogenesis, and accumulating evidence indicates that tumour neo-innervation propels tumour progression, inhibits tumour-related pro-inflammatory cytokines, promotes neovascularization, facilitates metastasis and regulates immune exhaustion and evasion. In this Review, we give an up-to-date overview of the dynamics of the tumour microenvironment with an emphasis on tumour innervation by the peripheral nervous system, as well as current preclinical and clinical evidence of the benefits of targeting the nervous system in cancer, laying a scientific foundation for further clinical trials. Combining empirical data with a biomarker-driven approach to identify and hone neuronal targets implicated in cancer and its spread can pave the way for swift clinical integration. Targeting the interactions between neurons, cancer cells and other elements in the tumour microenvironment represents a potential paradigm shift in cancer treatment. This Review article provides an overview of the dynamics of the nerve–cancer cell interplay as well as a discussion of current preclinical and clinical evidence of the benefits of targeting the nervous system in cancer.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 10","pages":"780-796"},"PeriodicalIF":122.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0