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Nature Reviews. Drug Discovery最新文献

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Newest glue degrader nabs multiple myeloma approval. 最新的胶水降解剂获得多发性骨髓瘤批准。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-04 DOI: 10.1038/d41573-026-00147-w
Asher Mullard
{"title":"Newest glue degrader nabs multiple myeloma approval.","authors":"Asher Mullard","doi":"10.1038/d41573-026-00147-w","DOIUrl":"https://doi.org/10.1038/d41573-026-00147-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Click chemistry platform enhances ADC tumour targeting. 点击化学平台增强ADC肿瘤靶向。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-02 DOI: 10.1038/d41573-026-00146-x
Alex Eccleston
{"title":"Click chemistry platform enhances ADC tumour targeting.","authors":"Alex Eccleston","doi":"10.1038/d41573-026-00146-x","DOIUrl":"https://doi.org/10.1038/d41573-026-00146-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solute carrier membrane transporters: emerging targets in CNS disorders. 溶质载体膜转运蛋白：中枢神经系统疾病的新靶点。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-01 DOI: 10.1038/s41573-026-01513-4
Yee Kwan Law, Selene Glück, Enrico Girardi, Ariel Bensimon, S Andreas Angermayr, Giulio Superti-Furga
{"title":"Solute carrier membrane transporters: emerging targets in CNS disorders.","authors":"Yee Kwan Law, Selene Glück, Enrico Girardi, Ariel Bensimon, S Andreas Angermayr, Giulio Superti-Furga","doi":"10.1038/s41573-026-01513-4","DOIUrl":"https://doi.org/10.1038/s41573-026-01513-4","url":null,"abstract":"<p><p>Prominent members of the solute carrier (SLC) superfamily of membrane transporters are established targets of central nervous system (CNS) drugs, including the blockbuster neurotransmitter reuptake inhibitors. Numerous other SLC transporters exhibit dysregulated expression in the CNS relative to other tissues, many of which have been genetically or functionally linked to neurological disorders and may therefore represent tractable therapeutic targets. As key regulators of metabolite and ion fluxes, SLCs shape developmental programmes and cellular states associated with epilepsy, neurodegeneration and autism spectrum disorders. Recent advances in assigning biochemical and cellular functions to previously uncharacterized SLCs, together with emerging chemical strategies to increase or decrease transporter abundance, are expanding the therapeutic landscape and positioning SLC biology at the forefront of next-generation CNS drug discovery.</p>","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serotonin receptor agonist suppresses colorectal cancer. 血清素受体激动剂抑制结直肠癌。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00144-z
Sarah Crunkhorn
{"title":"Serotonin receptor agonist suppresses colorectal cancer.","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00144-z","DOIUrl":"https://doi.org/10.1038/d41573-026-00144-z","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral protease-initiated pyroptosis. 病毒蛋白酶引发的焦亡。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00141-2
Sarah Crunkhorn
{"title":"Viral protease-initiated pyroptosis.","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00141-2","DOIUrl":"https://doi.org/10.1038/d41573-026-00141-2","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The landscape for in vivo CAR T cell therapies. 体内CAR - T细胞疗法的前景。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00140-3
Margot Bleys, Kelly Farley, Bonnie Walton, Minsoo Khang, John Wu
{"title":"The landscape for in vivo CAR T cell therapies.","authors":"Margot Bleys, Kelly Farley, Bonnie Walton, Minsoo Khang, John Wu","doi":"10.1038/d41573-026-00140-3","DOIUrl":"https://doi.org/10.1038/d41573-026-00140-3","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A metabolically activated molecular glue. 一种代谢激活的分子胶。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00143-0
Sarah Crunkhorn
{"title":"A metabolically activated molecular glue.","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00143-0","DOIUrl":"https://doi.org/10.1038/d41573-026-00143-0","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAR-T cell therapy for multiple sclerosis. CAR-T细胞治疗多发性硬化症。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00142-1
Sarah Crunkhorn
{"title":"CAR-T cell therapy for multiple sclerosis.","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00142-1","DOIUrl":"https://doi.org/10.1038/d41573-026-00142-1","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RevMed's RAS inhibitor gains landmark FDA approval for pancreatic cancer. RevMed RAS抑制剂获FDA批准用于胰腺癌
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-27 DOI: 10.1038/d41573-026-00145-y
Asher Mullard
{"title":"RevMed's RAS inhibitor gains landmark FDA approval for pancreatic cancer.","authors":"Asher Mullard","doi":"10.1038/d41573-026-00145-y","DOIUrl":"https://doi.org/10.1038/d41573-026-00145-y","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small molecule boosts Parkinson disease treatment. 小分子促进帕金森病的治疗。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-26 DOI: 10.1038/d41573-026-00139-w
Katie Kingwell
{"title":"Small molecule boosts Parkinson disease treatment.","authors":"Katie Kingwell","doi":"10.1038/d41573-026-00139-w","DOIUrl":"https://doi.org/10.1038/d41573-026-00139-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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