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Nature Reviews. Drug Discovery最新文献

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Wrestling with the RAS cancer drug pipeline
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-14 DOI: 10.1038/d41573-025-00043-9
Asher Mullard
{"title":"Wrestling with the RAS cancer drug pipeline","authors":"Asher Mullard","doi":"10.1038/d41573-025-00043-9","DOIUrl":"10.1038/d41573-025-00043-9","url":null,"abstract":"Alice Shaw, Chief of Strategic Partnerships at Dana-Farber Cancer Institute, discusses the newly launched Center for RAS Therapeutics. Alice Shaw, Chief of Strategic Partnerships at Dana-Farber Cancer Institute, discusses the newly launched Center for RAS Therapeutics.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"242-243"},"PeriodicalIF":122.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Top companies and drugs by sales in 2024
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-12 DOI: 10.1038/d41573-025-00049-3
Paul Verdin
{"title":"Top companies and drugs by sales in 2024","authors":"Paul Verdin","doi":"10.1038/d41573-025-00049-3","DOIUrl":"10.1038/d41573-025-00049-3","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"240-240"},"PeriodicalIF":122.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upcoming FDA approval decisions in Q2 2025
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-11 DOI: 10.1038/d41573-025-00050-w
Andrew Shui-Jezierski
{"title":"Upcoming FDA approval decisions in Q2 2025","authors":"Andrew Shui-Jezierski","doi":"10.1038/d41573-025-00050-w","DOIUrl":"10.1038/d41573-025-00050-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"241-241"},"PeriodicalIF":122.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered nasal bacteria slide drugs into the brain
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-11 DOI: 10.1038/d41573-025-00048-4
M. Teresa Villanueva
{"title":"Engineered nasal bacteria slide drugs into the brain","authors":"M. Teresa Villanueva","doi":"10.1038/d41573-025-00048-4","DOIUrl":"10.1038/d41573-025-00048-4","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"247-247"},"PeriodicalIF":122.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves CSF1R inhibitor for rare, non-cancerous joint tumours
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-10 DOI: 10.1038/d41573-025-00045-7
Asher Mullard
{"title":"FDA approves CSF1R inhibitor for rare, non-cancerous joint tumours","authors":"Asher Mullard","doi":"10.1038/d41573-025-00045-7","DOIUrl":"10.1038/d41573-025-00045-7","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"238-238"},"PeriodicalIF":122.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves MEK inhibitor for rare neurofibromas
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-10 DOI: 10.1038/d41573-025-00044-8
Asher Mullard
{"title":"FDA approves MEK inhibitor for rare neurofibromas","authors":"Asher Mullard","doi":"10.1038/d41573-025-00044-8","DOIUrl":"10.1038/d41573-025-00044-8","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"238-238"},"PeriodicalIF":122.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bluebird Bio’s cut-price sale highlights challenges for gene therapy field
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-10 DOI: 10.1038/d41573-025-00046-6
Asher Mullard
{"title":"Bluebird Bio’s cut-price sale highlights challenges for gene therapy field","authors":"Asher Mullard","doi":"10.1038/d41573-025-00046-6","DOIUrl":"10.1038/d41573-025-00046-6","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"239-239"},"PeriodicalIF":122.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASO targets DNA repair protein to combat Huntington disease
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-03-05 DOI: 10.1038/d41573-025-00042-w
Katie Kingwell
{"title":"ASO targets DNA repair protein to combat Huntington disease","authors":"Katie Kingwell","doi":"10.1038/d41573-025-00042-w","DOIUrl":"10.1038/d41573-025-00042-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"248-248"},"PeriodicalIF":122.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induced proximity pushes beyond protein degraders, as first RIPTAC moves into the clinic 首台 RIPTAC 进入临床，诱导接近技术超越了蛋白质降解器的范畴
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-28 DOI: 10.1038/d41573-025-00037-7
Asher Mullard
{"title":"Induced proximity pushes beyond protein degraders, as first RIPTAC moves into the clinic","authors":"Asher Mullard","doi":"10.1038/d41573-025-00037-7","DOIUrl":"10.1038/d41573-025-00037-7","url":null,"abstract":"Halda Therapeutics has started a clinical trial of its first-in-modality RIPTAC drug HLD-0915 in prostate cancer, to see if bifunctional drugs can provide tissue-specific activity. Halda Therapeutics has started a clinical trial of its first-in-modality RIPTAC drug HLD-0915 in prostate cancer, to see if bifunctional drugs can provide tissue-specific activity.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"235-237"},"PeriodicalIF":122.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics opens new route to degrader discovery
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-26 DOI: 10.1038/d41573-025-00040-y
Alex Eccleston
{"title":"Genetics opens new route to degrader discovery","authors":"Alex Eccleston","doi":"10.1038/d41573-025-00040-y","DOIUrl":"10.1038/d41573-025-00040-y","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"248-248"},"PeriodicalIF":122.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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