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Nature Reviews. Drug Discovery最新文献

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FDA approves L-amino acid decarboxylase deficiency gene therapy. 美国食品和药物管理局批准 L-氨基酸脱羧酶缺乏症基因疗法。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-15 DOI: 10.1038/d41573-024-00184-3
Asher Mullard
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引用次数: 0
Benchmarking recruitment rates for phase III trials 第三阶段试验的招募率基准
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-08 DOI: 10.1038/d41573-024-00183-4
Subha B. Basu
{"title":"Benchmarking recruitment rates for phase III trials","authors":"Subha B. Basu","doi":"10.1038/d41573-024-00183-4","DOIUrl":"10.1038/d41573-024-00183-4","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"887-888"},"PeriodicalIF":122.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimalarial drug hits cardiac fibrosis 抗疟药物治疗心脏纤维化
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-05 DOI: 10.1038/d41573-024-00182-5
M. Teresa Villanueva
{"title":"Antimalarial drug hits cardiac fibrosis","authors":"M. Teresa Villanueva","doi":"10.1038/d41573-024-00182-5","DOIUrl":"10.1038/d41573-024-00182-5","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"893-893"},"PeriodicalIF":122.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAK inhibition combats adverse skin reaction 抑制 JAK 可消除皮肤不良反应
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-05 DOI: 10.1038/d41573-024-00181-6
Sarah Crunkhorn
{"title":"JAK inhibition combats adverse skin reaction","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00181-6","DOIUrl":"10.1038/d41573-024-00181-6","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"897-897"},"PeriodicalIF":122.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lundbeck pays US$2.6 billion for Longboard and its lead epilepsy drug 灵北斥资 26 亿美元收购 Longboard 及其主要癫痫药物
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-05 DOI: 10.1038/d41573-024-00178-1
Asher Mullard
{"title":"Lundbeck pays US$2.6 billion for Longboard and its lead epilepsy drug","authors":"Asher Mullard","doi":"10.1038/d41573-024-00178-1","DOIUrl":"10.1038/d41573-024-00178-1","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"885-885"},"PeriodicalIF":122.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bivalent molecules unmute silenced genes 双价分子能解除沉默基因的哑音
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-01 DOI: 10.1038/d41573-024-00179-0
Alex Eccleston
{"title":"Bivalent molecules unmute silenced genes","authors":"Alex Eccleston","doi":"10.1038/d41573-024-00179-0","DOIUrl":"10.1038/d41573-024-00179-0","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"896-896"},"PeriodicalIF":122.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How GLP-1 went from being a hard-to-handle hormone to a blockbuster success GLP-1 如何从一种难以驾驭的激素变成成功的大片
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-01 DOI: 10.1038/d41573-024-00177-2
Asher Mullard
{"title":"How GLP-1 went from being a hard-to-handle hormone to a blockbuster success","authors":"Asher Mullard","doi":"10.1038/d41573-024-00177-2","DOIUrl":"10.1038/d41573-024-00177-2","url":null,"abstract":"Lotte Bjerre Knudsen, chief scientific advisor in research and early development at Novo Nordisk, discusses the past and future of GLP-1s and related anti-obesity drugs. Lotte Bjerre Knudsen, chief scientific advisor in research and early development at Novo Nordisk, discusses the past and future of GLP-1s and related anti-obesity drugs.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"889-890"},"PeriodicalIF":122.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-tau antibody stumbles in phase II Alzheimer trial 抗 tau 抗体在阿尔茨海默症二期试验中磕磕绊绊
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-01 DOI: 10.1038/d41573-024-00180-7
Asher Mullard
{"title":"Anti-tau antibody stumbles in phase II Alzheimer trial","authors":"Asher Mullard","doi":"10.1038/d41573-024-00180-7","DOIUrl":"10.1038/d41573-024-00180-7","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"883-883"},"PeriodicalIF":122.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves PI3Kα inhibitor that does double duty as a degrader 美国 FDA 批准兼具降解作用的 PI3Kα 抑制剂
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-10-30 DOI: 10.1038/d41573-024-00176-3
Asher Mullard
{"title":"FDA approves PI3Kα inhibitor that does double duty as a degrader","authors":"Asher Mullard","doi":"10.1038/d41573-024-00176-3","DOIUrl":"10.1038/d41573-024-00176-3","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"885-885"},"PeriodicalIF":122.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multivalent vaccine tackles C. difficile 应对艰难梭菌的多价疫苗
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-10-30 DOI: 10.1038/d41573-024-00174-5
Katie Kingwell
{"title":"Multivalent vaccine tackles C. difficile","authors":"Katie Kingwell","doi":"10.1038/d41573-024-00174-5","DOIUrl":"10.1038/d41573-024-00174-5","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 12","pages":"895-895"},"PeriodicalIF":122.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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