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Nature Reviews. Drug Discovery最新文献

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NaV1.8 inhibitor poised to provide opioid-free pain relief NaV1.8抑制剂有望提供无阿片类药物疼痛缓解
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-12-12 DOI: 10.1038/d41573-024-00203-3
Katie Kingwell
{"title":"NaV1.8 inhibitor poised to provide opioid-free pain relief","authors":"Katie Kingwell","doi":"10.1038/d41573-024-00203-3","DOIUrl":"10.1038/d41573-024-00203-3","url":null,"abstract":"Vertex’s first-in-class suzetrigine could soon usher in a new class of analgesic. Vertex’s first-in-class suzetrigine could soon usher in a new class of analgesic.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"3-5"},"PeriodicalIF":122.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upcoming FDA approval decisions in Q1 2025 FDA将于2025年第一季度做出批准决定
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-12-11 DOI: 10.1038/d41573-024-00202-4
Kaniaw Dilzer
{"title":"Upcoming FDA approval decisions in Q1 2025","authors":"Kaniaw Dilzer","doi":"10.1038/d41573-024-00202-4","DOIUrl":"10.1038/d41573-024-00202-4","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"9-9"},"PeriodicalIF":122.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Top product forecasts for 2025 2025年的顶级产品预测
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-12-10 DOI: 10.1038/d41573-024-00199-w
Paul Verdin
{"title":"Top product forecasts for 2025","authors":"Paul Verdin","doi":"10.1038/d41573-024-00199-w","DOIUrl":"10.1038/d41573-024-00199-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"8-8"},"PeriodicalIF":122.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can non-canonical amino acids open up non-canonical drug discovery opportunities? 非规范氨基酸能打开非规范药物发现的机会吗？
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-12-09 DOI: 10.1038/d41573-024-00201-5
Asher Mullard
{"title":"Can non-canonical amino acids open up non-canonical drug discovery opportunities?","authors":"Asher Mullard","doi":"10.1038/d41573-024-00201-5","DOIUrl":"10.1038/d41573-024-00201-5","url":null,"abstract":"Jason Chin, head of Cambridge’s Centre for Chemical & Synthetic Biology and CSO of Constructive Bio, discusses the role for unnatural amino acids in biologic therapies. Jason Chin, head of Cambridge’s Centre for Chemical & Synthetic Biology and CSO of Constructive Bio, discusses the role for unnatural amino acids in biologic therapies.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"10-11"},"PeriodicalIF":122.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Showing tau the exit 显示出口
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-12-05 DOI: 10.1038/d41573-024-00200-6
M. Teresa Villanueva
{"title":"Showing tau the exit","authors":"M. Teresa Villanueva","doi":"10.1038/d41573-024-00200-6","DOIUrl":"10.1038/d41573-024-00200-6","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"16-16"},"PeriodicalIF":122.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142777214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covalent inhibitor engages oncogenic AKT kinase 共价抑制剂参与致癌AKT激酶
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-12-03 DOI: 10.1038/d41573-024-00197-y
Alex Eccleston
{"title":"Covalent inhibitor engages oncogenic AKT kinase","authors":"Alex Eccleston","doi":"10.1038/d41573-024-00197-y","DOIUrl":"10.1038/d41573-024-00197-y","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"16-16"},"PeriodicalIF":122.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves first menin inhibitor, for acute leukaemia FDA批准首个治疗急性白血病的menin抑制剂
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-12-03 DOI: 10.1038/d41573-024-00198-x
Asher Mullard
{"title":"FDA approves first menin inhibitor, for acute leukaemia","authors":"Asher Mullard","doi":"10.1038/d41573-024-00198-x","DOIUrl":"10.1038/d41573-024-00198-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"7-7"},"PeriodicalIF":122.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-TACs target solid tumours 针对实体瘤的 Multi-TACs
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-27 DOI: 10.1038/d41573-024-00193-2
Sarah Crunkhorn
{"title":"Multi-TACs target solid tumours","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00193-2","DOIUrl":"10.1038/d41573-024-00193-2","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"17-17"},"PeriodicalIF":122.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding cholestatic itch 了解胆汁淤积性瘙痒
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-27 DOI: 10.1038/d41573-024-00191-4
Sarah Crunkhorn
{"title":"Understanding cholestatic itch","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00191-4","DOIUrl":"10.1038/d41573-024-00191-4","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"17-17"},"PeriodicalIF":122.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ENGases to treat IgG-mediated diseases 治疗 IgG 媒介疾病的 ENGases
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-11-27 DOI: 10.1038/d41573-024-00190-5
Sarah Crunkhorn
{"title":"ENGases to treat IgG-mediated diseases","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00190-5","DOIUrl":"10.1038/d41573-024-00190-5","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 1","pages":"17-17"},"PeriodicalIF":122.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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