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Nature Reviews. Drug Discovery最新文献

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Can large, simple trials bring drug developers back to common diseases?
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-18 DOI: 10.1038/d41573-025-00030-0
Asher Mullard
{"title":"Can large, simple trials bring drug developers back to common diseases?","authors":"Asher Mullard","doi":"10.1038/d41573-025-00030-0","DOIUrl":"10.1038/d41573-025-00030-0","url":null,"abstract":"Clinical trials for common diseases can be done much more cheaply, says Martin Landray, a physician and epidemiologist at Oxford University and CEO of Protas, a non-profit clinical trial organization. Clinical trials for common diseases can be done much more cheaply, says Martin Landray, a physician and epidemiologist at Oxford University and CEO of Protas, a non-profit clinical trial organization.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"162-163"},"PeriodicalIF":122.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/d41573-025-00030-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First muscle-growing antibody heads to the FDA, with obesity opportunities on the horizon 首款肌肉生长抗体即将提交美国食品药品管理局，肥胖症治疗机会近在眼前
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-17 DOI: 10.1038/d41573-025-00029-7
Ken Garber
{"title":"First muscle-growing antibody heads to the FDA, with obesity opportunities on the horizon","authors":"Ken Garber","doi":"10.1038/d41573-025-00029-7","DOIUrl":"10.1038/d41573-025-00029-7","url":null,"abstract":"Scholar Rock’s myostatin blocker has shown its efficacy in spinal muscular atrophy, and the 28-year-old myostatin field is now looking to muscle in on obesity. Scholar Rock’s myostatin blocker has shown its efficacy in spinal muscular atrophy, and the 28-year-old myostatin field is now looking to muscle in on obesity.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"155-157"},"PeriodicalIF":122.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approvals by the China NMPA in 2024
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-14 DOI: 10.1038/d41573-025-00028-8
Xiecheng Zhi,  Qiu Li,  Liming Shao
{"title":"Approvals by the China NMPA in 2024","authors":"Xiecheng Zhi, \u0000 Qiu Li, \u0000 Liming Shao","doi":"10.1038/d41573-025-00028-8","DOIUrl":"10.1038/d41573-025-00028-8","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"160-161"},"PeriodicalIF":122.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves TROP2-targeted antibody–drug conjugate for breast cancer
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-10 DOI: 10.1038/d41573-025-00027-9
Asher Mullard
{"title":"FDA approves TROP2-targeted antibody–drug conjugate for breast cancer","authors":"Asher Mullard","doi":"10.1038/d41573-025-00027-9","DOIUrl":"10.1038/d41573-025-00027-9","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"159-159"},"PeriodicalIF":122.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Directing autophagy to degrade cell surface receptors
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-10 DOI: 10.1038/d41573-025-00026-w
M. Teresa Villanueva
{"title":"Directing autophagy to degrade cell surface receptors","authors":"M. Teresa Villanueva","doi":"10.1038/d41573-025-00026-w","DOIUrl":"10.1038/d41573-025-00026-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"169-169"},"PeriodicalIF":122.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designer proteins take the bite out of snake venom
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-06 DOI: 10.1038/d41573-025-00025-x
Katie Kingwell
{"title":"Designer proteins take the bite out of snake venom","authors":"Katie Kingwell","doi":"10.1038/d41573-025-00025-x","DOIUrl":"10.1038/d41573-025-00025-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"167-167"},"PeriodicalIF":122.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide blocks phase separation and oncogenic transcription
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-05 DOI: 10.1038/d41573-025-00023-z
Alex Eccleston
{"title":"Peptide blocks phase separation and oncogenic transcription","authors":"Alex Eccleston","doi":"10.1038/d41573-025-00023-z","DOIUrl":"10.1038/d41573-025-00023-z","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"168-168"},"PeriodicalIF":122.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PKC modulator promotes remyelination
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-03 DOI: 10.1038/d41573-025-00020-2
Sarah Crunkhorn
{"title":"PKC modulator promotes remyelination","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00020-2","DOIUrl":"10.1038/d41573-025-00020-2","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"170-170"},"PeriodicalIF":122.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New target to tackle coronaviruses
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-02-03 DOI: 10.1038/d41573-025-00021-1
Sarah Crunkhorn
{"title":"New target to tackle coronaviruses","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00021-1","DOIUrl":"10.1038/d41573-025-00021-1","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"170-170"},"PeriodicalIF":122.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing proteins targeting neosurfaces 设计针对新表面的蛋白质
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-31 DOI: 10.1038/d41573-025-00019-9
Sarah Crunkhorn
{"title":"Designing proteins targeting neosurfaces","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00019-9","DOIUrl":"10.1038/d41573-025-00019-9","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"170-170"},"PeriodicalIF":122.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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